{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:41:57Z","timestamp":1788838917136,"version":"build-2803163510"},"reference-count":72,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-111-2320-B-001-024-MY3"],"award-info":[{"award-number":["MOST-111-2320-B-001-024-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016004","name":"Institute of Biomedical Sciences, Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ymthe.2023.09.002","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:08:42Z","timestamp":1694286522000},"page":"3322-3336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2397-7868","authenticated-orcid":false,"given":"Cheng-Pu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Wen","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-I","family":"Tsung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Feng","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Jiun","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yee","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Jhe","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ni","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Che","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hui","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Jiun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Che","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Shin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Draczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Chih","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Siou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Cheung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh-Hwa","family":"Kau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Chung","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Te","family":"Danny Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hsuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4307-5729","authenticated-orcid":false,"given":"Mi-Hua","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2023.09.002_bib1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41586-021-04386-2","article-title":"Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift","volume":"602","author":"Cameroni","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cell.2021.12.046","article-title":"SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses","volume":"185","author":"Dejnirattisai","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib3","doi-asserted-by":"crossref","first-page":"eabj5365","DOI":"10.1126\/sciadv.abj5365","article-title":"Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination","volume":"7","author":"Caniels","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2023.09.002_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2021.12.033","article-title":"mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant","volume":"185","author":"Garcia-Beltran","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 Omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib6","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.cell.2022.06.005","article-title":"Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum","volume":"185","author":"Tuekprakhon","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-022-04980-y","article-title":"BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection","volume":"608","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib8","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1038\/s41467-022-32396-9","article-title":"Omicron BA.4\/BA.5 escape neutralizing immunity elicited by BA.1 infection","volume":"13","author":"Khan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2023.09.002_bib9","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S1473-3099(22)00422-4","article-title":"Augmented neutralisation resistance of emerging omicron subvariants BA.2.12.1, BA.4, and BA.5. The Lancet","volume":"22","author":"Arora","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ymthe.2023.09.002_bib10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-022-05053-w","article-title":"Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5","volume":"608","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41591-021-01678-y","article-title":"An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies","volume":"28","author":"VanBlargan","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41586-021-04385-3","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","volume":"602","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2021.12.032","article-title":"The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic","volume":"185","author":"Hoffmann","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-021-04388-0","article-title":"Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2","volume":"602","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib15","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0140-6736(22)00462-7","article-title":"Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study","volume":"399","author":"Nyberg","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2023.09.002_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s40265-020-01258-3","article-title":"Ibalizumab: A Review in Multidrug-Resistant HIV-1 Infection","volume":"80","author":"Blair","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.ymthe.2023.09.002_bib17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJMoa1711460","article-title":"Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1","volume":"379","author":"Emu","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib18","doi-asserted-by":"crossref","first-page":"17411","DOI":"10.3390\/ijms151017411","article-title":"The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature","volume":"15","author":"Xiong","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2023.09.002_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-020-00426-x","article-title":"CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41392-021-00760-8","article-title":"CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma","volume":"6","author":"Geng","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41392-021-00603-6","article-title":"Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial","volume":"6","author":"Bian","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib23","doi-asserted-by":"crossref","first-page":"e12828","DOI":"10.15252\/emmm.202012828","article-title":"Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection","volume":"13","author":"Huang","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41594-021-00652-z","article-title":"Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function","volume":"28","author":"Yang","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib25","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cell.2022.01.001","article-title":"Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2","volume":"185","author":"Han","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib26","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2023.09.002_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib28","doi-asserted-by":"crossref","first-page":"17996","DOI":"10.1074\/jbc.M311191200","article-title":"ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis","volume":"279","author":"Towler","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2023.09.002_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41392-021-00740-y","article-title":"ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104935","article-title":"Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern","author":"Chaouat","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ymthe.2023.09.002_bib31","doi-asserted-by":"crossref","first-page":"eabp9312","DOI":"10.1126\/sciimmunol.abp9312","article-title":"An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern","volume":"7","author":"Du","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib32","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1038\/s41467-021-25331-x","article-title":"A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants","volume":"12","author":"Du","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2023.09.002_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41392-022-00913-3","article-title":"ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants","volume":"7","author":"Ou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41564-023-01389-9","article-title":"Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies","volume":"8","author":"Zhang","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/eji.1830180221","article-title":"The half-lives of serum immunoglobulins in adult mice","volume":"18","author":"Vieira","year":"1988","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib36","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nbt1087","article-title":"Stable antibody expression at therapeutic levels using the 2A peptide","volume":"23","author":"Fang","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nbt.2618","article-title":"Broad protection against influenza infection by vectored immunoprophylaxis in mice","volume":"31","author":"Balazs","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature10660","article-title":"Antibody-based protection against HIV infection by vectored immunoprophylaxis","volume":"481","author":"Balazs","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nm.3471","article-title":"Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission","volume":"20","author":"Balazs","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.immuni.2019.02.005","article-title":"Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression","volume":"50","author":"Martinez-Navio","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2023.09.002_bib41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-med-042921-020956","article-title":"COVID-19: Challenges of Viral Variants","volume":"74","author":"Jacobs","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib42","first-page":"162","article-title":"SARS-CoV-2 variant biology: immune escape, transmission and fitness","volume":"21","author":"Carabelli","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib43","doi-asserted-by":"crossref","first-page":"e822","DOI":"10.1093\/cid\/ciab1041","article-title":"Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients","volume":"75","author":"Lu","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ymthe.2023.09.002_bib44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1056\/NEJMc2119236","article-title":"SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons","volume":"386","author":"R\u00f6ssler","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib45","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1473-3099(22)00129-3","article-title":"Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study","volume":"22","author":"Sheward","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ymthe.2023.09.002_bib46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12929-022-00830-1","article-title":"A booster dose of Delta x Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants","volume":"29","author":"Lee","year":"2022","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.ymthe.2023.09.002_bib47","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.cell.2022.03.038","article-title":"mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron","volume":"185","author":"Gagne","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib48","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.cell.2022.03.037","article-title":"Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice","volume":"185","author":"Ying","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.09.002_bib49","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41591-022-02162-x","article-title":"Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster","volume":"29","author":"Kurhade","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib50","doi-asserted-by":"crossref","first-page":"eabq0839","DOI":"10.1126\/science.abq0839","article-title":"Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models","volume":"377","author":"Cohen","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2023.09.002_bib51","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1038\/s41467-021-24013-y","article-title":"Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2","volume":"12","author":"Higuchi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2023.09.002_bib52","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41589-021-00965-6","article-title":"Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants","volume":"18","author":"Zhang","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib53","doi-asserted-by":"crossref","first-page":"e16109","DOI":"10.15252\/emmm.202216109","article-title":"An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2","volume":"14","author":"Zhang","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib54","doi-asserted-by":"crossref","first-page":"187ra72","DOI":"10.1126\/scitranslmed.3006299","article-title":"Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza","volume":"5","author":"Limberis","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib55","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.omtm.2022.08.003","article-title":"AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge","volume":"26","author":"van Lieshout","year":"2022","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2023.09.002_bib56","doi-asserted-by":"crossref","first-page":"m3862","DOI":"10.1136\/bmj.m3862","article-title":"Virology, transmission, and pathogenesis of SARS-CoV-2","volume":"371","author":"Cevik","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.ymthe.2023.09.002_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.omtm.2018.04.005","article-title":"A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice","volume":"9","author":"van Lieshout","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2023.09.002_bib58","doi-asserted-by":"crossref","first-page":"12993","DOI":"10.1073\/pnas.0601433103","article-title":"Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered","volume":"103","author":"Limberis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2023.09.002_bib59","doi-asserted-by":"crossref","first-page":"e1009544","DOI":"10.1371\/journal.ppat.1009544","article-title":"Intranasal gene therapy to prevent infection by SARS-CoV-2 variants","volume":"17","author":"Sims","year":"2021","journal-title":"Plos Pathog."},{"key":"10.1016\/j.ymthe.2023.09.002_bib60","article-title":"Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis","author":"Rghei","year":"2023","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib61","doi-asserted-by":"crossref","first-page":"108790","DOI":"10.1016\/j.celrep.2021.108790","article-title":"Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2","volume":"34","author":"Gasser","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2023.09.002_bib62","doi-asserted-by":"crossref","first-page":"eabd2223","DOI":"10.1126\/scitranslmed.abd2223","article-title":"IgA dominates the early neutralizing antibody response to SARS-CoV-2","volume":"13","author":"Sterlin","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib63","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aaz5807","article-title":"Structure of the secretory immunoglobulin A core","volume":"367","author":"Kumar","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2023.09.002_bib64","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.aaz5425","article-title":"Structural insights into immunoglobulin M","volume":"367","author":"Li","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2023.09.002_bib65","doi-asserted-by":"crossref","first-page":"eabf1555","DOI":"10.1126\/scitranslmed.abf1555","article-title":"Enhanced SARS-CoV-2 neutralization by dimeric IgA","volume":"13","author":"Wang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2023.09.002_bib66","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1038\/s41467-020-18058-8","article-title":"A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction","volume":"11","author":"Ejemel","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2023.09.002_bib67","doi-asserted-by":"crossref","first-page":"839433","DOI":"10.3389\/fimmu.2022.839433","article-title":"Mind the \"Vaccine Fatigue\"","volume":"13","author":"Su","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2023.09.002_bib68","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/d41586-022-00495-8","article-title":"COVID-19: talk of 'vaccine hesitancy' lets governments off the hook","volume":"602","author":"Attwell","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2023.09.002_bib69","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/mt.2008.245","article-title":"Comparative study of anti-hepatitis B virus RNA interference by double-stranded adeno-associated virus serotypes 7, 8, and 9","volume":"17","author":"Chen","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2023.09.002_bib70","doi-asserted-by":"crossref","first-page":"e1009758","DOI":"10.1371\/journal.ppat.1009758","article-title":"Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19","volume":"17","author":"Sun","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ymthe.2023.09.002_bib71","doi-asserted-by":"crossref","first-page":"e123158","DOI":"10.1172\/jci.insight.123158","article-title":"Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection","volume":"4","author":"Liu","year":"2019","journal-title":"JCI insight"},{"key":"10.1016\/j.ymthe.2023.09.002_bib72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cell.2020.05.027","article-title":"Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2","volume":"182","author":"Jiang","year":"2020","journal-title":"Cell"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001623004902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001623004902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:11:05Z","timestamp":1761502265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001623004902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":72,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1525001623004902"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2023.09.002","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2023.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}]}}