{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:39:40Z","timestamp":1767850780327,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC016295"],"award-info":[{"award-number":["R01DC016295"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ymthe.2023.10.017","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:12:06Z","timestamp":1697775126000},"page":"3490-3501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dual AAV-based PCDH15 gene therapy achieves sustained rescue of visual function in a mouse model of Usher syndrome 1F"],"prefix":"10.1016","volume":"31","author":[{"given":"Sehar","family":"Riaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumil","family":"Sethna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad A.","family":"Naeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Michael","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh","family":"Riazuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saima","family":"Riazuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia S.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-4502","authenticated-orcid":false,"given":"Zubair M.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2023.10.017_bib1","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/hmg\/ddg358","article-title":"PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23","volume":"12","author":"Ahmed","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymthe.2023.10.017_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ajmg.1320500107","article-title":"Clinical diagnosis of the Usher syndromes. Usher Syndrome Consortium","volume":"50","author":"Smith","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ymthe.2023.10.017_bib3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/bjo.67.7.449","article-title":"A genetic analysis of retinitis pigmentosa","volume":"67","author":"Boughman","year":"1983","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1203\/01.PDR.0000125258.58267.56","article-title":"The R245X mutation of PCDH15 in Ashkenazi Jewish children diagnosed with nonsyndromic hearing loss foreshadows retinitis pigmentosa","volume":"55","author":"Brownstein","year":"2004","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ymthe.2023.10.017_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1044\/jshr.1203.541","article-title":"Sociological and psychological factors associated with hearing loss","volume":"12","author":"Vernon","year":"1969","journal-title":"J.\u00a0Speech Hear. Res."},{"key":"10.1016\/j.ymthe.2023.10.017_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/GIM.0b013e3181e5afb8","article-title":"Frequency of Usher syndrome in two pediatric populations: Implications for genetic screening of deaf and hard of hearing children","volume":"12","author":"Kimberling","year":"2010","journal-title":"Genet. Med."},{"key":"10.1016\/j.ymthe.2023.10.017_bib7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/01.mlg.0000205167.08415.9e","article-title":"Audiologic performance and benefit of cochlear implantation in Usher syndrome type I","volume":"116","author":"Pennings","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ymthe.2023.10.017_bib8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00439-022-02448-7","article-title":"The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification","volume":"141","author":"Delmaghani","year":"2022","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ymthe.2023.10.017_bib9","doi-asserted-by":"crossref","first-page":"737632","DOI":"10.3389\/fgeed.2021.737632","article-title":"Progress in Gene Editing Tools and Their Potential for Correcting Mutations Underlying Hearing and Vision Loss","volume":"3","author":"Botto","year":"2021","journal-title":"Front. Genome Ed."},{"key":"10.1016\/j.ymthe.2023.10.017_bib10","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1056\/NEJMoa021502","article-title":"A mutation of PCDH15 among Ashkenazi Jews with the type 1\u00a0Usher syndrome","volume":"348","author":"Ben-Yosef","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2023.10.017_bib11","doi-asserted-by":"crossref","first-page":"e67361","DOI":"10.7554\/eLife.67361","article-title":"Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome","volume":"10","author":"Sethna","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ymthe.2023.10.017_bib12","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/hmg\/10.16.1709","article-title":"Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F","volume":"10","author":"Alagramam","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymthe.2023.10.017_bib13","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1083\/jcb.201612030","article-title":"Usher syndrome type 1-associated cadherins shape the photoreceptor outer segment","volume":"216","author":"Schietroma","year":"2017","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.201202012","article-title":"Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice","volume":"199","author":"Sahly","year":"2012","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib15","doi-asserted-by":"crossref","first-page":"dmm048965","DOI":"10.1242\/dmm.048965","article-title":"Usher syndrome type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish","volume":"14","author":"Miles","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ymthe.2023.10.017_bib16","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1093\/hmg\/ddi417","article-title":"Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2","volume":"14","author":"Reiners","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymthe.2023.10.017_bib17","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1167\/iovs.06-0108","article-title":"Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts","volume":"47","author":"Haywood-Watson","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2023.10.017_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2023.10.017_bib19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molmed.2018.06.006","article-title":"Seeing the Light after 25 Years of Retinal Gene Therapy","volume":"24","author":"Trapani","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ymthe.2023.10.017_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-7522-8_11","article-title":"Dual AAV Vectors for Stargardt Disease","volume":"1715","author":"Trapani","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1517\/21678707.2015.1039511","article-title":"Recombinant adeno-associated virus vectors in the treatment of rare diseases","volume":"3","author":"Hastie","year":"2015","journal-title":"Expert Opin. Orphan Drugs"},{"key":"10.1016\/j.ymthe.2023.10.017_bib22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/13816810.2018.1533027","article-title":"Gene therapy for RPE65-related retinal disease","volume":"39","author":"Miraldi Utz","year":"2018","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.ymthe.2023.10.017_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fnins.2017.00503","article-title":"Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting","volume":"11","author":"Carvalho","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ymthe.2023.10.017_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/hum.2010.122","article-title":"Efficient transgene reconstitution with hybrid dual AAV vectors carrying the minimized bridging sequences","volume":"22","author":"Ghosh","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2023.10.017_bib25","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1089\/hum.2017.154","article-title":"Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In\u00a0Vivo","volume":"29","author":"Carvalho","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2023.10.017_bib26","doi-asserted-by":"crossref","first-page":"e53463","DOI":"10.1371\/journal.pone.0053463","article-title":"AAV9 targets cone photoreceptors in the nonhuman primate retina","volume":"8","author":"Vandenberghe","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2023.10.017_bib27","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1523\/JNEUROSCI.1163-06.2006","article-title":"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15","volume":"26","author":"Ahmed","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2023.10.017_bib28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/humu.23706","article-title":"Aberrant RNA splicing is the major pathogenic effect in a knock-in mouse model of the dominantly inherited c.1430A>G human RPE65 mutation","volume":"40","author":"Li","year":"2019","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ymthe.2023.10.017_bib29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1146\/annurev.neuro.24.1.779","article-title":"Activation, deactivation, and adaptation in vertebrate photoreceptor cells","volume":"24","author":"Burns","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2023.10.017_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0896-6273(02)00937-6","article-title":"Like night and day: rods and cones have different pigment regeneration pathways","volume":"36","author":"Arshavsky","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2023.10.017_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.physiol.64.082701.102229","article-title":"G proteins and phototransduction","volume":"64","author":"Arshavsky","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib32","first-page":"1662","article-title":"Molecular epidemiology of Usher syndrome in Italy","volume":"17","author":"Vozzi","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ymthe.2023.10.017_bib33","doi-asserted-by":"crossref","first-page":"eaav4523","DOI":"10.1126\/scitranslmed.aav4523","article-title":"Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina","volume":"11","author":"Tornabene","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2023.10.017_bib34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/IIO.0000000000000361","article-title":"Viral Vector Technologies and Strategies: Improving on Nature","volume":"61","author":"Croze","year":"2021","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.ymthe.2023.10.017_bib35","doi-asserted-by":"crossref","first-page":"189ra76","DOI":"10.1126\/scitranslmed.3005708","article-title":"In\u00a0vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous","volume":"5","author":"Dalkara","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2023.10.017_bib36","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1002\/bit.26031","article-title":"Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8","volume":"113","author":"Khabou","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymthe.2023.10.017_bib37","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/hum.2016.111","article-title":"Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina","volume":"28","author":"Ramachandran","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2023.10.017_bib38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1167\/tvst.8.2.14","article-title":"Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy","volume":"8","author":"Lee","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib39","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1089\/hum.2022.159","article-title":"Update on Viral Gene Therapy Clinical Trials for Retinal Diseases","volume":"33","author":"Cheng","year":"2022","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2023.10.017_bib40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(17)31868-8","article-title":"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial","volume":"390","author":"Russell","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2023.10.017_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/mthe.2001.0456","article-title":"Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison","volume":"4","author":"Duan","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2023.10.017_bib42","first-page":"29","article-title":"Dual vector expansion of the recombinant AAV packaging capacity","volume":"219","author":"Duan","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib43","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/sj.mt.6300322","article-title":"A hybrid vector system expands adeno-associated viral vector packaging capacity in a transgene-independent manner","volume":"16","author":"Ghosh","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2023.10.017_bib44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0076-6879(02)46065-X","article-title":"Recombinant AAV-mediated gene delivery using dual vector heterodimerization","volume":"346","author":"Yan","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib45","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1073\/pnas.97.12.6716","article-title":"Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy","volume":"97","author":"Yan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2023.10.017_bib46","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.3390\/ijms21124197","article-title":"Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays","volume":"21","author":"Buck","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2023.10.017_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.omtm.2018.11.008","article-title":"Adeno-Associated Viral Vector 2 and 9 Transduction Is Enhanced in Streptozotocin-Induced Diabetic Mouse Retina","volume":"13","author":"Lee","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2023.10.017_bib48","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.celrep.2015.07.019","article-title":"In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector","volume":"12","author":"Zinn","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2023.10.017_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.omtn.2022.12.007","article-title":"Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model","volume":"31","author":"Hsu","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ymthe.2023.10.017_bib50","doi-asserted-by":"crossref","first-page":"e0182473","DOI":"10.1371\/journal.pone.0182473","article-title":"Single stranded adeno-associated virus achieves efficient gene transfer to anterior segment in the mouse eye","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2023.10.017_bib51","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1038\/s41467-021-24056-1","article-title":"CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function","volume":"12","author":"Sethna","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2023.10.017_bib52","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.15-18920","article-title":"Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography","volume":"57","author":"Zeng","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2023.10.017_bib53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0076-6879(00)16731-X","article-title":"High-performance liquid chromatography analysis of visual cycle retinoids","volume":"316","author":"Garwin","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-62703-080-9_17","article-title":"Analysis of photoreceptor rod outer segment phagocytosis by RPE cells in situ","volume":"935","author":"Sethna","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2023.10.017_bib55","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1074\/jbc.M115.687004","article-title":"Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision","volume":"291","author":"Sethna","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2023.10.017_bib56","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2023.10.017_bib57","first-page":"e47","article-title":"High-contrast enzymatic immunohistochemistry of pigmented tissues","volume":"3","author":"Duncan","year":"2016","journal-title":"J.\u00a0Biol. Methods"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001623005580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001623005580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:10:08Z","timestamp":1761502208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001623005580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1525001623005580"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2023.10.017","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual AAV-based PCDH15 gene therapy achieves sustained rescue of visual function in a mouse model of Usher syndrome 1F","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2023.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023","name":"copyright","label":"Copyright"}]}}