{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:08:17Z","timestamp":1790741297077,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/X004597\/1"],"award-info":[{"award-number":["MR\/X004597\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013121","name":"Fondation Voir et Entendre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013121","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["469177153"],"award-info":[{"award-number":["469177153"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["VO 2138\/7-1"],"award-info":[{"award-number":["VO 2138\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["665807"],"award-info":[{"award-number":["665807"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000262","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","award":["PPA-0922-0840-INSERM"],"award-info":[{"award-number":["PPA-0922-0840-INSERM"]}],"id":[{"id":"10.13039\/501100000262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019671","name":"Fondation Pour l'Audition","doi-asserted-by":"publisher","award":["FPA-19-Stg"],"award-info":[{"award-number":["FPA-19-Stg"]}],"id":[{"id":"10.13039\/100019671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-RHUS-0001"],"award-info":[{"award-number":["ANR-15-RHUS-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-CE16-0017"],"award-info":[{"award-number":["ANR-17-CE16-0017"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-ENM3-0003-04"],"award-info":[{"award-number":["ANR-21-ENM3-0003-04"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ymthe.2024.01.021","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:09:43Z","timestamp":1705579783000},"page":"800-817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss"],"prefix":"10.1016","volume":"32","author":[{"given":"Clara","family":"Mendia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Peineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Felgerolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Yahiaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Christophersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Papal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Maudoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Maroofian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Patni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Nouaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bowl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Delmaghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Galehdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Vitry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"El-Amraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.01.021_bib1","article-title":"Inner Ear Gene Therapies Take Off: Current Promises and Future Challenges","volume":"9","author":"Delmaghani","year":"2020","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/14992027.2021.1883197","article-title":"Estimating the global costs of hearing loss","volume":"60","author":"McDaid","year":"2021","journal-title":"Int. J. Audiol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-genom-121321-094136","article-title":"The Genomics of Auditory Function and Disease","volume":"23","author":"Taiber","year":"2022","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2024.01.021_bib5","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215798","article-title":"Is there an unmet medical need for improved hearing restoration?","volume":"14","author":"Wolf","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10162-021-00811-5","article-title":"Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update","volume":"22","author":"Carlyon","year":"2021","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107947","article-title":"Adeno-associated virus gene replacement for recessive inner ear dysfunction: Progress and challenges","volume":"394","author":"Askew","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.ymthe.2024.01.021_bib8","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1073\/pnas.1708894114","article-title":"Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G","volume":"114","author":"Emptoz","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.01.021_bib9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ymthe.2017.01.007","article-title":"Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome","volume":"25","author":"Isgrig","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2024.01.021_bib10","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1172\/JCI94351","article-title":"Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome","volume":"128","author":"Dulon","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2024.01.021_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtm.2018.11.003","article-title":"Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate","volume":"13","author":"Gy\u00f6rgy","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2024.01.021_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013259","article-title":"Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness","volume":"13","author":"Taiber","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ymthe.2020.11.016","article-title":"Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice","volume":"29","author":"Wu","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2024.01.021_bib14","doi-asserted-by":"crossref","first-page":"295ra108","DOI":"10.1126\/scitranslmed.aab1996","article-title":"Tmc gene therapy restores auditory function in deaf mice","volume":"7","author":"Askew","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910288","article-title":"Clarin-2 is essential for hearing by maintaining stereocilia integrity and function","volume":"11","author":"Dunbar","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00439-020-02254-z","article-title":"A biallelic variant in CLRN2 causes non-syndromic hearing loss in humans","volume":"140","author":"Vona","year":"2021","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib17","doi-asserted-by":"crossref","first-page":"9485","DOI":"10.1523\/JNEUROSCI.0311-12.2012","article-title":"The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene","volume":"32","author":"Geng","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.01.021_bib18","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ajhg.2019.09.008","article-title":"GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank","volume":"105","author":"Wells","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.24661","article-title":"Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells","volume":"6","author":"V\u00e9lez-Ortega","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.ymthe.2024.01.021_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nbt.3440","article-title":"Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain","volume":"34","author":"Deverman","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107882","article-title":"Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP","volume":"394","author":"Lee","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.ymthe.2024.01.021_bib22","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nn.4593","article-title":"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems","volume":"20","author":"Chan","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2024.01.021_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/biom12070914","article-title":"Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7\/11","volume":"12","author":"Marcovich","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ymthe.2024.01.021_bib24","article-title":"Distributional comparison of different AAV vectors after unilateral cochlear administration","author":"Han","year":"2023","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymthe.2024.01.021_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107930","article-title":"Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea","volume":"394","author":"Ivanchenko","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.ymthe.2024.01.021_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2013.01.005","article-title":"A historical to present-day account of efforts to answer the question: \"what puts the brakes on mammalian hair cell regeneration?\"","volume":"297","author":"Burns","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.ymthe.2024.01.021_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.816534","article-title":"Vestibular deficits in deafness: clinical presentation, animal modeling and treatment solutions","volume":"13","author":"Maudoux","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature10745","article-title":"Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.01.021_bib29","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1038\/ncomms7873","article-title":"Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear","volume":"6","author":"Drummond","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.01.021_bib30","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1038\/ncomms7855","article-title":"Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins","volume":"6","author":"Narayanan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.01.021_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.cb.08.110192.001353","article-title":"Actin filaments, stereocilia, and hair cells: how cells count and measure","volume":"8","author":"Tilney","year":"1992","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.semcdb.2016.08.017","article-title":"Stereocilia morphogenesis and maintenance through regulation of actin stability","volume":"65","author":"McGrath","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.heares.2018.12.012","article-title":"Building and repairing the stereocilia cytoskeleton in mammalian auditory hair cells","volume":"376","author":"V\u00e9lez-Ortega","year":"2019","journal-title":"Hear. Res."},{"key":"10.1016\/j.ymthe.2024.01.021_bib34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.tins.2019.03.006","article-title":"Mechanisms of Hair Cell Damage and Repair","volume":"42","author":"Wagner","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ymthe.2024.01.021_bib35","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033209","article-title":"Molecular Composition of Vestibular Hair Bundles","volume":"9","author":"Krey","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib36","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/sj.jp.7200439","article-title":"Development of the ear and hearing","volume":"20","author":"Hall","year":"2000","journal-title":"J.\u00a0Perinatol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib37","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1242\/dev.012922","article-title":"A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth","volume":"135","author":"Lef\u00e8vre","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ymthe.2024.01.021_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107932","article-title":"Disease mechanisms and gene therapy for Usher syndrome","volume":"394","author":"G\u00e9l\u00e9oc","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.ymthe.2024.01.021_bib39","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00439-022-02448-7","article-title":"The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification","volume":"141","author":"Delmaghani","year":"2022","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib40","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/jmg.40.10.767","article-title":"Genetic homogeneity and phenotypic variability among Ashkenazi Jews with Usher syndrome type III","volume":"40","author":"Ness","year":"2003","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib41","first-page":"p52","article-title":"Rabbit Models of USH3A Have Progressive Hearing Loss. 45th Association for Research in Otolaryngology (ARO)","volume":"PD13","author":"Yang","year":"2022","journal-title":"Abst."},{"key":"10.1016\/j.ymthe.2024.01.021_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009025","article-title":"Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty","volume":"16","author":"Kalra","year":"2020","journal-title":"Plos Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib43","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s42003-021-02224-9","article-title":"The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis","volume":"4","author":"Ivarsdottir","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ymthe.2024.01.021_bib44","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.ajhg.2022.04.010","article-title":"Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss","volume":"109","author":"Trpchevska","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymthe.2024.01.021_bib45","doi-asserted-by":"crossref","first-page":"31278","DOI":"10.1073\/pnas.2010782117","article-title":"Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis","volume":"117","author":"Boucher","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.01.021_bib46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13073-016-0273-4","article-title":"Correction of the auditory phenotype in C57BL\/6N mice via CRISPR\/Cas9-mediated homology directed repair","volume":"8","author":"Miann\u00e9","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.ymthe.2024.01.021_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.756449","article-title":"Synaptic Release Potentiation at Aging Auditory Ribbon Synapses","volume":"13","author":"Peineau","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ymthe.2024.01.021_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105628","article-title":"The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses","volume":"25","author":"Calvet","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ymthe.2024.01.021_bib49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41467-020-20584-4","article-title":"AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data","volume":"12","author":"Quinodoz","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624000212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624000212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:06:24Z","timestamp":1778616384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624000212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1525001624000212"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.021","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors.","name":"copyright","label":"Copyright"}]}}