{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:58:39Z","timestamp":1790546319524,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Nationale Contre Le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024037","name":"Institut Cochin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006678","name":"Association Fran\u00e7aise pour l'Etude du Foie","doi-asserted-by":"publisher","award":["AAP 2017"],"award-info":[{"award-number":["AAP 2017"]}],"id":[{"id":"10.13039\/501100006678","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["DLK1-EPILIV 2018\\u20132021"],"award-info":[{"award-number":["DLK1-EPILIV 2018\\u20132021"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["INCa_TRANSLA_2013_209"],"award-info":[{"award-number":["INCa_TRANSLA_2013_209"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche Medicale","doi-asserted-by":"publisher","award":["DBI20131228566"],"award-info":[{"award-number":["DBI20131228566"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ymthe.2024.01.036","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T11:33:08Z","timestamp":1706959988000},"page":"1125-1143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["DLK1\/DIO3 locus upregulation by a \u03b2-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis"],"prefix":"10.1016","volume":"32","author":[{"given":"Julie","family":"Sanceau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Poupel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Joubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lagoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christ\u00e8le","family":"Desbois-Mouthon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Godard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akila","family":"Hamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Montmory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Dulary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Chantalat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Roehrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Muret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Saint-Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Deleuze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Mouillet-Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Forn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe F.","family":"Grosset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Zucman-Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Colnot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Gougelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.01.036_bib1","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1073\/pnas.95.15.8847","article-title":"Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas","volume":"95","author":"de La Coste","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.01.036_bib2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.onc.1203356","article-title":"Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas","volume":"19","author":"Wei","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.ymthe.2024.01.036_bib3","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1158\/2159-8290.CD-20-1809","article-title":"Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer","volume":"11","author":"Hirsch","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ymthe.2024.01.036_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007906","article-title":"TCF\/LEFs and Wnt signaling in the nucleus","volume":"4","author":"Cadigan","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib5","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.26924","article-title":"T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice","volume":"59","author":"Gougelet","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2024.01.036_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/816125","article-title":"A Complex Interplay between Wnt\/beta-Catenin Signalling and the Cell Cycle in the Adult Liver","volume":"2012","author":"Gougelet","year":"2012","journal-title":"Int. J. Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrm2654","article-title":"Beta-catenin hits chromatin: regulation of Wnt target gene activation","volume":"10","author":"Mosimann","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/hep.21467","article-title":"Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets","volume":"45","author":"Boyault","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2024.01.036_bib9","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1038\/s41467-021-25430-9","article-title":"Genetic and epigenetic basis of hepatoblastoma diversity","volume":"12","author":"Nagae","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.01.036_bib10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt\/beta-catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Cancer cell"},{"key":"10.1016\/j.ymthe.2024.01.036_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.tig.2008.03.011","article-title":"Genomic imprinting at the mammalian Dlk1-Dio3 domain","volume":"24","author":"da Rocha","year":"2008","journal-title":"Trends Genet."},{"key":"10.1016\/j.ymthe.2024.01.036_bib12","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1007\/s00018-014-1698-9","article-title":"DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist","volume":"71","author":"Benetatos","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ymthe.2024.01.036_bib13","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.15252\/embj.201387038","article-title":"The miR-379\/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation","volume":"33","author":"Labialle","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2024.01.036_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00018-012-1080-8","article-title":"The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis","volume":"70","author":"Benetatos","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ymthe.2024.01.036_bib15","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/carcin\/bgl215","article-title":"Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma","volume":"28","author":"Huang","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ymthe.2024.01.036_bib16","doi-asserted-by":"crossref","first-page":"30706","DOI":"10.1074\/jbc.M111.229831","article-title":"DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival","volume":"286","author":"Luk","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2024.01.036_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.513601","article-title":"A MicroRNA Cluster in the DLK1-DIO3 Imprinted Region on Chromosome 14q32.2 Is Dysregulated in Metastatic Hepatoblastomas","volume":"10","author":"Honda","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jhep.2020.03.025","article-title":"Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications","volume":"73","author":"Carrillo-Reixach","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.devcel.2006.03.015","article-title":"Apc tumor suppressor gene is the \"zonation-keeper\" of mouse liver","volume":"10","author":"Benhamouche","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ymthe.2024.01.036_bib20","doi-asserted-by":"crossref","first-page":"17216","DOI":"10.1073\/pnas.0404761101","article-title":"Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas","volume":"101","author":"Colnot","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.01.036_bib21","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2014-308969","article-title":"Antitumour activity of an inhibitor of miR-34a in liver cancer with beta-catenin-mutations","volume":"65","author":"Gougelet","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.ymthe.2024.01.036_bib22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1053\/j.gastro.2019.05.069","article-title":"Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography","volume":"157","author":"Gougelet","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ymthe.2024.01.036_bib23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jhep.2022.02.023","article-title":"Deleting the beta-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth","volume":"77","author":"Loesch","year":"2022","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib24","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/hep.32680","article-title":"Hepatocyte beta-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration","volume":"77","author":"Hu","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2024.01.036_bib25","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1002\/hep.26573","article-title":"Hepatocyte nuclear factor-4alpha reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region","volume":"58","author":"Yin","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2024.01.036_bib26","doi-asserted-by":"crossref","first-page":"18612","DOI":"10.1074\/jbc.M801883200","article-title":"Genomic matrix attachment region and chromosome conformation capture quantitative real time PCR assays identify novel putative regulatory elements at the imprinted Dlk1\/Gtl2 locus","volume":"283","author":"Braem","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2024.01.036_bib27","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s13059-019-1896-8","article-title":"CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains","volume":"20","author":"Ll\u00e8res","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib28","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature14299","article-title":"In\u00a0vivo genome editing using Staphylococcus aureus Cas9","volume":"520","author":"Ran","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.01.036_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-407190-2.00016-2","article-title":"FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy","volume":"119","author":"Wierstra","year":"2013","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.ymthe.2024.01.036_bib30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1172\/JCI43937","article-title":"Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice","volume":"122","author":"Anson","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2024.01.036_bib31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/hep4.1029","article-title":"MicroRNA therapy inhibits hepatoblastoma growth in\u00a0vivo by targeting beta-catenin and Wnt signaling","volume":"1","author":"Indersie","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.ymthe.2024.01.036_bib32","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1128\/MCB.00744-08","article-title":"A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression","volume":"28","author":"Yochum","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1073\/pnas.0912294107","article-title":"A beta-catenin\/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers","volume":"107","author":"Yochum","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.01.036_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.devcel.2014.08.009","article-title":"ICR noncoding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain","volume":"31","author":"Kota","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ymthe.2024.01.036_bib35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2015.11.048","article-title":"Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression","volume":"469","author":"Zhu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymthe.2024.01.036_bib36","doi-asserted-by":"crossref","first-page":"344","DOI":"10.15252\/embj.201490464","article-title":"microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis","volume":"34","author":"de Guia","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2024.01.036_bib37","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jhep.2021.04.049","article-title":"Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis","volume":"75","author":"Pinyol","year":"2021","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib38","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/hep.28638","article-title":"Genotype-phenotype correlation of CTNNB1 mutations reveals different ss-catenin activity associated with liver tumor progression","volume":"64","author":"Rebouissou","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2024.01.036_bib39","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/jcp.25175","article-title":"Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells","volume":"231","author":"You","year":"2016","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","article-title":"MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response","volume":"46","author":"Essandoh","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.ymthe.2024.01.036_bib41","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4049\/jimmunol.1402088","article-title":"MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway","volume":"194","author":"Ying","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib42","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/embor.2012.12","article-title":"Cell cycle control of Wnt\/beta-catenin signalling by conductin\/axin2 through CDC20","volume":"13","author":"Hadjihannas","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ymthe.2024.01.036_bib43","article-title":"A Comprehensive Genomic Analysis Constructs miRNA-mRNA Interaction Network in Hepatoblastoma. (2021)","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib44","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.21873\/anticanres.11143","article-title":"Therapeutic Innovations for Targeting Hepatoblastoma","volume":"36","author":"Garnier","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ymthe.2024.01.036_bib45","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1158\/1535-7163.MCT-18-0709","article-title":"The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear beta-Catenin","volume":"18","author":"Shukla","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ymthe.2024.01.036_bib46","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development","volume":"128","author":"Brault","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ymthe.2024.01.036_bib47","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jhep.2010.10.021","article-title":"The transforming growth factor-alpha and cyclin D1 genes are direct targets of beta-catenin signaling in hepatocyte proliferation","volume":"55","author":"Torre","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib48","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/MCB.21.4.1393-1403.2001","article-title":"Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis","volume":"21","author":"Hayhurst","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib49","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/liv.14068","article-title":"The concomitant loss of APC and HNF4alpha in adult hepatocytes does not contribute to hepatocarcinogenesis driven by beta-catenin activation","volume":"39","author":"Sartor","year":"2019","journal-title":"Liver Int."},{"key":"10.1016\/j.ymthe.2024.01.036_bib50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jhep.2012.02.019","article-title":"Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells","volume":"57","author":"Blivet-Van Eggelpo\u00ebl","year":"2012","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib52","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1038\/s41467-018-07552-9","article-title":"Cyclin A2\/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress","volume":"9","author":"Bayard","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.01.036_bib53","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jhep.2019.12.006","article-title":"BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA","volume":"72","author":"Hirsch","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib54","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-2497-5_1","article-title":"Quantitative Chromosome Conformation Capture (3C-qPCR)","volume":"2532","author":"Rebouissou","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib55","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s12864-015-1786-8","article-title":"Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains","volume":"16","author":"Ea","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ymthe.2024.01.036_bib56","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.3646","article-title":"Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution","volume":"48","author":"Corces","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2024.01.036_bib57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.ymthe.2024.01.036_bib58","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nmeth.4396","article-title":"An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues","volume":"14","author":"Corces","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2024.01.036_bib59","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.immuni.2020.06.003","article-title":"Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis","volume":"53","author":"Tran","year":"2020","journal-title":"Immunity"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:47:32Z","timestamp":1778816852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1525001624000376"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.036","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DLK1\/DIO3 locus upregulation by a \u03b2-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s).","name":"copyright","label":"Copyright"}]}}