{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:36:11Z","timestamp":1789875371179,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0800504"],"award-info":[{"award-number":["2018YFA0800504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["R26R-TLR"],"award-info":[{"award-number":["R26R-TLR"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["31922020"],"award-info":[{"award-number":["31922020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["31771645"],"award-info":[{"award-number":["31771645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["32170743"],"award-info":[{"award-number":["32170743"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ymthe.2024.02.024","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T23:21:57Z","timestamp":1708989717000},"page":"2984-2991","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Osr1-mediated mesothelial transition of liver mesenchymal cells exacerbates fibrotic liver damage"],"prefix":"10.1016","volume":"32","author":[{"given":"Xinxin","family":"Nian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-2724","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.02.024_bib1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.ymthe.2024.02.024_bib2","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: A multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.02.024_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101167","article-title":"Imaging biomarkers of NAFLD, NASH, and fibrosis","volume":"50","author":"Ajmera","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.ymthe.2024.02.024_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1570161115666170622074007","article-title":"NAFLD-NASH: An Under-Recognized Epidemic","volume":"16","author":"Jennings","year":"2018","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.02.024_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5152\/tjg.2018.17330","article-title":"Liver fibrosis","volume":"29","author":"Ayd\u0131n","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.ymthe.2024.02.024_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.ymthe.2024.02.024_bib7","first-page":"425","article-title":"Pathogenesis of Liver Fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011"},{"key":"10.1016\/j.ymthe.2024.02.024_bib8","series-title":"Liver Fibrosis Determination","first-page":"281","volume":"48","author":"Lai","year":"2019"},{"key":"10.1016\/j.ymthe.2024.02.024_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12701-9","article-title":"Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1","volume":"10","author":"Kendall","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.02.024_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2024.02.024_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2018.09.026","article-title":"RNA Velocity: Molecular Kinetics from Single-Cell RNA-Seq","volume":"72","author":"Svensson","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2024.02.024_bib12","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1073\/pnas.1214136110","article-title":"Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.02.024_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5009\/gnl15226","article-title":"The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration","volume":"10","author":"Lua","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.ymthe.2024.02.024_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.semcdb.2018.09.003","article-title":"The contributions of mesoderm-derived cells in liver development","volume":"92","author":"Yang","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ymthe.2024.02.024_bib15","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.02.024_bib16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/08916934.2021.1975274","article-title":"OSR1 suppresses acute myeloid leukaemia cell proliferation by inhibiting LGR5-mediated JNK signalling","volume":"54","author":"Zong","year":"2021","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ymthe.2024.02.024_bib17","article-title":"Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis","volume":"11","author":"Xu","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.ymthe.2024.02.024_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212387","article-title":"Osr1 Is Required for Mesenchymal Derivatives That Produce Collagen in the Bladder","volume":"22","author":"Murugapoopathy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2024.02.024_bib19","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jcmgh.2022.12.010","article-title":"Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression","volume":"15","author":"Liu","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ymthe.2024.02.024_bib20","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1053\/j.gastro.2020.03.075","article-title":"Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells","volume":"159","author":"Gupta","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ymthe.2024.02.024_bib21","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0021-9258(17)49927-3","article-title":"Triple-cell lineage tracing by a dual reporter on a single allele","volume":"295","author":"Liu","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2024.02.024_bib22","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cell.2019.04.010","article-title":"Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease","volume":"177","author":"Hern\u00e1ndez-Alvarez","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2024.02.024_bib23","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.02.024_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCRESAHA.118.314028","article-title":"Tissue Resident CCR2-and CCR2+Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury","volume":"124","author":"Bajpai","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2024.02.024_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2015.017","article-title":"High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers","volume":"10","author":"Mederacke","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ymthe.2024.02.024_bib26","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.stemcr.2021.03.032","article-title":"The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells","volume":"16","author":"Wang","year":"2021","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.ymthe.2024.02.024_bib27","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ymthe.2024.02.024_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2024.02.024_bib29","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624000935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624000935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:42:13Z","timestamp":1762548133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624000935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1525001624000935"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.02.024","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osr1-mediated mesothelial transition of liver mesenchymal cells exacerbates fibrotic liver damage","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.02.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}