{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:44:49Z","timestamp":1793083489443,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34590001"],"award-info":[{"award-number":["19CDA34590001"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["916172"],"award-info":[{"award-number":["916172"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08-HL-138269"],"award-info":[{"award-number":["K08-HL-138269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL-153510"],"award-info":[{"award-number":["R01-HL-153510"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL-160694"],"award-info":[{"award-number":["R01-HL-160694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99HL153696"],"award-info":[{"award-number":["K99HL153696"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL143806"],"award-info":[{"award-number":["R01 HL143806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 HL154662-01"],"award-info":[{"award-number":["F31 HL154662-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99"],"award-info":[{"award-number":["K99"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["23PRE1014444"],"award-info":[{"award-number":["23PRE1014444"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL155106"],"award-info":[{"award-number":["R01 HL155106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-AI-166778-01"],"award-info":[{"award-number":["R21-AI-166778-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL128398"],"award-info":[{"award-number":["R01 HL128398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL-157189"],"award-info":[{"award-number":["R01-HL-157189"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ymthe.2024.03.004","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T03:39:03Z","timestamp":1709782743000},"page":"1344-1358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9210-7707","authenticated-orcid":false,"given":"Jia","family":"Nong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Glassman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir V.","family":"Shuvaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahily","family":"Reyes-Esteves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene C.","family":"Descamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa Y.","family":"Kiseleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler E.","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad-Gabriel","family":"Alameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying K.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"Mui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Omo-Lamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco E.","family":"Zamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea","family":"Shuvaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evguenia","family":"Arguiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor V.","family":"Brysgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley G.","family":"Woolfork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aalim","family":"Weljie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph A.","family":"Thaiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob W.","family":"Myerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Kasner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Parhiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir R.","family":"Muzykantov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob S.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar A.","family":"Marcos-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.03.004_bib1","first-page":"3238165","article-title":"Stroke in the 21(st) Century: A Snapshot of the Burden, Epidemiology, and Quality of Life","author":"Donkor","year":"2018","journal-title":"Stroke Res. Treat"},{"key":"10.1016\/j.ymthe.2024.03.004_bib2","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics-2022\u00a0Update: A Report From the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2024.03.004_bib3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging","volume":"378","author":"Albers","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2024.03.004_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"A randomized trial of intraarterial treatment for acute ischemic stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2024.03.004_bib5","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","year":"1995","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2024.03.004_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2024.03.004_bib7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1189\/jlb.0710432","article-title":"Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions","volume":"89","author":"Rossi","year":"2011","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib8","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1161\/01.STR.0000021902.33129.69","article-title":"Inflammatory cell adhesion molecules in ischemic cerebrovascular disease","volume":"33","author":"Frijns","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/01.STR.25.1.202","article-title":"P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion","volume":"25","author":"Okada","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1179\/174313208X341085","article-title":"Cell adhesion molecules and ischemic stroke","volume":"30","author":"Yilmaz","year":"2008","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ymthe.2024.03.004_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-8993(97)01343-7","article-title":"The expression of P- and E-selectins in three models of middle cerebral artery occlusion","volume":"785","author":"Zhang","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ymthe.2024.03.004_bib12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/ana.20741","article-title":"1,026 experimental treatments in acute stroke","volume":"59","author":"O'Collins","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib13","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.ymthe.2024.03.004_bib14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/09687688.2010.521200","article-title":"Receptor-targeted nanocarriers for therapeutic delivery to cancer","volume":"27","author":"Yu","year":"2010","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12975-017-0536-4","article-title":"In\u00a0Vivo Molecular MRI of ICAM-1 Expression on Endothelium and Leukocytes from Subacute to Chronic Stages After Experimental Stroke","volume":"8","author":"Deddens","year":"2017","journal-title":"Transl Stroke Res."},{"key":"10.1016\/j.ymthe.2024.03.004_bib16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/039463200601900320","article-title":"Immunoinflammatory activation during the acute phase of lacunar and non-lacunar ischemic stroke: association with time of onset and diabetic state","volume":"19","author":"Licata","year":"2006","journal-title":"Int. J. Immunopathol Pharmacol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib17","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1161\/STROKEAHA.111.000544","article-title":"Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes","volume":"44","author":"Gauberti","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib18","first-page":"3957","article-title":"Dexmedetomidine pretreatment inhibits cerebral ischemia\/reperfusioninduced neuroinflammation via activation of AMPK","volume":"18","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ymthe.2024.03.004_bib19","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1161\/01.STR.25.9.1794","article-title":"Role of angiogenesis in patients with cerebral ischemic stroke","volume":"25","author":"Krupinski","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/01.STR.0000106479.53235.3E","article-title":"Inhibition of intercellular adhesion molecule-1 protein expression by antisense oligonucleotides is neuroprotective after transient middle cerebral artery occlusion in rat","volume":"35","author":"Vemuganti","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/00004647-200209000-00004","article-title":"Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury","volume":"22","author":"Berti","year":"2002","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ymthe.2024.03.004_bib22","doi-asserted-by":"crossref","first-page":"18170","DOI":"10.1038\/s41598-020-75034-4","article-title":"Characterization of a novel model of global forebrain ischaemia-reperfusion injury in mice and comparison with focal ischaemic and haemorrhagic stroke","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2024.03.004_bib23","doi-asserted-by":"crossref","first-page":"114180","DOI":"10.1016\/j.addr.2022.114180","article-title":"Targeting vascular inflammation through emerging methods and drug carriers","volume":"184","author":"Nong","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ymthe.2024.03.004_bib24","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1073\/pnas.1912012117","article-title":"Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier","volume":"117","author":"Marcos-Contreras","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.03.004_bib25","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1186\/ar3089","article-title":"Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis","volume":"12","author":"Anderson","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ymthe.2024.03.004_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2018.10.015","article-title":"PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake","volume":"291","author":"Parhiz","year":"2018","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.ymthe.2024.03.004_bib27","doi-asserted-by":"crossref","first-page":"13121","DOI":"10.1021\/acsnano.2c08275","article-title":"Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain","volume":"17","author":"Nong","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ymthe.2024.03.004_bib28","doi-asserted-by":"crossref","first-page":"2200106","DOI":"10.1002\/anbr.202200106","article-title":"Mechanisms by Which Liposomes Improve Inhaled Drug Delivery for Alveolar Diseases","volume":"3","author":"Ferguson","year":"2023","journal-title":"Adv. Nanobiomed Res."},{"key":"10.1016\/j.ymthe.2024.03.004_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1208\/s12248-021-00630-9","article-title":"The Nano-War Against Complement Proteins","volume":"23","author":"Wang","year":"2021","journal-title":"AAPS J."},{"key":"10.1016\/j.ymthe.2024.03.004_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1750-3639.2012.00614.x","article-title":"Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models","volume":"23","author":"Zhou","year":"2013","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fncel.2014.00365","article-title":"Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains","volume":"8","author":"Kim","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ymthe.2024.03.004_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1479-5876-7-97","article-title":"Inflammatory mechanisms in ischemic stroke: therapeutic approaches","volume":"7","author":"Lakhan","year":"2009","journal-title":"J.\u00a0Transl Med."},{"key":"10.1016\/j.ymthe.2024.03.004_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00441-013-1762-z","article-title":"Glucocorticoids and endothelial cell barrier function","volume":"355","author":"Salvador","year":"2014","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ymthe.2024.03.004_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-3565(25)21838-9","article-title":"Mechanisms of anti-inflammatory action of dexamethasone: blockade by hydrocortisone mesylate and actinomycin D of the inhibitory effect of dexamethasone on leukocyte infiltration in inflammatory sites","volume":"229","author":"Tsurufuji","year":"1984","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ymthe.2024.03.004_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.omtm.2019.08.010","article-title":"Targeting Adeno-Associated Virus Vectors for Local Delivery to Fractures and Systemic Delivery to the Skeleton","volume":"15","author":"Lee","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2024.03.004_bib36","first-page":"1567","article-title":"Advances in CLARITY-based tissue clearing and imaging","volume":"16","author":"Du","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ymthe.2024.03.004_bib37","first-page":"450","article-title":"Effect of dexamethasone on brain oedema following acute ischemic stroke","volume":"20","author":"Shaikh","year":"2011","journal-title":"Mymensingh Med. J."},{"key":"10.1016\/j.ymthe.2024.03.004_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/01.STR.10.1.68","article-title":"Corticosteroids in ischemic stroke","volume":"10","author":"Anderson","year":"1979","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib39","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1210\/endo.139.4.5917","article-title":"Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice","volume":"139","author":"Meijer","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.ymthe.2024.03.004_bib40","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1172\/JCI118214","article-title":"Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A","volume":"96","author":"Schinkel","year":"1995","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.ymthe.2024.03.004_bib41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2015.08.007","article-title":"Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes","volume":"217","author":"Pardi","year":"2015","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.ymthe.2024.03.004_bib42","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fneur.2017.00244","article-title":"Role of Interleukin-10 in Acute Brain Injuries","volume":"8","author":"Garcia","year":"2017","journal-title":"Front Neurol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12974-021-02316-7","article-title":"Interleukin-10 improves stroke\u00a0outcome by controlling the detrimental Interleukin-17A response","volume":"18","author":"Piepke","year":"2021","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.03.004_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1203\/00006450-200301000-00022","article-title":"Comparison of L-selectin and CD11b on neutrophils of adults and neonates during the first month of life","volume":"53","author":"Kim","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ymthe.2024.03.004_bib45","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1001\/jama.2015.12319","article-title":"Temporal Trends in Mortality in the United States, 1969-2013","volume":"314","author":"Ma","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.ymthe.2024.03.004_bib46","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00401-018-1930-z","article-title":"Post-stroke inflammation-target or tool for therapy?","volume":"137","author":"Lambertsen","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib47","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205786120","article-title":"Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates","volume":"120","author":"Callegari","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.03.004_bib48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5853\/jos.2014.16.3.146","article-title":"Critical care for patients with massive ischemic stroke","volume":"16","author":"Jeon","year":"2014","journal-title":"J.\u00a0Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib49","doi-asserted-by":"crossref","first-page":"eabm4459","DOI":"10.1126\/science.abm4459","article-title":"Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders","volume":"375","author":"Martin","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2024.03.004_bib50","article-title":"Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain","volume":"53658","author":"Posel","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2024.03.004_bib51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5607\/en.2016.25.5.241","article-title":"Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells","volume":"25","author":"Kim","year":"2016","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1742-2094-10-115","article-title":"Leukocyte infiltration in experimental stroke","volume":"10","author":"Gronberg","year":"2013","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.03.004_bib53","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10495-019-01556-6","article-title":"Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins","volume":"24","author":"Uzdensky","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.ymthe.2024.03.004_bib54","series-title":"Goodman\u00a0& Gilman's: The Pharmacological Basis of Therapeutics, 13e","article-title":"Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex","author":"Schimmer","year":"2017"},{"key":"10.1016\/j.ymthe.2024.03.004_bib55","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/01.STR.0000105930.29558.DB","article-title":"Steroids may have a role in stroke therapy","volume":"35","author":"Norris","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib56","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/01.STR.0000105931.81723.26","article-title":"Steroids have no role in stroke therapy","volume":"35","author":"Poungvarin","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.03.004_bib57","doi-asserted-by":"crossref","first-page":"828447","DOI":"10.3389\/fimmu.2022.828447","article-title":"Interleukins and Ischemic Stroke","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib58","doi-asserted-by":"crossref","first-page":"544","DOI":"10.14336\/AD.2018.0820","article-title":"The Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke","volume":"10","author":"Li","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.ymthe.2024.03.004_bib59","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/iub.1429","article-title":"Pre-existing interleukin 10 in cerebral arteries attenuates subsequent brain injury caused by ischemia\/reperfusion","volume":"67","author":"Liang","year":"2015","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ymthe.2024.03.004_bib60","doi-asserted-by":"crossref","DOI":"10.3791\/2423","article-title":"Modeling stroke in mice - middle cerebral artery occlusion with the filament model","author":"Engel","year":"2011","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2024.03.004_bib61","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1021\/acs.bioconjchem.8b00564","article-title":"Vascular Targeting of Radiolabeled Liposomes with Bio-Orthogonally Conjugated Ligands: Single Chain Fragments Provide Higher Specificity than Antibodies","volume":"29","author":"Hood","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ymthe.2024.03.004_bib62","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-62703-260-5_2","article-title":"In\u00a0vitro transcription of long RNA containing modified nucleosides","volume":"969","author":"Pardi","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-62703-260-5_3","article-title":"HPLC purification of in\u00a0vitro transcribed long RNA","volume":"969","author":"Weissman","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2024.03.004_bib64","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/mt.2013.124","article-title":"Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics","volume":"21","author":"Maier","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2024.03.004_bib65","article-title":"Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals","author":"Connors","year":"2022","journal-title":"Res. Sq"},{"key":"10.1016\/j.ymthe.2024.03.004_bib66","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2021.12.027","article-title":"Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)","volume":"344","author":"Parhiz","year":"2022","journal-title":"J.\u00a0Control Release"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500162400145X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500162400145X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:20:13Z","timestamp":1746091213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152500162400145X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S152500162400145X"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.03.004","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.06.12.544645","asserted-by":"object"}]},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024","name":"copyright","label":"Copyright"}]}}