{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:16:25Z","timestamp":1791684985071,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2304102"],"award-info":[{"award-number":["2022YFC2304102"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009076","name":"University of Science and Technology of China","doi-asserted-by":"publisher","award":["YD9100002040"],"award-info":[{"award-number":["YD9100002040"]}],"id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ymthe.2024.04.028","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T21:40:12Z","timestamp":1713908412000},"page":"1779-1789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice"],"prefix":"10.1016","volume":"32","author":[{"given":"Jinge","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Entao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-4550","authenticated-orcid":false,"given":"Xia","family":"Chuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.04.028_bib1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/infdis\/jiaa559","article-title":"Exportation of Monkeypox Virus From the African Continent","volume":"225","author":"Mauldin","year":"2022","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.04.028_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1037598","article-title":"Evolution of monkeypox virus from 2017 to 2022: In the light of point mutations","volume":"13","author":"Desingu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/jama.2022.12513","article-title":"The WHO Declaration of Monkeypox as a Global Public Health Emergency","volume":"328","author":"Nuzzo","year":"2022","journal-title":"Jama"},{"key":"10.1016\/j.ymthe.2024.04.028_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/ije\/17.3.643","article-title":"The transmission potential of monkeypox virus in human populations","volume":"17","author":"Fine","year":"1988","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/infdis\/154.4.551","article-title":"Human monkeypox: a study of 2,510 contacts of 214 patients","volume":"154","author":"Jezek","year":"1986","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.04.028_bib6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s40265-022-01742-y","article-title":"Prevention and Treatment of Monkeypox","volume":"82","author":"Rizk","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ymthe.2024.04.028_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines11071163","article-title":"Safety of Monkeypox Vaccine Using Active Surveillance, Two-Center Observational Study in Italy","volume":"11","author":"Montalti","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.ymthe.2024.04.028_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110206","article-title":"Efficacy of the modified vaccinia Ankara virus vaccine and the replication-competent vaccine ACAM2000 in monkeypox prevention","volume":"119","author":"Kandeel","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.virusres.2004.08.015","article-title":"The exit of vaccinia virus from infected cells","volume":"106","author":"Smith","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.ymthe.2024.04.028_bib10","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm1457","article-title":"Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination","volume":"12","author":"P\u00fctz","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2024.04.028_bib11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.virs.2022.07.006","article-title":"Monkeypox virus: a re-emergent threat to humans","volume":"37","author":"Gong","year":"2022","journal-title":"Virol. Sin."},{"key":"10.1016\/j.ymthe.2024.04.028_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003850","article-title":"BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-\/-) Mice from Monkeypoxvirus Lethal Challenge","volume":"9","author":"Franceschi","year":"2015","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2024.04.028_bib13","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.177.4.2552","article-title":"Subunit recombinant vaccine protects against monkeypox","volume":"177","author":"Heraud","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib14","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1038\/s41467-022-31929-6","article-title":"Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.04.028_bib15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2024.04.028_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.103458","article-title":"Current state of, prospects for, and obstacles to mRNA vaccine development","volume":"28","author":"Aljabali","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ymthe.2024.04.028_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12020102","article-title":"Opportunities and Challenges in the Delivery of mRNA-based Vaccines","volume":"12","author":"Wadhwa","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymthe.2024.04.028_bib18","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molcel.2018.06.034","article-title":"The Biogenesis, Functions, and Challenges of Circular RNAs","volume":"71","author":"Li","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2024.04.028_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jconrel.2022.05.043","article-title":"Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines","volume":"348","author":"Liu","year":"2022","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.ymthe.2024.04.028_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1261\/rna.048272.114","article-title":"Efficient backsplicing produces translatable circular mRNAs","volume":"21","author":"Wang","year":"2015","journal-title":"Rna"},{"key":"10.1016\/j.ymthe.2024.04.028_bib21","doi-asserted-by":"crossref","first-page":"975","DOI":"10.7150\/ijms.71840","article-title":"Advances in Circular RNA and Its Applications","volume":"19","author":"Zhao","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ymthe.2024.04.028_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ymthe.2024.04.028_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.molcel.2019.02.015","article-title":"RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In\u00a0Vivo","volume":"74","author":"Wesselhoeft","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2024.04.028_bib24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.omtn.2022.04.017","article-title":"What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses","volume":"28","author":"Breuer","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ymthe.2024.04.028_bib25","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1038\/s41467-018-05096-6","article-title":"Engineering circular RNA for potent and stable translation in eukaryotic cells","volume":"9","author":"Wesselhoeft","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.04.028_bib26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/jmcb\/mjz091","article-title":"IRES-mediated cap-independent translation, a path leading to hidden proteome","volume":"11","author":"Yang","year":"2019","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib27","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1038\/s41467-022-31327-y","article-title":"Pervasive translation of circular RNAs driven by short IRES-like elements","volume":"13","author":"Fan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.04.028_bib28","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular RNAs driven by N(6)-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.ymthe.2024.04.028_bib29","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.cell.2022.03.044","article-title":"Circular RNA vaccines against SARS-CoV-2 and emerging variants","volume":"185","author":"Qu","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2024.04.028_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105370","article-title":"A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera","volume":"204","author":"Seephetdee","year":"2022","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ymthe.2024.04.028_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01775-23","article-title":"Circular RNA vaccines with long-term lymph node-targeting delivery stability after lyophilization induce potent and persistent immune responses","volume":"15","author":"Wan","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.ymthe.2024.04.028_bib32","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1038\/s41467-023-41628-5","article-title":"mRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge","volume":"14","author":"Hou","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.04.028_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","article-title":"Poxvirus genomes: a phylogenetic analysis","volume":"85","author":"Gubser","year":"2004","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41392-023-01432-5","article-title":"Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus","volume":"8","author":"Sang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2024.04.028_bib35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41392-023-01574-6","article-title":"Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2024.04.028_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01504-21","article-title":"A Nucleic Acid-Based Orthopoxvirus Vaccine Targeting the Vaccinia Virus L1, A27, B5, and A33 Proteins Protects Rabbits against Lethal Rabbitpox Virus Aerosol Challenge","volume":"96","author":"Mucker","year":"2022","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2024.04.028_bib37","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s11427-023-2378-x","article-title":"Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity. Science China","volume":"66","author":"Zhang","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.ymthe.2024.04.028_bib38","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nm1261","article-title":"Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus","volume":"11","author":"Edghill-Smith","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2024.04.028_bib39","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2622-0","article-title":"SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness","volume":"586","author":"Corbett","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.04.028_bib40","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N.\u00a0Engl. J. Med."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500162400251X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500162400251X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:23:31Z","timestamp":1776803011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152500162400251X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S152500162400251X"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.04.028","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}