{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:30:43Z","timestamp":1792765843845,"version":"4.5.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ymthe.2024.05.001","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:22:19Z","timestamp":1716477739000},"page":"2113-2129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy"],"prefix":"10.1016","volume":"32","author":[{"given":"Benedikt","family":"Gr\u00fcnewald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Rahmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha-Yeun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Haselmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja S.","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Schmidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hempel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Gr\u00fcnewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus V.","family":"Toyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Blaess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf A.","family":"Claus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-581X","authenticated-orcid":false,"given":"Christian","family":"Geis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.05.001_bib1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1001\/jama.2010.1553","article-title":"Long-term cognitive impairment and functional disability among survivors of severe sepsis","volume":"304","author":"Iwashyna","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S1473-3099(21)00144-4","article-title":"Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort","volume":"21","author":"Sipila","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.05.001_bib3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib5","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","article-title":"Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit","volume":"291","author":"Ely","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jama.1996.03530300054040","article-title":"The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities","volume":"275","author":"Eidelman","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-associated encephalopathy","volume":"8","author":"Gofton","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib8","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1056\/NEJMoa1301372","article-title":"Long-term cognitive impairment after critical illness","volume":"369","author":"Pandharipande","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12035-013-8433-7","article-title":"Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis","volume":"48","author":"Dal-Pizzol","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib10","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1038\/s41380-020-00955-5","article-title":"Temporal unsnarling of brain's acute neuroinflammatory transcriptional profiles reveals panendothelitis as the earliest event preceding microgliosis","volume":"26","author":"Kodali","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ymthe.2024.05.001_bib11","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.4049\/jimmunol.1900317","article-title":"Long-Term Microgliosis Driven by Acute Systemic Inflammation","volume":"203","author":"Trzeciak","year":"2019","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.immuni.2020.09.018","article-title":"Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge","volume":"53","author":"Shemer","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2024.05.001_bib13","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00134-011-2151-2","article-title":"Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis","volume":"37","author":"Comim","year":"2011","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/nan.12502","article-title":"Pro-inflammatory activation of microglia in the brain of patients with sepsis","volume":"45","author":"Zrzavy","year":"2019","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-5-38","article-title":"Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism","volume":"5","author":"Semmler","year":"2008","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.05.001_bib16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/mp.2016.243","article-title":"Lipocalin-2 protects the brain during inflammatory conditions","volume":"23","author":"Kang","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ymthe.2024.05.001_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/SHK.0000000000001435","article-title":"Persistent Neuroinflammation and Brain-Specific Immune Priming in a Novel Survival Model of Murine Pneumosepsis","volume":"54","author":"Denstaedt","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.ymthe.2024.05.001_bib18","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s00134-003-1789-9","article-title":"Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation","volume":"29","author":"Ritter","year":"2003","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib19","doi-asserted-by":"crossref","first-page":"14177","DOI":"10.1523\/JNEUROSCI.3238-09.2009","article-title":"NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits","volume":"29","author":"Weberpals","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1750-3639.2004.tb00494.x","article-title":"The neuropathology of septic shock","volume":"14","author":"Sharshar","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12974-016-0693-5","article-title":"A murine model of inflammation-induced cerebral microbleeds","volume":"13","author":"Sumbria","year":"2016","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.05.001_bib22","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.3389\/fimmu.2017.01673","article-title":"Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors","volume":"8","author":"Zaghloul","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib23","article-title":"Sepsis-Associated Encephalopathy: From Delirium to Dementia?","volume":"9","author":"Chung","year":"2020","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s13311-020-00862-1","article-title":"Septic-Associated Encephalopathy: a Comprehensive Review","volume":"17","author":"Mazeraud","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ymthe.2024.05.001_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroscience.2011.04.063","article-title":"Interleukin-1beta causes long-term potentiation deficiency in a mouse model of septic encephalopathy","volume":"187","author":"Imamura","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ymthe.2024.05.001_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/SHK.0000000000000847","article-title":"Minocycline Prevents the Impairment of Hippocampal Long-Term Potentiation in the Septic Mouse","volume":"48","author":"Hoshino","year":"2017","journal-title":"Shock"},{"key":"10.1016\/j.ymthe.2024.05.001_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.637703","article-title":"Interleukin-1beta Modulates Synaptic Transmission and Synaptic Plasticity During the Acute Phase of Sepsis in the Senescence-Accelerated Mouse Hippocampus","volume":"13","author":"Hoshino","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib28","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1172\/JCI124485","article-title":"Circulating heparan sulfate fragments mediate septic cognitive dysfunction","volume":"129","author":"Hippensteel","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2024.05.001_bib29","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/j.jss.2011.05.019","article-title":"Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model","volume":"170","author":"Gonnert","year":"2011","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.ymthe.2024.05.001_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nn.2708","article-title":"New views of Arc, a master regulator of synaptic plasticity","volume":"14","author":"Shepherd","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib31","doi-asserted-by":"crossref","first-page":"10286","DOI":"10.1128\/MCB.25.23.10286-10300.2005","article-title":"The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors","volume":"25","author":"Li","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib32","doi-asserted-by":"crossref","first-page":"11232","DOI":"10.1073\/pnas.210184697","article-title":"Involvement of neurogranin in the modulation of calcium\/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice","volume":"97","author":"Pak","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib33","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1523\/JNEUROSCI.2410-07.2007","article-title":"Actin polymerization and ERK phosphorylation are required for Arc\/Arg3.1 mRNA targeting to activated synaptic sites on dendrites","volume":"27","author":"Huang","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib36","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuron.2006.08.034","article-title":"Arc\/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors","volume":"52","author":"Shepherd","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib37","doi-asserted-by":"crossref","first-page":"9182","DOI":"10.1073\/pnas.1700866114","article-title":"Arc restores juvenile plasticity in adult mouse visual cortex","volume":"114","author":"Jenks","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2006.09.031","article-title":"Increased expression of the immediate-early gene arc\/arg3.1 reduces AMPA receptor-mediated synaptic transmission","volume":"52","author":"Rial Verde","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib39","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0144-15.2016","article-title":"Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2","volume":"3","author":"DaSilva","year":"2016","journal-title":"eneuro"},{"key":"10.1016\/j.ymthe.2024.05.001_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12035-017-0716-y","article-title":"Environmental Enrichment Reverses Tyrosine Kinase Inhibitor-Mediated Impairment Through BDNF-TrkB Pathway","volume":"55","author":"Bengoetxea","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib41","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1523\/JNEUROSCI.4486-04.2005","article-title":"Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha","volume":"25","author":"Stellwagen","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2003.11.040","article-title":"Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP","volume":"124","author":"Butler","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ymthe.2024.05.001_bib43","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1471-4159.2000.0750634.x","article-title":"The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK","volume":"75","author":"Tancredi","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ymthe.2024.05.001_bib44","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.1073\/pnas.1014557107","article-title":"Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline","volume":"107","author":"Terrando","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib45","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0896-6273(00)80591-7","article-title":"Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites","volume":"21","author":"Steward","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/cne.21003","article-title":"Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium\/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain","volume":"498","author":"Vazdarjanova","year":"2006","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib47","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1523\/JNEUROSCI.0008-20.2021","article-title":"The Immediate Early Gene Arc Is Not Required for Hippocampal Long-Term Potentiation","volume":"41","author":"Kyrke-Smith","year":"2021","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib48","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuron.2015.03.030","article-title":"Structural basis of arc binding to synaptic proteins: implications for cognitive disease","volume":"86","author":"Zhang","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.celrep.2017.09.045","article-title":"Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence","volume":"21","author":"Fernandez","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.05.001_bib50","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuron.2006.08.024","article-title":"Arc\/Arg3.1 is essential for the consolidation of synaptic plasticity and memories","volume":"52","author":"Plath","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib51","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1073\/pnas.0505519103","article-title":"Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons","volume":"103","author":"Guzowski","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib52","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nn.3429","article-title":"Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity","volume":"16","author":"Korb","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib53","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cell.2012.02.062","article-title":"Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc\/Arg3.1 with CaMKIIbeta","volume":"149","author":"Okuno","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2024.05.001_bib54","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuron.2008.05.014","article-title":"Rapid translation of Arc\/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate","volume":"59","author":"Waung","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib55","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2018.03.024","article-title":"The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer","volume":"173","author":"Pastuzyn","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2024.05.001_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1140785","article-title":"Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling","volume":"16","author":"Avallone","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112814","article-title":"Enriched environment effect on lipopolysaccharide-induced spatial learning, memory impairment and hippocampal inflammatory cytokine levels in male rats","volume":"394","author":"Keymoradzadeh","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ymthe.2024.05.001_bib58","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cell.2005.01.015","article-title":"Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice","volume":"120","author":"Lazarov","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2024.05.001_bib59","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib60","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1523\/JNEUROSCI.0782-06.2006","article-title":"Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus","volume":"26","author":"Bruel-Jungerman","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib61","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/72945","article-title":"Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice","volume":"3","author":"Rampon","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1210361","article-title":"Enriched environment-induced neuroplasticity in ischemic stroke and its underlying mechanisms","volume":"17","author":"Han","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0169-328X(01)00121-8","article-title":"Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: implications for molecular plasticity","volume":"91","author":"Pinaud","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.ymthe.2024.05.001_bib64","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1523\/JNEUROSCI.4342-04.2005","article-title":"Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation","volume":"25","author":"Ramirez-Amaya","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib65","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41467-017-02748-x","article-title":"Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.05.001_bib66","article-title":"Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis","volume":"12","author":"Corneo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2024.05.001_bib67","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/JIR.S345108","article-title":"Environmental Enrichment Protects Against Sepsis-Associated Encephalopathy-Induced Learning and Memory Deficits by Enhancing the Synthesis and Release of Vasopressin in the Supraoptic Nucleus","volume":"15","author":"Jiang","year":"2022","journal-title":"J.\u00a0Inflamm. Res."},{"key":"10.1016\/j.ymthe.2024.05.001_bib68","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1101\/lm.36301","article-title":"Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory","volume":"8","author":"Duffy","year":"2001","journal-title":"Learn. Mem."},{"key":"10.1016\/j.ymthe.2024.05.001_bib69","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.bbi.2011.06.006","article-title":"Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis","volume":"25","author":"Erickson","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ymthe.2024.05.001_bib70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1742-2094-8-124","article-title":"Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration","volume":"8","author":"Ip","year":"2011","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.05.001_bib71","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1042\/CS20191322","article-title":"Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis","volume":"134","author":"Michels","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib72","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1007\/s12035-020-02089-9","article-title":"NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats","volume":"57","author":"Danielski","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq7806","article-title":"Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy","volume":"9","author":"Chung","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2024.05.001_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109646","article-title":"Complement C1q drives microglia-dependent synaptic loss and cognitive impairments in a mouse model of lipopolysaccharide-induced neuroinflammation","volume":"237","author":"Wu","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ymthe.2024.05.001_bib75","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02756-3","article-title":"HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy","volume":"20","author":"Yin","year":"2023","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.05.001_bib76","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s00134-008-1129-1","article-title":"Time-dependent behavioral recovery after sepsis in rats","volume":"34","author":"Tuon","year":"2008","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib77","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJMe1309482","article-title":"Disability after critical illness","volume":"369","author":"Herridge","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib78","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1073\/pnas.042693699","article-title":"The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes","volume":"99","author":"Yin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.05.001_bib79","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuropharm.2013.06.024","article-title":"BDNF mechanisms in late LTP formation: A synthesis and breakdown","volume":"76","author":"Panja","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ymthe.2024.05.001_bib80","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm.1912","article-title":"Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease","volume":"15","author":"Nagahara","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2024.05.001_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib82","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fneur.2015.00136","article-title":"Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex\u00a0vivo","volume":"6","author":"Haselmann","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib83","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28685","article-title":"Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis","volume":"6","author":"Gr\u00fcnewald","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.ymthe.2024.05.001_bib84","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease","volume":"25","author":"Jankowsky","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib85","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction","volume":"472","author":"Peca","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.05.001_bib86","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nmeth.1668","article-title":"Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function","volume":"8","author":"Zhao","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2024.05.001_bib87","first-page":"3144","article-title":"LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory","volume":"141","author":"Petit-Pedrol","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.ymthe.2024.05.001_bib88","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ana.24721","article-title":"Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity","volume":"80","author":"Planaguma","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2024.05.001_bib89","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.neuron.2015.04.007","article-title":"Theta Burst Firing Recruits BDNF Release and Signaling in Postsynaptic CA1 Neurons in Spike-Timing-Dependent LTP","volume":"86","author":"Edelmann","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib90","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.1523\/JNEUROSCI.0359-09.2009","article-title":"Faithful expression of multiple proteins via 2A-peptide self-processing: a versatile and reliable method for manipulating brain circuits","volume":"29","author":"Tang","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.05.001_bib91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuron.2018.07.048","article-title":"Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction","volume":"100","author":"Haselmann","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.05.001_bib92","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","article-title":"lumi: a pipeline for processing Illumina microarray","volume":"24","author":"Du","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ymthe.2024.05.001_bib93","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1093\/nar\/gkt111","article-title":"Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods","volume":"41","author":"Varemo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2024.05.001_bib94","first-page":"20","article-title":"Reshaping Data with the reshape Package","volume":"21","author":"Wickham","year":"2007","journal-title":"J.\u00a0Stat. Softw."},{"key":"10.1016\/j.ymthe.2024.05.001_bib95","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data","volume":"18","author":"Doncheva","year":"2019","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.ymthe.2024.05.001_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113166","article-title":"Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony","volume":"42","author":"Ceanga","year":"2023","journal-title":"Cell Rep."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624003010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624003010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T07:02:06Z","timestamp":1737615726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624003010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":96,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1525001624003010"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.05.001","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s).","name":"copyright","label":"Copyright"}]}}