{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:21Z","timestamp":1791216501944,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["323858"],"award-info":[{"award-number":["323858"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["TSGH-E110-213"],"award-info":[{"award-number":["TSGH-E110-213"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2314-B-016 -058-MY2"],"award-info":[{"award-number":["108-2314-B-016 -058-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2314-B-303-022"],"award-info":[{"award-number":["MOST 107-2314-B-303-022"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-016-034"],"award-info":[{"award-number":["MOST 110-2314-B-016-034"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015697","name":"Academy of Applied Science Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007456","name":"Technology Academy Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022871","name":"National Defense Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ymthe.2024.09.005","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:50Z","timestamp":1725926450000},"page":"4021-4044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeting Rap1b signaling cascades with CDNF: Mitigating platelet activation, plasma oxylipins and reperfusion injury in stroke"],"prefix":"10.1016","volume":"32","author":[{"given":"Jui-Sheng","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helike","family":"L\u00f5helaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chin","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hock-Kean","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Fen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart","family":"Saarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-1609","authenticated-orcid":false,"given":"Mikko","family":"Airavaara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-0409","authenticated-orcid":false,"given":"Kuan-Yin","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.09.005_bib1","first-page":"3238165","article-title":"Stroke in the 21(st) Century: A Snapshot of the Burden, Epidemiology, and Quality of Life","volume":"2018","author":"Donkor","year":"2018","journal-title":"Stroke Res. Treat."},{"key":"10.1016\/j.ymthe.2024.09.005_bib2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/STROKEAHA.115.011238","article-title":"Thromboinflammation in Stroke Brain Damage","volume":"47","author":"De Meyer","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.09.005_bib3","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/STROKEAHA.122.038733","article-title":"Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives","volume":"53","author":"De Meyer","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.09.005_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ijms23010014","article-title":"Neuroinflammation in Cerebral Ischemia and Ischemia\/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies","volume":"23","author":"Jurcau","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke - implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib6","doi-asserted-by":"crossref","first-page":"548631","DOI":"10.3389\/fimmu.2020.548631","article-title":"Platelets as Mediators of Neuroinflammation and Thrombosis","volume":"11","author":"Rawish","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib7","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1182\/bloodadvances.2020002888","article-title":"Platelets as drivers of ischemia\/reperfusion injury after stroke","volume":"5","author":"Shaik","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.ymthe.2024.09.005_bib8","series-title":"Cerebral Ischemia","article-title":"Neuroinflammation in Post-Ischemic Brain","author":"Zivancevic","year":"2021"},{"key":"10.1016\/j.ymthe.2024.09.005_bib9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3324\/haematol.2008.003178","article-title":"Platelet receptors and signaling in the dynamics of thrombus formation","volume":"94","author":"Rivera","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.ymthe.2024.09.005_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI122955","article-title":"Functional significance of the platelet immune receptors GPVI and CLEC-2","volume":"129","author":"Rayes","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2024.09.005_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.blre.2006.06.001","article-title":"Platelet-neutrophil-interactions: linking hemostasis and inflammation","volume":"21","author":"Zarbock","year":"2007","journal-title":"Blood Rev."},{"key":"10.1016\/j.ymthe.2024.09.005_bib12","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.114.301597","article-title":"Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets","volume":"114","author":"O'Donnell","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2024.09.005_bib13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00109-017-1542-4","article-title":"The expansive role of oxylipins on platelet biology","volume":"95","author":"Yeung","year":"2017","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.ymthe.2024.09.005_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature05957","article-title":"Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in\u00a0vivo","volume":"448","author":"Lindholm","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.09.005_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40478-023-01701-y","article-title":"MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects","volume":"12","author":"Anttila","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ymthe.2024.09.005_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00441-020-03263-0","article-title":"Trophic activities of endoplasmic reticulum proteins CDNF and MANF","volume":"382","author":"J\u04d3ntti","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ymthe.2024.09.005_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00018-022-04157-w","article-title":"CDNF and MANF regulate ER stress in a tissue-specific manner","volume":"79","author":"Pakarinen","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib18","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1093\/brain\/awad087","article-title":"CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress","volume":"146","author":"De Lorenzo","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.ymthe.2024.09.005_bib19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41467-019-08450-4","article-title":"MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP","volume":"10","author":"Yan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.09.005_bib20","doi-asserted-by":"crossref","first-page":"aaf3646","DOI":"10.1126\/science.aaf3646","article-title":"Immune modulation by MANF promotes tissue repair and regenerative success in the retina","volume":"353","author":"Neves","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2024.09.005_bib21","doi-asserted-by":"crossref","first-page":"eaap8957","DOI":"10.1126\/sciadv.aap8957","article-title":"Poststroke delivery of MANF promotes functional recovery in rats","volume":"4","author":"Matlik","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2024.09.005_bib22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-022-05520-2","article-title":"Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage","volume":"14","author":"Tseng","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2024.09.005_bib23","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/biomedicines10061446","article-title":"Modulating Microglia\/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model","volume":"10","author":"Tseng","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ymthe.2024.09.005_bib24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41467-017-00750-x","article-title":"MANF regulates hypothalamic control of food intake and body weight","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.09.005_bib25","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3390\/ijms19071905","article-title":"Cerebral Dopamine Neurotrophic Factor (CDNF) Has Neuroprotective Effects against Cerebral Ischemia That May Occur through the Endoplasmic Reticulum Stress Pathway","volume":"19","author":"Zhang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib26","doi-asserted-by":"crossref","first-page":"104502","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104502","article-title":"Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Stroke Patients","volume":"29","author":"Joshi","year":"2020","journal-title":"J.\u00a0Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.ymthe.2024.09.005_bib27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1089\/1523086041361677","article-title":"Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis","volume":"6","author":"Peng","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ymthe.2024.09.005_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.107.158998","article-title":"Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide","volume":"101","author":"True","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2024.09.005_bib29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1182\/blood-2007-05-092684","article-title":"Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis","volume":"111","author":"Jobe","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2024.09.005_bib30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/vox.12364","article-title":"Functional characteristics and clinical effectiveness of platelet concentrates treated with riboflavin and ultraviolet light in plasma and in platelet additive solution","volume":"110","author":"Ignatova","year":"2016","journal-title":"Vox Sang."},{"key":"10.1016\/j.ymthe.2024.09.005_bib31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.redox.2017.08.021","article-title":"Regulation of platelet activation and thrombus formation by reactive oxygen species","volume":"14","author":"Qiao","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib32","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1083\/jcb.200207119","article-title":"Intercellular calcium communication regulates platelet aggregation and thrombus growth","volume":"160","author":"Nesbitt","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ab.2006.06.034","article-title":"Development and validation of a platelet calcium flux assay using a fluorescent imaging plate reader","volume":"357","author":"Liu","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ymthe.2024.09.005_bib34","doi-asserted-by":"crossref","first-page":"e00121","DOI":"10.1002\/phy2.121","article-title":"TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cells","volume":"1","author":"Parker","year":"2013","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.ymthe.2024.09.005_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00109-015-1346-3","article-title":"RAP1-GTPase signaling and platelet function","volume":"94","author":"Stefanini","year":"2016","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.ymthe.2024.09.005_bib36","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.3390\/ijms23169489","article-title":"CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival","volume":"23","author":"Eesmaa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/WAD.0000000000000488","article-title":"Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Probable Alzheimer Patients","volume":"36","author":"Joshi","year":"2022","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ymthe.2024.09.005_bib38","doi-asserted-by":"crossref","DOI":"10.1177\/1756286418789854","article-title":"Anti-inflammatory treatments for stroke: from bench to bedside","volume":"11","author":"Drieu","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.ymthe.2024.09.005_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00018-014-1743-8","article-title":"Of von Willebrand factor and platelets","volume":"72","author":"Bryckaert","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib40","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262695","article-title":"Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results","volume":"17","author":"Induruwa","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2024.09.005_bib42","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.3390\/ijms21144866","article-title":"ROS in Platelet Biology: Functional Aspects and Methodological Insights","volume":"21","author":"Masselli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1538-7836.2010.04091.x","article-title":"TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets","volume":"9","author":"Arthur","year":"2011","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.ymthe.2024.09.005_bib44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2008.03.021","article-title":"Spatially distinct production of reactive oxygen species regulates platelet activation","volume":"45","author":"Bakdash","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ymthe.2024.09.005_bib45","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1182\/blood.V91.2.484","article-title":"Hydrogen peroxide is involved in collagen-induced platelet activation","volume":"91","author":"Pignatelli","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2024.09.005_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-016-2770-6","article-title":"The increased level of COX-dependent arachidonic acid metabolism in blood platelets from secondary progressive multiple sclerosis patients","volume":"420","author":"Morel","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ymthe.2024.09.005_bib47","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1182\/blood-2005-03-1047","article-title":"Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO\/cGMP pathway","volume":"106","author":"Begonja","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2024.09.005_bib48","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1194\/jlr.M800447-JLR200","article-title":"Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species","volume":"50","author":"Wilson","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2024.09.005_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2217\/clp.10.11","article-title":"Thromboxane and the thromboxane receptor in cardiovascular disease","volume":"5","author":"Smyth","year":"2010","journal-title":"Clin. Lipidol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib50","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2141.2008.07506.x","article-title":"Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin\/convulxin stimulated platelets\/particles of different\u00a0sizes","volume":"144","author":"Rukoyatkina","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib51","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0022-3565(25)11468-7","article-title":"Mechanism of inositol 1,4,5-trisphosphate-induced aggregation in saponin-permeabilized platelets","volume":"260","author":"Knezevic","year":"1992","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ymthe.2024.09.005_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41392-020-0119-9","article-title":"C3G contributes to platelet activation and aggregation by regulating major signaling pathways","volume":"5","author":"Gutierrez-Herrero","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ymthe.2024.09.005_bib53","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1182\/blood-2015-12-638700","article-title":"The Rap1-RIAM-talin axis of integrin activation and blood cell function","volume":"128","author":"Lagarrigue","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2024.09.005_bib54","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1128\/MCB.20.3.779-785.2000","article-title":"Sequential regulation of the small GTPase Rap1 in human platelets","volume":"20","author":"Franke","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib55","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1182\/blood-2009-04-218768","article-title":"CalDAG-GEFI is at the nexus of calcium-dependent platelet activation","volume":"114","author":"Stefanini","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2024.09.005_bib56","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/s41467-017-01822-8","article-title":"Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation","volume":"8","author":"Zhu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.09.005_bib57","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1042\/bj3100469","article-title":"Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach","volume":"310","author":"Magnier","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.ymthe.2024.09.005_bib58","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/bj3320173","article-title":"Platelet sarco\/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology","volume":"332","author":"Lacabaratz-Porret","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.ymthe.2024.09.005_bib59","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3390\/ijms21051616","article-title":"Integration of Rap1 and Calcium Signaling","volume":"21","author":"Kosuru","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2024.09.005_bib60","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.celrep.2019.06.062","article-title":"Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice","volume":"28","author":"Carestia","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.09.005_bib61","doi-asserted-by":"crossref","first-page":"107615","DOI":"10.1016\/j.celrep.2020.107615","article-title":"Platelets Fuel the Inflammasome Activation of Innate Immune Cells","volume":"31","author":"Rolfes","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.09.005_bib62","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-0038-1669450","article-title":"The Mutual Relation of Platelet Activation and Innate Immunity","volume":"38","author":"Eisinger","year":"2018","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.ymthe.2024.09.005_bib63","doi-asserted-by":"crossref","first-page":"106760","DOI":"10.1016\/j.prostaglandins.2023.106760","article-title":"Cross-talk between bioactive lipid mediators and the unfolded protein response in ischemic stroke","volume":"168","author":"Teder","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.ymthe.2024.09.005_bib64","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1182\/blood-2012-04-416594","article-title":"The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways","volume":"120","author":"Burkhart","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2024.09.005_bib65","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1194\/jlr.M026385","article-title":"Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation","volume":"53","author":"Ikei","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2024.09.005_bib66","first-page":"313","article-title":"The Role of Platelets in Ischemic Conditioning","volume":"1","author":"Alpuche","year":"2018","journal-title":"Cond. Med."},{"key":"10.1016\/j.ymthe.2024.09.005_bib67","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jth.13919","article-title":"Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation","volume":"16","author":"Induruwa","year":"2018","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.ymthe.2024.09.005_bib68","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/ATVBAHA.115.305873","article-title":"Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury","volume":"36","author":"Pachel","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib69","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12974-017-0792-y","article-title":"Blocking of platelet glycoprotein receptor Ib reduces \"thrombo-inflammation\" in mice with acute ischemic stroke","volume":"14","author":"Schuhmann","year":"2017","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.09.005_bib70","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbi.2017.11.019","article-title":"Platelet glycoprotein receptor Ib blockade ameliorates experimental cerebral ischemia-reperfusion injury by strengthening the blood-brain barrier function and anti-thrombo-inflammatory property","volume":"69","author":"Chen","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ymthe.2024.09.005_bib71","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1111\/bph.15659","article-title":"Platelet inhibition by P2Y(12) antagonists is potentiated by adenosine signalling activators","volume":"178","author":"Shih","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib72","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12974-016-0543-5","article-title":"6-Mercaptopurine attenuates tumor necrosis factor-\u03b1 production in microglia through Nur77-mediated transrepression and PI3K\/Akt\/mTOR signaling-mediated translational regulation","volume":"13","author":"Huang","year":"2016","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.09.005_bib73","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/01.STR.17.4.738","article-title":"A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction","volume":"17","author":"Chen","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2024.09.005_bib74","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.redox.2016.12.002","article-title":"New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia","volume":"11","author":"Gonzalez-Pena","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib75","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1742-2094-9-13","article-title":"Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats","volume":"9","author":"Liew","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ymthe.2024.09.005_bib76","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/cne.22039","article-title":"Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats","volume":"515","author":"Airavaara","year":"2009","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.ymthe.2024.09.005_bib77","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0395-17.2018","article-title":"Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury","volume":"5","author":"Anttila","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.ymthe.2024.09.005_bib78","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.nbd.2016.07.008","article-title":"Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease","volume":"96","author":"Runeberg-Roos","year":"2016","journal-title":"Neurobiol. Dis."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624005926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624005926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:30:50Z","timestamp":1783020650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624005926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":78,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1525001624005926"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.09.005","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Rap1b signaling cascades with CDNF: Mitigating platelet activation, plasma oxylipins and reperfusion injury in stroke","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}