{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:30:31Z","timestamp":1789583431356,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1179"],"award-info":[{"award-number":["2023NSFSC1179"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374120"],"award-info":[{"award-number":["82374120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2020YFQ0022"],"award-info":[{"award-number":["2020YFQ0022"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ymthe.2024.09.021","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T05:15:09Z","timestamp":1726636509000},"page":"3990-4005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intranasal vaccination with engineered BCG expressing CCL2 induces a stronger immune barrier against Mycobacterium tuberculosis than BCG"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-1992","authenticated-orcid":false,"given":"Shaohua","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangshan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7275-2214","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.09.021_bib1","series-title":"World Health Organization Global Tuberculosis Report","year":"2023"},{"key":"10.1016\/j.ymthe.2024.09.021_bib2","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/S1473-3099(21)00403-5","article-title":"100 years of Mycobacterium bovis bacille Calmette-Gu\u00e9rin","volume":"22","author":"Lange","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.09.021_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fimmu.2020.00316","article-title":"Vaccination Against Tuberculosis: Revamping BCG by Molecular Genetics Guided by Immunology","volume":"11","author":"Kaufmann","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/cid\/cit790","article-title":"Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials","volume":"58","author":"Mangtani","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.09.021_bib5","article-title":"Vaccines against Tuberculosis: Where Are We Now?","volume":"11","author":"Srivastava","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ymthe.2024.09.021_bib6","article-title":"Innate and Adaptive Cellular Immune Responses to Mycobacterium tuberculosis Infection","volume":"5","author":"Mayer-Barber","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ymthe.2024.09.021_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01686-16","article-title":"Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis","volume":"7","author":"Perdomo","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.ymthe.2024.09.021_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41591-018-0319-9","article-title":"Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques","volume":"25","author":"Dijkman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2024.09.021_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2018.08.001","article-title":"Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination","volume":"24","author":"Cohen","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2024.09.021_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw068","article-title":"Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases","volume":"74","author":"McClean","year":"2016","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.ymthe.2024.09.021_bib11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib12","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1586\/erv.10.119","article-title":"Effective control of viral infections by the adaptive immune system requires assistance from innate immunity","volume":"9","author":"Barra","year":"2010","journal-title":"Expert Rev. Vaccin."},{"key":"10.1016\/j.ymthe.2024.09.021_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","article-title":"Cell-mediated immune responses in tuberculosis","volume":"27","author":"Cooper","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000355628","article-title":"Long-lasting effects of BCG vaccination on both heterologous Th1\/Th17 responses and innate trained immunity","volume":"6","author":"Kleinnijenhuis","year":"2014","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.ymthe.2024.09.021_bib15","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/eji.200940279","article-title":"A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination","volume":"40","author":"Connor","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.chom.2023.05.006","article-title":"Airway T\u00a0cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques","volume":"31","author":"Darrah","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2024.09.021_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41590-023-01700-0","article-title":"BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance","volume":"25","author":"Lee","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib18","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016303","article-title":"The chemokine system in innate immunity","volume":"7","author":"Sokol","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"Serbina","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib21","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.09.021_bib22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1164\/rccm.2112012","article-title":"The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice","volume":"166","author":"Maus","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ymthe.2024.09.021_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41590-023-01468-3","article-title":"MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation","volume":"24","author":"Vanneste","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib24","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.4049\/jimmunol.171.12.6788","article-title":"Role of monocyte chemotactic protein-1\/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guerin","volume":"171","author":"Penido","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib25","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2567.2003.01680.x","article-title":"Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis","volume":"109","author":"Kipnis","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.ymthe.2024.09.021_bib26","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.3389\/fimmu.2019.02759","article-title":"More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis","volume":"10","author":"Gschwandtner","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib27","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3389\/fimmu.2018.01930","article-title":"Chemokine-Induced Macrophage Polarization in Inflammatory Conditions","volume":"9","author":"Ruytinx","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib28","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.131207398","article-title":"Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis","volume":"98","author":"Peters","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.09.021_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01086","article-title":"Essential yet limited role for CCR2(+) inflammatory monocytes during Mycobacterium tuberculosis-specific T\u00a0cell priming","volume":"2","author":"Samstein","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.ymthe.2024.09.021_bib30","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.4049\/jimmunol.172.12.7647","article-title":"CCR2-dependent trafficking of F4\/80dim macrophages and CD11cdim\/intermediate dendritic cells is crucial for T\u00a0cell recruitment to lungs infected with Mycobacterium tuberculosis","volume":"172","author":"Peters","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib31","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/591501","article-title":"Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guerin","volume":"198","author":"Schreiber","year":"2008","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.09.021_bib32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.187.4.601","article-title":"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice","volume":"187","author":"Lu","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ymthe.2024.09.021_bib33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.175.4.1111","article-title":"Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages","volume":"175","author":"Chan","year":"1992","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ymthe.2024.09.021_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1044-5323(02)00125-2","article-title":"The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)","volume":"15","author":"Mahad","year":"2003","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abc2934","article-title":"Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis","volume":"6","author":"Mata","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/infdis\/jiv503","article-title":"Pulmonary but Not Subcutaneous Delivery of BCG Vaccine Confers Protection to Tuberculosis-Susceptible Mice by an Interleukin 17-Dependent Mechanism","volume":"213","author":"Aguilo","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.09.021_bib37","article-title":"Protective intravenous BCG vaccination induces enhanced immune signaling in the airways","author":"Peters","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.ymthe.2024.09.021_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009096","article-title":"Protective efficacy of an attenuated Mtb DeltaLprG vaccine in mice","volume":"16","author":"Martinot","year":"2020","journal-title":"Plos Pathog."},{"key":"10.1016\/j.ymthe.2024.09.021_bib39","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1080\/21645515.2021.2007711","article-title":"BCG vaccination strategies against tuberculosis: updates and perspectives","volume":"17","author":"Qu","year":"2021","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.ymthe.2024.09.021_bib40","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1038\/ncomms9533","article-title":"Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis","volume":"6","author":"Kaushal","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2024.09.021_bib41","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI40817","article-title":"Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte\/macrophage population","volume":"120","author":"Antonelli","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2024.09.021_bib42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.immuni.2022.04.004","article-title":"Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control","volume":"55","author":"Gideon","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2024.09.021_bib43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.coi.2007.07.004","article-title":"Interleukin-12 and tuberculosis: an old story revisited","volume":"19","author":"Cooper","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib44","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1128\/IAI.69.12.7262-7270.2001","article-title":"Human macrophage gamma interferon decreases gene expression but not replication of Mycobacterium tuberculosis: analysis of the host-pathogen reciprocal influence on transcription in a comparison of strains H37Rv and CMT97","volume":"69","author":"Cappelli","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ymthe.2024.09.021_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2020.151951","article-title":"Natural and trained innate immunity against Mycobacterium tuberculosis","volume":"225","author":"Ferluga","year":"2020","journal-title":"Immunobiology"},{"key":"10.1016\/j.ymthe.2024.09.021_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2024.09.021_bib47","first-page":"37","article-title":"Impact of Tumor-Derived CCL2 on Macrophage Effector Function","volume":"2005","author":"Brault","year":"2005","journal-title":"J.\u00a0Biomed. Biotechnol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/science.abp8964","article-title":"The extracellular matrix and the immune system: A mutually dependent relationship","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2024.09.021_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004603","article-title":"Variability in tuberculosis granuloma T\u00a0cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization","volume":"11","author":"Gideon","year":"2015","journal-title":"Plos Pathog."},{"key":"10.1016\/j.ymthe.2024.09.021_bib50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mi.2009.100","article-title":"Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa","volume":"2","author":"Khader","year":"2009","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib51","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41577-022-00746-9","article-title":"IL-17 and IL-17-producing cells in protection versus pathology","volume":"23","author":"Mills","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib52","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1086\/593174","article-title":"Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis","volume":"198","author":"Harris","year":"2008","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ymthe.2024.09.021_bib53","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.4049\/jimmunol.160.3.1290","article-title":"Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages","volume":"160","author":"Schaible","year":"1998","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib54","article-title":"A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2024.09.021_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2021.102054","article-title":"Immunological characterization of chimeras of high specificity antigens from Mycobacterium tuberculosis H37Rv","volume":"127","author":"Fatma","year":"2021","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.ymthe.2024.09.021_bib56","article-title":"Optimizing the Boosting Schedule of Subunit Vaccines Consisting of BCG and \"Non-BCG\" Antigens to Induce Long-Term Immune Memory","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib57","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1134\/S0003683820050129","article-title":"Vaccines Against Tuberculosis: Problems and Prospects (Review)","volume":"56","author":"Nadolinskaia","year":"2020","journal-title":"Appl. Biochem. Microbiol."},{"key":"10.1016\/j.ymthe.2024.09.021_bib58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41586-019-1817-8","article-title":"Prevention of tuberculosis in macaques after intravenous BCG immunization","volume":"577","author":"Darrah","year":"2020","journal-title":"Nature"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624006099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624006099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:31:34Z","timestamp":1783020694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624006099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1525001624006099"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.09.021","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal vaccination with engineered BCG expressing CCL2 induces a stronger immune barrier against Mycobacterium tuberculosis than BCG","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}