{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:08:12Z","timestamp":1791065292035,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004352","name":"DuPont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["N08.11.0147"],"award-info":[{"award-number":["N08.11.0147"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2019-1661"],"award-info":[{"award-number":["075-15-2019-1661"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007840","name":"Moscow State University of Geodesy and Cartography","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["17-74-10239"],"award-info":[{"award-number":["17-74-10239"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-15-00100"],"award-info":[{"award-number":["20-15-00100"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ymthe.2024.12.036","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:34:51Z","timestamp":1735648491000},"page":"771-785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potent painkiller from spider venom antagonizes P2X3 receptors without dysgeusia"],"prefix":"10.1016","volume":"33","author":[{"given":"Peter","family":"Oparin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Khokhlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Cherkashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Nadezhdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Palikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Palikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Korolkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Mosharova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Rogachevskaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Baranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenia","family":"Shaidullova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Ermakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Lushpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bruter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Deykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Silaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Dyachenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Bocharov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzel","family":"Sitdikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Andreev-Andrievskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Poteryaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Shuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkady","family":"Murashev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Kolesnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliy","family":"Stepanenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Grishin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-0076","authenticated-orcid":false,"given":"Alexander","family":"Vassilevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.12.036_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrd.2017.87","article-title":"Breaking barriers to novel analgesic drug development","volume":"16","author":"Yekkirala","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2024.12.036_bib2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ymthe.2024.12.036_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pain.2006.02.032","article-title":"The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint","volume":"123","author":"Seino","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.ymthe.2024.12.036_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2982.2001.00276.x","article-title":"ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease","volume":"13","author":"Yiangou","year":"2001","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.ymthe.2024.12.036_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00210-007-0197-z","article-title":"Therapeutic effects of the putative P2X3\/P2X2\/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats","volume":"377","author":"Ito","year":"2008","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib6","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.22-18-08139.2002","article-title":"Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain","volume":"22","author":"Barclay","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.036_bib7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11302-016-9521-8","article-title":"Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions","volume":"12","author":"Yegutkin","year":"2016","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ymthe.2024.12.036_bib8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(14)61255-1","article-title":"P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study","volume":"385","author":"Abdulqawi","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2024.12.036_bib9","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.bjp.0702001","article-title":"2\u2032,3\u2032-O-(2,4,6- trinitrophenyl) adenosine 5\u2032-triphosphate (TNP-ATP)--a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels","volume":"124","author":"Lewis","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib10","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/sj.bjp.0705574","article-title":"Effects of A-317491, a novel and selective P2X3\/P2X2\/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration","volume":"140","author":"McGaraughty","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173054","article-title":"P2X3 and P2X2\/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint","volume":"879","author":"Teixeira","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib12","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.04240-2020","article-title":"Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study","volume":"58","author":"Morice","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ymthe.2024.12.036_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41573-019-0013-8","article-title":"Antibodies and venom peptides: new modalities for ion channels","volume":"18","author":"Wulff","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2024.12.036_bib14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ana.21949","article-title":"Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain","volume":"67","author":"Grishin","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib15","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0167-7799(00)88996-9","article-title":"Combinatorial peptide libraries in drug design: lessons from venomous cone snails","volume":"13","author":"Olivera","year":"1995","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib16","first-page":"1505","article-title":"Molecular diversity of spider venom","volume":"74","author":"Vassilevski","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymthe.2024.12.036_bib17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0141-0229(94)90014-0","article-title":"C-terminal amidated peptides: production by the in\u00a0vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity","volume":"16","author":"Merkler","year":"1994","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib18","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","article-title":"A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides","volume":"3","author":"Pallaghy","year":"1994","journal-title":"Protein Sci."},{"key":"10.1016\/j.ymthe.2024.12.036_bib19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2024.12.036_bib20","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/bph.14677","article-title":"Action of MK-7264 (gefapixant) at human P2X3 and P2X2\/3 receptors and in\u00a0vivo efficacy in models of sensitisation","volume":"176","author":"Richards","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s40265-022-01700-8","article-title":"Gefapixant: first approval","volume":"82","author":"Markham","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ymthe.2024.12.036_bib22","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ymthe.2024.12.036_bib23","first-page":"588","article-title":"P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain","volume":"8","author":"Shinoda","year":"2007","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.ymthe.2024.12.036_bib24","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994","article-title":"Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve","volume":"14","author":"Vos","year":"1994","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.036_bib25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuroscience.2013.09.002","article-title":"Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system","volume":"253","author":"Shatillo","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.ymthe.2024.12.036_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/164_2021_518","article-title":"The role of ATP and purinergic receptors in taste signaling","volume":"275","author":"Kinnamon","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pupt.2019.03.007","article-title":"BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration","volume":"56","author":"Garceau","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ymthe.2024.12.036_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00725-2021","article-title":"Randomised trial of the P2X(3) receptor antagonist sivopixant for refractory chronic cough","volume":"59","author":"Niimi","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ymthe.2024.12.036_bib29","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026873","article-title":"Evaluation of analgesic effect, joint function recovery and safety of meloxicam in knee osteoarthritis patients who receive total knee arthroplasty: A randomized, controlled, double-blind study","volume":"100","author":"Hu","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.ymthe.2024.12.036_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejphar.2019.04.011","article-title":"Comparison of the antinociceptive profiles of morphine and oxycodone in two models of inflammatory and osteoarthritic pain in rat","volume":"854","author":"Garcia","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib31","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/practneurol-2020-002782","article-title":"Trigeminal neuralgia: a practical guide","volume":"21","author":"Lambru","year":"2021","journal-title":"Pract. Neurol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/prot.20390","article-title":"A novel strategy for the identification of toxinlike structures in spider venom","volume":"59","author":"Kozlov","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.ymthe.2024.12.036_bib33","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2024.12.036_bib34","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.bbamem.2012.07.016","article-title":"Modulation of P2X3 receptors by spider toxins","volume":"1818","author":"Kabanova","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ymthe.2024.12.036_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1046-5928(03)00159-1","article-title":"Expression, purification, and characterization of human enteropeptidase catalytic subunit in Escherichia coli","volume":"31","author":"Gasparian","year":"2003","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ymthe.2024.12.036_bib36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ab.2010.07.023","article-title":"Cyanogen bromide cleavage of proteins in salt and buffer solutions","volume":"407","author":"Andreev","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ymthe.2024.12.036_bib37","first-page":"355","article-title":"MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy","volume":"65","author":"Bax","year":"1985","journal-title":"J.\u00a0Magn. Reson."},{"key":"10.1016\/j.ymthe.2024.12.036_bib38","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1063\/1.438208","article-title":"Investigation of exchange processes by two-dimensional NMR spectroscopy","volume":"71","author":"Jeener","year":"1979","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.ymthe.2024.12.036_bib39","first-page":"301","article-title":"A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients","volume":"4","author":"Schleucher","year":"1994","journal-title":"J.\u00a0Biomol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/BF02192855","article-title":"Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions","volume":"2","author":"Piotto","year":"1992","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.ymthe.2024.12.036_bib41","series-title":"NMR of Proteins and Nucleic Acids","author":"W\u00fcthrich","year":"1986"},{"key":"10.1016\/j.ymthe.2024.12.036_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1021614115432","article-title":"Protein NMR structure determination with automated NOE-identification in the NOESY spectra using the new software ATNOS","volume":"24","author":"Herrmann","year":"2002","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.ymthe.2024.12.036_bib43","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0076-6879(89)77009-9","article-title":"Proton nuclear magnetic resonance assignments","volume":"177","author":"Basus","year":"1989","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ymthe.2024.12.036_bib44","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/bi00185a040","article-title":"Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation","volume":"33","author":"Farrow","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymthe.2024.12.036_bib45","series-title":"Protein NMR Spectroscopy: Principles and Practice","author":"Cavanagh","year":"2006"},{"key":"10.1016\/j.ymthe.2024.12.036_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneumeth.2008.04.013","article-title":"Chronic constriction injury of the infraorbital nerve in the rat using modified syringe needle","volume":"172","author":"Kernisant","year":"2008","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.ymthe.2024.12.036_bib47","first-page":"287","article-title":"Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers","volume":"9","author":"Zakharov","year":"2015","journal-title":"Front. Cel. Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.036_bib48","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/head.12371","article-title":"Innervation of rat and human dura mater and pericranial tissues in the parieto-temporal region by meningeal afferents","volume":"54","author":"Schueler","year":"2014","journal-title":"Headache"},{"key":"10.1016\/j.ymthe.2024.12.036_bib49","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gky354","article-title":"CRISPOR: intuitive guide selection for CRISPR\/Cas9 genome editing experiments and screens","volume":"46","author":"Concordet","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2024.12.036_bib50","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2024.12.036_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.24075\/brsmu.2022.066","article-title":"Transgenic mice for study of the CDK8\/19 cyclin-dependent kinase kinase-independent mechanisms of action","volume":"6","author":"Stavskaya","year":"2022","journal-title":"Bull. RSMU"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624008360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624008360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:53:22Z","timestamp":1770252802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624008360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1525001624008360"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.12.036","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent painkiller from spider venom antagonizes P2X3 receptors without dysgeusia","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.12.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society of Gene and Cell Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}