{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:13:26Z","timestamp":1791504806272,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002089","name":"Fight for Sight","doi-asserted-by":"publisher","award":["5065-5066"],"award-info":[{"award-number":["5065-5066"]}],"id":[{"id":"10.13039\/100002089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0161kolstv\u00ed ml\u00e1de\u017ee a t\u011blov\u00fdchovy \u010cesk\u00e9 republiky","doi-asserted-by":"publisher","award":["LM2018124"],"award-info":[{"award-number":["LM2018124"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001722","name":"KNAW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["G105497"],"award-info":[{"award-number":["G105497"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V002694\/1"],"award-info":[{"award-number":["MR\/V002694\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022290","name":"Institute for Research on Poverty","doi-asserted-by":"publisher","award":["OPJAK EXREGMED CZ.02.01.01\/00\/22_008\/0004562"],"award-info":[{"award-number":["OPJAK EXREGMED CZ.02.01.01\/00\/22_008\/0004562"]}],"id":[{"id":"10.13039\/100022290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022290","name":"Institute for Research on Poverty","doi-asserted-by":"publisher","award":["P186"],"award-info":[{"award-number":["P186"]}],"id":[{"id":"10.13039\/100022290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001708","name":"International Foundation For Research In Paraplegia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ymthe.2024.12.040","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T10:17:07Z","timestamp":1735726627000},"page":"752-770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract"],"prefix":"10.1016","volume":"33","author":[{"given":"Kristyna","family":"Karova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Polcanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepanka","family":"Suchankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Nieuwenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Holota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit","family":"Herynek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Machova Urdzikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostislav","family":"Turecek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"van den Herik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Verhaagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Fawcett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavla","family":"Jendelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2024.12.040_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2017.03.034","article-title":"An Intrinsic Epigenetic Barrier for Functional Axon Regeneration","volume":"94","author":"Weng","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.12.040_bib2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3390\/cancers14071652","article-title":"PI3K\/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression","volume":"14","author":"Deng","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ymthe.2024.12.040_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2014.00023","article-title":"Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders","volume":"7","author":"Kreis","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN\/mTOR Pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2024.12.040_bib5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nn.2603","article-title":"PTEN deletion enhances the regenerative ability of adult corticospinal neurons","volume":"13","author":"Liu","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.celrep.2016.03.028","article-title":"Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System","volume":"15","author":"Geoffroy","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.12.040_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1042\/BST0340647","article-title":"Signalling through Class I PI3Ks in mammalian cells","volume":"34","author":"Hawkins","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ymthe.2024.12.040_bib8","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911674","article-title":"PI3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS","volume":"12","author":"Nieuwenhuis","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2024.12.040_bib9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1242\/jcs.02801","article-title":"PTEN couples Sema3A signalling to growth cone collapse","volume":"119","author":"Chadborn","year":"2006","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.neuron.2017.07.037","article-title":"A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions","volume":"95","author":"Liu","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2024.12.040_bib11","doi-asserted-by":"crossref","first-page":"e26956","DOI":"10.7554\/eLife.26956","article-title":"Selective rab11 transport and the intrinsic regenerative ability of CNS axons","volume":"6","author":"Koseki","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.ymthe.2024.12.040_bib12","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1523\/JNEUROSCI.2850-14.2015","article-title":"Exclusion of Integrins from CNS Axons Is Regulated by Arf6 Activation and the AIS","volume":"35","author":"Franssen","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib13","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1073\/pnas.0810624106","article-title":"Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation","volume":"106","author":"Hollis","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.12.040_bib14","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1523\/JNEUROSCI.3637-14.2015","article-title":"Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord\u00a0Injury","volume":"35","author":"Du","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib15","doi-asserted-by":"crossref","first-page":"e869","DOI":"10.1371\/journal.pone.0000869","article-title":"Control of Axonal Growth and Regeneration of Sensory Neurons by the p110\u03b4 PI 3-Kinase","volume":"2","author":"Eickholt","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2024.12.040_bib16","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1242\/jcs.207423","article-title":"EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment","volume":"130","author":"Eva","year":"2017","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-12-407178-0.00004-1","article-title":"Intrinsic Mechanisms Regulating Axon Regeneration","volume":"106","author":"Eva","year":"2012","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113961","article-title":"Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures","volume":"349","author":"Campion","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib19","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/cercor\/bhh089","article-title":"Selective Neurofilament (SMI-32, FNP-7 and N200) Expression in Subpopulations of Layer V Pyramidal Neurons In\u00a0Vivo and In\u00a0Vitro","volume":"14","author":"Voelker","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ymthe.2024.12.040_bib38","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cmet.2020.02.002","article-title":"Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury","volume":"31","author":"Han","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2024.12.040_bib20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/BF00234340","article-title":"Projections and termination of the corticospinal tract in rodents","volume":"13","author":"Brown","year":"1971","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ymthe.2024.12.040_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0304-3940(89)90009-8","article-title":"Collateralization of the cervical corticospinal tract in the rat","volume":"105","author":"Gribnau","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ymthe.2024.12.040_bib22","first-page":"298","article-title":"The pyramidal tract in rodents. A study of its relations with the posterior column nuclei, dorsolateral reticular formation of the medulla oblongata, and cervical spinal cord. (Golgi and electron microscopic observations)","volume":"71","author":"Valverde","year":"1966","journal-title":"Z.\u00a0Zellforsch. Mikrosk. Anat."},{"key":"10.1016\/j.ymthe.2024.12.040_bib23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/cne.24826","article-title":"Somatosensory corticospinal tract axons sprout within the cervical cord following a dorsal root\/dorsal column spinal injury in the rat","volume":"528","author":"McCann","year":"2020","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib24","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.12.040_bib25","doi-asserted-by":"crossref","first-page":"12923","DOI":"10.1073\/pnas.2132711100","article-title":"mTor is required for hypertrophy of Pten-deficient neuronal soma in\u00a0vivo","volume":"100","author":"Kwon","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2024.12.040_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111574","article-title":"Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss","volume":"41","author":"Tariq","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.12.040_bib27","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuroscience.2017.04.026","article-title":"Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders","volume":"354","author":"Nikolaeva","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.ymthe.2024.12.040_bib28","doi-asserted-by":"crossref","first-page":"15350","DOI":"10.1523\/JNEUROSCI.2510-13.2013","article-title":"Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury","volume":"33","author":"Zukor","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41580-019-0129-z","article-title":"PI3K isoforms in cell signalling and vesicle trafficking","volume":"20","author":"Bilanges","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05972-2","article-title":"A small-molecule PI3K\u03b1 activator for cardioprotection and neuroregeneration","volume":"618","author":"Gong","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2024.12.040_bib31","doi-asserted-by":"crossref","first-page":"11654","DOI":"10.1523\/JNEUROSCI.2425-10.2010","article-title":"Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of \u03b21 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells","volume":"30","author":"Eva","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib32","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1523\/JNEUROSCI.2370-17.2018","article-title":"Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis","volume":"38","author":"Umegaki","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113136","article-title":"Single-session cortical electrical stimulation enhances the efficacy of rehabilitative motor training after spinal cord injury in rats","volume":"324","author":"Batty","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/jnr.24209","article-title":"Cortical electrical stimulation in female rats with a cervical spinal cord injury to promote axonal outgrowth","volume":"96","author":"Jack","year":"2018","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.ymthe.2024.12.040_bib35","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/ejn.12119","article-title":"Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injury","volume":"37","author":"Carmel","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib36","first-page":"1718","article-title":"Alternating current stimulation promotes neurite outgrowth and plasticity in neurons through activation of the PI3K\/AKT signaling pathway","volume":"55","author":"Zhong","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.ymthe.2024.12.040_bib37","first-page":"623","article-title":"Chronic activation of corticospinal tract neurons after pyramidotomy injury enhances neither behavioral recovery nor axonal sprouting","volume":"31","author":"Wang","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.ymthe.2024.12.040_bib39","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1523\/JNEUROSCI.20-21-08061.2000","article-title":"Regeneration of Lesioned Corticospinal Tract Fibers in the Adult Rat Induced by a Recombinant, Humanized IN-1 Antibody Fragment","volume":"20","author":"Br\u00f6samle","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hipo.10010","article-title":"Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches","volume":"12","author":"Guzowski","year":"2002","journal-title":"Hippocampus"},{"key":"10.1016\/j.ymthe.2024.12.040_bib41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13041-021-00798-3","article-title":"In\u00a0vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events","volume":"14","author":"Meenakshi","year":"2021","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ymthe.2024.12.040_bib42","doi-asserted-by":"crossref","first-page":"12185","DOI":"10.1523\/JNEUROSCI.1740-10.2010","article-title":"Nerve Growth Factor Induces Axonal Filopodia through Localized Microdomains of Phosphoinositide 3-Kinase Activity That Drive the Formation of Cytoskeletal Precursors to Filopodia","volume":"30","author":"Ketschek","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib43","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.celrep.2013.11.022","article-title":"Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis","volume":"5","author":"Spillane","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.12.040_bib44","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.celrep.2019.10.039","article-title":"The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches","volume":"29","author":"Brosig","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2024.12.040_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/exnr.2002.7909","article-title":"Anatomical Correlates of Locomotor Recovery Following Dorsal and Ventral Lesions of the Rat Spinal Cord","volume":"176","author":"Schucht","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib46","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1523\/JNEUROSCI.0649-19.2019","article-title":"Dynamic Interaction between Cortico-Brainstem Pathways during Training-Induced Recovery in Stroke Model Rats","volume":"39","author":"Ishida","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib47","doi-asserted-by":"crossref","first-page":"9778","DOI":"10.1523\/JNEUROSCI.3368-16.2017","article-title":"Reticulospinal Contributions to Gross Hand Function after Human Spinal Cord Injury","volume":"37","author":"Baker","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib48","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1523\/JNEUROSCI.0627-21.2022","article-title":"Both Corticospinal and Reticulospinal Tracts Control Force of Contraction","volume":"42","author":"Glover","year":"2022","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2018.00030","article-title":"Reticulospinal Systems for Tuning Motor Commands","volume":"12","author":"Brownstone","year":"2018","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.ymthe.2024.12.040_bib50","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1523\/JNEUROSCI.0474-20.2020","article-title":"The Gigantocellular Reticular Nucleus Plays a Significant Role in Locomotor Recovery after Incomplete Spinal Cord Injury","volume":"40","author":"Engmann","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib51","article-title":"Alpha 9 integrin expression enables reconstruction of the spinal cord sensory pathway","author":"Stepankova","year":"2023","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.ymthe.2024.12.040_bib52","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1523\/JNEUROSCI.0931-17.2017","article-title":"The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury","volume":"37","author":"Al-Ali","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2024.12.040_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-7522-8_1","article-title":"Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System","volume":"1715","author":"Verhaagen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib54","doi-asserted-by":"crossref","DOI":"10.3791\/1204","article-title":"The Ladder Rung Walking Task: A Scoring System and its Practical Application","author":"Metz","year":"2009","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2024.12.040_bib55","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1152\/jn.00820.2003","article-title":"Lack of Monosynaptic Corticomotoneuronal EPSPs in Rats: Disynaptic EPSPs Mediated Via Reticulospinal Neurons and Polysynaptic EPSPs Via Segmental Interneurons","volume":"91","author":"Alstermark","year":"2004","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.ymthe.2024.12.040_bib56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neures.2004.02.001","article-title":"Conduction properties of identified neural pathways in the central nervous system of mice in\u00a0vivo","volume":"49","author":"Tanaka","year":"2004","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ymthe.2024.12.040_bib57","doi-asserted-by":"crossref","DOI":"10.3791\/51843-v","article-title":"Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies","author":"Kathe","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2024.12.040_bib58","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.sc.3101862","article-title":"Use of c-fos to identify activity-dependent spinal neurons after stepping in intact adult rats","volume":"44","author":"Ahn","year":"2006","journal-title":"Spinal Cord"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624008384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001624008384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:47:05Z","timestamp":1778816825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001624008384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1525001624008384"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.12.040","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2024.12.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}