{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:45:30Z","timestamp":1787316330816,"version":"build-2736575974"},"reference-count":76,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007230","name":"Foundation King Gustaf V Jubilee Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Lars Hierta Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007949","name":"Swedish Rheumatism Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009806","name":"Ulla and Gustaf af Ugglas Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Government of Spain Ministry of Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ymthe.2025.04.034","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T23:02:56Z","timestamp":1745535776000},"page":"3528-3545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tolerogenic antigen-specific vaccine induces VISTA-enriched regulatory T cells and protects against arthritis in DRB1\u221704:01 mice"],"prefix":"10.1016","volume":"33","author":[{"given":"Laura","family":"Romero-Castillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan Kumar","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingze","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Beusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Oliveira-Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejsi","family":"Zeqiraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huqiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Sareila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changrong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Urbonaviciute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Haag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Viljanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman A.","family":"Zubarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kihlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Linusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikard","family":"Holmdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2025.04.034_bib1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1186\/s12889-024-19290-3","article-title":"Age standardized incidence, prevalence, and mortality rates of autoimmune diseases in adolescents and young adults (15-39 years): an analysis based on the global burden of disease study 2021","volume":"24","author":"Zhao","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ymthe.2025.04.034_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrg.2015.33","article-title":"Autoimmune diseases - connecting risk alleles with molecular traits of the immune system","volume":"17","author":"Gutierrez-Arcelus","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ymthe.2025.04.034_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaut.2009.09.008","article-title":"Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases","volume":"33","author":"Cooper","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ymthe.2025.04.034_bib4","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2025.04.034_bib5","doi-asserted-by":"crossref","first-page":"ITC1","DOI":"10.7326\/AITC201901010","article-title":"Rheumatoid Arthritis","volume":"170","author":"Sparks","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00296-020-04731-0","article-title":"The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review","volume":"41","author":"Almutairi","year":"2021","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.ymthe.2025.04.034_bib7","first-page":"591","article-title":"Global epidemiology of rheumatoid arthritis","volume":"18","author":"Finckh","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ymthe.2025.04.034_bib8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2025.04.034_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2025.04.034_bib10","article-title":"Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice","volume":"220","author":"Aoun","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib11","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/eji.200526000","article-title":"Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis","volume":"35","author":"Burkhardt","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-065X.1990.tb00817.x","article-title":"Type II collagen autoimmunity in animals and provocations leading to arthritis","volume":"118","author":"Holmdahl","year":"1990","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ymthe.2025.04.034_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202401513","article-title":"Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association","volume":"11","author":"Romero-Castillo","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ymthe.2025.04.034_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1084\/jem.146.3.857","article-title":"Autoimmunity to type II collagen an experimental model of arthritis","volume":"146","author":"Trentham","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib15","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1073\/pnas.95.13.7574","article-title":"Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice","volume":"95","author":"Andersson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.04.034_bib16","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.4049\/jimmunol.160.6.2573","article-title":"Induction of autoimmune arthritis in HLA-DR4 (DRB1\u22170401) transgenic mice by immunization with human and bovine type II collagen","volume":"160","author":"Rosloniec","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109740","article-title":"Therapeutic potential of tolerance-based peptide vaccines in autoimmune diseases","volume":"116","author":"Yu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib18","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1073\/pnas.132254199","article-title":"Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis","volume":"99","author":"Backlund","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.04.034_bib19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/annrheumdis-2021-220500","article-title":"Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1\u221704:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor","volume":"81","author":"Ge","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ymthe.2025.04.034_bib20","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1212\/WNL.0b013e318233b240","article-title":"A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS","volume":"77","author":"Freedman","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ymthe.2025.04.034_bib21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1468-1331.2006.01533.x","article-title":"Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment","volume":"13","author":"Warren","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib22","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.4049\/jimmunol.0802972","article-title":"Antigen-specific suppression of inflammatory arthritis using liposomes","volume":"182","author":"Capini","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jaut.2017.12.010","article-title":"Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells","volume":"89","author":"Prasad","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ymthe.2025.04.034_bib24","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.4049\/jimmunol.176.3.1525","article-title":"Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules","volume":"176","author":"Dzhambazov","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib25","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2218668120","article-title":"Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis","volume":"120","author":"Urbonaviciute","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.04.034_bib26","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/dc12-0038","article-title":"Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children","volume":"35","author":"Marek-Trzonkowska","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ymthe.2025.04.034_bib27","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.1001322","article-title":"Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity","volume":"186","author":"Papenfuss","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s10020-018-0017-6","article-title":"Targeting DEC-205(-)DCIR2(+) dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis","volume":"24","author":"Tabansky","year":"2018","journal-title":"Mol. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay0524","article-title":"VISTA is a checkpoint regulator for naive T cell quiescence and peripheral tolerance","volume":"367","author":"ElTanbouly","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2025.04.034_bib30","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/art.34459","article-title":"Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis","volume":"64","author":"Snir","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ymthe.2025.04.034_bib31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/art.23049","article-title":"Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation","volume":"58","author":"Nandakumar","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ymthe.2025.04.034_bib32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ni.3331","article-title":"CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors","volume":"17","author":"Kalekar","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4049\/jimmunol.1101311","article-title":"Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells","volume":"188","author":"Martinez","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.704578","article-title":"Conversion of Anergic T Cells Into Foxp3(-) IL-10(+) Regulatory T Cells by a Second Antigen Stimulus In Vivo","volume":"12","author":"Thomann","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1194421","article-title":"Immune-checkpoint protein VISTA in allergic, autoimmune disease and transplant rejection","volume":"14","author":"Zheng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.20100619","article-title":"VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses","volume":"208","author":"Wang","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib37","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.4049\/jimmunol.161.10.5296","article-title":"Impaired cutaneous immune responses in Thy-1-deficient mice","volume":"161","author":"Beissert","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1073\/pnas.96.3.1019","article-title":"CD48-deficient mice have a pronounced defect in CD4(+) T cell activation","volume":"96","author":"Gonzalez-Cabrero","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.04.034_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/713609354","article-title":"Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV","volume":"40","author":"Lambeir","year":"2003","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.ymthe.2025.04.034_bib40","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1172\/JCI130426","article-title":"IRF4 instructs effector Treg differentiation and immune suppression in human cancer","volume":"130","author":"Alvisi","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymthe.2025.04.034_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107906","article-title":"The MAPK dual specific phosphatase (DUSP) proteins: A versatile wrestler in T cell functionality","volume":"98","author":"Sun","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib42","first-page":"387","article-title":"Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function","volume":"119","author":"Urry","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymthe.2025.04.034_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051241","article-title":"Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes","volume":"20","author":"Welz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2025.04.034_bib44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.5606\/ArchRheumatol.2018.6595","article-title":"Cathepsin G and Its Role in Inflammation and Autoimmune Diseases","volume":"33","author":"Gao","year":"2018","journal-title":"Arch. Rheumatol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib45","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1084\/jem.20122798","article-title":"Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells","volume":"210","author":"Giltiay","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221042","article-title":"Ion channel TRPV2 is critical in enhancing B cell activation and function","volume":"221","author":"Li","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib47","doi-asserted-by":"crossref","first-page":"R1001","DOI":"10.1186\/ar1776","article-title":"Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus","volume":"7","author":"Henneken","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ymthe.2025.04.034_bib48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.32607\/20758251-2018-10-4-115-120","article-title":"Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors","volume":"10","author":"Sharapova","year":"2018","journal-title":"Acta Naturae"},{"key":"10.1016\/j.ymthe.2025.04.034_bib49","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1136\/annrheumdis-2013-205061","article-title":"FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis","volume":"74","author":"Wixler","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ymthe.2025.04.034_bib50","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1074\/jbc.M115.643767","article-title":"TRAF Family Member-associated NF-kappaB Activator (TANK) Inhibits Genotoxic Nuclear Factor kappaB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.034_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw0475","article-title":"Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers","volume":"11","author":"Michel","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib52","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.4049\/jimmunol.1101542","article-title":"EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center","volume":"187","author":"Gatto","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/ar4605","article-title":"Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice","volume":"16","author":"Lindh","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ymthe.2025.04.034_bib54","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1002\/1521-4141(200212)32:12<3776::AID-IMMU3776>3.0.CO;2-A","article-title":"Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis","volume":"32","author":"Backlund","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib55","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nri1805","article-title":"MHC class II proteins and disease: a structural perspective","volume":"6","author":"Jones","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib56","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1021\/acs.jmedchem.7b01880","article-title":"Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis","volume":"61","author":"Lindgren","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ymthe.2025.04.034_bib57","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.celrep.2019.07.073","article-title":"Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation","volume":"28","author":"Mehta","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2025.04.034_bib58","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1158\/0008-5472.CAN-13-1504","article-title":"VISTA is an immune checkpoint molecule for human T cells","volume":"74","author":"Lines","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2025.04.034_bib59","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1073\/pnas.1420370112","article-title":"Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses","volume":"112","author":"Liu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.04.034_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax1159","article-title":"PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus","volume":"11","author":"Han","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2025.04.034_bib61","doi-asserted-by":"crossref","first-page":"8948","DOI":"10.1021\/jo990853d","article-title":"Preparation of a Diglycosylated Hydroxylysine Building Block Used in Solid-Phase Synthesis of a Glycopeptide from Type II Collagen","volume":"64","author":"Broddefalk","year":"1999","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ymthe.2025.04.034_bib62","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1021\/bi00776a005","article-title":"Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin","volume":"11","author":"Miller","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymthe.2025.04.034_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74549","article-title":"Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation","volume":"11","author":"James","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.ymthe.2025.04.034_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.892251","article-title":"Standardization of Antigen-Emulsion Preparations for the Induction of Autoimmune Disease Models","volume":"13","author":"Topping","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib65","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fimmu.2018.00451","article-title":"A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis","volume":"9","author":"Tong","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib66","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1021\/acschembio.0c00680","article-title":"Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis","volume":"15","author":"Viljanen","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib67","doi-asserted-by":"crossref","first-page":"5915","DOI":"10.4049\/jimmunol.160.12.5915","article-title":"Expression and characterization of recombinant soluble peptide: I-A complexes associated with murine experimental autoimmune diseases","volume":"160","author":"Radu","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/cpim.75","article-title":"Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4(+) T Cells","volume":"125","author":"Kotov","year":"2019","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib69","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2025.04.034_bib70","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1038\/s41467-023-39869-5","article-title":"Analysis of DIA proteomics data using MSFragger-DIA and FragPipe computational platform","volume":"14","author":"Yu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2025.04.034_bib71","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"Kall","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2025.04.034_bib72","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41592-020-0912-y","article-title":"Philosopher: a versatile toolkit for shotgun proteomics data analysis","volume":"17","author":"da Veiga Leprevost","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2025.04.034_bib73","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2025.04.034_bib74","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1021\/acs.jproteome.5b00981","article-title":"Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies","volume":"15","author":"Lazar","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ymthe.2025.04.034_bib75","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625003132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625003132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:33:05Z","timestamp":1783020785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001625003132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":76,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1525001625003132"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.04.034","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tolerogenic antigen-specific vaccine induces VISTA-enriched regulatory T cells and protects against arthritis in DRB1\u221704:01 mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}