{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:11:54Z","timestamp":1792872714101,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["647849"],"award-info":[{"award-number":["647849"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011733","name":"Glasgow Children's Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018703","name":"Cancer Research UK Beatson Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A17196"],"award-info":[{"award-number":["A17196"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A31287"],"award-info":[{"award-number":["A31287"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["OGI-119"],"award-info":[{"award-number":["OGI-119"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A29799"],"award-info":[{"award-number":["A29799"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A29800"],"award-info":[{"award-number":["A29800"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A23278 \/ A29256"],"award-info":[{"award-number":["A23278 \/ A29256"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ymthe.2025.04.042","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T19:43:21Z","timestamp":1746474201000},"page":"3624-3643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-2538","authenticated-orcid":false,"given":"Syed Feroj","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Buetow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loveena","family":"Rishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bohlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Sibbet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina A.","family":"Majorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zanivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta C.","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachdev S.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Blyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-259X","authenticated-orcid":false,"given":"Danny T.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2025.04.042_bib1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/emboj.2008.18","article-title":"Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates","volume":"27","author":"Ng","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2025.04.042_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/416187a","article-title":"The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met","volume":"416","author":"Petrelli","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2025.04.042_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/416183a","article-title":"Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors","volume":"416","author":"Soubeyran","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2025.04.042_bib4","doi-asserted-by":"crossref","first-page":"35185","DOI":"10.1074\/jbc.M102219200","article-title":"Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins","volume":"276","author":"Yokouchi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7150\/ijms.1.101","article-title":"Tyrosine kinase - Role and significance in Cancer","volume":"1","author":"Paul","year":"2004","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ymthe.2025.04.042_bib6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(00)00057-X","article-title":"Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases","volume":"102","author":"Zheng","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2025.04.042_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nsmb.2231","article-title":"Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl","volume":"19","author":"Dou","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib8","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nsmb.2621","article-title":"Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3","volume":"20","author":"Dou","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib9","doi-asserted-by":"crossref","first-page":"28017","DOI":"10.1074\/jbc.M404114200","article-title":"Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations","volume":"279","author":"Kassenbrock","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib10","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S1097-2765(00)80231-2","article-title":"Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl\/Sli-1","volume":"4","author":"Levkowitz","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2025.04.042_bib11","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1158\/0008-5472.CAN-10-0610","article-title":"Cbl and human myeloid neoplasms: the Cbl oncogene comes of age","volume":"70","author":"Kales","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2025.04.042_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.20892\/j.issn.2095-3941.2016.0043","article-title":"Clinical management of myelodysplastic syndrome\/myeloproliferative neoplasm overlap syndromes","volume":"13","author":"Clara","year":"2016","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.ymthe.2025.04.042_bib13","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00277-012-1521-3","article-title":"Activating CBL mutations are associated with a distinct MDS\/MPN phenotype","volume":"91","author":"Schwaab","year":"2012","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41408-018-0074-7","article-title":"Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome","volume":"8","author":"Hou","year":"2018","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.ymthe.2025.04.042_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14030839","article-title":"Role of CBL Mutations in Cancer and Non-Malignant Phenotype","volume":"14","author":"Leardini","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ymthe.2025.04.042_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/sj.bjc.6601894","article-title":"The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website","volume":"91","author":"Bamford","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ymthe.2025.04.042_bib17","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1182\/blood-2006-12-061176","article-title":"Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia","volume":"110","author":"Caligiuri","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2025.04.042_bib18","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1182\/blood-2008-12-190934","article-title":"E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease","volume":"114","author":"Bandi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2025.04.042_bib19","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/ng.641","article-title":"Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia","volume":"42","author":"Niemeyer","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2025.04.042_bib20","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature08240","article-title":"Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms","volume":"460","author":"Sanada","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2025.04.042_bib21","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1182\/blood-2007-01-066076","article-title":"Flt3-dependent transformation by inactivating c-Cbl mutations in AML","volume":"110","author":"Sargin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2025.04.042_bib22","article-title":"Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins","volume":"Suppl 6","author":"Nadeau","year":"2012","journal-title":"Biochem. Anal. Biochem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib23","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1182\/blood-2016-06-724658","article-title":"Acquired expression of Cbl(Q367P) in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia","volume":"129","author":"Nakata","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2025.04.042_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ccr.2010.09.008","article-title":"Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling","volume":"18","author":"Rathinam","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ymthe.2025.04.042_bib25","doi-asserted-by":"crossref","first-page":"32596","DOI":"10.1074\/jbc.M110.106161","article-title":"Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism","volume":"285","author":"Fernandes","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib26","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1074\/jbc.M116.772723","article-title":"Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene","volume":"292","author":"Nadeau","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1097-2765(01)00183-6","article-title":"RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation","volume":"7","author":"Thien","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2025.04.042_bib28","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1038\/s41388-021-01684-x","article-title":"E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis","volume":"40","author":"Ahmed","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.ymthe.2025.04.042_bib29","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1182\/blood.2020006528","article-title":"CBL mutations drive PI3K\/AKT signaling via increased interaction with LYN and PIK3R1","volume":"137","author":"Belizaire","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2025.04.042_bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/MCB.20.3.851-867.2000","article-title":"The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation","volume":"20","author":"Andoniou","year":"2000","journal-title":"Mol. Cel. Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib31","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1074\/jbc.271.11.6159","article-title":"Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation","volume":"271","author":"Buday","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib32","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nsmb1000","article-title":"Cbl promotes clustering of endocytic adaptor proteins","volume":"12","author":"Jozic","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib33","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/MCB.15.7.3571","article-title":"Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells","volume":"15","author":"Meisner","year":"1995","journal-title":"Mol. Cel. Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib34","doi-asserted-by":"crossref","first-page":"38495","DOI":"10.1074\/jbc.M305656200","article-title":"Cbl-mediated ubiquitinylation and negative regulation of Vav","volume":"278","author":"Miura-Shimura","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib35","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1073\/pnas.062055999","article-title":"Negative regulation of Lck by Cbl ubiquitin ligase","volume":"99","author":"Rao","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.04.042_bib36","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1074\/jbc.271.14.8435","article-title":"Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G","volume":"271","author":"Reedquist","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib37","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/sj.leu.2400768","article-title":"Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23)","volume":"11","author":"Matsuo","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.ymthe.2025.04.042_bib38","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/leu.2012.7","article-title":"CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors","volume":"26","author":"Makishima","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.ymthe.2025.04.042_bib39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12915-016-0298-6","article-title":"Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation","volume":"14","author":"Buetow","year":"2016","journal-title":"BMC Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib40","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nm.4134","article-title":"Inhibition of CBLB protects from lethal Candida albicans sepsis","volume":"22","author":"Wirnsberger","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2025.04.042_bib41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.30802\/AALAS-JAALAS-20-000020","article-title":"Reference Values for Hematology, Plasma Biochemistry, Bone Marrow Cytology and Bone Histology of NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)\/SzJ Immunodeficient Mice","volume":"60","author":"Layssol-Lamour","year":"2021","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.ymthe.2025.04.042_bib42","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1021\/acs.jmedchem.3c02083","article-title":"Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors","volume":"67","author":"Mfuh","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib43","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1021\/acsmedchemlett.3c00439","article-title":"Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity","volume":"14","author":"Boerth","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ymthe.2025.04.042_bib44","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s42003-023-05655-8","article-title":"The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition","volume":"6","author":"Kimani","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.abb.2015.02.006","article-title":"N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle","volume":"570","author":"Ochi","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ymthe.2025.04.042_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116130","article-title":"An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern","volume":"38","author":"Hu","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ymthe.2025.04.042_bib47","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1111\/jcmm.14820","article-title":"The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations","volume":"24","author":"Weisberg","year":"2020","journal-title":"J. Cel. Mol. Med."},{"key":"10.1016\/j.ymthe.2025.04.042_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10143084","article-title":"Current Treatment of Juvenile Myelomonocytic Leukemia","volume":"10","author":"Mayerhofer","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ymthe.2025.04.042_bib49","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1182\/blood-2010-01-266742","article-title":"FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo","volume":"117","author":"Sato","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2025.04.042_bib50","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.drudis.2016.06.012","article-title":"Stapled peptide design: principles and roles of computation","volume":"21","author":"Tan","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ymthe.2025.04.042_bib51","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/s41467-020-15783-y","article-title":"Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain","volume":"11","author":"Magnussen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2025.04.042_bib52","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1083\/jcb.200911091","article-title":"Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions","volume":"189","author":"Hubner","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ymthe.2025.04.042_bib53","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol. Cel. Proteomics"},{"key":"10.1016\/j.ymthe.2025.04.042_bib54","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ymthe.2025.04.042_bib55","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2025.04.042_bib56","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2025.04.042_bib57","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbrc.2016.01.050","article-title":"Rapid isolation of peptidic inhibitors of the solute carrier family transporters OATP1B1 and OATP1B3 by cell-based phage display selections","volume":"473","author":"Arita","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymthe.2025.04.042_bib58","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/nprot.2007.151","article-title":"Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries","volume":"2","author":"Tonikian","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ymthe.2025.04.042_bib59","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.molcel.2017.09.027","article-title":"A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants","volume":"68","author":"Gabrielsen","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2025.04.042_bib60","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1158\/0008-5472.CAN-21-0613","article-title":"A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability","volume":"81","author":"Temps","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2025.04.042_bib61","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1107\/S0021889809045701","article-title":"xia2: an expert system for macromolecular crystallography data reduction","volume":"43","author":"Winter","year":"2010","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.ymthe.2025.04.042_bib62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Xds","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.ymthe.2025.04.042_bib63","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.ymthe.2025.04.042_bib64","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.ymthe.2025.04.042_bib65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.ymthe.2025.04.042_bib66","first-page":"716","article-title":"Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies","volume":"109","author":"McCarty","year":"1985","journal-title":"Arch. Pathol. Lab. Med."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625003612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625003612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:32:42Z","timestamp":1783020762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001625003612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1525001625003612"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.04.042","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.04.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}