{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:01:30Z","timestamp":1770271290755,"version":"3.49.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI171201"],"award-info":[{"award-number":["AI171201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI152190"],"award-info":[{"award-number":["AI152190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HV22C0009"],"award-info":[{"award-number":["HV22C0009"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience & Biotechnology","doi-asserted-by":"publisher","award":["KGM4572532"],"award-info":[{"award-number":["KGM4572532"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2024-00467046"],"award-info":[{"award-number":["RS-2024-00467046"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ymthe.2025.10.044","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:36:25Z","timestamp":1761316585000},"page":"1084-1103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recombinant Dabie bandavirus as a bivalent vaccine platform inducing protective immunity against intracellular pathogens and cancer"],"prefix":"10.1016","volume":"34","author":[{"given":"Hyo-Jin","family":"Ro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yebeen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ho","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Green","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joowan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Gu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Yoon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Hyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Young","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ki","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae U.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Joo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam-Hyuk","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2025.10.044_bib1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s12276-021-00610-1","article-title":"Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy","volume":"53","author":"Casel","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ymthe.2025.10.044_bib2","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ymthe.2025.10.044_bib3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/infdis\/jit603","article-title":"The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan","volume":"209","author":"Takahashi","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3201\/eid2505.181463","article-title":"Endemic severe fever with thrombocytopenia syndrome, Vietnam","volume":"25","author":"Tran","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib5","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.3201\/eid1911.130792","article-title":"Severe fever with thrombocytopenia syndrome, South Korea, 2012","volume":"19","author":"Kim","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4269\/ajtmh.15-0047","article-title":"Phylogenetic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in South Korea and Migratory Bird Routes Between China, South Korea, and Japan","volume":"93","author":"Yun","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ymthe.2025.10.044_bib7","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.3201\/eid2608.200135","article-title":"Genotypic Heterogeneity of Orientia tsutsugamushi in Scrub Typhus Patients and Thrombocytopenia Syndrome Co-infection, Myanmar","volume":"26","author":"Win","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib8","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3201\/eid2607.190611","article-title":"Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan","volume":"26","author":"Zohaib","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib9","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.3201\/eid2812.221183","article-title":"Severe Fever with Thrombocytopenia Syndrome Virus Infection, Thailand, 2019-2020","volume":"28","author":"Rattanakomol","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib10","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.4269\/ajtmh.19-0392","article-title":"Severe Fever with Thrombocytopenia Syndrome Virus Infection or Mixed Infection with Scrub Typhus in South Korea in 2000-2003","volume":"101","author":"Thi Hai Yen","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ymthe.2025.10.044_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/s12879-020-05303-0","article-title":"Severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis of epidemiology, clinical signs, routine laboratory diagnosis, risk factors, and outcomes","volume":"20","author":"He","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jiac.2018.07.009","article-title":"Pathophysiology of severe fever with thrombocytopenia syndrome and development of specific antiviral therapy","volume":"24","author":"Saijo","year":"2018","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.ymthe.2025.10.044_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiph.2025.102685","article-title":"Transmission of Severe Fever with Thrombocytopenia Syndrome (SFTS) to humans: A systematic review of individual participant data and meta-analysis","volume":"18","author":"Woo","year":"2025","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.ymthe.2025.10.044_bib14","series-title":"Annual Review of Diseases Prioritized under the Research and Development Blueprint","year":"2018"},{"key":"10.1016\/j.ymthe.2025.10.044_bib15","article-title":"NIAID Biodefense Research Agenda for Category B and C Priority Pathogens","volume":"03-5315","year":"2003","journal-title":"NIH Pub. No."},{"key":"10.1016\/j.ymthe.2025.10.044_bib16","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1128\/JVI.00110-16","article-title":"Characterization of glycoprotein-mediated entry of severe fever with thrombocytopenia syndrome virus","volume":"90","author":"Tani","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib17","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1073\/pnas.1603827113","article-title":"Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion","volume":"113","author":"Halldorsson","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.10.044_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166013","article-title":"Evidence that processing of the severe fever with thrombocytopenia syndrome virus Gn\/Gc polyprotein is critical for viral infectivity and requires an internal Gc signal peptide","volume":"11","author":"Plegge","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2025.10.044_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s13238-013-3901-4","article-title":"The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation","volume":"4","author":"Zhou","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.ymthe.2025.10.044_bib20","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/JVI.03021-13","article-title":"Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses","volume":"88","author":"Santiago","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib21","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1128\/JVI.00154-15","article-title":"Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies","volume":"89","author":"Ning","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/jmcb\/mju015","article-title":"Viral suppression of innate immunity via spatial isolation of TBK1\/IKK\u03b5 from mitochondrial antiviral platform","volume":"6","author":"Ning","year":"2014","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib23","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1128\/JVI.03510-13","article-title":"Evasion of antiviral immunity through sequestering of TBK1\/IKK\u03b5\/IRF3 into viral inclusion bodies","volume":"88","author":"Wu","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib24","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1099\/jgv.0.000280","article-title":"Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation","volume":"96","author":"Chaudhary","year":"2015","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib25","doi-asserted-by":"crossref","first-page":"e00234-17","DOI":"10.1128\/mSphere.00234-17","article-title":"Differential antagonism of human innate immune responses by tick-borne phlebovirus nonstructural proteins","volume":"2","author":"Rezelj","year":"2017","journal-title":"Msphere"},{"key":"10.1016\/j.ymthe.2025.10.044_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41564-018-0329-x","article-title":"Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis","volume":"4","author":"Choi","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib27","first-page":"e981","article-title":"Current Advances in Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV)","volume":"5","author":"Ro","year":"2025","journal-title":"Zoonoses (Ireland)"},{"key":"10.1016\/j.ymthe.2025.10.044_bib28","doi-asserted-by":"crossref","first-page":"26900","DOI":"10.1073\/pnas.1914704116","article-title":"Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model","volume":"116","author":"Yu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.10.044_bib29","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1080\/22221751.2022.2081617","article-title":"Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethality","volume":"11","author":"Dai","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.10.044_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011630","article-title":"Genome-informed investigation of the molecular evolution and genetic reassortment of severe fever with thrombocytopenia syndrome virus","volume":"17","author":"Lee","year":"2023","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib31","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/JVI.03432-14","article-title":"Reverse genetics system for severe fever with thrombocytopenia syndrome virus","volume":"89","author":"Brennan","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29099","article-title":"A natural variation in the RNA polymerase of severe fever with thrombocytopenia syndrome virus enhances viral replication and in vivo virulence","volume":"95","author":"Jeon","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005408","article-title":"Diversification of Orientia tsutsugamushi genotypes by intragenic recombination and their potential expansion in endemic areas","volume":"11","author":"Kim","year":"2017","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib34","first-page":"2279","article-title":"Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis","volume":"6","author":"Mosca","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib35","article-title":"Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib36","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/s41467-018-05746-9","article-title":"Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection","volume":"9","author":"Song","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2025.10.044_bib37","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41418-024-01385-4","article-title":"DNA damage-inducible transcript 3 positively regulates RIPK1-mediated necroptosis","volume":"32","author":"Ni","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ymthe.2025.10.044_bib38","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1038\/s41467-024-47990-2","article-title":"Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2025.10.044_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010718","article-title":"Viral-mediated activation and inhibition of programmed cell death","volume":"18","author":"Verburg","year":"2022","journal-title":"Plos Pathog."},{"key":"10.1016\/j.ymthe.2025.10.044_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-07609-w","article-title":"Inflammation and cancer cell survival: TRAF2 as a key player","volume":"16","author":"Albini","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib41","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12935-024-03356-8","article-title":"MDM2: current research status and prospects of tumor treatment","volume":"24","author":"Yao","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ymthe.2025.10.044_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1561102","article-title":"FAS mediates apoptosis, inflammation, and treatment of pathogen infection","volume":"15","author":"Hu","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib43","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.2147\/JIR.S519885","article-title":"Biological Functions and Clinical Implications of CFLAR: From Cell Death Mechanisms to Therapeutic Targeting in Immune Regulation","volume":"18","author":"Zhang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ymthe.2025.10.044_bib44","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1073\/pnas.1120246109","article-title":"Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57\/BL6 mouse model","volume":"109","author":"Jin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.10.044_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1452739","article-title":"Limitations of a proper SFTSV mouse model using human C-type lectin receptors","volume":"15","author":"Kim","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007813","article-title":"Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice","volume":"14","author":"Kang","year":"2020","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1348276","article-title":"Comparative analysis of the efficacy of vaccines using structural protein subunits of the severe fever with thrombocytopenia syndrome virus","volume":"15","author":"Kim","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib48","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/22221751.2019.1632676","article-title":"Immunization with a recombinant antigen composed of conserved blocks from TSA56 provides broad genotype protection against scrub typhus","volume":"8","author":"Kim","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.10.044_bib49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40794-022-00176-4","article-title":"Vaccines platforms and COVID-19: what you need to know","volume":"8","author":"Acosta-Coley","year":"2022","journal-title":"Trop. Dis. Trav. Med. Vaccin."},{"key":"10.1016\/j.ymthe.2025.10.044_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/v16010128","article-title":"Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development","volume":"16","author":"Kim","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.10.044_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012411","article-title":"Recent research advances in the development of Dabie Banda virus vaccines","volume":"18","author":"Yu","year":"2024","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41541-023-00771-2","article-title":"mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice","volume":"8","author":"Kim","year":"2023","journal-title":"NPJ Vaccin."},{"key":"10.1016\/j.ymthe.2025.10.044_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29203","article-title":"SFTSV Gn-Head mRNA vaccine confers efficient protection against lethal viral challenge","volume":"95","author":"Kim","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2025.127631","article-title":"The mRNA vaccine encoding Gc protein confers complete protection against severe fever with thrombocytopaenia syndrome virus","volume":"63","author":"Zhang","year":"2025","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.10.044_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00769-24","article-title":"A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses","volume":"98","author":"Lu","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01868-23","article-title":"Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets","volume":"14","author":"Kim","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.ymthe.2025.10.044_bib57","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41541-018-0096-y","article-title":"Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus","volume":"4","author":"Dong","year":"2019","journal-title":"npj Vaccin."},{"key":"10.1016\/j.ymthe.2025.10.044_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008859","article-title":"A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome","volume":"17","author":"Yoshikawa","year":"2021","journal-title":"Plos Pathog."},{"key":"10.1016\/j.ymthe.2025.10.044_bib59","article-title":"Safety, Immunogenicity, and Efficacy of a Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever with Thrombocytopenia Syndrome Virus and Heartland Bandavirus","volume":"12","author":"Hicks","year":"2024","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ymthe.2025.10.044_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109076","article-title":"A rabies virus vectored severe fever with thrombocytopenia syndrome (SFTS) bivalent candidate vaccine confers protective immune responses in mice","volume":"257","author":"Tian","year":"2021","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib61","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fmicb.2020.01473","article-title":"Recombinant human adenovirus type 5 co-expressing RABV G and SFTSV Gn induces protective immunity against rabies virus and severe fever with thrombocytopenia syndrome virus in mice","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib62","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41541-024-00993-y","article-title":"Adenovirus type 5-expressing Gn induces better protective immunity than Gc against SFTSV infection in mice","volume":"9","author":"Qian","year":"2024","journal-title":"npj Vaccin."},{"key":"10.1016\/j.ymthe.2025.10.044_bib63","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1038\/s41598-023-35328-9","article-title":"Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2025.10.044_bib64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41541-022-00503-y","article-title":"The use of viral vectors in vaccine development","volume":"7","author":"Travieso","year":"2022","journal-title":"NPJ Vaccin."},{"key":"10.1016\/j.ymthe.2025.10.044_bib65","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S1473-3099(17)30313-4","article-title":"Safety and immunogenicity of the rVSV\u0394 G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study","volume":"17","author":"Heppner","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib66","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(16)32621-6","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola \u00c7a Suffit!)","volume":"389","author":"Henao-Restrepo","year":"2017","journal-title":"The Lancet"},{"key":"10.1016\/j.ymthe.2025.10.044_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34927","article-title":"Viral vector-and virus-like particle-based vaccines against infectious diseases: A minireview","volume":"10","author":"Henr\u00edquez","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.ymthe.2025.10.044_bib68","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3390\/genes13081370","article-title":"Appraisal for the potential of viral and nonviral vectors in gene therapy: a review","volume":"13","author":"Butt","year":"2022","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.ymthe.2025.10.044_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/v17081095","article-title":"Homologous and Heterologous Vaccination Regimens with mRNA and rVSV Platforms Induce Potent Immune Responses Against SFTSV Glycoprotein","volume":"17","author":"Manzoni","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.10.044_bib70","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jebm.12525","article-title":"Cost-effectiveness of COVID-19 vaccination: A systematic review","volume":"16","author":"Fu","year":"2023","journal-title":"J. Evid. Based. Med."},{"key":"10.1016\/j.ymthe.2025.10.044_bib71","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.23688","article-title":"Cost-Effectiveness of 2023-2024 COVID-19 Vaccination in US Adults","volume":"8","author":"Prosser","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ymthe.2025.10.044_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0001693","article-title":"What, how and who: Cost-effectiveness analyses of COVID-19 vaccination to inform key policies in Nigeria","volume":"3","author":"Ruiz","year":"2023","journal-title":"PLOS Glob. Public Health"},{"key":"10.1016\/j.ymthe.2025.10.044_bib73","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.4269\/ajtmh.19-0242","article-title":"Coinfection of Severe Fever with Thrombocytopenia Syndrome and Scrub Typhus in Patients with Tick-Borne Illness","volume":"101","author":"Ra","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ymthe.2025.10.044_bib74","article-title":"CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection","volume":"11","author":"Xu","year":"2017","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004991","article-title":"Protective and Pathogenic Roles of CD8+ T Lymphocytes in Murine Orientia tsutsugamushi Infection","volume":"10","author":"Hauptmann","year":"2016","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.ymthe.2025.10.044_bib76","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8(+) T cells in cancer and cancer immunotherapy","volume":"124","author":"Raskov","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ymthe.2025.10.044_bib77","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.4049\/jimmunol.169.3.1326","article-title":"Regulation of class II MHC expression in APCs: roles of types I, III, and IV class II transactivator","volume":"169","author":"Pai","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib78","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/ijms22031074","article-title":"The MHC class II transactivator CIITA: not (quite) the odd-one-out anymore among NLR proteins","volume":"22","author":"Le\u00f3n Machado","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2025.10.044_bib79","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3390\/v4081335","article-title":"Herpesviruses placating the unwilling host: manipulation of the MHC class II antigen presentation pathway","volume":"4","author":"Zuo","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.10.044_bib80","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1128\/JVI.00250-13","article-title":"Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and-independent mechanisms: implications for oncogenesis","volume":"87","author":"Zuo","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib81","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1128\/JVI.06908-11","article-title":"Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3","volume":"86","author":"Butler","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib82","article-title":"Host responses and regulation by NF\u03baB signaling in the liver and liver epithelial cells infected with a novel tick-borne bunyavirus","volume":"5","author":"Sun","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2025.10.044_bib83","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1016\/j.celrep.2020.02.105","article-title":"SFTSV infection induces BAK\/BAX-dependent mitochondrial DNA release to trigger NLRP3 inflammasome activation","volume":"30","author":"Li","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2025.10.044_bib84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0092-8674(00)00008-8","article-title":"Smac, a mitochondrial protein that promotes cytochrome c\u2013dependent caspase activation by eliminating IAP inhibition","volume":"102","author":"Du","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2025.10.044_bib85","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ymthe.2025.10.044_bib86","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib87","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1111\/j.1742-4658.2008.06558.x","article-title":"Protein kinase Cepsilon: the mitochondria-mediated signaling pathway","volume":"275","author":"Yonekawa","year":"2008","journal-title":"Febs J."},{"key":"10.1016\/j.ymthe.2025.10.044_bib88","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.tranon.2018.01.006","article-title":"NHERF1 Between Promises and Hopes: Overview on Cancer and Prospective Openings","volume":"11","author":"Centonze","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib89","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-022-01080-1","article-title":"Hypoxia signaling in human health and diseases: implications and prospects for therapeutics","volume":"7","author":"Luo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2025.10.044_bib90","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/v9080230","article-title":"Interference of apoptosis by hepatitis B virus","volume":"9","author":"Lin","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.10.044_bib91","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1134\/S0026893322050132","article-title":"Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells","volume":"56","author":"Vinogradskaya","year":"2022","journal-title":"Mol. Biol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib92","article-title":"Programmed cell death-dependent host defense in ocular herpes simplex virus infection","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib93","article-title":"A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis","volume":"122","author":"Li","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2025.10.044_bib94","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1080\/21645515.2020.1814094","article-title":"Subcutaneous vaccine administration - an outmoded practice","volume":"17","author":"Cook","year":"2021","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.ymthe.2025.10.044_bib95","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fmicb.2017.00104","article-title":"Animal Models of Emerging Tick-Borne Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection","volume":"8","author":"Matsuno","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib96","doi-asserted-by":"crossref","first-page":"e00743-17","DOI":"10.1128\/JVI.00743-17","article-title":"Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated generation of NSs deletant viruses","volume":"91","author":"Brennan","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib97","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/IAI.01239-10","article-title":"An autotransporter protein from Orientia tsutsugamushi mediates adherence to nonphagocytic host cells","volume":"79","author":"Ha","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ymthe.2025.10.044_bib98","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fimmu.2018.02022","article-title":"A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses","volume":"9","author":"Min","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.10.044_bib99","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-1759(98)00170-7","article-title":"A statistically defined endpoint titer determination method for immunoassays","volume":"221","author":"Frey","year":"1998","journal-title":"J. Immunol. Methods"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625008652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625008652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:35:53Z","timestamp":1770222953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001625008652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1525001625008652"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.10.044","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant Dabie bandavirus as a bivalent vaccine platform inducing protective immunity against intracellular pathogens and cancer","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.10.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}