{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:08:27Z","timestamp":1773871707716,"version":"3.50.1"},"reference-count":9,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL147028"],"award-info":[{"award-number":["RO1HL147028"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ymthe.2025.10.058","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T01:43:26Z","timestamp":1763603006000},"page":"5940-5942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking the alternative chloride pathway in cystic fibrosis"],"prefix":"10.1016","volume":"33","author":[{"given":"Mounika","family":"Pathuri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-8004","authenticated-orcid":false,"given":"Raman","family":"Bahal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2025.10.058_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102793","article-title":"Therapeutic Approaches for Patients with Cystic Fibrosis Not Eligible for Current CFTR Modulators","volume":"10","author":"Fajac","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ymthe.2025.10.058_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2147\/JEP.S255377","article-title":"Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis","volume":"13","author":"Pinto","year":"2021","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.ymthe.2025.10.058_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/17534666241297877","article-title":"Modulator-refractory cystic fibrosis: Defining the scope and challenges of an emerging at-risk population","volume":"18","author":"Somerville","year":"2024","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.ymthe.2025.10.058_bib4","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1016\/j.ymthe.2025.08.045","article-title":"Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides","volume":"33","author":"Mitri","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2025.10.058_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2022.102206","article-title":"TMEM16A (ANO1) as a therapeutic target in cystic fibrosis","volume":"64","author":"Galietta","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ymthe.2025.10.058_bib6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.tips.2022.06.006","article-title":"The pharmacology of the TMEM16A channel: therapeutic opportunities","volume":"43","author":"Al-Hosni","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ymthe.2025.10.058_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41467-017-00813-z","article-title":"MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology","volume":"8","author":"Sonneville","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2025.10.058_bib8","first-page":"7454","article-title":"Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells","volume":"48","author":"Michaels","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2025.10.058_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2114886119","article-title":"Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis","volume":"119","author":"Michaels","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625009335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625009335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:43:31Z","timestamp":1773845011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001625009335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1525001625009335"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.10.058","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unlocking the alternative chloride pathway in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.10.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.08.045","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}