{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:21:26Z","timestamp":1776374486566,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2511001"],"award-info":[{"award-number":["2024YFC2511001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20172015"],"award-info":[{"award-number":["20172015"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["22XD1431400"],"award-info":[{"award-number":["22XD1431400"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22140903900"],"award-info":[{"award-number":["22140903900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8197030261"],"award-info":[{"award-number":["8197030261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8247032470"],"award-info":[{"award-number":["8247032470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015796","name":"Shanghai Lingjun Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015796","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ymthe.2025.11.030","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:45:20Z","timestamp":1764348320000},"page":"1539-1553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phosphodiesterase 1A overexpression contributes to the progression of renal fibrosis"],"prefix":"10.1016","volume":"34","author":[{"given":"Wenkai","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingru","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangshu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahui","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayue","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renhua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulin","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2025.11.030_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41581-022-00590-z","article-title":"The fibrogenic niche in kidney fibrosis: components and mechanisms","volume":"18","author":"Li","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib3","doi-asserted-by":"crossref","first-page":"11925","DOI":"10.1096\/fj.202000754R","article-title":"Depletion of cyclic-GMP levels and inhibition of cGMP-dependent protein kinase activate p21Cip1\/p27Kip1 pathways and lead to renal fibrosis and dysfunction","volume":"34","author":"Das","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.ymthe.2025.11.030_bib4","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.3390\/ijms16022320","article-title":"Cyclic nucleotide signalling in kidney fibrosis","volume":"16","author":"Schinner","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2025.11.030_bib5","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/HYPERTENSIONAHA.114.04187","article-title":"Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study","volume":"64","author":"Lankhorst","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.ymthe.2025.11.030_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ajh\/hpx130","article-title":"Tadalafil Improves L-NG-Nitroarginine Methyl Ester-Induced Preeclampsia With Fetal Growth Restriction-Like Symptoms in Pregnant Mice","volume":"31","author":"Yoshikawa","year":"2017","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ymthe.2025.11.030_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jphs.2022.03.003","article-title":"Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model","volume":"149","author":"Tomita","year":"2022","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ymthe.2025.11.030_bib8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12929-017-0390-4","article-title":"Therapeutic efficacy of pentoxifylline on proteinuria and renal progression: an update","volume":"24","author":"Chen","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ymthe.2025.11.030_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfae261","article-title":"The soluble guanylate cyclase activator runcaciguat significantly improves albuminuria in patients with chronic kidney disease: a randomized placebo-controlled clinical trial","volume":"40","author":"Gansevoort","year":"2025","journal-title":"Nephrol. Dial Transpl."},{"key":"10.1016\/j.ymthe.2025.11.030_bib10","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1681\/ASN.0000000000000418","article-title":"Effect of Avenciguat on Albuminuria in Patients with CKD: Two Randomized Placebo-Controlled Trials","volume":"35","author":"Heerspink","year":"2024","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173852","article-title":"Protective effect of a novel phosphodiesterase 4 selective inhibitor, compound A, in diabetic nephropathy model mice","volume":"894","author":"Ookawara","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib12","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1681\/ASN.2015010057","article-title":"Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies","volume":"27","author":"Ye","year":"2016","journal-title":"JASN"},{"key":"10.1016\/j.ymthe.2025.11.030_bib13","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1681\/ASN.2013040421","article-title":"Phosphodiesterase 1A modulates cystogenesis in zebrafish","volume":"25","author":"Sussman","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1186\/s12864-017-4247-8","article-title":"PDE1A polymorphism contributes to the susceptibility of nephrolithiasis","volume":"18","author":"Yang","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ymthe.2025.11.030_bib15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1074\/jbc.271.2.796","article-title":"Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3\u2019,5\u2019-cyclic nucleotide phosphodiesterases","volume":"271","author":"Loughney","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.11.030_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107858","article-title":"Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities","volume":"226","author":"Samidurai","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ymthe.2025.11.030_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuropharm.2010.05.004","article-title":"Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues","volume":"59","author":"Lakics","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ymthe.2025.11.030_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.119750","article-title":"Urinary exosomal mRNAs as biomarkers for predicting the therapeutic effect of renin-angiotensin system inhibitors in IgA nephropathy patients","volume":"561","author":"Zhao","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ymthe.2025.11.030_bib19","article-title":"Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib20","article-title":"Generation and phenotypic characterization of Pde1a mutant mice","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2025.11.030_bib21","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1042\/BST20190225","article-title":"cGMP signalling in cardiomyocyte microdomains","volume":"47","author":"Bork","year":"2019","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ymthe.2025.11.030_bib22","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1681\/ASN.2005010030","article-title":"Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts","volume":"16","author":"Huang","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib23","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/me.2005-0330","article-title":"Role of nitric oxide in high glucose-induced mitogenic response in renal fibroblasts","volume":"20","author":"Chuang","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib24","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1152\/jappl.2001.91.3.1421","article-title":"Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression","volume":"91","author":"Lincoln","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib25","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of \u03b2-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2025.11.030_bib26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1101\/gad.13.3.270","article-title":"The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro","volume":"13","author":"Winston","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ymthe.2025.11.030_bib27","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1074\/jbc.M508778200","article-title":"Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase","volume":"281","author":"Taurin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2025.11.030_bib28","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41392-025-02142-w","article-title":"Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances","volume":"10","author":"Xue","year":"2025","journal-title":"Sig Transduct Target Ther."},{"key":"10.1016\/j.ymthe.2025.11.030_bib29","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1242\/jcs.02594","article-title":"TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN","volume":"118","author":"Vogelmann","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ymthe.2025.11.030_bib30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","article-title":"Control of \u03b2-Catenin Phosphorylation\/Degradation by a Dual-Kinase Mechanism","volume":"108","author":"Liu","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2025.11.030_bib31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1124\/jpet.122.001423","article-title":"The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease","volume":"384","author":"Reinhart","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ymthe.2025.11.030_bib32","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/jpet.115.230706","article-title":"A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat","volume":"356","author":"Boustany-Kari","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ymthe.2025.11.030_bib33","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2174\/092986708784567725","article-title":"NO signaling through cGMP in renal tissue fibrosis and beyond: key pathway and novel therapeutic target","volume":"15","author":"Wang-Rosenke","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ymthe.2025.11.030_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfad098","article-title":"Sacubitril\/valsartan ameliorates renal tubulointerstitial injury through increasing renal plasma flow in a mouse model of type 2 diabetes with aldosterone excess","volume":"38","author":"Nishio","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ymthe.2025.11.030_bib35","first-page":"493","article-title":"Avenciguat reduces albuminuria in patients with chronic kidney disease","volume":"20","author":"Carney","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1083\/jcb.200211041","article-title":"Direct activation of PDE5 by cGMP: long-term effects within NO\/cGMP signaling","volume":"160","author":"Mullershausen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib37","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1111\/dom.15099","article-title":"Safety, tolerability, pharmacodynamics and pharmacokinetics of the soluble guanylyl cyclase activator BI 685509 in patients with diabetic kidney disease: A randomized trial","volume":"25","author":"Cherney","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ymthe.2025.11.030_bib38","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13316","article-title":"Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice","volume":"5","author":"Wakui","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.ymthe.2025.11.030_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s12882-023-03427-4","article-title":"Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive","volume":"24","author":"Sabra","year":"2023","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.ymthe.2025.11.030_bib40","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/bph.14939","article-title":"Ca2+ signalling in fibroblasts and the therapeutic potential of KCa3.1 channel blockers in fibrotic diseases","volume":"177","author":"Roach","year":"2020","journal-title":"Br. J. Pharmacol."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625010172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625010172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:38:55Z","timestamp":1776371935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001625010172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1525001625010172"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.11.030","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphodiesterase 1A overexpression contributes to the progression of renal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}