{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:11:55Z","timestamp":1787508715673,"version":"build-2736575974"},"reference-count":75,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200759"],"award-info":[{"award-number":["32200759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370998"],"award-info":[{"award-number":["32370998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA10920001"],"award-info":[{"award-number":["2024YFA10920001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515110549"],"award-info":[{"award-number":["2021A1515110549"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012002"],"award-info":[{"award-number":["2022A1515012002"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Chinese Academy of Sciences Youth Innovation Promotion Association","doi-asserted-by":"publisher","award":["2022361"],"award-info":[{"award-number":["2022361"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M682942"],"award-info":[{"award-number":["2020M682942"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["SKLRD-Z-202208"],"award-info":[{"award-number":["SKLRD-Z-202208"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["SKLRD-Z-202109"],"award-info":[{"award-number":["SKLRD-Z-202109"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["SKLRD-Z-202319"],"award-info":[{"award-number":["SKLRD-Z-202319"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013262","name":"State Key Laboratory of Respiratory Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ymthe.2025.12.027","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T08:14:39Z","timestamp":1765440879000},"page":"1597-1615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A replication-incompetent adenovirus type 55 vaccine induces broad and durable protective immunity against pathogenic adenoviruses"],"prefix":"10.1016","volume":"34","author":[{"given":"Ying","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfa","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikai","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmiao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xikui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-1626","authenticated-orcid":false,"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2025.12.027_bib1","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001721","article-title":"ICTV Virus Taxonomy Profile: Adenoviridae 2022","volume":"103","author":"Benk\u0151","year":"2022","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jcv.2011.11.001","article-title":"Molecular typing of adenoviruses in pediatric respiratory infections in Buenos Aires, Argentina (1999-2010)","volume":"53","author":"Barrero","year":"2012","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib3","article-title":"Prevalence and Burden of Human Adenovirus-Associated Acute Respiratory Illness in the Republic of Korea Military, 2013 to 2022","volume":"39","author":"Kim","year":"2024","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.ymthe.2025.12.027_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3904\/kjim.2019.092","article-title":"Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018","volume":"36","author":"Ko","year":"2021","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.ymthe.2025.12.027_bib5","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3201\/eid2211.160728","article-title":"Severe Pneumonia Associated with Adenovirus Type 55 Infection, France, 2014","volume":"22","author":"Lafolie","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcv.2016.03.002","article-title":"Outbreak of adenovirus type 55 infection in Israel","volume":"78","author":"Salama","year":"2016","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/JCM.01769-08","article-title":"Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11","volume":"47","author":"Zhu","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/dmp.2015.185","article-title":"Dynamic Changes in Clinical Characteristics During an Outbreak of Human Adenovirus Serotype 55 in China","volume":"12","author":"Gao","year":"2018","journal-title":"Disaster Med. Public Health Prep."},{"key":"10.1016\/j.ymthe.2025.12.027_bib9","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001445","article-title":"Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections","volume":"70","author":"Zhu","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib10","article-title":"Severe pneumonia caused by human adenovirus type 55 in children","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.ymthe.2025.12.027_bib11","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s10096-019-03471-9","article-title":"Prolonged shedding of type 55 human adenovirus in immunocompetent adults with adenoviral respiratory infections","volume":"38","author":"Huh","year":"2019","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/23744235.2015.1055585","article-title":"Fatal pneumonia cases caused by human adenovirus 55 in immunocompetent adults","volume":"48","author":"Zhang","year":"2016","journal-title":"Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib13","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1038\/emi.2017.29","article-title":"Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China","volume":"6","author":"Zheng","year":"2017","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.12.027_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105034","article-title":"Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies","volume":"188","author":"Dodge","year":"2021","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ymthe.2025.12.027_bib15","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.vaccine.2012.12.029","article-title":"History of the restoration of adenovirus type 4 and type 7 vaccine, live oral (Adenovirus Vaccine) in the context of the Department of Defense acquisition system","volume":"31","author":"Hoke","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib16","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1016\/j.vaccine.2008.03.037","article-title":"A double-blind, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults","volume":"26","author":"Lyons","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib17","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1128\/JCM.00282-09","article-title":"Genomic analyses of recombinant adenovirus type 11a in China","volume":"47","author":"Yang","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1086\/653083","article-title":"Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States","volume":"202","author":"Kajon","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib19","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3201\/1708.101760","article-title":"Deaths associated with human adenovirus-14p1 infections, Europe, 2009-2010","volume":"17","author":"Carr","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197308162890704","article-title":"Further study on acute hemorrhagic cystitis due to adenovirus type 11","volume":"289","author":"Numazaki","year":"1973","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ymthe.2025.12.027_bib21","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0022-5347(17)36227-4","article-title":"Acute hemorrhagic cystitis caused by adenovirus following renal transplantation: review of the literature","volume":"149","author":"Koga","year":"1993","journal-title":"J. Urol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib22","doi-asserted-by":"crossref","first-page":"e00747-20","DOI":"10.1128\/JVI.00747-20","article-title":"Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles","volume":"94","author":"Feng","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.virol.2018.03.002","article-title":"Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity","volume":"518","author":"Feng","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.ymthe.2025.12.027_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.antiviral.2018.04.001","article-title":"A tetravalent vaccine comprising hexon-chimeric adenoviruses elicits balanced protective immunity against human adenovirus types 3, 7, 14 and 55","volume":"154","author":"Tian","year":"2018","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ymthe.2025.12.027_bib25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41426-018-0197-8","article-title":"Broadly neutralizing monoclonal antibodies against human adenovirus types 55, 14p, 7, and 11 generated with recombinant type 11 fiber knob","volume":"7","author":"Tian","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.12.027_bib26","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1128\/JVI.02061-12","article-title":"Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis","volume":"87","author":"Koyuncu","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib27","article-title":"Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors","volume":"6","author":"Yan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2025.12.027_bib28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1128\/JVI.06254-11","article-title":"Adenovirus serotype 5 neutralizing antibodies target both hexon and fiber following vaccination and natural infection","volume":"86","author":"Bradley","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib29","article-title":"Live Oral Adenovirus Type 4 and Type 7 Vaccine Induces Durable Antibody Response","volume":"8","author":"Collins","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ymthe.2025.12.027_bib30","first-page":"29","article-title":"Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways","volume":"273","author":"Windheim","year":"2004","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/v13122502","article-title":"Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy","volume":"13","author":"Watanabe","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.12.027_bib32","doi-asserted-by":"crossref","first-page":"e00015-15","DOI":"10.1128\/mSphere.00015-15","article-title":"The Human Adenovirus Type 5 E4orf6\/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity","volume":"1","author":"Dallaire","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.ymthe.2025.12.027_bib33","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/v2081681","article-title":"Adenoviral producer cells","volume":"2","author":"Kovesdi","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.12.027_bib34","doi-asserted-by":"crossref","first-page":"12441","DOI":"10.1128\/JVI.02225-12","article-title":"Genome sequence of human adenovirus type 55, a re-emergent acute respiratory disease pathogen in China","volume":"86","author":"Zhang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/JCM.01694-09","article-title":"Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen","volume":"48","author":"Walsh","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib36","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s12250-021-00414-7","article-title":"Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia","volume":"36","author":"Zhang","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.ymthe.2025.12.027_bib37","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/cid\/ciu507","article-title":"Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines","volume":"59","author":"Radin","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib38","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1016\/j.vaccine.2016.07.033","article-title":"Safety evaluation of adenovirus type 4 and type 7 vaccine live, oral in military recruits","volume":"34","author":"Choudhry","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib39","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/rccm.201603-0654OC","article-title":"Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial","volume":"195","author":"van Zyl-Smit","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ymthe.2025.12.027_bib40","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa2034201","article-title":"Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine","volume":"384","author":"Sadoff","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ymthe.2025.12.027_bib41","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S1473-3099(21)00396-0","article-title":"Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial","volume":"21","author":"Wu","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ymthe.2025.12.027_bib42","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1080\/22221751.2021.1981157","article-title":"A bivalent live-attenuated vaccine candidate elicits protective immunity against human adenovirus types 4 and 7","volume":"10","author":"Guo","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.12.027_bib43","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1016\/j.vaccine.2021.05.023","article-title":"Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family","volume":"39","author":"Tufail","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib44","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12250-020-00234-1","article-title":"Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: \u201cAdenovirus Vaccine Within an Adenovirus Vector\u201d","volume":"36","author":"Yan","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.ymthe.2025.12.027_bib45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41541-023-00754-3","article-title":"A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response","volume":"8","author":"Mazboudi","year":"2023","journal-title":"NPJ Vaccin."},{"key":"10.1016\/j.ymthe.2025.12.027_bib46","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ymthe.2025.12.027_bib47","article-title":"Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients","volume":"147","author":"Cederwall","year":"2020","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.ymthe.2025.12.027_bib48","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.3390\/v7102896","article-title":"Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein","volume":"7","author":"Tian","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2025.12.027_bib49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41392-020-00352-y","article-title":"A systematic review of SARS-CoV-2 vaccine candidates","volume":"5","author":"Dong","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2025.12.027_bib50","article-title":"Virus-Like Particles: Revolutionary Platforms for Developing Vaccines Against Emerging Infectious Diseases","volume":"12","author":"Tariq","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.reprotox.2021.07.010","article-title":"Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice","volume":"104","author":"Stebbings","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib52","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1038\/s41467-022-33937-y","article-title":"A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection","volume":"13","author":"Calvert","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2025.12.027_bib53","doi-asserted-by":"crossref","DOI":"10.1177\/10760296211068487","article-title":"Thrombosis with Thrombocytopenia Syndrome After Administration of AZD1222 or Ad26.COV2.S Vaccine for COVID-19: A Systematic Review","volume":"27","author":"Waqar","year":"2021","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.ymthe.2025.12.027_bib54","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1016\/j.vaccine.2023.07.013","article-title":"Thrombosis with thrombocytopenia syndrome: A database review of clinical trial and post-marketing experience with Ad26.COV2.S","volume":"41","author":"Struyf","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib55","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2475831","article-title":"The seroprevalence of adenoviruses since 2000(1)","volume":"14","author":"Hong","year":"2025","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.12.027_bib56","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1016\/j.vaccine.2013.04.035","article-title":"A phase 3, randomized, double-blind, placebo-controlled study of the safety and efficacy of the live, oral adenovirus type 4 and type 7 vaccine, in U.S. military recruits","volume":"31","author":"Kuschner","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.197886","article-title":"Infection and replication of human adenovirus type 3 possessing type 5 fiber protein in rodent cells","volume":"279","author":"Liu","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.ymthe.2025.12.027_bib58","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2025.12.027_bib59","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1128\/JVI.00205-12","article-title":"A new human DSG2-transgenic mouse model for studying the tropism and pathology of human adenoviruses","volume":"86","author":"Wang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib60","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2307513","article-title":"Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews","volume":"13","author":"Liu","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ymthe.2025.12.027_bib61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-virology-092818-015550","article-title":"Adenovirus Entry: From Infection to Immunity","volume":"6","author":"Greber","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib62","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/sj.mt.6300031","article-title":"Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors","volume":"15","author":"Cerullo","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2025.12.027_bib63","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/hum.2014.001","article-title":"Innate immunity to adenovirus","volume":"25","author":"Hendrickx","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2025.12.027_bib64","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cyto.2015.02.007","article-title":"B cells responses and cytokine production are regulated by their immune microenvironment","volume":"74","author":"Vazquez","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.ymthe.2025.12.027_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198555","article-title":"Inactivation of SARS-CoV-2 by beta-propiolactone causes aggregation of viral particles and loss of antigenic potential","volume":"305","author":"Gupta","year":"2021","journal-title":"Virus Res."},{"key":"10.1016\/j.ymthe.2025.12.027_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181012","article-title":"Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells","volume":"12","author":"Saha","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2025.12.027_bib67","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1182\/bloodadvances.2021004456","article-title":"Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted","volume":"5","author":"Rubinstein","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.ymthe.2025.12.027_bib68","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3324\/haematol.2019.240101","article-title":"T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients","volume":"106","author":"Sanchez-Cespedes","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.ymthe.2025.12.027_bib69","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-065X.2010.00937.x","article-title":"T cells and follicular dendritic cells in germinal center B-cell formation and selection","volume":"237","author":"Vinuesa","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ymthe.2025.12.027_bib70","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2567.2011.03487.x","article-title":"The regulation and role of T follicular helper cells in immunity","volume":"134","author":"Deenick","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.ymthe.2025.12.027_bib71","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nri.2015.10","article-title":"The multifaceted role of CD4(+) T cells in CD8(+) T cell memory","volume":"16","author":"Laidlaw","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib72","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.4110\/in.2023.23.e41","article-title":"The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer","volume":"23","author":"Topchyan","year":"2023","journal-title":"Immune Netw."},{"key":"10.1016\/j.ymthe.2025.12.027_bib73","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4049\/jimmunol.1801003","article-title":"Measuring Antiviral Capacity of T Cell Responses to Adenovirus","volume":"202","author":"Keib","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2025.12.027_bib74","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3324\/haematol.2010.022947","article-title":"Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection","volume":"95","author":"Zandvliet","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.ymthe.2025.12.027_bib75","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-024-01906-0","article-title":"Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625010500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001625010500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:38:01Z","timestamp":1776371881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001625010500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1525001625010500"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.12.027","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A replication-incompetent adenovirus type 55 vaccine induces broad and durable protective immunity against pathogenic adenoviruses","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2025.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}