{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:06:10Z","timestamp":1793307970512,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130035"],"award-info":[{"award-number":["32130035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031910","name":"Changping Laboratory","doi-asserted-by":"publisher","award":["2025B-07-15"],"award-info":[{"award-number":["2025B-07-15"]}],"id":[{"id":"10.13039\/100031910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2024YFA1108000"],"award-info":[{"award-number":["2024YFA1108000"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2021ZD0202500"],"award-info":[{"award-number":["2021ZD0202500"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012600","name":"ShanghaiTech University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ymthe.2026.04.037","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:53:18Z","timestamp":1776927198000},"page":"4482-4501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["SEC62-mediated ER-phagy activation alleviates Alzheimer\u2019s disease pathology and restores cognitive function in 5\u00d7FAD mice"],"prefix":"10.1016","volume":"34","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Jue","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-0542","authenticated-orcid":false,"given":"Zhen-Ge","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2026.04.037_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13195-017-0297-z","article-title":"Alzheimer's disease prevention: from risk factors to early intervention","volume":"9","author":"Crous-Bou","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.ymthe.2026.04.037_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101914","article-title":"The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: A calcium dyshomeostasis perspective","volume":"87","author":"Lim","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ymthe.2026.04.037_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jocn.2020.09.018","article-title":"Recent advances in research on Alzheimer's disease in China","volume":"81","author":"Zhang","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102309","article-title":"Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease","volume":"97","author":"Rajendran","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ymthe.2026.04.037_bib5","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1002\/alz.13847","article-title":"Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions","volume":"20","author":"Hou","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ymthe.2026.04.037_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer's disease","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ymthe.2026.04.037_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer's disease","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ymthe.2026.04.037_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101464","article-title":"Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives","volume":"72","author":"Zhang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ymthe.2026.04.037_bib9","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.7150\/thno.47408","article-title":"Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2026.04.037_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115650","article-title":"Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease","volume":"492","author":"Li","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ymthe.2026.04.037_bib11","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41419-022-05153-5","article-title":"ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments","volume":"13","author":"Ajoolabady","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2026.04.037_bib12","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","article-title":"The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus","volume":"174","author":"Hoozemans","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib13","first-page":"247","article-title":"ER-stress in Alzheimer's disease: turning the scale?","volume":"2","author":"Endres","year":"2013","journal-title":"Am. J. Neurodegener. Dis."},{"key":"10.1016\/j.ymthe.2026.04.037_bib14","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041256","article-title":"ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophagy","volume":"15","author":"Chino","year":"2023","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn1007","article-title":"Unfolding the role of protein misfolding in neurodegenerative diseases","volume":"4","author":"Soto","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrd3050","article-title":"Protein aggregation diseases: pathogenicity and therapeutic perspectives","volume":"9","author":"Aguzzi","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2026.04.037_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib19","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1007\/s12035-020-01929-y","article-title":"Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer's Disease","volume":"57","author":"Uddin","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15548627.2015.1121360","article-title":"Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders","volume":"12","author":"Cai","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.ymthe.2026.04.037_bib21","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/endrev\/bnab006","article-title":"ER Stress in Cardiometabolic Diseases: From Molecular Mechanisms to Therapeutics","volume":"42","author":"Ajoolabady","year":"2021","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ymthe.2026.04.037_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121983","article-title":"Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects","volume":"330","author":"Nagar","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib24","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1016\/j.ymthe.2023.03.028","article-title":"The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis","volume":"31","author":"Duran-Aniotz","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2026.04.037_bib25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ceb.2004.09.012","article-title":"Misfolded proteins, endoplasmic reticulum stress and neurodegeneration","volume":"16","author":"Rao","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tcb.2020.02.001","article-title":"ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum","volume":"30","author":"Chino","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib27","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255192","article-title":"ER-phagy: selective autophagy of the endoplasmic reticulum","volume":"23","author":"Mochida","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ymthe.2026.04.037_bib28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ncb3423","article-title":"Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery","volume":"18","author":"Fumagalli","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.cub.2019.01.041","article-title":"ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy","volume":"29","author":"Chen","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib30","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.molcel.2019.03.033","article-title":"Intrinsically Disordered Protein TEX264 Mediates ER-phagy","volume":"74","author":"Chino","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2026.04.037_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ncb2979","article-title":"Cargo recognition and trafficking in selective autophagy","volume":"16","author":"Stolz","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib32","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.15252\/embr.201643587","article-title":"Structural and functional analysis of the GABARAP interaction motif (GIM)","volume":"18","author":"Rogov","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ymthe.2026.04.037_bib33","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41586-023-06089-2","article-title":"Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum","volume":"618","author":"Gonz\u00e1lez","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.04.037_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/NRR.NRR-D-23-00995","article-title":"Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases","volume":"20","author":"Zhao","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ymthe.2026.04.037_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114255","article-title":"Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity","volume":"43","author":"Mou","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2026.04.037_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2025.102601","article-title":"Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids","volume":"20","author":"Zeng","year":"2025","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ymthe.2026.04.037_bib37","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib38","doi-asserted-by":"crossref","first-page":"222","DOI":"10.7150\/thno.49860","article-title":"Selective autophagy of intracellular organelles: recent research advances","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2026.04.037_bib39","article-title":"Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model","volume":"120","author":"Chen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2026.04.037_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26125502","article-title":"Co-Aggregation of Syndecan-3 with \u03b2-Amyloid Aggravates Neuroinflammation and Cognitive Impairment in 5\u00d7FAD Mice","volume":"26","author":"Ye","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.112891","article-title":"Recognition memory impairments and amyloid-beta deposition of the retrosplenial cortex at the early stage of 5XFAD mice","volume":"222","author":"Kim","year":"2020","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ymthe.2026.04.037_bib42","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-023-00388-4","article-title":"Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer's disease","volume":"13","author":"Zhang","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ymthe.2026.04.037_bib43","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.3390\/ijms25126766","article-title":"Behaviour Hallmarks in Alzheimer's Disease 5xFAD Mouse Model","volume":"25","author":"P\u00e1dua","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib44","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/febs.14332","article-title":"Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease","volume":"285","author":"Gerakis","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.ymthe.2026.04.037_bib45","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2026.04.037_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00401-015-1462-8","article-title":"The unfolded protein response in neurodegenerative diseases: a neuropathological perspective","volume":"130","author":"Scheper","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuron.2008.07.013","article-title":"Linking calcium to Abeta and Alzheimer's disease","volume":"59","author":"Green","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2026.04.037_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.3114pe10","article-title":"ER calcium and Alzheimer's disease: in a state of flux","volume":"3","author":"Mattson","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ymthe.2026.04.037_bib49","article-title":"ER-Phagy: A New Regulator of ER Homeostasis","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib50","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s11064-021-03389-9","article-title":"FAM134B-Mediated ER-Phagy in Mg(2+)-Free Solution-Induced Mitochondrial Calcium Homeostasis and Cell Death in Epileptic Hippocampal Neurons","volume":"46","author":"Wang","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ymthe.2026.04.037_bib51","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jcp.30593","article-title":"The molecular structure and role of LECT2 or CHM-II in arthritis, cancer, and other diseases","volume":"237","author":"Zhu","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ymthe.2026.04.037_bib52","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/s41467-017-01799-4","article-title":"ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating \u03b3-secretase activity","volume":"8","author":"Zhu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2026.04.037_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176127","article-title":"Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases","volume":"21","author":"Ghemrawi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib54","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41392-025-02501-7","article-title":"The role of ER-associated degradation and ER-phagy in health and disease","volume":"11","author":"Jeon","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2026.04.037_bib55","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1523\/JNEUROSCI.2422-09.2010","article-title":"Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation","volume":"30","author":"Kaneko","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/ijms23010117","article-title":"EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-\u03b2 Production","volume":"23","author":"Nowakowska-Go\u0142acka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.037_bib57","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/15548627.2024.2447206","article-title":"The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease","volume":"21","author":"Shen","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.ymthe.2026.04.037_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221929120","article-title":"A selective ER-phagy exerts neuroprotective effects via modulation of \u03b1-synuclein clearance in parkinsonian models","volume":"120","author":"Kim","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2026.04.037_bib59","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1016\/j.ymthe.2023.09.018","article-title":"Intrathecal delivery of AAV-NDNF ameliorates disease progression of ALS mice","volume":"31","author":"Cheng","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2026.04.037_bib60","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10821","article-title":"Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells","volume":"482","author":"Israel","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.04.037_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114548","article-title":"A hominoid-specific signaling axis regulating the tempo of synaptic maturation","volume":"43","author":"Dong","year":"2024","journal-title":"Cell Rep."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626003023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626003023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:47:23Z","timestamp":1786078043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001626003023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1525001626003023"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.04.037","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SEC62-mediated ER-phagy activation alleviates Alzheimer\u2019s disease pathology and restores cognitive function in 5\u00d7FAD mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.04.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}