{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:18:59Z","timestamp":1788297539393,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["SL2023A04J02257"],"award-info":[{"award-number":["SL2023A04J02257"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Department of Science and Technology of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274179"],"award-info":[{"award-number":["82274179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370734"],"award-info":[{"award-number":["82370734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274489"],"award-info":[{"award-number":["82274489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["KS0120240293"],"award-info":[{"award-number":["KS0120240293"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ymthe.2026.04.062","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:52:31Z","timestamp":1778050351000},"page":"4903-4920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Herbacetin as a novel therapeutic agent for pulmonary and renal fibrosis by targeting TGFBR2 for degradation"],"prefix":"10.1016","volume":"34","author":[{"given":"Feng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liumei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingjing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4944-764X","authenticated-orcid":false,"given":"Wenbiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2026.04.062_bib1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.yjmcc.2016.02.011","article-title":"Epigenetic regulation of cardiac fibrosis","volume":"92","author":"Stratton","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107983","article-title":"Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy","volume":"229","author":"Han","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ymthe.2026.04.062_bib3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.04.062_bib4","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.molmed.2023.08.010","article-title":"Pulmonary fibrosis: from pathogenesis to clinical decision-making","volume":"29","author":"Koudstaal","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ymthe.2026.04.062_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.744","article-title":"Pulmonary fibrosis: pathogenesis and therapeutic strategies","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.ymthe.2026.04.062_bib6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mam.2018.06.002","article-title":"Cellular and molecular mechanisms of kidney fibrosis","volume":"65","author":"Djudjaj","year":"2019","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.ymthe.2026.04.062_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2026.04.062_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2021.03.017","article-title":"Emerging drug delivery strategies for idiopathic pulmonary fibrosis treatment","volume":"164","author":"Ghumman","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ymthe.2026.04.062_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tem.2023.09.001","article-title":"Mechanisms of kidney fibrosis and routes towards therapy","volume":"35","author":"Yamashita","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ymthe.2026.04.062_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S2213-2600(18)30502-2","article-title":"Lung transplantation for idiopathic pulmonary fibrosis","volume":"7","author":"George","year":"2019","journal-title":"Lancet. Respir. Med."},{"key":"10.1016\/j.ymthe.2026.04.062_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/2041731414557112","article-title":"The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering","volume":"5","author":"Kular","year":"2014","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.ymthe.2026.04.062_bib12","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2026.04.062_bib13","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.14336\/AD.2023.0222","article-title":"TGF-\u03b2 as A Master Regulator of Aging-Associated Tissue Fibrosis","volume":"14","author":"Ren","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.ymthe.2026.04.062_bib14","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/s41401-025-01476-z","article-title":"Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies","volume":"46","author":"Zhao","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2026.04.062_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ymthe.2026.04.062_bib16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.04.062_bib17","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022053","article-title":"Signaling Receptors for TGF-\u03b2 Family Members","volume":"8","author":"Heldin","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tibs.2004.03.008","article-title":"New insights into TGF-beta-Smad signalling","volume":"29","author":"ten Dijke","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/acsptsci.3c00371","article-title":"Expanding the Chemical Space of Transforming Growth Factor-\u03b2 (TGF\u03b2) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives","volume":"7","author":"L\u00e4ngle","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib20","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/labinvest.2012.127","article-title":"Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-\u03b2 type II receptor","volume":"92","author":"Noh","year":"2012","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ymthe.2026.04.062_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116836","article-title":"Chinese medicine as a therapeutic option for pulmonary fibrosis: Clinical efficacies and underlying mechanisms","volume":"318","author":"Hao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib22","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41401-024-01404-7","article-title":"Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology","volume":"46","author":"Guo","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2026.04.062_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115928","article-title":"Rheum officinale and Salvia miltiorrhiza inhibit renal fibrosis via miR-21\/PTEN\/Akt signaling pathway in vitro and in vivo","volume":"304","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104065","article-title":"Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase","volume":"102","author":"Zhao","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ymthe.2026.04.062_bib25","article-title":"Preventive Effects of Rhodiola rosea L. on Bleomycin-Induced Pulmonary Fibrosis in Rats","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib26","article-title":"Traditional Tibetan medicine: therapeutic potential in lung diseases","volume":"15","author":"Li","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.phymed.2010.02.002","article-title":"Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy","volume":"17","author":"Panossian","year":"2010","journal-title":"Phytomedicine."},{"key":"10.1016\/j.ymthe.2026.04.062_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1541-4337.2005.tb00073.x","article-title":"Rhodiola rosea: A Versatile Adaptogen","volume":"4","author":"Khanum","year":"2005","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.ymthe.2026.04.062_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1017\/S0007114523001988","article-title":"Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature","volume":"131","author":"Tinsley","year":"2024","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ymthe.2026.04.062_bib30","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1089\/end.2013.0319","article-title":"Alleviation of kidney damage induced by unilateral ureter obstruction in rats by Rhodiola rosea","volume":"27","author":"Uyeturk","year":"2013","journal-title":"J. Endourol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib31","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3748\/wjg.v9.i7.1559","article-title":"Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms","volume":"9","author":"Wu","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib32","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2024.13338","article-title":"Exploring the anti-oxidative mechanisms of Rhodiola rosea in ameliorating myocardial fibrosis through network pharmacology and in vitro experiments","volume":"30","author":"Zhang","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ymthe.2026.04.062_bib33","article-title":"Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4\/NF-\u03baB and MAPK Signaling Pathways","volume":"20","author":"Li","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710148","article-title":"Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death","volume":"23","author":"Albadawy","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/13880209.2019.1577460","article-title":"Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control?","volume":"57","author":"P\u00e9ter Zomborszki","year":"2019","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114356","article-title":"A comprehensive review of herbacetin: From chemistry to pharmacological activities","volume":"279","author":"Wei","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib37","article-title":"Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib38","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2147\/JAA.S468689","article-title":"Herbacetin Inhibits Asthma Development by Blocking the SGK1\/NF-\u03baB Signaling Pathway","volume":"17","author":"Chen","year":"2024","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.ymthe.2026.04.062_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157489","article-title":"Multi-scale discovery of herbacetin as a macrophage-targeted SGK1-STAT1 signaling inhibitor alleviating lung inflammation and barrier dysfunction","volume":"148","author":"Ge","year":"2025","journal-title":"Phytomedicine."},{"key":"10.1016\/j.ymthe.2026.04.062_bib40","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1158\/0008-5472.CAN-15-0442","article-title":"Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity","volume":"76","author":"Kim","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2026.04.062_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117117","article-title":"Herbacetin mitigates oxidative stress and ferroptosis to protect against doxorubicin-induced cardiotoxicity","volume":"240","author":"Yang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/09603271221132140","article-title":"Ameliorative effect of herbacetin against cyclophosphamide-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction","volume":"41","author":"Ijaz","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib43","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1364\/BOE.7.003519","article-title":"Characterizing fibrosis in UUO mice model using multiparametric analysis of phasor distribution from FLIM images","volume":"7","author":"Ranjit","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.ymthe.2026.04.062_bib44","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1039\/D3CS00344B","article-title":"Targeted protein degradation directly engaging lysosomes or proteasomes","volume":"53","author":"Kim","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ymthe.2026.04.062_bib45","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.7150\/ijbs.106843","article-title":"Integrated thermal proteome and thermal proximity co-aggregation profiling identifies ATP6V1C1 as a novel anti-cancer drug target","volume":"21","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116203","article-title":"CETSA-MS-based target profiling of anti-aging natural compound quercetin","volume":"267","author":"Bai","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ymthe.2026.04.062_bib47","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.2147\/DDDT.S521265","article-title":"Anthraquinones from Rheum officinale Ameliorate Renal Fibrosis in Acute Kidney Injury and Chronic Kidney Disease","volume":"19","author":"Feng","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ymthe.2026.04.062_bib48","article-title":"Traditional Chinese herbs and natural products in hyperuricemia-induced chronic kidney disease","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib49","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/imna.imna_22_21","article-title":"Tangshen Formula Attenuates Renal Fibrosis by Downregulating Transforming Growth Factor \u03b21\/Smad3 and LncRNA-MEG3 in Rats with Diabetic Kidney Disease","volume":"8","author":"Zhou","year":"2021","journal-title":"Integr. Med. Nephrol. Androl."},{"key":"10.1016\/j.ymthe.2026.04.062_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154390","article-title":"Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism","volume":"106","author":"Tao","year":"2022","journal-title":"Phytomedicine."},{"key":"10.1016\/j.ymthe.2026.04.062_bib51","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/ptr.5486","article-title":"The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms","volume":"29","author":"Cropley","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ymthe.2026.04.062_bib52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s13167-024-00367-3","article-title":"Rhodiola rosea: a review in the context of PPPM approach","volume":"15","author":"Xu","year":"2024","journal-title":"Epma j"},{"key":"10.1016\/j.ymthe.2026.04.062_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114186","article-title":"Total glycosides of Rhodiola rosea L. attenuate LPS-induced acute lung injury by inhibiting TLR4\/NF-\u03baB pathway","volume":"158","author":"Jia","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ymthe.2026.04.062_bib54","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/mc.20780","article-title":"Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy","volume":"51","author":"Liu","year":"2012","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ymthe.2026.04.062_bib55","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/13880209.2024.2319117","article-title":"Elucidating the role of Rhodiola rosea L. in sepsis-induced acute lung injury via network pharmacology: emphasis on inflammatory response, oxidative stress, and the PI3K-AKT pathway","volume":"62","author":"Jiang","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib56","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1038\/s41401-023-01106-6","article-title":"Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36\/fibrosis pathway","volume":"44","author":"Zou","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2026.04.062_bib57","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1002\/ptr.7569","article-title":"The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta-analysis","volume":"36","author":"Guo","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ymthe.2026.04.062_bib58","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s10787-025-01678-1","article-title":"Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis","volume":"33","author":"Wu","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ymthe.2026.04.062_bib59","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41401-023-01156-w","article-title":"Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2026.04.062_bib60","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00051","article-title":"Therapeutic Effects of Quercetin on Renal Fibrosis and Injury","volume":"12","author":"Wang","year":"2025","journal-title":"Integr. Med. Nephrol. Androl."},{"key":"10.1016\/j.ymthe.2026.04.062_bib61","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00064","article-title":"The Clinical Effectiveness of Anti-TGF-\u03b2 Therapy in Chronic Kidney Disease: A Systematic Review of Western and Traditional Chinese Medicine","volume":"12","author":"Wang","year":"2025","journal-title":"Integr. Med. Nephrol. Androl."},{"key":"10.1016\/j.ymthe.2026.04.062_bib62","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.7150\/ijbs.89568","article-title":"The Role of TGF-\u03b2\/SMAD Signaling in Hepatocellular Carcinoma: from Mechanism to Therapy and Prognosis","volume":"20","author":"Xin","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib63","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41401-022-00977-5","article-title":"Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-\u03b2 receptor II","volume":"44","author":"Ni","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2026.04.062_bib64","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.15252\/embr.201540750","article-title":"miR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2","volume":"16","author":"Fierro-Fern\u00e1ndez","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ymthe.2026.04.062_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155286","article-title":"HSP90 Inhibition and Modulation of the Proteome: Therapeutical Implications for Idiopathic Pulmonary Fibrosis (IPF)","volume":"21","author":"Colunga Biancatelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib66","article-title":"Pentabromophenol suppresses TGF-\u03b2 signaling by accelerating degradation of type II TGF-\u03b2 receptors via caveolae-mediated endocytosis","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2026.04.062_bib67","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1080\/14756366.2018.1465416","article-title":"Pentabromopseudilin: a myosin V inhibitor suppresses TGF-\u03b2 activity by recruiting the type II TGF-\u03b2 receptor to lysosomal degradation","volume":"33","author":"Shih-Wei","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ymthe.2026.04.062_bib68","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1073\/pnas.1806217115","article-title":"MARCH3 attenuates IL-1\u03b2-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI","volume":"115","author":"Lin","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2026.04.062_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217004","article-title":"m(6)A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21\/IGF2BP2\/FOXM1 positive feedback loop","volume":"596","author":"Bian","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ymthe.2026.04.062_bib70","doi-asserted-by":"crossref","DOI":"10.4028\/b-7TThNX","article-title":"A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42-mediated GSK-3\u03b2\/\u03b2-catenin Signaling","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ymthe.2026.04.062_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119314","article-title":"Fuzheng Jiedu decoction alleviates H1N1 virus-induced acute lung injury in mice by suppressing the NLRP3 inflammasome activation","volume":"341","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ymthe.2026.04.062_bib72","article-title":"A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms","volume":"11","author":"Huang","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2026.04.062_bib73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: An open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminform."},{"key":"10.1016\/j.ymthe.2026.04.062_bib74","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ymthe.2026.04.062_bib75","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/ci200454v","article-title":"Combining global and local measures for structure-based druggability predictions","volume":"52","author":"Volkamer","year":"2012","journal-title":"J. Chem. Inf. Model."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626003837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626003837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:47:16Z","timestamp":1785962836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001626003837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1525001626003837"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.04.062","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Herbacetin as a novel therapeutic agent for pulmonary and renal fibrosis by targeting TGFBR2 for degradation","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.04.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}