{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:52:27Z","timestamp":1786114347459,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K07268"],"award-info":[{"award-number":["JP22K07268"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ymthe.2026.05.013","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:10:49Z","timestamp":1779808249000},"page":"4729-4742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Restricting efferocytosis pathway to CD91 via phosphatidylserine-targeting chimeric protein augments antitumor immune responses"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9662-322X","authenticated-orcid":false,"given":"Yu","family":"Mizote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Hashiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Okuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Akane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Minomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2026.05.013_bib1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nri2438","article-title":"Immunotherapy of autoimmunity and cancer: the penalty for success","volume":"8","author":"Caspi","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.immuni.2017.10.010","article-title":"The Silent Undertakers: Macrophages Programmed for Efferocytosis","volume":"47","author":"Allen","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.05.013_bib3","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/cdd.2016.11","article-title":"Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer","volume":"23","author":"Birge","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ymthe.2026.05.013_bib5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/417182a","article-title":"Identification of a factor that links apoptotic cells to phagocytes","volume":"417","author":"Hanayama","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.05.013_bib6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.20040342","article-title":"Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice","volume":"200","author":"Asano","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2026.05.013_bib7","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/cas.16099","article-title":"Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG-E8","volume":"115","author":"Mizote","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ymthe.2026.05.013_bib8","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1084\/jem.20082614","article-title":"Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms","volume":"206","author":"Jinushi","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2026.05.013_bib9","doi-asserted-by":"crossref","DOI":"10.4161\/onci.28222","article-title":"The heat shock protein-CD91 pathway mediates tumor immunosurveillance","volume":"3","author":"Zhou","year":"2014","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.ymthe.2026.05.013_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/77835","article-title":"CD91: a receptor for heat shock protein gp96","volume":"1","author":"Binder","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(01)00111-X","article-title":"CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin","volume":"14","author":"Basu","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.05.013_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2005.08.032","article-title":"Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte","volume":"123","author":"Gardai","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2026.05.013_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2026.05.013_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41568-023-00637-8","article-title":"Fcgamma receptors and immunomodulatory antibodies in cancer","volume":"24","author":"Galvez-Cancino","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ymthe.2026.05.013_bib15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1152066","article-title":"Membrane phosphatidylserine regulates surface charge and protein localization","volume":"319","author":"Yeung","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2026.05.013_bib16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.biophys.093008.131234","article-title":"The distribution and function of phosphatidylserine in cellular membranes","volume":"39","author":"Leventis","year":"2010","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.ymthe.2026.05.013_bib17","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/j.1460-2075.1995.tb07221.x","article-title":"39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein","volume":"14","author":"Bu","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2026.05.013_bib18","doi-asserted-by":"crossref","first-page":"17986","DOI":"10.1074\/jbc.M212592200","article-title":"Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain","volume":"278","author":"Migliorini","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2026.05.013_bib19","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncomms1524","article-title":"CD91-dependent programming of T-helper cell responses following heat shock protein immunization","volume":"2","author":"Pawaria","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2026.05.013_bib20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nature14001","article-title":"Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing","volume":"515","author":"Yadav","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.05.013_bib21","article-title":"Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer","volume":"9","author":"Hos","year":"2019","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.ymthe.2026.05.013_bib22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1084\/jem.184.3.923","article-title":"Constitutive class I-restricted exogenous presentation of self antigens in vivo","volume":"184","author":"Kurts","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymthe.2026.05.013_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tcb.2006.02.003","article-title":"Phosphatidylserine recognition by phagocytes: a view to a kill","volume":"16","author":"Wu","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.113","article-title":"Molecular insights of Gas6\/TAM in cancer development and therapy","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2026.05.013_bib25","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2007.11.011","article-title":"TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells","volume":"27","author":"Kobayashi","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.05.013_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature06307","article-title":"Identification of Tim4 as a phosphatidylserine receptor","volume":"450","author":"Miyanishi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.05.013_bib27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/intimm\/dxs064","article-title":"Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity","volume":"24","author":"Miyanishi","year":"2012","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib28","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1158\/1078-0432.CCR-04-1645","article-title":"Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice","volume":"11","author":"Ran","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ymthe.2026.05.013_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1097-2765(04)00237-0","article-title":"Clearance of apoptotic cells: getting rid of the corpses","volume":"14","author":"Lauber","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2026.05.013_bib30","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00262-012-1250-4","article-title":"Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo","volume":"61","author":"Yan","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.ymthe.2026.05.013_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lab.2006.03.006","article-title":"Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5","volume":"148","author":"Dasgupta","year":"2006","journal-title":"Transl. Res."},{"key":"10.1016\/j.ymthe.2026.05.013_bib32","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/cyto.a.20345","article-title":"Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death","volume":"69A","author":"Shi","year":"2006","journal-title":"Cytometry A"},{"key":"10.1016\/j.ymthe.2026.05.013_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1158\/2326-6066.CIR-13-0132","article-title":"Establishment of tumor-associated immunity requires interaction of heat shock proteins with CD91","volume":"2","author":"Zhou","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ymthe.2026.05.013_bib34","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1074\/jbc.271.16.9785","article-title":"Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl","volume":"271","author":"Mark","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2026.05.013_bib35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.1061663","article-title":"Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family","volume":"293","author":"Lu","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2026.05.013_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00262-019-02421-w","article-title":"TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting","volume":"69","author":"Peeters","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.ymthe.2026.05.013_bib37","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1091\/mbc.e13-04-0212","article-title":"The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis","volume":"25","author":"Flannagan","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ymthe.2026.05.013_bib38","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/bjc.2015.323","article-title":"TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner","volume":"113","author":"Zhang","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ymthe.2026.05.013_bib39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2007.11.008","article-title":"Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds","volume":"27","author":"Santiago","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.05.013_bib40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib41","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/bjc.2017.183","article-title":"Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies","volume":"117","author":"Sharma","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ymthe.2026.05.013_bib42","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-immunol-041015-055700","article-title":"Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells","volume":"36","author":"Lindenbergh","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib43","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41564-024-01637-6","article-title":"Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens","volume":"9","author":"Gro\u00df","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib44","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0598-594","article-title":"Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes","volume":"4","author":"Zitvogel","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2026.05.013_bib45","doi-asserted-by":"crossref","first-page":"e003217","DOI":"10.1136\/jitc-2021-003217","article-title":"Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment","volume":"9","author":"Ma","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ymthe.2026.05.013_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-025-02233-w","article-title":"Extracellular vesicles in tumor immunity: mechanisms and novel insights","volume":"24","author":"Kuang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ymthe.2026.05.013_bib47","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41571-025-01074-2","article-title":"Clinical relevance of extracellular vesicles in cancer - therapeutic and diagnostic potential","volume":"22","author":"Greening","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib48","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI200113992","article-title":"LRP: a multifunctional scavenger and signaling receptor","volume":"108","author":"Herz","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymthe.2026.05.013_bib49","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1152\/physrev.00033.2007","article-title":"LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies","volume":"88","author":"Lillis","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ymthe.2026.05.013_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029385","article-title":"Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E","volume":"7","author":"Laatsch","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2026.05.013_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038330","article-title":"Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice","volume":"7","author":"Gordts","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2026.05.013_bib52","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/cdd.2016.5","article-title":"Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation","volume":"23","author":"Garg","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ymthe.2026.05.013_bib53","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1158\/2326-6066.CIR-14-0079","article-title":"Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91","volume":"3","author":"Salimu","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ymthe.2026.05.013_bib54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4049\/jimmunol.172.1.70","article-title":"A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens","volume":"172","author":"Hart","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib55","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1158\/2326-6066.CIR-24-0326","article-title":"CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors","volume":"12","author":"Nayak","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ymthe.2026.05.013_bib56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","article-title":"Immunogenic cell death in cancer therapy","volume":"31","author":"Kroemer","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib57","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/cdd.2016.7","article-title":"Exposure of phosphatidylserine on the cell surface","volume":"23","author":"Nagata","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ymthe.2026.05.013_bib58","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12964-019-0437-0","article-title":"Flipping the dogma - phosphatidylserine in non-apoptotic cell death","volume":"17","author":"Shlomovitz","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ymthe.2026.05.013_bib59","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/gtc.12521","article-title":"Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells","volume":"22","author":"Ooishi","year":"2017","journal-title":"Genes Cells."},{"key":"10.1016\/j.ymthe.2026.05.013_bib60","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s42003-024-06235-0","article-title":"Overcoming thermostability challenges in mRNA-lipid nanoparticle systems with piperidine-based ionizable lipids","volume":"7","author":"Hashiba","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib61","first-page":"12758","article-title":"Impact of Lipid Tail Length on the Organ Selectivity of mRNA-Lipid Nanoparticles","volume":"24","author":"Hashiba","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.ymthe.2026.05.013_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2022.102803","article-title":"The journey of a lifetime - development of Pfizer's COVID-19 vaccine","volume":"78","author":"Thorn","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.ymthe.2026.05.013_bib63","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2144\/000112001","article-title":"High-throughput phagocytosis assay utilizing a pH-sensitive fluorescent dye","volume":"39","author":"Beletskii","year":"2005","journal-title":"Biotechniques"},{"key":"10.1016\/j.ymthe.2026.05.013_bib64","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626004004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626004004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:47:48Z","timestamp":1785962868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001626004004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1525001626004004"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.05.013","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Restricting efferocytosis pathway to CD91 via phosphatidylserine-targeting chimeric protein augments antitumor immune responses","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}