{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:21:28Z","timestamp":1792592488552,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ymthe.2026.06.031","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:15:34Z","timestamp":1781738134000},"page":"5382-5398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p\/ELOVL5 axis"],"prefix":"10.1016","volume":"34","author":[{"given":"Marie","family":"Rhee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonyub","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Woon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Gun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hye","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon-Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-3877","authenticated-orcid":false,"given":"Seung-Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2026.06.031_bib1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2026.06.031_bib2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib3","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib4","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1097\/HEP.0000000000000670","article-title":"Metabolic dysfunction\u2013associated steatotic liver disease: Update and impact of new nomenclature on the American Association for the Study of Liver Diseases practice guidance on nonalcoholic fatty liver disease","volume":"79","author":"Kanwal","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2026.06.031_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076388","article-title":"Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study","volume":"384","author":"Kim","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.ymthe.2026.06.031_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4093\/dmj.2021.0327","article-title":"Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study","volume":"47","author":"Kim","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ymthe.2026.06.031_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00392-020-01709-7","article-title":"NAFLD and cardiovascular diseases: a clinical review","volume":"110","author":"Kasper","year":"2021","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCULATIONAHA.124.070535","article-title":"Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach","volume":"151","author":"Chew","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2026.06.031_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7570\/jomes23052","article-title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review","volume":"32","author":"Chan","year":"2023","journal-title":"JOMES"},{"key":"10.1016\/j.ymthe.2026.06.031_bib10","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1056\/NEJMoa2029349","article-title":"Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease","volume":"385","author":"Sanyal","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ymthe.2026.06.031_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4093\/dmj.2023.0350","article-title":"Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective","volume":"48","author":"Jung","year":"2024","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ymthe.2026.06.031_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S2213-8587(22)00003-1","article-title":"A global view of the interplay between non-alcoholic fatty liver disease and diabetes","volume":"10","author":"Stefan","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib13","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","article-title":"Exosomes as mediators of intercellular crosstalk in metabolism","volume":"33","author":"Isaac","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.06.031_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tem.2023.06.002","article-title":"Extracellular vesicle-mediated interorgan communication in metabolic diseases","volume":"34","author":"Hu","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ymthe.2026.06.031_bib15","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/jdi.13654","article-title":"New mediators in diabetes pathogenesis: Exosomes and metabolites","volume":"12","author":"Lee","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.ymthe.2026.06.031_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.tcb.2023.01.002","article-title":"Extracellular vesicles and nanoparticles: emerging complexities","volume":"33","author":"Jeppesen","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2026.06.031_bib18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/ATVBAHA.117.309795","article-title":"Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration","volume":"38","author":"Nguyen","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2019.09.014","article-title":"Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1","volume":"72","author":"Jiang","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111948","article-title":"Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis","volume":"42","author":"Tang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2026.06.031_bib21","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1161\/ATVBAHA.123.319026","article-title":"Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p","volume":"43","author":"Li","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib22","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jhep.2023.08.023","article-title":"Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux","volume":"79","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ajpath.2022.12.007","article-title":"Contribution of Hepatic Steatosis-Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice","volume":"193","author":"Yuan","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4093\/dmj.2025.0184","article-title":"Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease","volume":"49","author":"Lee","year":"2025","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ymthe.2026.06.031_bib25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12944-017-0514-6","article-title":"Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease","volume":"16","author":"Yamagata","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ymthe.2026.06.031_bib26","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/ATVBAHA.119.313286","article-title":"Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid","volume":"40","author":"Mason","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102292","article-title":"Metabolic dysfunction-associated steatotic liver disease increases the risk of incident cardiovascular disease: a nationwide cohort study","volume":"65","author":"Moon","year":"2023","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ymthe.2026.06.031_bib28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S2468-1253(21)00308-3","article-title":"Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis","volume":"6","author":"Mantovani","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2016.05.013","article-title":"Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis","volume":"65","author":"Targher","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/STROKEAHA.120.030433","article-title":"Severity of Nonalcoholic Fatty Liver Disease and Risk of Future Ischemic Stroke Events","volume":"52","author":"Xu","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2026.06.031_bib31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2020.01.013","article-title":"NAFLD as a driver of chronic kidney disease","volume":"72","author":"Byrne","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib32","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/hep.23890","article-title":"Functional and morphological vascular changes in pediatric nonalcoholic fatty liver disease","volume":"52","author":"Pacifico","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2026.06.031_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.12997\/jla.2024.13.3.232","article-title":"Extracellular Vesicles as Mediators in Atherosclerotic Cardiovascular Disease","volume":"13","author":"Zisser","year":"2024","journal-title":"J. Lipid Atheroscler."},{"key":"10.1016\/j.ymthe.2026.06.031_bib34","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ymthe.2017.03.031","article-title":"Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis","volume":"25","author":"Zheng","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2026.06.031_bib35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1194\/jlr.M800383-JLR200","article-title":"Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice","volume":"50","author":"Moon","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ymthe.2026.06.031_bib36","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1074\/jbc.M110.193037","article-title":"De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation","volume":"286","author":"Wei","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2026.06.031_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149292","article-title":"Deletion of Elovl5 leads to dyslipidemia and atherosclerosis in LDLR-deficient mice","volume":"690","author":"Bae","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymthe.2026.06.031_bib38","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL\u2013EASD\u2013EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib39","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3803\/EnM.2023.1915","article-title":"Lipid Variability Induces Endothelial Dysfunction by Increasing Inflammation and Oxidative Stress","volume":"39","author":"Rhee","year":"2024","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"10.1016\/j.ymthe.2026.06.031_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.153977","article-title":"Preadipocyte factor 1 regulates adipose tissue browning via TNF-\u03b1-converting enzyme-mediated cleavage","volume":"101","author":"Rhee","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.ymthe.2026.06.031_bib41","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3. 0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2026.06.031_bib42","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","article-title":"Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics","volume":"49","author":"Matyash","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ymthe.2026.06.031_bib43","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1039\/D1EN00145K","article-title":"Exposure to nano-polystyrene induces metabolic alteration in lipid homeostasis in Caco-2","volume":"8","author":"Kim","year":"2021","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.ymthe.2026.06.031_bib44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-230X-6-33","article-title":"The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population","volume":"6","author":"Bedogni","year":"2006","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.ymthe.2026.06.031_bib45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4093\/dmj.2022.0444","article-title":"Fatty Liver & Diabetes Statistics in Korea: Nationwide Data 2009 to 2017","volume":"47","author":"Han","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ymthe.2026.06.031_bib46","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease","volume":"42","author":"Lee","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.ymthe.2026.06.031_bib47","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s13679-024-00574-z","article-title":"Non-invasive Scores and Serum Biomarkers for Fatty Liver in the Era of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): A Comprehensive Review From NAFLD to MAFLD and MASLD","volume":"13","author":"Abdelhameed","year":"2024","journal-title":"Curr. Obes. Rep."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626005083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626005083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:21:03Z","timestamp":1788362463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001626005083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1525001626005083"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.06.031","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p\/ELOVL5 axis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}