{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:52:16Z","timestamp":1786114336048,"version":"build-2736575974"},"reference-count":10,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100013779","name":"Retina Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ymthe.2026.07.024","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:35:45Z","timestamp":1784691345000},"page":"4387-4389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered tRNA: Beyond one gene, restoring function, not just full-length protein"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-3078","authenticated-orcid":false,"given":"Pawan K.","family":"Shahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash R.","family":"Pattnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2026.07.024_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41573-023-00829-9","article-title":"tRNA therapeutics for genetic diseases","volume":"23","author":"Coller","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2026.07.024_bib2","article-title":"Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis","volume":"11","author":"Shahi","year":"2026","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ymthe.2026.07.024_bib3","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.ymthe.2025.03.045","article-title":"A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again","volume":"33","author":"Lentini","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2026.07.024_bib4","doi-asserted-by":"crossref","first-page":"10092","DOI":"10.1073\/pnas.94.19.10092","article-title":"Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo","volume":"94","author":"Liu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2026.07.024_bib5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41467-019-08329-4","article-title":"Engineered transfer RNAs for suppression of premature termination codons","volume":"10","author":"Lueck","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2026.07.024_bib6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41586-023-06133-1","article-title":"Engineered tRNAs suppress nonsense mutations in cells and in vivo","volume":"618","author":"Albers","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.07.024_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf532","article-title":"An engineered glutamic acid tRNA for efficient suppression of pathogenic nonsense mutations","volume":"53","author":"Specht","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2026.07.024_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-025-02982-5","article-title":"An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery","author":"Xu","year":"2026","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2026.07.024_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41586-025-09732-2","article-title":"Prime editing-installed suppressor tRNAs for disease-agnostic genome editing","volume":"648","author":"Pierce","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.07.024_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66176-y","article-title":"AAV-delivered engineered suppressor tRNA rescues visual function in mice with an inherited retinal disease","volume":"16","author":"Ren","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626005927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626005927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:45:55Z","timestamp":1785962755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001626005927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1525001626005927"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.07.024","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered tRNA: Beyond one gene, restoring function, not just full-length protein","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}