{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T07:10:38Z","timestamp":1788678638712,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ymthe.2026.08.033","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:59:39Z","timestamp":1787669979000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["ACC1 inhibition enhances BCG-induced trained immunity by reprogramming acetyl-CoA metabolism"],"prefix":"10.1016","author":[{"given":"Ilayda","family":"Baydemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Nikolka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00edsa V.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fcsra","family":"Geckin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbin","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cuenca-Escalona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Floor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5714-1590","authenticated-orcid":false,"given":"Marisol","family":"B\u00e1ez-Maga\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Matzaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Deckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Anbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"van Elsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thijs","family":"Beldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone JCFM.","family":"Moorlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Charlotte J de Bree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Spanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theano","family":"Andriopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4022-7341","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Karagianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya","family":"Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Hiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-1961","authenticated-orcid":false,"given":"Jorge","family":"Dom\u00ednguez-Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2026.08.033_bib3","series-title":"Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations (Review on Antimicrobial Resistance)","author":"O\u2019Neill","year":"2016"},{"key":"10.1016\/j.ymthe.2026.08.033_bib4","series-title":"Tackling drug-resistant infections globally: final report and recommendations","author":"O\u2019Neill","year":"2019"},{"key":"10.1016\/j.ymthe.2026.08.033_bib5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cmet.2020.12.016","article-title":"Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis","volume":"33","author":"Palma","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib6","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cmet.2024.02.013","article-title":"Physiologic disruption and metabolic reprogramming in infection and sepsis","volume":"36","author":"Willmann","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cmet.2022.02.003","article-title":"Metabolic programs tailor T cell immunity in viral infection, cancer, and aging","volume":"34","author":"M\u00f8ller","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-023-06803-0","article-title":"Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes","volume":"624","author":"Nobs","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2026.08.033_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: A memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2026.08.033_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001765","article-title":"Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination","volume":"20","author":"Koeken","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2026.08.033_bib11","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1126\/sciadv.adk8093","article-title":"Multi-omics analysis reveals that linoleic acid metabolism is associated with variations of trained immunity induced by distinct BCG strains","volume":"10","author":"Xu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2026.08.033_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines10122127","article-title":"Therapeutic Potentials of Immunometabolomic Modulations Induced by Tuberculosis Vaccination","volume":"10","author":"Rawat","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.ymthe.2026.08.033_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008404","article-title":"New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia","volume":"16","author":"Taranc\u00f3n","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ymthe.2026.08.033_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000512280","article-title":"The Role of Cell Metabolism in Innate Immune Memory","volume":"14","author":"Ferreira","year":"2022","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.ymthe.2026.08.033_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109930","article-title":"Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery","volume":"261","author":"Baydemir","year":"2024","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.ymthe.2026.08.033_bib16","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cmet.2024.02.009","article-title":"Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment","volume":"36","author":"Hunt","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib17","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.cmet.2021.11.010","article-title":"Coenzyme A fuels T cell anti-tumor immunity","volume":"33","author":"St. Paul","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41573-021-00163-y","article-title":"Emerging concepts in the science of vaccine adjuvants","volume":"20","author":"Pulendran","year":"2021","journal-title":"Nature Reviews Drug Discovery"},{"key":"10.1016\/j.ymthe.2026.08.033_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105518","article-title":"Mucosal recombinant BCG vaccine induces lung-resident memory macrophages and enhances trained immunity via mTORC2\/HK1-mediated metabolic rewiring","volume":"300","author":"Peng","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2026.08.033_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00281-024-01015-8","article-title":"Metabolic Regulation in the Induction of Trained Immunity","volume":"46","author":"Ferreira","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ymthe.2026.08.033_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100365","article-title":"In vitro induction of trained immunity in adherent human monocytes","volume":"2","author":"Dom\u00ednguez-Andr\u00e9s","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.ymthe.2026.08.033_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2015.05.014","article-title":"Cell Metabolism Review Acetyl Coenzyme A: A Central Metabolite and Second Messenger","volume":"21","author":"Pietrocola","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/13543784.2019.1657825","article-title":"Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1\/2 inhibitors","volume":"28","author":"Chen","year":"2019","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.ymthe.2026.08.033_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2026.08.033_bib25","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","article-title":"ATP-citrate lyase links cellular metabolism to histone acetylation","volume":"324","author":"Wellen","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2026.08.033_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/19491034.2022.2160551","article-title":"The chromatin signatures of enhancers and their dynamic regulation","volume":"14","author":"Barral","year":"2023","journal-title":"Nucleus"},{"key":"10.1016\/j.ymthe.2026.08.033_bib27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chom.2020.05.014","article-title":"BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment","volume":"28","author":"Cirovic","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2026.08.033_bib28","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.immuni.2021.10.007","article-title":"Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity","volume":"54","author":"Vega-P\u00e9rez","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.08.033_bib29","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1172\/JCI133935","article-title":"BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner","volume":"130","author":"Koeken","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymthe.2026.08.033_bib30","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic Pathways in BCG-Induced Trained Immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2026.08.033_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq1984","article-title":"Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism","volume":"8","author":"Yeudall","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2026.08.033_bib32","article-title":"Acetyl-CoA Carboxylases and Diseases","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ymthe.2026.08.033_bib33","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI63967","article-title":"Malonyl-CoA: the regulator of fatty acid synthesis and oxidation","volume":"122","author":"Foster","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymthe.2026.08.033_bib34","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.immuni.2024.07.021","article-title":"BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses","volume":"57","author":"Sun","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.08.033_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2026.08.033_bib36","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Gu\u00e9rin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2026.08.033_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf0115","article-title":"Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis","volume":"9","author":"Izzo","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2026.08.033_bib38","doi-asserted-by":"crossref","first-page":"23865","DOI":"10.1074\/jbc.M112.380519","article-title":"Acetyl-CoA Carboxylase Regulates Global Histone Acetylation","volume":"287","author":"Galdieri","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymthe.2026.08.033_bib39","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/nm.3704","article-title":"De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells","volume":"20","author":"Berod","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2026.08.033_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2025.102111","article-title":"ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance","volume":"94","author":"St\u00fcve","year":"2025","journal-title":"Mol. Metab."},{"key":"10.1016\/j.ymthe.2026.08.033_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100923","article-title":"Immunometabolic control of hematopoiesis","volume":"77","author":"Hajishengallis","year":"2021","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.ymthe.2026.08.033_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2026.08.033_bib43","doi-asserted-by":"crossref","first-page":"994","DOI":"10.4049\/immunohorizons.2100086","article-title":"Large Peritoneal Macrophages and Transitional Premonocytes Promote Survival during Abdominal Sepsis","volume":"5","author":"Goswami","year":"2021","journal-title":"Immunohorizons"},{"key":"10.1016\/j.ymthe.2026.08.033_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.immuni.2023.12.005","article-title":"Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity","volume":"57","author":"Moorlag","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2026.08.033_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2024.126505","article-title":"Trained immunity-based vaccines: A vision from the one health initiative","volume":"43","author":"Angulo","year":"2025","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2026.08.033_bib46","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/ac802689c","article-title":"MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC\/MS based metabolome analysis","volume":"81","author":"Hiller","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ymthe.2026.08.033_bib47","doi-asserted-by":"crossref","first-page":"e2350770","DOI":"10.1002\/eji.202350770","article-title":"PGE2-EP4 signaling steers cDC2 maturation toward the induction of suppressive T-cell responses","volume":"54","author":"Cuenca-Escalona","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ymthe.2026.08.033_bib48","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jviromet.2010.11.024","article-title":"Comparison of hemagglutination inhibition assay, an ELISA-based micro-neutralization assay and colorimetric microneutralization assay to detect antibody responses to vaccination against influenza A H1N1 2009 virus","volume":"171","author":"Grund","year":"2011","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.ymthe.2026.08.033_bib49","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106230","article-title":"SARS-CoV-2 targets neurons of 3D human brain organoids","volume":"39","author":"Ramani","year":"2020","journal-title":"EMBO J"},{"key":"10.1016\/j.ymthe.2026.08.033_bib50","doi-asserted-by":"crossref","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2026.08.033_bib51","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/eji.202149577","article-title":"An integrative genomics approach identifies KDM4 as a modulator of trained immunity","volume":"52","author":"Moorlag","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ymthe.2026.08.033_bib52","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","article-title":"Matrix eQTL: ultra fast eQTL analysis via large matrix operations","volume":"28","author":"Shabalin","year":"2012","journal-title":"Bioinformatics"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626007148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001626007148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:39:40Z","timestamp":1788676780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001626007148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":50,"alternative-id":["S1525001626007148"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.08.033","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACC1 inhibition enhances BCG-induced trained immunity by reprogramming acetyl-CoA metabolism","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2026.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}