{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:56:33Z","timestamp":1790621793097,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010571","name":"Reseau de Bio-imagerie du Quebec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroimage: Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ynirp.2021.100014","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:03:11Z","timestamp":1622034191000},"page":"100014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cerebral stiffness changes during visual stimulation: Differential physiological mechanisms characterized by opposing mechanical effects"],"prefix":"10.1016","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-4318","authenticated-orcid":false,"given":"Reihaneh","family":"Forouhandehpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9960-1062","authenticated-orcid":false,"given":"Guillaume","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Whittingstall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Van Houten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"365","key":"10.1016\/j.ynirp.2021.100014_bib1","first-page":"1","article-title":"Advanced normalization tools (ANTS)","volume":"2","author":"Avants","year":"2009","journal-title":"Insight j"},{"issue":"12","key":"10.1016\/j.ynirp.2021.100014_bib2","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1002\/hbm.24337","article-title":"The morphology of the human cerebrovascular system","volume":"39","author":"Bernier","year":"2018","journal-title":"Hum. Brain Mapp."},{"issue":"3","key":"10.1016\/j.ynirp.2021.100014_bib3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/0271678X17701948","article-title":"Stimulus-evoked changes in cerebral vessel diameter: a study in healthy humans","volume":"38","author":"Bizeau","year":"2018","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"4","key":"10.1016\/j.ynirp.2021.100014_bib4","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1121\/1.4969831","article-title":"Passive elastography: a seismo-inspired tomography of the human body","volume":"140","author":"Catheline","year":"2016","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.ynirp.2021.100014_bib5","series-title":"In Biennial International Conference on Information Processing In Medical Imaging","first-page":"210","article-title":"ANIMAL+ insect: improved cortical structure segmentation","author":"Collins","year":"1999"},{"issue":"5","key":"10.1016\/j.ynirp.2021.100014_bib6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0361-9230(81)90007-1","article-title":"Cortical blood vessels of the human brain","volume":"7","author":"Duvernoy","year":"1981","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ynirp.2021.100014_bib7","series-title":"In Proceedings of the 22nd Annual Meeting of ISMRM , Milan","article-title":"The viscoelastic response of the human brain to functional activation detected by magnetic resonance elastography","author":"Fehlner","year":"2014"},{"key":"10.1016\/j.ynirp.2021.100014_bib8","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S1053-8119(09)70884-5","article-title":"Unbiased nonlinear average age-appropriate brain templates from birth to adulthood","volume":"47","author":"Fonov","year":"2009","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.ynirp.2021.100014_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroimage.2010.07.033","article-title":"Unbiased average age-appropriate atlases for pediatric studies","volume":"54","author":"Fonov","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2021.100014_bib10","series-title":"In Biomechanics,Mechanical Properties of Living Tissues","first-page":"321","article-title":"8-Mechanical properties and active remodeling of blood vessels","author":"Fung","year":"1993"},{"key":"10.1016\/j.ynirp.2021.100014_bib11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jmr.2018.08.012","article-title":"MR elastography at 1 Hz of gelatin phantoms using 3D or 4D acquisition","volume":"296","author":"Gordon-Wylie","year":"2018","journal-title":"J. Magn. Reson."},{"issue":"12","key":"10.1016\/j.ynirp.2021.100014_bib12","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1177\/0271678X18799241","article-title":"Hypercapnia increases brain viscoelasticity","volume":"39","author":"Hetzer","year":"2019","journal-title":"J. Cereb. blood flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ynirp.2021.100014_bib13","series-title":"14- MRE of the Brain","author":"Hirsch","year":"2017"},{"key":"10.1016\/j.ynirp.2021.100014_bib14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neurobiolaging.2018.01.010","article-title":"High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults","volume":"65","author":"Hiscox","year":"2018","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.ynirp.2021.100014_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/mrm.24916","article-title":"Slab-selective, BOLD-corrected VASO at 7 Tesla provides measures of cerebral blood volume reactivity with high signal-to-noise ratio","volume":"72","author":"Huber","year":"2014","journal-title":"Magn. Reson. Med."},{"issue":"1","key":"10.1016\/j.ynirp.2021.100014_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ynirp.2021.100014_bib17","first-page":"7425","article-title":"Are rapid changes in brain elasticity possible?","volume":"64","author":"K","year":"2017","journal-title":"Phys. Med. Biol."},{"issue":"6","key":"10.1016\/j.ynirp.2021.100014_bib18","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1152::AID-MRM11>3.0.CO;2-T","article-title":"Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation","volume":"41","author":"Kim","year":"1999","journal-title":"Magn. Reson. Med. An Off. J. Int. Soc. Magn. Reson. Med."},{"issue":"4","key":"10.1016\/j.ynirp.2021.100014_bib19","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ultrasmedbio.2019.12.019","article-title":"Time-resolved response of cerebral stiffness to hypercapnia in humans","volume":"46","author":"Kreft","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.ynirp.2021.100014_bib20","doi-asserted-by":"crossref","first-page":"116592","DOI":"10.1016\/j.neuroimage.2020.116592","article-title":"Imaging brain function with simultaneous BOLD and viscoelasticity contrast: fMRI\/fMRE","volume":"211","author":"Lan","year":"2020","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.ynirp.2021.100014_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nn.4533","article-title":"Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow","volume":"20","author":"Longden","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.ynirp.2021.100014_bib22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1148\/radiographics.22.3.g02ma11651","article-title":"Cardiovascular flow measurement with phase-contrast MR imaging: basic facts and implementation","volume":"22","author":"Lotz","year":"2002","journal-title":"Radiographics"},{"key":"10.1016\/j.ynirp.2021.100014_bib23","series-title":"In Brain Mapping: the Methods","first-page":"315","article-title":"13 - functional MRI","author":"Mandeville","year":"2002"},{"issue":"5","key":"10.1016\/j.ynirp.2021.100014_bib24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ca.21006","article-title":"Magnetic resonance elastography: a review","volume":"23","author":"Mariappan","year":"2010","journal-title":"Clin. Anat."},{"issue":"12","key":"10.1016\/j.ynirp.2021.100014_bib25","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1161\/01.STR.27.12.2256","article-title":"Visually evoked blood flow response assessed by simultaneous two-channel transcranial Doppler using flow velocity averaging","volume":"27","author":"Matthias","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.ynirp.2021.100014_bib26","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab0a7d","article-title":"Uniqueness of poroelastic and viscoelastic nonlinear inversion MR elastography at low frequencies","author":"McGarry","year":"2019","journal-title":"Phys. Med. Biol., Feb."},{"issue":"10","key":"10.1016\/j.ynirp.2021.100014_bib27","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1118\/1.4754649","article-title":"Multiresolution MR elastography using nonlinear inversion","volume":"39","author":"McGarry","year":"2012","journal-title":"Med. Phys."},{"issue":"6","key":"10.1016\/j.ynirp.2021.100014_bib28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1088\/0031-9120\/36\/6\/301","article-title":"X-ray computed tomography","volume":"36","author":"Michael","year":"2001","journal-title":"Phys. Educ."},{"issue":"4","key":"10.1016\/j.ynirp.2021.100014_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav3816","article-title":"Imaging localized neuronal activity at fast time scales through biomechanics","volume":"5","author":"Patz","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ynirp.2021.100014_bib30","first-page":"615406","article-title":"Hemispheric asymmetry of visual cortical response by means of functional transcranial Doppler","author":"Roje-Bedekovi\u0107","year":"2012","journal-title":"Stroke Res. Treat."},{"issue":"8","key":"10.1016\/j.ynirp.2021.100014_bib31","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.mri.2009.04.003","article-title":"Neural activity-induced modulation of BOLD poststimulus undershoot independent of the positive signal","volume":"27","author":"Sadaghiani","year":"2009","journal-title":"Magn. Reson. Imaging"},{"issue":"5","key":"10.1016\/j.ynirp.2021.100014_bib32","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1121\/1.4987758","article-title":"Reduced vessel tone leads to vasodilation and decreased cerebral rigidity","volume":"141","author":"Schregel","year":"2017","journal-title":"J. Acoust. Soc. Am."},{"issue":"6","key":"10.1016\/j.ynirp.2021.100014_bib33","doi-asserted-by":"crossref","first-page":"65010","DOI":"10.1088\/1361-6560\/ab0290","article-title":"Phantom evaluations of low frequency MR elastography","volume":"64","author":"Solamen","year":"2019","journal-title":"Phys. Med. Biol."},{"issue":"9","key":"10.1016\/j.ynirp.2021.100014_bib34","doi-asserted-by":"crossref","first-page":"H1143","DOI":"10.1152\/ajpheart.00303.2012","article-title":"A lumped parameter model of cerebral blood flow control combining cerebral autoregulation and neurovascular coupling","volume":"303","author":"Spronck","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.ynirp.2021.100014_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.fl.25.010193.000245","article-title":"The history of Poiseuille's law","volume":"25","author":"Sutera","year":"1993","journal-title":"Annu. Rev. Fluid Mech."},{"issue":"2","key":"10.1016\/j.ynirp.2021.100014_bib36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/jcbfm.2013.194","article-title":"Cerebrovascular reactivity in the brain white matter: magnitude, temporal characteristics, and age effects","volume":"34","author":"Thomas","year":"2014","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"24","key":"10.1016\/j.ynirp.2021.100014_bib37","doi-asserted-by":"crossref","first-page":"R401","DOI":"10.1088\/0031-9155\/61\/24\/R401","article-title":"Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications","volume":"61","author":"V Hiscox","year":"2016","journal-title":"Phys. Med. Biol."},{"issue":"1","key":"10.1016\/j.ynirp.2021.100014_bib38","doi-asserted-by":"crossref","DOI":"10.1118\/1.598861","article-title":"Elasticity reconstruction from experimental MR displacement data: initial experience with an overlapping subzone finite element inversion process","volume":"27","author":"Van Houten","year":"2000","journal-title":"Med. Phys."},{"issue":"2","key":"10.1016\/j.ynirp.2021.100014_bib39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuron.2007.10.012","article-title":"Visual field maps in human cortex","volume":"56","author":"Wandell","year":"2007","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.ynirp.2021.100014_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cercor\/3.2.79","article-title":"Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging","volume":"3","author":"Watson","year":"1993","journal-title":"Cereb. cortex"},{"issue":"22","key":"10.1016\/j.ynirp.2021.100014_bib41","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1088\/0031-9155\/57\/22\/7275","article-title":"Brain mechanical property measurement using MRE with intrinsic activation","volume":"57","author":"Weaver","year":"2012","journal-title":"Phys. Med. Biol."},{"issue":"1\u20132","key":"10.1016\/j.ynirp.2021.100014_bib42","first-page":"28","article-title":"The generalization OF \u2018STUDENT\u2019S\u2019 problem when several different population varlances are involved","volume":"34","author":"Welch","year":"1947","journal-title":"Biometrika"},{"key":"10.1016\/j.ynirp.2021.100014_bib43","series-title":"In Cerebrovascular Ultrasound: Theory, Practice And Future Developments","first-page":"324","article-title":"Cerebral vasoreactivity","author":"Widder","year":"2001"},{"issue":"1","key":"10.1016\/j.ynirp.2021.100014_bib44","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.neuroimage.2008.10.055","article-title":"Bayesian analysis of neuroimaging data in FSL","volume":"45","author":"Woolrich","year":"2009","journal-title":"Neuroimage"}],"container-title":["Neuroimage: Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266695602100012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266695602100012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:13:55Z","timestamp":1763018035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266695602100012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S266695602100012X"],"URL":"https:\/\/doi.org\/10.1016\/j.ynirp.2021.100014","relation":{},"ISSN":["2666-9560"],"issn-type":[{"value":"2666-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebral stiffness changes during visual stimulation: Differential physiological mechanisms characterized by opposing mechanical effects","name":"articletitle","label":"Article Title"},{"value":"Neuroimage: Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynirp.2021.100014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100014"}}