{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:24:50Z","timestamp":1746181490135,"version":"3.30.2"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Reports"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ynirp.2024.100218","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T21:02:56Z","timestamp":1727125376000},"page":"100218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-2170","authenticated-orcid":false,"given":"Roberta","family":"Poceviciute","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6564-0349","authenticated-orcid":false,"given":"Kenneth","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1621-4965","authenticated-orcid":false,"given":"Angeliki Maria","family":"Nikolakopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suehyun K.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan J.","family":"Sarmiento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oren","family":"Hartstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Loudon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Cros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander S.","family":"Kiselyov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynirp.2024.100218_bib1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.149.3685.754","article-title":"Adenovirus-associated defective virus particles","volume":"149","author":"Atchinson","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.ynirp.2024.100218_bib2","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"Ilastik: interactive machine learning for (bio) image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat. Methods"},{"issue":"106472","key":"10.1016\/j.ynirp.2024.100218_bib3","first-page":"1","article-title":"Design and development of microformulations for rapid release of small molecules and oligonucleotides","volume":"188","author":"Brown","year":"2023","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"10","key":"10.1016\/j.ynirp.2024.100218_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.ynirp.2024.100218_bib5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1109\/TRO.2004.829463","article-title":"Image moments: a general and useful set of features for visual servoing","volume":"20","author":"Chaumette","year":"2004","journal-title":"IEEE Trans. Robot."},{"key":"10.1016\/j.ynirp.2024.100218_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41565-023-01419-x","article-title":"Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain","author":"Chuapoco","year":"2023","journal-title":"Nat. Nanotechnol."},{"issue":"4","key":"10.1016\/j.ynirp.2024.100218_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biopsych.2017.08.010","article-title":"Anti-Amyloid-\u03b2 monoclonal antibodies for Alzheimer's disease: pitfalls and promise","volume":"83","author":"Dyck","year":"2018","journal-title":"Biol. Psychiatr."},{"issue":"6","key":"10.1016\/j.ynirp.2024.100218_bib8","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1378\/chest.120.6.2013","article-title":"Time course of hemosiderin production by alveolar macrophages in a murine model","volume":"120","author":"Epstein","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.ynirp.2024.100218_bib9","first-page":"226","article-title":"A density-based algorithm for discovering clusters in large spatial databases with noise","volume":"96","author":"Ester","year":"1996","journal-title":"Proc. Second Int. Conf. Knowl. Discov. Data Min."},{"issue":"1","key":"10.1016\/j.ynirp.2024.100218_bib10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41593-021-00969-4","article-title":"AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset","volume":"25","author":"Goertsen","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"37","key":"10.1016\/j.ynirp.2024.100218_bib11","first-page":"1","article-title":"Nutil : a pre- and post-processing toolbox for histological rodent brain section images","volume":"14","author":"Groeneboom","year":"2020","journal-title":"Front. Neuroinf."},{"issue":"17936","key":"10.1016\/j.ynirp.2024.100218_bib12","first-page":"1","article-title":"Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor","volume":"9","author":"Han","year":"2019","journal-title":"Sci. Rep."},{"issue":"32","key":"10.1016\/j.ynirp.2024.100218_bib13","doi-asserted-by":"crossref","first-page":"12138","DOI":"10.1073\/pnas.0604911103","article-title":"Cellular scaling rules for rodent brains","volume":"103","author":"Herculano-Houzel","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5979","key":"10.1016\/j.ynirp.2024.100218_bib14","first-page":"1","article-title":"On evaluation metrics for medical applications of artificial intelligence","volume":"12","author":"Hicks","year":"2022","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ynirp.2024.100218_bib15","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuron.2019.02.017","article-title":"Therapeutic AAV gene transfer to the nervous system: a clinical reality","volume":"101","author":"Hudry","year":"2019","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.ynirp.2024.100218_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.celrep.2014.12.014","article-title":"Mapping social behavior-induced brain activation at cellular resolution in the mouse","volume":"10","author":"Kim","year":"2015","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.ynirp.2024.100218_bib17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2017.09.020","article-title":"Brain-wide maps reveal stereotyped cell-type-based cortical architecture and subcortical sexual dimorphism","volume":"171","author":"Kim","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ynirp.2024.100218_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nbd.2011.09.014","article-title":"Viral vectors for gene delivery to the central nervous system","volume":"48","author":"Lentz","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.ynirp.2024.100218_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41576-019-0205-4","article-title":"Engineering adeno-associated virus vectors for gene therapy","volume":"21","author":"Li","year":"2020","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.ynirp.2024.100218_bib20","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1038\/nm1064","article-title":"Stem cell therapy for human neurodegenerative disorders-how to make it work","volume":"10","author":"Lindvall","year":"2004","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ynirp.2024.100218_bib21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3171\/2014.10.JNS14229","article-title":"Convection-enhanced delivery to the central nervous system","volume":"122","author":"Lonser","year":"2015","journal-title":"J. Neurosurg."},{"issue":"15041","key":"10.1016\/j.ynirp.2024.100218_bib22","first-page":"1","article-title":"High-accuracy biodistribution analysis of adeno-associated virus variants by double barcode sequencing","volume":"2","author":"Marsic","year":"2015","journal-title":"Mol. Ther. - Methods Clin. Dev."},{"issue":"February","key":"10.1016\/j.ynirp.2024.100218_bib23","first-page":"1","article-title":"The translational benefits of sheep as large animal models of human neurological disorders","volume":"9","author":"Murray","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"7","key":"10.1016\/j.ynirp.2024.100218_bib24","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41593-019-0434-z","article-title":"Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss","volume":"22","author":"Nikolakopoulou","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.ynirp.2024.100218_bib25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nmeth.3964","article-title":"Shrinkage-mediated imaging of entire organs and organisms using UDISCO","volume":"13","author":"Pan","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ynirp.2024.100218_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuroimage.2014.04.001","article-title":"Waxholm space atlas of the Sprague Dawley rat brain","volume":"97","author":"Papp","year":"2014","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.ynirp.2024.100218_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0216796","article-title":"Spatial registration of serial microscopic brain images to three-dimensional reference atlases with the QuickNII tool","volume":"14","author":"Puchades","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ynirp.2024.100218_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nmeth.1854","article-title":"Serial two-photon tomography for automated ex vivo mouse brain imaging","volume":"9","author":"Ragan","year":"2012","journal-title":"Nat. Methods"},{"volume":"vol. 223","year":"2018","author":"Ricard","key":"10.1016\/j.ynirp.2024.100218_bib29"},{"issue":"1","key":"10.1016\/j.ynirp.2024.100218_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0163-7258(98)00020-5","article-title":"Viral vectors for gene therapy","volume":"80","author":"Robbins","year":"1998","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.ynirp.2024.100218_bib31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41593-020-00778-1","article-title":"Gene-based therapies for neurodegenerative diseases","volume":"24","author":"Sun","year":"2021","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.ynirp.2024.100218_bib32","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","article-title":"Strategies for delivering therapeutics across the blood\u2013brain barrier","volume":"20","author":"Terstappen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ynirp.2024.100218_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41583-019-0250-1","article-title":"Tissue clearing and its applications in neuroscience","volume":"21","author":"Ueda","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.ynirp.2024.100218_bib34","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00429-014-0774-0","article-title":"Whole-brain mapping of behaviourally induced neural activation in mice","volume":"220","author":"Vousden","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"4","key":"10.1016\/j.ynirp.2024.100218_bib35","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.cell.2014.07.017","article-title":"Single-cell phenotyping within transparent intact tissue through whole-body clearing","volume":"158","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"75","key":"10.1016\/j.ynirp.2024.100218_bib36","first-page":"1","article-title":"Quint : workflow for quantification and spatial analysis of features in histological images from rodent brain","volume":"13","author":"Yates","year":"2019","journal-title":"Front. Neuroinf."},{"issue":"15","key":"10.1016\/j.ynirp.2024.100218_bib37","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.7150\/thno.26946","article-title":"Label-free imaging of hemoglobin degradation and hemosiderin formation in brain tissues with femtosecond pump-probe microscopy","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"}],"container-title":["NeuroImage: Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666956024000242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666956024000242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T01:42:49Z","timestamp":1728610969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666956024000242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2666956024000242"],"URL":"https:\/\/doi.org\/10.1016\/j.ynirp.2024.100218","relation":{},"ISSN":["2666-9560"],"issn-type":[{"type":"print","value":"2666-9560"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynirp.2024.100218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100218"}}