{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:21:32Z","timestamp":1777904492598,"version":"3.51.4"},"reference-count":108,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000241","name":"Physicians' Services Inc Foundation","doi-asserted-by":"publisher","award":["21-31"],"award-info":[{"award-number":["21-31"]}],"id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003321","name":"Queen's University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006127","name":"Queen's University Faculty of Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Reports"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ynirp.2026.100330","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:15:36Z","timestamp":1771982136000},"page":"100330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-7369","authenticated-orcid":false,"given":"Karla Batista","family":"Garcia-Ramo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Finn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-5041","authenticated-orcid":false,"given":"Theodore S.","family":"Aliyianis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Falah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke C.","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-1364","authenticated-orcid":false,"given":"Garima","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysa","family":"Boiss\u00e9-Lomax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason P.","family":"Gallivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9395-1478","authenticated-orcid":false,"given":"Gavin P.","family":"Winston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynirp.2026.100330_bib1","series-title":"Robotic Assessment of Neurocognitive Deficits in Adults with Temporal Lobe Epilepsy and Genetic Generalized Epilepsy","author":"Aliyianis","year":"2023"},{"key":"10.1016\/j.ynirp.2026.100330_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2023.121102","article-title":"An investigation of the validity of cognitive assessment via robotics in people with epilepsy","volume":"455","author":"Aliyianis","year":"2023","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ynirp.2026.100330_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2025.110875","article-title":"Identification of cognitive phenotypes in temporal lobe epilepsy and genetic generalized epilepsy using robotic assessment","author":"Aliyianis","year":"2026","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1163111","article-title":"Functional and effective connectivity analysis of drug-resistant epilepsy: a resting-state fMRI analysis","volume":"17","author":"Bacon","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109342","article-title":"Exploring the relationship between amygdala subnuclei volumes and cognitive performance in left-lateralized temporal lobe epilepsy with and without hippocampal sclerosis","volume":"145","author":"Ballerini","year":"2023","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/7854_2015_5001","article-title":"The Paired Associates Learning (PAL) test: 30 years of CANTAB translational neuroscience from laboratory to bedside in dementia research","volume":"28","author":"Barnett","year":"2016","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib7","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1002\/hbm.24685","article-title":"Impaired structural connectivity between dorsal attention network and pulvinar mediates the impact of premature birth on adult visual-spatial abilities","volume":"40","author":"Berndt","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ynirp.2026.100330_bib8","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1111\/epi.17795","article-title":"The relationship between mood and anxiety and cognitive phenotypes in adults with pharmacoresistant temporal lobe epilepsy","volume":"64","author":"Bingaman","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib9","article-title":"Cognition in adult patients with newly diagnosed non-lesional temporal lobe epilepsy","volume":"116","author":"Bj\u00f8rke","year":"2021","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.ynirp.2026.100330_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.seizure.2015.03.004","article-title":"Counting seizures: the primary outcome measure in epileptology from the patients' perspective","volume":"29","author":"Blachut","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.ynirp.2026.100330_bib12","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/hbm.20666","article-title":"Attention impairment in temporal lobe epilepsy: a neurophysiological approach via analysis of the P300 wave","volume":"30","author":"Bocquillon","year":"2008","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ynirp.2026.100330_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12984-016-0201-2","article-title":"A robot-based behavioural task to quantify impairments in rapid motor decisions and actions after stroke","volume":"13","author":"Bourke","year":"2016","journal-title":"J. NeuroEng. Rehabil."},{"key":"10.1016\/j.ynirp.2026.100330_bib14","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/nprot.2006.390","article-title":"Administration and interpretation of the trail making test","volume":"1","author":"Bowie","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ynirp.2026.100330_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eplepsyres.2017.09.001","article-title":"Altered functional connectivity in mesial temporal lobe epilepsy","volume":"137","author":"Burianov\u00e1","year":"2017","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ynirp.2026.100330_bib16","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1002\/hbm.22524","article-title":"Hemispheric lateralization of topological organization in structural brain networks","volume":"35","author":"Caeyenberghs","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ynirp.2026.100330_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109587","article-title":"Cognitive flexibility impairment in temporal lobe epilepsy: the impact of epileptic foci lateralization on executive functions","volume":"151","author":"Cair\u00f3s-Gonz\u00e1lez","year":"2024","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.yebeh.2018.10.034","article-title":"Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy","volume":"90","author":"Celiker Uslu","year":"2019","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.ynirp.2026.100330_bib19","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/epi.14736","article-title":"Differential sensitivity of structural, diffusion, and resting-state functional MRI for detecting brain alterations and verbal memory impairment in temporal lobe epilepsy","volume":"60","author":"Chang","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib20","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/1545968309356091","article-title":"Assessment of upper-limb sensorimotor function of subacute stroke patients using visually guided reaching","volume":"24","author":"Coderre","year":"2010","journal-title":"Neurorehabilitation Neural Repair"},{"key":"10.1016\/j.ynirp.2026.100330_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119612","article-title":"Micapipe: a pipeline for multimodal neuroimaging and connectome analysis","volume":"263","author":"Cruces","year":"2022","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100330_bib22","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1148\/radiol.13131044","article-title":"Altered structural connectome in temporal lobe epilepsy","volume":"270","author":"DeSalvo","year":"2014","journal-title":"Radiology"},{"key":"10.1016\/j.ynirp.2026.100330_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","article-title":"Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature","volume":"53","author":"Destrieux","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100330_bib24","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/epi.13051","article-title":"Hippocampal-thalamic wiring in medial temporal lobe epilepsy: enhanced connectivity per hippocampal voxel","volume":"56","author":"Dinkelacker","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154660","article-title":"Gray matter abnormalities in temporal Lobe Epilepsy: relationships with resting-state functional connectivity and episodic memory performance","volume":"11","author":"Doucet","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ynirp.2026.100330_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2025.1516058","article-title":"Precuneus activation correlates with the vividness of dynamic and static imagery: an fMRI study","volume":"19","author":"Duan","year":"2025","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/1545968309345267","article-title":"Quantitative assessment of limb position sense following stroke","volume":"24","author":"Dukelow","year":"2010","journal-title":"Neurorehabilitation Neural Repair"},{"key":"10.1016\/j.ynirp.2026.100330_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yebeh.2019.04.015","article-title":"Temporal lobe epilepsy is associated with distinct cognitive phenotypes","volume":"96","author":"Elverman","year":"2019","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.ynirp.2026.100330_bib29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ynirp.2026.100330_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0295142","article-title":"Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: insights from task-based and resting-state fMRI","volume":"19","author":"Fajardo-Valdez","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ynirp.2026.100330_bib31","series-title":"Robotic Assessment of Processing Speed and Longitudinal Cognitive Changes in Epilepsy","author":"Falah","year":"2024"},{"key":"10.1016\/j.ynirp.2026.100330_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.nicl.2014.12.018","article-title":"Multivariate pattern analysis reveals anatomical connectivity differences between the left and right mesial temporal lobe epilepsy","volume":"7","author":"Fang","year":"2015","journal-title":"Neuroimage, Clin."},{"key":"10.1016\/j.ynirp.2026.100330_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109613","article-title":"Robotic assessment of sensorimotor and cognitive deficits in patients with temporal lobe epilepsy","volume":"151","author":"Finn","year":"2024","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ynirp.2026.100330_bib35","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the international Bureau for epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib36","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1111\/epi.17370","article-title":"Episodic memory network connectivity in temporal lobe epilepsy","volume":"63","author":"Fleury","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00429-021-02418-1","article-title":"Is it left or is it right? A classification approach for investigating hemispheric differences in low and high dimensionality","volume":"227","author":"Friedrich","year":"2022","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.ynirp.2026.100330_bib38","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1093\/cercor\/bhad098","article-title":"Multi-shell connectome DWI-based graph theory measures for the prediction of temporal lobe epilepsy and cognition","volume":"33","author":"Garcia-Ramos","year":"2023","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.ynirp.2026.100330_bib39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00221-010-2186-6","article-title":"Hippocampal contribution to early and later stages of implicit motor sequence learning","volume":"202","author":"Gheysen","year":"2010","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ynirp.2026.100330_bib40","article-title":"Mixed spatial and movement representations in the primate posterior parietal cortex","volume":"13","author":"Hadjidimitrakis","year":"2019","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.ynirp.2026.100330_bib41","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3233\/JAD-140051","article-title":"Visuomotor impairments in older adults at increased Alzheimer's disease risk","volume":"42","author":"Hawkins","year":"2014","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.ynirp.2026.100330_bib42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1017\/S135561770707004X","article-title":"Cognitive phenotypes in temporal lobe epilepsy","volume":"13","author":"Hermann","year":"2007","journal-title":"J. Int. Neuropsychol. Soc. JINS"},{"key":"10.1016\/j.ynirp.2026.100330_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2024.108159","article-title":"Cognitive decline in adult-onset temporal lobe epilepsy: insights from aetiology","volume":"237","author":"Hern\u00e1ndez","year":"2024","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.ynirp.2026.100330_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/cercor\/bhq058","article-title":"Brain hemispheric structural efficiency and interconnectivity rightward asymmetry in human and nonhuman primates","volume":"21","author":"Iturria-Medina","year":"1991","journal-title":"Cereb. Cortex N. Y. N"},{"key":"10.1016\/j.ynirp.2026.100330_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107686","article-title":"Mechanisms of cognitive impairment in temporal lobe epilepsy: a systematic review of resting-state functional connectivity studies","volume":"115","author":"Ives-Deliperi","year":"2021","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107359","article-title":"A prospective pilot study of cognitive impairment and mood in adults with first seizure, new-onset epilepsy, and newly diagnosed epilepsy at time of initial seizure presentation","volume":"112","author":"Jackson-Tarlton","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yebeh.2018.06.045","article-title":"Altered attention networks and DMN in refractory epilepsy: a resting-state functional and causal connectivity study","volume":"88","author":"Jiang","year":"2018","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.ynirp.2026.100330_bib48","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/epi.16283","article-title":"Identifying the neural basis of a language-impaired phenotype of temporal lobe epilepsy","volume":"60","author":"Kaestner","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.878991","article-title":"Mechanisms for cognitive impairment in epilepsy: moving beyond seizures","volume":"13","author":"Khalife","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib50","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.neuroimage.2011.03.036","article-title":"Impaired attention and network connectivity in childhood absence epilepsy","volume":"56","author":"Killory","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100330_bib51","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/1073858411422754","article-title":"Epilepsy as a disorder of cortical network organization","volume":"18","author":"Kramer","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ynirp.2026.100330_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000513098","article-title":"Cognitive and behavioral disorders in patients with precuneal infarcts","volume":"84","author":"Kumral","year":"2021","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib53","article-title":"Volumetric and microstructural abnormalities of the amygdala in focal epilepsy with varied levels of SUDEP risk","author":"Legouhy","year":"2023","journal-title":"medRxiv"},{"key":"10.1016\/j.ynirp.2026.100330_bib54","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/hbm.21076","article-title":"Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI","volume":"32","author":"Liao","year":"2011","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ynirp.2026.100330_bib55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1073191115602552","article-title":"The trail making test","volume":"24","author":"Llin\u00e0s-Regl\u00e0","year":"2017","journal-title":"Assessment"},{"key":"10.1016\/j.ynirp.2026.100330_bib56","first-page":"2","article-title":"A novel robotic task for assessing impairments in bimanual coordination post-stroke","volume":"3","author":"Lowrey","year":"2014","journal-title":"Int. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.ynirp.2026.100330_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196205","article-title":"Test-retest reliability of the KINARM end-point robot for assessment of sensory, motor and neurocognitive function in young adult athletes","volume":"13","author":"Mang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ynirp.2026.100330_bib58","first-page":"1055","article-title":"Canonical correlation analysis and partial least squares for identifying brain-behavior associations: a tutorial and a comparative study","volume":"7","author":"Mihalik","year":"2022","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"10.1016\/j.ynirp.2026.100330_bib59","first-page":"5296","article-title":"Reduction of stroke assessment time for visually guided reaching task on KINARM exoskeleton robot","volume":"2014","author":"Mostafavi","year":"2014","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. IEEE Eng. Med. Biol. Soc. Annu. Int. Conf."},{"key":"10.1016\/j.ynirp.2026.100330_bib60","first-page":"457","article-title":"Neuropsychiatric and cognitive comorbidities in epilepsy","volume":"28","author":"Mula","year":"2022","journal-title":"Contin. Minneap. Minn."},{"key":"10.1016\/j.ynirp.2026.100330_bib61","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/01.WNL.0000125186.04867.34","article-title":"The nature and course of neuropsychological morbidity in chronic temporal lobe epilepsy","volume":"62","author":"Oyegbile","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ynirp.2026.100330_bib62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yebeh.2018.04.022","article-title":"Executive dysfunction is associated with an altered executive control network in pediatric temporal lobe epilepsy","volume":"86","author":"Oyegbile","year":"2018","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.ynirp.2026.100330_bib63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yebeh.2019.02.031","article-title":"Default mode network deactivation in pediatric temporal lobe epilepsy: relationship to a working memory task and executive function tests","volume":"94","author":"Oyegbile","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib64","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/j.0013-9580.2004.23304.x","article-title":"Memory in patients with drug-responsive mesial temporal lobe epilepsy and hippocampal sclerosis","volume":"45","author":"Ozkara","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib65","article-title":"Cognitive aging and the hippocampus in older adults","volume":"8","author":"O'Shea","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.820641","article-title":"Abnormal static and dynamic functional connectivity in left and right temporal Lobe Epilepsy","volume":"15","author":"Pang","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1062149","article-title":"Cerebellar functional disruption and compensation in mesial temporal lobe epilepsy","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib68","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00415-020-10307-6","article-title":"Cognitive impairment in temporal lobe epilepsy: contributions of lesion, localization and lateralization","volume":"268","author":"Phuong","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib69","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2006.04.004","article-title":"Attention and psychomotor speed decline in patients with temporal lobe epilepsy: a longitudinal study","volume":"72","author":"Piazzini","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ynirp.2026.100330_bib70","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/epi4.12909","article-title":"Cognitive and psychological dysfunction is present after a first seizure, prior to epilepsy diagnosis and treatment at a First Seizure Clinic","volume":"9","author":"Pugh","year":"2024","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.ynirp.2026.100330_bib71","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/epi4.13022","article-title":"Memory compromise at extended delays in people with new-onset epilepsy","volume":"9","author":"Pugh","year":"2024","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.ynirp.2026.100330_bib72","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3389\/fneur.2020.00625","article-title":"Alterations functional connectivity in temporal Lobe Epilepsy and their relationships with cognitive function: a longitudinal resting-state fMRI study","volume":"11","author":"Qin","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib73","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","article-title":"The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity","volume":"20","author":"Randolph","year":"1998","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.ynirp.2026.100330_bib74","doi-asserted-by":"crossref","first-page":"e1957","DOI":"10.1212\/WNL.0000000000007370","article-title":"Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities","volume":"92","author":"Reyes","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.ynirp.2026.100330_bib75","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/cercor\/bhx362","article-title":"The roles of left versus right anterior temporal lobes in semantic memory: a neuropsychological comparison of postsurgical temporal lobe epilepsy patients","volume":"28","author":"Rice","year":"2018","journal-title":"Cereb. Cortex N. Y. NY"},{"key":"10.1016\/j.ynirp.2026.100330_bib76","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1528-1167.2009.02508.x","article-title":"Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles","volume":"51","author":"Riley","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116706","article-title":"Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy","volume":"213","author":"Rodr\u00edguez-Cruces","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100330_bib78","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1162\/netn_a_00237","article-title":"Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies","volume":"6","author":"Rodriguez-Cruces","year":"2022","journal-title":"Netw. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib79","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yebeh.2017.07.037","article-title":"Multivariate trajectories across multiple domains of health-related quality of life in children with new-onset epilepsy","volume":"75","author":"Sajobi","year":"2017","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.ynirp.2026.100330_bib80","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0270(99)00053-9","article-title":"Apparatus for measuring and perturbing shoulder and elbow joint positions and torques during reaching","volume":"89","author":"Scott","year":"1999","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ynirp.2026.100330_bib81","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1682\/JRRD.2010.04.0057","article-title":"Potential of robots as next-generation technology for clinical assessment of neurological disorders and upper-limb therapy","volume":"48","author":"Scott","year":"2011","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.ynirp.2026.100330_bib82","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/15459683221115413","article-title":"Assessment of neurological impairment and recovery using statistical models of neurologically healthy behavior","volume":"37","author":"Scott","year":"2023","journal-title":"Neurorehabilitation Neural Repair"},{"key":"10.1016\/j.ynirp.2026.100330_bib83","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01405644","article-title":"Memory and the temporal lobe","volume":"28","author":"Scoville","year":"1973","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.ynirp.2026.100330_bib84","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/21678421.2018.1550515","article-title":"The feasibility of using robotic technology to quantify sensory, motor, and cognitive impairments associated with ALS","volume":"20","author":"Simmatis","year":"2019","journal-title":"Amyotroph. Lateral Scler. Front. Degener."},{"key":"10.1016\/j.ynirp.2026.100330_bib85","article-title":"The feasibility of assessing cognitive and motor function in multiple sclerosis patients using robotics","volume":"6","author":"Simmatis","year":"2020","journal-title":"Mult. Scler. J. - Exp. Transl. Clin."},{"key":"10.1016\/j.ynirp.2026.100330_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106859","article-title":"Assessing various sensorimotor and cognitive functions in people with epilepsy is feasible with robotics","volume":"103","author":"Simmatis","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib87","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neubiorev.2021.11.028","article-title":"An updated systematic review and meta-analysis of brain network organization in focal epilepsy: looking back and forth","volume":"132","author":"Slinger","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ynirp.2026.100330_bib88","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nn.4125","article-title":"A positive-negative mode of population covariation links brain connectivity, demographics and behavior","volume":"18","author":"Smith","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111587","article-title":"Alternations in static and dynamic functional connectivity density in temporal lobe epilepsy with and without hippocampal sclerosis","volume":"232","author":"Song","year":"2025","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ynirp.2026.100330_bib90","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1474-4422(18)30031-0","article-title":"The roles of surgery and technology in understanding focal epilepsy and its comorbidities","volume":"17","author":"Spencer","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib91","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.nicl.2013.01.009","article-title":"Disrupted segregation of working memory networks in temporal lobe epilepsy","volume":"2","author":"Stretton","year":"2013","journal-title":"Neuroimage, Clin."},{"key":"10.1016\/j.ynirp.2026.100330_bib92","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.eplepsyres.2012.08.011","article-title":"Age-accelerated psychomotor slowing in temporal Lobe Epilepsy","volume":"103","author":"Sung","year":"2013","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ynirp.2026.100330_bib93","first-page":"203","article-title":"Trail making test A and B: normative data stratified by age and education","volume":"19","author":"Tombaugh","year":"2004","journal-title":"Arch. Clin. Neuropsychol. Off. J. Natl. Acad. Neuropsychol."},{"key":"10.1016\/j.ynirp.2026.100330_bib94","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ima.22005","article-title":"MRtrix: diffusion tractography in crossing fiber regions","volume":"22","author":"Tournier","year":"2012","journal-title":"Int. J. Imag. Syst. Technol."},{"key":"10.1016\/j.ynirp.2026.100330_bib95","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-0003-11-47","article-title":"A robotic object hitting task to quantify sensorimotor impairments in participants with stroke","volume":"11","author":"Tyryshkin","year":"2014","journal-title":"J. NeuroEng. Rehabil."},{"key":"10.1016\/j.ynirp.2026.100330_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114606","article-title":"Brain network organization in focal epilepsy: a systematic review and meta-analysis","volume":"9","author":"van Diessen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ynirp.2026.100330_bib97","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/brain\/aws137","article-title":"Structural substrates for resting network disruption in temporal lobe epilepsy","volume":"135","author":"Voets","year":"2012","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.ynirp.2026.100330_bib98","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/1073858413494269","article-title":"Dorsal and ventral attention systems","volume":"20","author":"Vossel","year":"2014","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ynirp.2026.100330_bib99","article-title":"Factors for cognitive impairment in adult epileptic patients","volume":"10","author":"Wang","year":"2020","journal-title":"Brain Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib100","article-title":"Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100330_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2025.110335","article-title":"Unseen yet overcounted: the paradox of seizure frequency reporting","volume":"165","author":"Wong","year":"2025","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib102","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yebeh.2018.01.024","article-title":"Brain network alteration in patients with temporal lobe epilepsy with cognitive impairment","volume":"81","author":"Yang","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yebeh.2018.01.024","article-title":"Brain network alteration in patients with temporal lobe epilepsy with cognitive impairment","volume":"81","author":"Yang","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ynirp.2026.100330_bib104","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuroimage.2016.05.047","article-title":"Correction for diffusion MRI fibre tracking biases: the consequences for structural connectomic metrics","volume":"142","author":"Yeh","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100330_bib105","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/epi4.12793","article-title":"Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy","volume":"8","author":"Zanao","year":"2023","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.ynirp.2026.100330_bib106","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neulet.2009.04.040","article-title":"Impaired attention network in temporal lobe epilepsy: a resting FMRI study","volume":"458","author":"Zhang","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ynirp.2026.100330_bib107","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209800","article-title":"Association of normative and non-normative brain networks with cognitive function in patients with temporal Lobe Epilepsy","volume":"103","author":"Zhang","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.ynirp.2026.100330_bib108","doi-asserted-by":"crossref","DOI":"10.1111\/j.1528-1157.2000.tb02263.x","article-title":"Delayed reaction time in patients with temporal Lobe Epilepsy","volume":"41","author":"Zheng","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.ynirp.2026.100330_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107278","article-title":"Aberrant dorsal attention network homogeneity in patients with right temporal lobe epilepsy","volume":"111","author":"Zhou","year":"2020","journal-title":"Epilepsy Behav."}],"container-title":["NeuroImage: Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666956026000139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666956026000139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:26:25Z","timestamp":1777638385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666956026000139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":108,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2666956026000139"],"URL":"https:\/\/doi.org\/10.1016\/j.ynirp.2026.100330","relation":{},"ISSN":["2666-9560"],"issn-type":[{"value":"2666-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynirp.2026.100330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100330"}}