{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:31:40Z","timestamp":1793345500845,"version":"4.5.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG055428"],"award-info":[{"award-number":["R01AG055428"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG075166"],"award-info":[{"award-number":["K01AG075166"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG073578"],"award-info":[{"award-number":["K01AG073578"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ynirp.2026.100405","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:40:12Z","timestamp":1789191612000},"page":"100405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-7358","authenticated-orcid":false,"given":"Sarah","family":"Cote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-3229","authenticated-orcid":false,"given":"Marit F.L.","family":"Ruitenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-4208","authenticated-orcid":false,"given":"Jos N.","family":"van der Geest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-643X","authenticated-orcid":false,"given":"Nicholas Alonzo","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-0475","authenticated-orcid":false,"given":"Jace B.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-2400","authenticated-orcid":false,"given":"Kevin","family":"Duff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-7603","authenticated-orcid":false,"given":"Vincent","family":"Koppelmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ynirp.2026.100405_bib2","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/brain\/aww083","article-title":"Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit","volume":"139","author":"Aggleton","year":"2016","journal-title":"Brain"},{"issue":"18","key":"10.1016\/j.ynirp.2026.100405_bib1","article-title":"Fixel-based analysis reveals tau-related white matter changes in early stages of alzheimer's disease","volume":"44","author":"Ahmadi","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100405_bib5","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib6","first-page":"263","article-title":"The Alzheimer's disease clinical spectrum: diagnosis and management","volume":"103","author":"Atri","year":"2019","journal-title":"Med. Clin."},{"issue":"6","key":"10.1016\/j.ynirp.2026.100405_bib8","first-page":"2289","article-title":"Statistical inference in brain graphs using threshold\u2010free network\u2010based statistics","volume":"39","author":"Baggio","year":"2018"},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib7","article-title":"Precuneus and cingulate cortex atrophy and hypometabolism in patients with Alzheimer's disease and mild cognitive impairment: MRI and 18F-FDG PET quantitative analysis using FreeSurfer","volume":"2015","author":"Bailly","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib9","first-page":"820","article-title":"The use of a dynamometer with adjustable handle spacings","volume":"35","author":"Bechtol","year":"1953","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"issue":"6","key":"10.1016\/j.ynirp.2026.100405_bib10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ana.26353","article-title":"Greater diffusion restriction in white matter in preclinical Alzheimer disease","volume":"91","author":"Benitez","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ynirp.2026.100405_bib11","doi-asserted-by":"crossref","first-page":"2317.e1","DOI":"10.1016\/j.neurobiolaging.2010.03.017","article-title":"White matter integrity correlates of implicit sequence learning in healthy aging","volume":"32","author":"Bennett","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ynirp.2026.100405_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2023.102789","article-title":"SynthSeg: segmentation of brain MRI scans of any contrast and resolution without retraining","volume":"86","author":"Billot","year":"2023","journal-title":"Med. Image Anal."},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"issue":"11","key":"10.1016\/j.ynirp.2026.100405_bib14","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ynirp.2026.100405_bib15","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s00415-019-09429-3","article-title":"Structural integrity in subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease based on multicenter diffusion tensor imaging","volume":"266","author":"Brueggen","year":"2019","journal-title":"J. Neurol."},{"issue":"16","key":"10.1016\/j.ynirp.2026.100405_bib16","article-title":"The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline","volume":"13","author":"Cedres","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ynirp.2026.100405_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101911","article-title":"Abnormal white matter changes in Alzheimer's disease based on diffusion tensor imaging: a systematic review","author":"Chen","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ynirp.2026.100405_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.625551","article-title":"Grip strength and the risk of cognitive decline and dementia: a systematic review and meta-analysis of longitudinal cohort studies","volume":"13","author":"Cui","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ynirp.2026.100405_bib19","article-title":"Improved white matter response function estimation for 3-tissue constrained spherical deconvolution","volume":"555","author":"Dhollander","year":"2019"},{"key":"10.1016\/j.ynirp.2026.100405_bib20","article-title":"Unsupervised 3-tissue response function estimation from single-shell or multi-shell diffusion MR data without a co-registered T1 image","volume":"5","author":"Dhollander","year":"2016"},{"key":"10.1016\/j.ynirp.2026.100405_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jocn.2018.08.015","article-title":"Short-term repeat cognitive testing and its relationship to hippocampal volumes in older adults","volume":"57","author":"Duff","year":"2018","journal-title":"J. Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib22","first-page":"87","article-title":"Short-term practice effects and amyloid deposition: providing information above and beyond baseline cognition","volume":"4","author":"Duff","year":"2017","journal-title":"The journal of prevention of Alzheimer's disease"},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3233\/JAD-231392","article-title":"Short-term practice effects on cognitive tests across the late life cognitive spectrum and how they compare to biomarkers of Alzheimer's disease","volume":"99","author":"Duff","year":"2024","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/WAD.0000000000000293","article-title":"Long-term changes in 18F-Flutemetamol uptake in nondemented older adults","volume":"33","author":"Duff","year":"2019","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"8","key":"10.1016\/j.ynirp.2026.100405_bib25","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human brainnetome atlas: a new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.ynirp.2026.100405_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.833087","article-title":"The relationship between muscle strength and cognitive performance across Alzheimer's disease clinical continuum","volume":"13","author":"Filardi","year":"2022","journal-title":"Front. Neurol."},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/01.wnl.0000252358.03285.9d","article-title":"Conversion from subtypes of mild cognitive impairment to Alzheimer dementia","volume":"68","author":"Fischer","year":"2007","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1017\/S003329170002540X","article-title":"Neuropathological basis for drawing disability (constructional apraxia) in Alzheimer's disease","volume":"23","author":"F\u00f6rstl","year":"1993","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ynirp.2026.100405_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fninf.2011.00013","article-title":"Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python","volume":"5","author":"Gorgolewski","year":"2011","journal-title":"Front. Neuroinf."},{"key":"10.1016\/j.ynirp.2026.100405_bib32","article-title":"Nipype","author":"Gorgolewski","year":"2018","journal-title":"Zenodo"},{"issue":"13","key":"10.1016\/j.ynirp.2026.100405_bib30","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ynirp.2026.100405_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117012","article-title":"Fastsurfer-a fast and accurate deep learning based neuroimaging pipeline","volume":"219","author":"Henschel","year":"2020","journal-title":"Neuroimage"},{"issue":"12","key":"10.1016\/j.ynirp.2026.100405_bib34","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/pon.3796","article-title":"Late effects of adjuvant chemotherapy for breast cancer on fine motor function","volume":"24","author":"Hoogendam","year":"2015","journal-title":"Psychooncology"},{"key":"10.1016\/j.ynirp.2026.100405_bib35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3389\/fnagi.2014.00259","article-title":"Older age relates to worsening of fine motor skills: a population-based study of middle-aged and elderly persons","volume":"6","author":"Hoogendam","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ynirp.2026.100405_bib36","article-title":"SynthStrip: Skull-Stripping for any brain image","volume":"260","author":"Hoopes","year":"2022"},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA\u2010AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack Jr","year":"2018","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.ynirp.2026.100405_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2012.06.081","article-title":"White matter integrity, fiber count, and other fallacies: the do's and don\u2019ts of diffusion MRI","volume":"73","author":"Jones","year":"2013","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.ynirp.2026.100405_bib41","doi-asserted-by":"crossref","first-page":"666","DOI":"10.2471\/BLT.22.289310","article-title":"Differentiating sex and gender in health research to achieve gender equity","volume":"101","author":"Kaufman","year":"2023","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ynirp.2026.100405_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fnhum.2013.00142","article-title":"Neural correlates of the age-related changes in motor sequence learning and motor adaptation in older adults","volume":"7","author":"King","year":"2013","journal-title":"Front. Hum. Neurosci."},{"issue":"15","key":"10.1016\/j.ynirp.2026.100405_bib43","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1212\/WNL.0b013e31826e26b7","article-title":"Reversion from mild cognitive impairment to normal or near-normal cognition: risk factors and prognosis","volume":"79","author":"Koepsell","year":"2012","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/15459683241309591","article-title":"Using a functional upper limb motor task to predict cognitive and functional decline in mild cognitive impairment and Alzheimer's disease","volume":"39","author":"Koppelmans","year":"2025","journal-title":"Neurorehabilitation Neural Repair"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib45","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3233\/JAD-221297","article-title":"Delayed and more variable unimanual and bimanual finger tapping in Alzheimer's disease: associations with biomarkers and applications for classification","volume":"95","author":"Koppelmans","year":"2023","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000539800","article-title":"Classification of mild cognitive impairment and Alzheimer's disease using manual motor measures","volume":"24","author":"Koppelmans","year":"2024","journal-title":"Neurodegener. Dis."},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3233\/ADR-210065","article-title":"Neural mechanisms of motor dysfunction in mild cognitive impairment and Alzheimer's disease: a systematic review","volume":"6","author":"Koppelmans","year":"2022","journal-title":"Journal of Alzheimer's Disease Reports"},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib49","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/jon.12207","article-title":"Impact of apolipoprotein E4 polymorphism on the gray matter volume and the white matter integrity in subjective memory impairment without white matter hyperintensities: voxel\u2010based morphometry and tract\u2010based spatial statistics study under 3\u2010Tesla MRI","volume":"26","author":"Lee","year":"2016","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.ynirp.2026.100405_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102874","article-title":"Fusion analysis of gray matter and white matter in subjective cognitive decline and mild cognitive impairment by multimodal CCA-joint ICA","volume":"32","author":"Liang","year":"2021","journal-title":"Neuroimage, Clin."},{"key":"10.1016\/j.ynirp.2026.100405_bib51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/CIA.S438782","article-title":"Bridging reduced grip strength and altered executive function: specific brain white matter structural changes in patients with alzheimer's disease","author":"Liu","year":"2024","journal-title":"Clin. Interv. Aging"},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib52","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ana.21326","article-title":"Frequency and course of mild cognitive impairment in a multiethnic community","volume":"63","author":"Manly","year":"2008","journal-title":"Ann. Neurol.: Official Journal of the American Neurological Association and the Child Neurology Society"},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease","volume":"42","author":"Minoshima","year":"1997","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib53","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/brain\/awx355","article-title":"Fibre-specific white matter reductions in Alzheimer's disease and mild cognitive impairment","volume":"141","author":"Mito","year":"2018","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.ynirp.2026.100405_bib55","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1111\/j.1532-5415.2012.04209.x","article-title":"Gait and cognition: a complementary approach to understanding brain function and the risk of falling","volume":"60","author":"Montero-Odasso","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"issue":"11","key":"10.1016\/j.ynirp.2026.100405_bib56","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The clinical dementia rating (CDR) current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib58","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ana.10669","article-title":"Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment","volume":"54","author":"Nestor","year":"2003","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib59","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/S2666-7568(23)00019-3","article-title":"The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia","volume":"4","author":"Nichols","year":"2023","journal-title":"Lancet Healthy Longev."},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3233\/JAD-2012-121207","article-title":"Clinical and anatomical correlates of gait dysfunction in Alzheimer's disease","volume":"33","author":"Olazaran","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ynirp.2026.100405_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2021.621263","article-title":"Fractional anisotropy in selected, motor-related white matter tracts and its cross-sectional and longitudinal associations with motor function in healthy older adults","volume":"15","author":"Oschwald","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.ynirp.2026.100405_bib63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3758\/s13428-018-01193-y","article-title":"606 E. Kastman, and JK Lindel\u00f8v,\u201cPsychopy2: experiments in behavior 607 made easy,.\u201d","volume":"51","author":"Peirce","year":"2019","journal-title":"Behav. Res. Methods"},{"issue":"1\u20132","key":"10.1016\/j.ynirp.2026.100405_bib64","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jneumeth.2006.11.017","article-title":"PsychoPy\u2014psychophysics software in python","volume":"162","author":"Peirce","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ynirp.2026.100405_bib65","first-page":"343","article-title":"Generating stimuli for neuroscience using PsychoPy","volume":"2","author":"Peirce","year":"2009","journal-title":"Front. Neuroinf."},{"issue":"5","key":"10.1016\/j.ynirp.2026.100405_bib66","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1037\/0894-4105.21.5.549","article-title":"Amnestic mild cognitive impairment: difference of memory profile in subjects who converted or did not convert to Alzheimer's disease","volume":"21","author":"Perri","year":"2007","journal-title":"Neuropsychology"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib67","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1212\/WNL.0b013e3181cb3e25","article-title":"Alzheimer's disease neuroimaging initiative (ADNI)","volume":"74","author":"Petersen","year":"2010","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib69","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ynirp.2026.100405_bib70","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62929","article-title":"Bundle-specific associations between white matter microstructure and A\u03b2 and tau pathology in preclinical Alzheimer's disease","volume":"10","author":"Pichet Binette","year":"2021","journal-title":"eLife"},{"issue":"Suppl. C","key":"10.1016\/j.ynirp.2026.100405_bib71","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","article-title":"Methods to detect, characterize, and remove motion artifact in resting state fMRI","volume":"84","author":"Power","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100405_bib72","first-page":"3541","article-title":"Bias field correction and intensity normalisation for quantitative analysis of apparent fibre density","volume":"25","author":"Raffelt","year":"2017","journal-title":"Proceedings of the International Society for Magnetic Resonance in Medicine"},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib73","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1016\/j.neuroimage.2011.10.045","article-title":"Apparent fibre density: a novel measure for the analysis of diffusion-weighted magnetic resonance images","volume":"59","author":"Raffelt","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100405_bib74","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11065-009-9117-y","article-title":"Implicit learning in aging: extant patterns and new directions","volume":"19","author":"Rieckmann","year":"2009","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.ynirp.2026.100405_bib75","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.neuroimage.2010.01.015","article-title":"Activation in striatum and medial temporal lobe during sequence learning in younger and older adults: relations to performance","volume":"50","author":"Rieckmann","year":"2010","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib76","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/ageing\/afr051","article-title":"A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach","volume":"40","author":"Roberts","year":"2011","journal-title":"Age Ageing"},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib77","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1212\/WNL.0000000000000055","article-title":"Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal","volume":"82","author":"Roberts","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.ynirp.2026.100405_bib79","doi-asserted-by":"crossref","DOI":"10.1177\/13872877261485584","article-title":"Motor sequence learning and learning to learn across the Alzheimer's continuum: associations with biomarkers","author":"Ruitenberg","year":"2026","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ynirp.2026.100405_bib78","doi-asserted-by":"crossref","DOI":"10.1002\/alz.075603","article-title":"Motor sequence learning in mild cognitive impairment and alzheimer's disease and its relationship to biomarkers","volume":"19","author":"Ruitenberg","year":"2023","journal-title":"Alzheimer's Dement."},{"issue":"5 Suppl. l","key":"10.1016\/j.ynirp.2026.100405_bib80","first-page":"S112","article-title":"White matter imaging changes in subjective and mild cognitive impairment","volume":"8","author":"Selnes","year":"2012","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.ynirp.2026.100405_bib82","series-title":"2020 OHBM Annual Meeting","first-page":"1","article-title":"Hybrid surface-volume segmentation for improved anatomically-constrained tractography","author":"Smith","year":"2020"},{"key":"10.1016\/j.ynirp.2026.100405_bib81","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuroimage.2015.06.092","article-title":"SIFT2: enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography","volume":"119","author":"Smith","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.ynirp.2026.100405_bib85","article-title":"Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions","volume":"18","author":"Tournier","year":"2010","journal-title":"Proc. Intl. Soc. Mag. Reson. Med. (ISMRM)"},{"issue":"3","key":"10.1016\/j.ynirp.2026.100405_bib83","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.neuroimage.2004.07.037","article-title":"Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution","volume":"23","author":"Tournier","year":"2004","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib84","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuroimage.2008.05.002","article-title":"Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion-weighted imaging phantom data","volume":"42","author":"Tournier","year":"2008","journal-title":"Neuroimage"},{"issue":"6","key":"10.1016\/j.ynirp.2026.100405_bib86","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans. Med. Imag."},{"key":"10.1016\/j.ynirp.2026.100405_bib87","series-title":"Dutch Handedness Questionnaire [Database record]","author":"Van Strien","year":"2002"},{"key":"10.1016\/j.ynirp.2026.100405_bib88","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2016.08.016","article-title":"Denoising of diffusion MRI using random matrix theory","volume":"142","author":"Veraart","year":"2016","journal-title":"Neuroimage"},{"issue":"7","key":"10.1016\/j.ynirp.2026.100405_bib90","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1532-5415.2008.01758.x","article-title":"Gait dysfunction in mild cognitive impairment syndromes","volume":"56","author":"Verghese","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"issue":"11","key":"10.1016\/j.ynirp.2026.100405_bib91","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1177\/0284185118758122","article-title":"Subcortical nuclei in Alzheimer's disease: a volumetric and diffusion kurtosis imaging study","volume":"59","author":"Wang","year":"2018","journal-title":"Acta Radiol."},{"issue":"2","key":"10.1016\/j.ynirp.2026.100405_bib92","first-page":"591","article-title":"Regional amyloid accumulation and white matter integrity in cognitively normal individuals","volume":"77","author":"Wang","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ynirp.2026.100405_bib93","series-title":"Wechsler Memory scale-revised","author":"Wechsler","year":"1987"},{"key":"10.1016\/j.ynirp.2026.100405_bib94","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fnagi.2017.00261","article-title":"The abnormality of topological asymmetry between hemispheric brain white matter networks in Alzheimer's disease and mild cognitive impairment","volume":"9","author":"Yang","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.ynirp.2026.100405_bib96","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistics: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.ynirp.2026.100405_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2009.09.001","article-title":"Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimer's disease","volume":"49","author":"Zarei","year":"2010","journal-title":"Neuroimage"}],"container-title":["NeuroImage: Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666956026000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666956026000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:46:46Z","timestamp":1793342806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666956026000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":89,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S2666956026000887"],"URL":"https:\/\/doi.org\/10.1016\/j.ynirp.2026.100405","relation":{},"ISSN":["2666-9560"],"issn-type":[{"value":"2666-9560","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynirp.2026.100405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100405"}}