{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:19:40Z","timestamp":1787509180254,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS065926"],"award-info":[{"award-number":["R01NS065926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The University of Texas STARS program"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ynpai.2018.03.001","type":"journal-article","created":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T02:52:27Z","timestamp":1521255147000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model"],"prefix":"10.1016","volume":"4","author":[{"given":"Jamie K.","family":"Moy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper L.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Szabo-Pardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grishma","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynpai.2018.03.001_b0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41467-017-02449-5","article-title":"Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice","volume":"9","author":"Barragan-Iglesias","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ynpai.2018.03.001_b0010","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0304-3959(95)01441-1","article-title":"Characterization of a rat model of incisional pain","volume":"64","author":"Brennan","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2018.03.001_b0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ynpai.2018.03.001_b0020","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1523\/JNEUROSCI.3388-05.2006","article-title":"Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors","volume":"26","author":"Djouhri","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0025","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.1005320107","article-title":"eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression","volume":"107","author":"Furic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ynpai.2018.03.001_b0030","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.celrep.2014.10.064","article-title":"Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes","volume":"9","author":"Gkogkas","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ynpai.2018.03.001_b0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1515\/bmc-2011-1057","article-title":"Mnk kinases in cytokine signaling and regulation of cytokine responses","volume":"3","author":"Joshi","year":"2012","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.ynpai.2018.03.001_b0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-662-46450-2_2","article-title":"The pharmacology of nociceptor priming","volume":"227","author":"Kandasamy","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ynpai.2018.03.001_b0045","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tins.2017.11.006","article-title":"Translational control mechanisms in persistent pain","volume":"41","author":"Khoutorsky","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0050","article-title":"A critical role for dopamine D5 receptors in pain chronicity in male mice","author":"Megat","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0055","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1523\/JNEUROSCI.3947-10.2010","article-title":"IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex","volume":"30","author":"Melemedjian","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0060","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1744-8069-7-70","article-title":"Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain","volume":"7","author":"Melemedjian","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ynpai.2018.03.001_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00029","article-title":"eIF4E phosphorylation influences Bdnf mRNA translation in mouse dorsal root ganglion neurons","author":"Moy","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0070","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1523\/JNEUROSCI.0220-17.2017","article-title":"The MNK-eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain","volume":"37","author":"Moy","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0075","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.4049\/jimmunol.1600467","article-title":"The role of the p38-MNK-eIF4E signaling axis in TNF production downstream of the NOD1 receptor","volume":"198","author":"Pashenkov","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ynpai.2018.03.001_b0080","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/bs.pmbts.2014.11.010","article-title":"Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain","volume":"131","author":"Price","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0085","article-title":"From mechanism to cure: renewing the goal to eliminate the disease of pain","author":"Price","year":"2017","journal-title":"Pain Med."},{"key":"10.1016\/j.ynpai.2018.03.001_b0090","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tins.2009.07.007","article-title":"Critical role of nociceptor plasticity in chronic pain","volume":"32","author":"Reichling","year":"2009","journal-title":"Trends Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.ynpai.2018.03.001_b0095","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2013.05.037","article-title":"The fundamental unit of pain is the cell","volume":"154","author":"Reichling","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2018.03.001_b0100","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awy009","article-title":"Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain","author":"Sikandar","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.ynpai.2018.03.001_b0105","article-title":"Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation","author":"Silva Amorim","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2018.03.001_b0110","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2016.09.051","article-title":"Re-energizing the development of pain therapeutics in light of the opioid epidemic","volume":"92","author":"Skolnick","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ynpai.2018.03.001_b0115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMsr1706626","article-title":"The role of science in addressing the opioid crisis","volume":"377","author":"Volkow","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ynpai.2018.03.001_b0120","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1128\/MCB.19.3.1871","article-title":"Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo","volume":"19","author":"Waskiewicz","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ynpai.2018.03.001_b0125","doi-asserted-by":"crossref","first-page":"e74706","DOI":"10.1371\/journal.pone.0074706","article-title":"Mu opioid receptors on primary afferent Nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice","author":"Weibel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ynpai.2018.03.001_b0130","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.pain.2009.05.019","article-title":"Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons","volume":"144","author":"Xu","year":"2009","journal-title":"Pain"}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X18300059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X18300059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:24:13Z","timestamp":1762529053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X18300059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":26,"alternative-id":["S2452073X18300059"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2018.03.001","relation":{},"ISSN":["2452-073X"],"issn-type":[{"value":"2452-073X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2018.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}