{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:49:34Z","timestamp":1791254974393,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ynpai.2019.100036","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T19:24:41Z","timestamp":1567538681000},"page":"100036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats"],"prefix":"10.1016","volume":"6","author":[{"given":"Kristina","family":"\u00c4ngeby M\u00f6ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Seeliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Finn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Stenfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla I.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynpai.2019.100036_b0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4081\/reumatismo.2014.766","article-title":"The sources of pain in osteoarthritis: a pathophysiological review","volume":"66","author":"Salaffi","year":"2014","journal-title":"Reumatismo"},{"key":"10.1016\/j.ynpai.2019.100036_b0010","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartil."},{"key":"10.1016\/j.ynpai.2019.100036_b0015","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.ynpai.2019.100036_b0020","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1292\/jvms.65.1195","article-title":"Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats","volume":"65","author":"Kobayashi","year":"2003","journal-title":"J. Vet. Med. Sci."},{"issue":"3","key":"10.1016\/j.ynpai.2019.100036_b0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pain.2004.11.008","article-title":"Development and pharmacological characterization of a rat model of osteoarthritic pain","volume":"114","author":"Pomonis","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2019.100036_b0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2004.08.004","article-title":"Pain related behavior in two models of osteoarthritis","volume":"112","author":"Fernihough","year":"2004","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100036_b0035","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pain.2006.12.022","article-title":"Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation","volume":"128","author":"Ivanavicius","year":"2007","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.ynpai.2019.100036_b0040","first-page":"88","article-title":"The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain","volume":"17","author":"Sagar","year":"2011","journal-title":"Mol. Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100036_b0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jpain.2015.12.001","article-title":"Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis","volume":"17","author":"Havelin","year":"2016","journal-title":"J. Pain"},{"key":"10.1016\/j.ynpai.2019.100036_b0050","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13075-016-0921-5","article-title":"Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat","volume":"18","author":"TenBroek","year":"2016","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.ynpai.2019.100036_b0055","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1136\/annrheumdis-2014-207203","article-title":"Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis","volume":"75","author":"Nwosu","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ynpai.2019.100036_b0060","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2147\/JPR.S132026","article-title":"Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis","volume":"10","author":"Comi","year":"2017","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ynpai.2019.100036_b0065","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2147\/JPR.S186413","article-title":"Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats","volume":"12","author":"Jimbo","year":"2019","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ynpai.2019.100036_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046129","article-title":"Gait analysis in rats with single joint inflammation: influence of experimental factors","volume":"7","author":"\u00c4ngeby M\u00f6ller","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ynpai.2019.100036_b0075","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(05)71086-2","article-title":"Pathogenesis and management of pain in osteoarthritis","volume":"365","author":"Dieppe","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ynpai.2019.100036_b0080","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ynpai.2019.100036_b0085","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/art.20698","article-title":"A comparison of the efficacy and safety of nonsteroidal anti-inflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis","volume":"51","author":"Lee","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ynpai.2019.100036_b0090","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jbspin.2006.02.008","article-title":"Clinical response to intra-articular injections of hylan G-F 20 in symptomatic hip osteoarthritis: the OMERACT-OARSI criteria applied to the results of a pilot study","volume":"73","author":"Conrozier","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.ynpai.2019.100036_b0095","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","article-title":"Tanezumab for the treatment of pain from osteoarthritis of the knee","volume":"363","author":"Lane","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ynpai.2019.100036_b0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ynpai.2019.100036_b0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"issue":"5","key":"10.1016\/j.ynpai.2019.100036_b0110","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1152\/jn.00222.2006","article-title":"MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia","volume":"96","author":"Sun","year":"2006","journal-title":"J. Neurophysiol."},{"issue":"9","key":"10.1016\/j.ynpai.2019.100036_b0115","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1074\/jbc.272.9.5846","article-title":"Molecular cloning of a novel human CC chemokines liver and activation-regulated chemokine (LARC) expressed in the liver","volume":"272","author":"Hieshima","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ynpai.2019.100036_b0120","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/bio.20148128","article-title":"Autocrine signaling is a key regulatory element during osteoclastogenesis","volume":"3","author":"Kopesky","year":"2014","journal-title":"Biol. Open"},{"key":"10.1016\/j.ynpai.2019.100036_b0125","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.autrev.2009.01.012","article-title":"Interleukin-6 as a key player in systemic inflammation and joint destruction","volume":"8","author":"Fonseca","year":"2009","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ynpai.2019.100036_b0130","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-0035-1549022","article-title":"Identification of synovial fluid biomarkers for knee osteoarthritis and correlation with radiographic assessment","volume":"29","author":"Monibi","year":"2016","journal-title":"J. Knee Surg."},{"issue":"7","key":"10.1016\/j.ynpai.2019.100036_b0135","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/art.24598","article-title":"Interleukin-6 is a significant predictor of radiographic knee osteoarthritis","volume":"60","author":"Livshits","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ynpai.2019.100036_b0140","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.joca.2015.05.035","article-title":"Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy","volume":"23","author":"Larsson","year":"2015","journal-title":"Osteoarthritis Cartil."},{"key":"10.1016\/j.ynpai.2019.100036_b0145","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00011-009-0107-6","article-title":"Can L(+)-lactate be used as a marker of experimentally induced inflammation in rats?","volume":"59","author":"Finn","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ynpai.2019.100036_b0150","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/rheumatology\/keu281","article-title":"Influence of model and matrix on cytokine profile in rat and human","volume":"53","author":"Finn","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.ynpai.2019.100036_b0155","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ynpai.2019.100036_b0160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodeling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ynpai.2019.100036_b0165","first-page":"283","article-title":"Function of proteoglycans in the extracellular matrix","volume":"43","author":"Yanagishita","year":"1993","journal-title":"Acta Pathol. Jpn."},{"key":"10.1016\/j.ynpai.2019.100036_b0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ynpai.2019.100036_b0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Meth."},{"key":"10.1016\/j.ynpai.2019.100036_b0180","article-title":"Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy","volume":"569068","author":"Bolon","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"issue":"9","key":"10.1016\/j.ynpai.2019.100036_b0185","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.joca.2013.04.001","article-title":"Relationship between knee pain and the presence, location, size and phenotype offemorotibial denuded areas of subchondral bone as visualized by MRI","volume":"21","author":"Cotofana","year":"2013","journal-title":"Osteoarthritis Cartil."},{"key":"10.1016\/j.ynpai.2019.100036_b0190","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bone.2011.10.010","article-title":"Osteochondral alterations in osteoarthritis","volume":"51","author":"Suri","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.ynpai.2019.100036_b0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gaitpost.2018.04.023","article-title":"Quadrupal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis","volume":"63","author":"Lakes","year":"2018","journal-title":"Gait Posture"},{"issue":"6","key":"10.1016\/j.ynpai.2019.100036_b0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nmeth.2935","article-title":"Olfactory exposure to males, including men, causes stress and related analgesia in rodents","volume":"11","author":"Sorge","year":"2014","journal-title":"Nat. Meth."},{"issue":"3","key":"10.1016\/j.ynpai.2019.100036_b0205","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pneurobio.2009.04.003","article-title":"Stress-induced analgesia","volume":"88","author":"Butler","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ynpai.2019.100036_b0210","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ynpai.2019.100036_b0215","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s13075-014-0470-8","article-title":"Nociceptive neurons detect cytokines in arthritis","volume":"16","author":"Schaible","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.ynpai.2019.100036_b0220","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12264-012-1208-8","article-title":"Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO\/KC","volume":"28","author":"Dong","year":"2012","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ynpai.2019.100036_b0225","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/jir.1996.16.695","article-title":"Interleukin-6-mediated hyperalgesia\/allodynia and increased spinal IL-6 expression in a rat mononeurophathy model","volume":"16","author":"DeLeo","year":"1996","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.ynpai.2019.100036_b0230","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3959(01)00420-1","article-title":"Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo","volume":"96","author":"Obreja","year":"2002","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100036_b0235","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/art.22282","article-title":"Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat","volume":"56","author":"Brenn","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ynpai.2019.100036_b0240","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2474-11-86","article-title":"Clinical predictors of elective total joint replacement in persons with end-stage knee osteoarthritis","volume":"11","author":"Zeni","year":"2010","journal-title":"BMC Musculoskelet. Disord."},{"issue":"4","key":"10.1016\/j.ynpai.2019.100036_b0245","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ynpai.2019.100036_b0250","series-title":"Osteoarthritis Disorders","article-title":"The epidemiology of osteoarthritis: prevalence and risk factors","author":"Felson","year":"1995"},{"key":"10.1016\/j.ynpai.2019.100036_b0255","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.joca.2004.11.006","article-title":"Cartilage degeneration in different human joints","volume":"13","author":"Kuettner","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ynpai.2019.100036_b0260","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0736-0266(01)00125-5","article-title":"Human knee and ankle cartilage explants: catabolic differences","volume":"20","author":"Eger","year":"2002","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.ynpai.2019.100036_b0265","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jor.1100160505","article-title":"Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments","volume":"16","author":"Kang","year":"1998","journal-title":"J Orthopaedic Res"},{"key":"10.1016\/j.ynpai.2019.100036_b0270","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/art.20740","article-title":"Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints","volume":"52","author":"Aurich","year":"2005","journal-title":"Arthritis Rheum."}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X1930011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X1930011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:24:45Z","timestamp":1762529085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X1930011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":54,"alternative-id":["S2452073X1930011X"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2019.100036","relation":{},"ISSN":["2452-073X"],"issn-type":[{"value":"2452-073X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2019.100036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100036"}}