{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:19:17Z","timestamp":1762543157116,"version":"build-2065373602"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD083133-01A1"],"award-info":[{"award-number":["R01HD083133-01A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ynpai.2019.100038","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T21:32:44Z","timestamp":1575408764000},"page":"100038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Biological and behavioral markers of pain following nerve injury in humans"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-7983","authenticated-orcid":false,"given":"S.A.","family":"Holmes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6633-7237","authenticated-orcid":false,"given":"N.","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bhasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.I.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zurakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-5894","authenticated-orcid":false,"given":"K.E.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-1243","authenticated-orcid":false,"given":"R.","family":"Borra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Burstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3395-9483","authenticated-orcid":false,"given":"L.E.","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Borsook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynpai.2019.100038_b0005","first-page":"26","article-title":"Diffusion tensor imaging of the brain","author":"Alexander","year":"2008","journal-title":"Neurotherapeutics"},{"issue":"5","key":"10.1016\/j.ynpai.2019.100038_b0010","doi-asserted-by":"crossref","DOI":"10.4172\/2329-6895.1000393","article-title":"Central executive and default mode network intranetwork functional connectivity patterns in chronic migraine","volume":"6","author":"Androulakis","year":"2018","journal-title":"J. Neurol. Disord."},{"issue":"6","key":"10.1016\/j.ynpai.2019.100038_b0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/infdis\/jiu188","article-title":"HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis","volume":"210","author":"Angin","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ynpai.2019.100038_b0020","article-title":"Peripheral and central viewpoints of chronic pain, and translational implications","author":"Apkarian","year":"2018","journal-title":"Neuroscience Letters"},{"issue":"2","key":"10.1016\/j.ynpai.2019.100038_b0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/j.pain.0000000000000753","article-title":"Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles","volume":"158","author":"Baron","year":"2017","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.ynpai.2019.100038_b0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mri.2009.07.008","article-title":"The connectivity of the superior longitudinal fasciculus: a tractography DTI study","volume":"28","author":"Bernal","year":"2010","journal-title":"Magnetic Resonance Imaging"},{"key":"10.1016\/j.ynpai.2019.100038_b0035","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1586\/14737175.2013.846218","article-title":"Losses and gains: Chronic pain adn altered brain morphology","volume":"13","author":"Borsook","year":"2013","journal-title":"Expert Rev. Neurother."},{"issue":"12","key":"10.1016\/j.ynpai.2019.100038_b0040","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1097\/j.pain.0000000000001401","article-title":"When pain gets stuck: The evolution of pain chronification and treatment resistance","volume":"159","author":"Borsook","year":"2018","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neurobiolaging.2010.02.004","article-title":"Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance","volume":"33","author":"Bosch","year":"2012","journal-title":"Neurobiology of Aging"},{"issue":"2","key":"10.1016\/j.ynpai.2019.100038_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004542","article-title":"Altered resting state in diabetic neuropathic pain","volume":"4","author":"Cauda","year":"2009","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0055","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jmri.25395","article-title":"DTI metrics can be used as biomarkers to determine the therapeutic effect of stem cells in acute peripheral nerve injury: DTI of stem cell therapy in nerve injury","volume":"45","author":"Chen","year":"2017","journal-title":"Journal of Magnetic Resonance Imaging"},{"key":"10.1016\/j.ynpai.2019.100038_b0060","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nature Reviews Disease Primers"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0065","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pain.2013.08.029","article-title":"Abnormal trigeminal nerve microstructure and brain white matter in idiopathic trigeminal neuralgia","volume":"155","author":"DeSouza","year":"2014","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/157339510791823835","article-title":"The concept of depression as a dysfunction of the immune system","volume":"6","author":"Leonard","year":"2010","journal-title":"Current Immunology Reviews"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/bja\/aet128","article-title":"Neuroinflammation and the generation of neuropathic pain","volume":"111","author":"Ellis","year":"2013","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.ynpai.2019.100038_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00029","article-title":"Threat response system: parallel brain processes in pain vis-\u00e0-vis fear and anxiety","volume":"9","author":"Elman","year":"2018","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.ynpai.2019.100038_b0085","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ynpai.2019.100038_b0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2015.12.007","article-title":"Decreased functional connectivity density in pain-related brain regions of female migraine patients without aura","volume":"1632","author":"Gao","year":"2016","journal-title":"Brain Research"},{"year":"2018","series-title":"Anatomy, Sciatic Nerve","author":"Giuffre","key":"10.1016\/j.ynpai.2019.100038_b0095"},{"issue":"4","key":"10.1016\/j.ynpai.2019.100038_b0100","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/brain\/awh098","article-title":"Pain catastrophizing and neural responses to pain among persons with fibromyalgia","volume":"127","author":"Gracely","year":"2004","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0105","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.celrep.2016.06.018","article-title":"Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury","volume":"16","author":"Gu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ynpai.2019.100038_b0110","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916646784","article-title":"Interleukin-1\u03b2 overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents","volume":"12","author":"Gui","year":"2016","journal-title":"Mol. Pain"},{"issue":"9","key":"10.1016\/j.ynpai.2019.100038_b0115","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1093\/brain\/awt211","article-title":"Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits","volume":"136","author":"Hashmi","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.ynpai.2019.100038_b0120","article-title":"Pain modulation and the transition from acute to chronic pain","volume":"Vol. 904","author":"Heinricher","year":"2016"},{"issue":"8","key":"10.1016\/j.ynpai.2019.100038_b0125","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1007\/s00429-015-1161-1","article-title":"Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms","volume":"221","author":"Hemington","year":"2016","journal-title":"Brain Structure & Function"},{"key":"10.1016\/j.ynpai.2019.100038_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2018.00077","article-title":"Functional anatomy of the inferior longitudinal fasciculus: from historical reports to current hypotheses","volume":"12","author":"Herbet","year":"2018","journal-title":"Frontiers in Neuroanatomy"},{"key":"10.1016\/j.ynpai.2019.100038_b0135","first-page":"10","article-title":"Brain changes in responders vs. non-responders in chronic migraine: markers of disease reversal","author":"Hubbard","year":"2016","journal-title":"Front. Human Neurosci."},{"key":"10.1016\/j.ynpai.2019.100038_b0140","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.nicl.2017.06.017","article-title":"Predicting pain relief: use of pre-surgical trigeminal nerve diffusion metrics in trigeminal neuralgia","volume":"15","author":"Hung","year":"2017","journal-title":"NeuroImage: Clin."},{"key":"10.1016\/j.ynpai.2019.100038_b0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0958-2592(02)00114-1","article-title":"Injuries of peripheral nerves of the leg, foot and ankle: an often unrecognized consequence of ankle sprains","volume":"13","author":"Hunt","year":"2003","journal-title":"Foot"},{"issue":"2","key":"10.1016\/j.ynpai.2019.100038_b0150","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ynpai.2019.100038_b0155","first-page":"1","article-title":"The plasticity of brain gray matter and white matter following lower limb amputation","volume":"2015","author":"Jiang","year":"2015","journal-title":"Neural Plast."},{"issue":"5","key":"10.1016\/j.ynpai.2019.100038_b0160","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/ana.25231","article-title":"Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain: C-nociceptor activation by sinusoidal stimulation","volume":"83","author":"Jonas","year":"2018","journal-title":"Annals of Neurology"},{"issue":"9","key":"10.1016\/j.ynpai.2019.100038_b0165","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/lm.037291.114","article-title":"Stress effects on the hippocampus: a critical review","volume":"22","author":"Kim","year":"2015","journal-title":"Learn. Mem."},{"key":"10.1016\/j.ynpai.2019.100038_b0170","article-title":"Nucleus accumbens modulation in reward and aversion","volume":"037457","author":"Klawonn","year":"2019","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"year":"2010","series-title":"Children\u2019s Depression Inventory 2","author":"Kovacs","key":"10.1016\/j.ynpai.2019.100038_b0175"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0180","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.0b013e31823fcd9c","article-title":"Effects of limb immobilization on brain plasticity","volume":"78","author":"Langer","year":"2012","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.ynpai.2019.100038_b0185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4103\/2152-7806.163816","article-title":"Electromyography in musculoskeletal pain: a reappraisal and practical considerations","volume":"28","author":"Lazaro","year":"2015","journal-title":"Surg. Neurol. Int."},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0190","doi-asserted-by":"crossref","first-page":"15977","DOI":"10.1038\/s41598-017-16039-4","article-title":"Encoding of menstrual pain experience with theta oscillations in women with primary dysmenorrhea","volume":"7","author":"Lee","year":"2017","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0195","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuroimage.2011.11.095","article-title":"Neuroimaging of the periaqueductal gray: state of the field","volume":"60","author":"Linnman","year":"2012","journal-title":"NeuroImage"},{"issue":"11","key":"10.1016\/j.ynpai.2019.100038_b0200","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2015.100","article-title":"Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome","volume":"11","author":"Littlejohn","year":"2015","journal-title":"Nature Reviews Rheumatology"},{"issue":"11","key":"10.1016\/j.ynpai.2019.100038_b0205","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1007\/s11427-017-9108-6","article-title":"Altered small-world, functional brain networks in patients with lower back pain","volume":"61","author":"Liu","year":"2018","journal-title":"Sci. China Life Sci."},{"issue":"4","key":"10.1016\/j.ynpai.2019.100038_b0210","article-title":"The multidimensional anxiety scale for children (MASC): factor structure, reliability, and validity","volume":"36","author":"March","year":"2013","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0215","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00002508-200505000-00005","article-title":"Self-report and pain behavior among patients with chronic pain","volume":"21","author":"McCahon","year":"2005","journal-title":"Clin. J. Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0220","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.hcl.2013.04.002","article-title":"Nerve physiology","volume":"29","author":"Menorca","year":"2013","journal-title":"Hand Clinics"},{"issue":"2","key":"10.1016\/j.ynpai.2019.100038_b0225","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainresrev.2005.11.004","article-title":"Immune and inflammatory mechanisms in neuropathic pain","volume":"51","author":"Moalem","year":"2006","journal-title":"Brain Research Reviews"},{"key":"10.1016\/j.ynpai.2019.100038_b0230","article-title":"Amygdala pain mechanisms","volume":"Vol. 227","author":"Neugebauer","year":"2015"},{"key":"10.1016\/j.ynpai.2019.100038_b0235","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neuroimage.2013.02.029","article-title":"Gray matter volume reduction reflects chronic pain in trigeminal neuralgia","volume":"74","author":"Obermann","year":"2013","journal-title":"NeuroImage"},{"issue":"5","key":"10.1016\/j.ynpai.2019.100038_b0240","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0749-8063(97)90181-X","article-title":"Chronic pain following ankle sprains in athletes: the role of arthroscopic surgery","volume":"13","author":"Ogilvie-Harris","year":"1997","journal-title":"Arthroscopy"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0245","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12029","article-title":"Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury","volume":"7","author":"Peng","year":"2016","journal-title":"Nature Communications"},{"issue":"6","key":"10.1016\/j.ynpai.2019.100038_b0250","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/ana.24665","article-title":"Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache","volume":"79","author":"Perry","year":"2016","journal-title":"Annals of Neurology"},{"issue":"2","key":"10.1016\/j.ynpai.2019.100038_b0255","article-title":"A self-report measure of pubertal status: reliability, validity, and initial norms","volume":"17","author":"Peterson","year":"1988","journal-title":"J. Youth Adolecs."},{"author":"R Core Team","key":"10.1016\/j.ynpai.2019.100038_b0260"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(02)00368-8","article-title":"Descending modulation in persistent pain: an update","volume":"100","author":"Ren","year":"2002","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.ynpai.2019.100038_b0270","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.ynpai.2019.100038_b0275","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.24","article-title":"BAG3: a multifaceted protein that regulates major cell pathways","volume":"2","author":"Rosati","year":"2011","journal-title":"Cell Death and Disease"},{"issue":"7","key":"10.1016\/j.ynpai.2019.100038_b0280","doi-asserted-by":"crossref","first-page":"S429","DOI":"10.1097\/00005768-199907001-00004","article-title":"Lateral ankle sprains: a comprehensive review Part 1: Etiology, pathoanatomy, histopahogenesis, and diagnosis","volume":"31","author":"Safran","year":"1999","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"10.1016\/j.ynpai.2019.100038_b0285","unstructured":"Schafers M., Lee D.H., Brors D., Yaksh T.L., Sorkin L.S. (n.d.). Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-after spinal nerve ligation. 11."},{"issue":"10","key":"10.1016\/j.ynpai.2019.100038_b0290","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.pain.2012.07.008","article-title":"Microneurography: towards a biomarker of spontaneous pain","volume":"153","author":"Serra","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2019.100038_b0295","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1097\/j.pain.0000000000000377","article-title":"Fear of pain in children and adolescents with neuropathic pain and complex regional pain syndrome","volume":"157","author":"Simons","year":"2016","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.ynpai.2019.100038_b0300","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/j.pain.0000000000000199","article-title":"Pediatric pain screening tool: rapid identification of risk in youth with pain complaints","volume":"156","author":"Simons","year":"2015","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.ynpai.2019.100038_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2010.12.008","article-title":"The fear of pain questionnaire (FOPQ): assessment of pain-related fear among children and adolescents with chornic pain","volume":"12","author":"Simons","year":"2011","journal-title":"J. Pain"},{"issue":"703","key":"10.1016\/j.ynpai.2019.100038_b9000","article-title":"Fear and reward circuit alterations in pediatric CRPS","volume":"9","author":"Simons","year":"2016","journal-title":"Front. Human Neurosci."},{"issue":"50","key":"10.1016\/j.ynpai.2019.100038_b0310","doi-asserted-by":"crossref","first-page":"16431","DOI":"10.1523\/JNEUROSCI.2119-15.2015","article-title":"Role of IL-10 in resolution of inflammation and functional recovery after peripheral nerve injury","volume":"35","author":"Siqueira Mietto","year":"2015","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0315","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.neuroimage.2003.07.005","article-title":"Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia","volume":"20","author":"Song","year":"2003","journal-title":"NeuroImage"},{"year":"1995","series-title":"The Pain Catastrophizing Scale","author":"Sullivan","key":"10.1016\/j.ynpai.2019.100038_b0320"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0325","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.expneurol.2004.09.008","article-title":"Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation","volume":"191","author":"Sun","year":"2005","journal-title":"Experimental Neurology"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2007.11.049","article-title":"Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging","volume":"40","author":"Sun","year":"2008","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0335","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1213\/01.ane.0000275190.42912.37","article-title":"Pathophysiology of peripheral neuropathic pain: immune cells and molecules","volume":"105","author":"Thacker","year":"2007","journal-title":"Anesthesia and Analgesia"},{"issue":"9","key":"10.1016\/j.ynpai.2019.100038_b0340","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/AJP.0b013e31824549d6","article-title":"Preoperative anxiety and catastrophizing: a systematic review and meta-analysis of the association with chronic postsurgical pain","volume":"28","author":"Theunissen","year":"2012","journal-title":"Clin. J. Pain"},{"issue":"5","key":"10.1016\/j.ynpai.2019.100038_b0345","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2019.02.019","article-title":"Composite pain biomarker signatures for objective assessment and effective treatment","volume":"101","author":"Tracey","year":"2019","journal-title":"Neuron"},{"issue":"02","key":"10.1016\/j.ynpai.2019.100038_b0350","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1055\/s-0035-1547371","article-title":"Neuropathic pain mechanisms and imaging","volume":"19","author":"Tung","year":"2015","journal-title":"Semin. Musculoskel. Radiol."},{"issue":"7","key":"10.1016\/j.ynpai.2019.100038_b0355","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2337\/db16-1049","article-title":"Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with type 1 diabetes and neuropathy","volume":"66","author":"Vaeggemose","year":"2017","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.ynpai.2019.100038_b0360","doi-asserted-by":"crossref","first-page":"E78","DOI":"10.1002\/mus.25691","article-title":"Magnetic resonance neurography and diffusion tensor imaging of the peripheral nerves in patients with Charcot-Marie-Tooth Type 1A: DTI of peripheral nerves in CMT1A","volume":"56","author":"Vaeggemose","year":"2017","journal-title":"Muscle and Nerve"},{"issue":"11","key":"10.1016\/j.ynpai.2019.100038_b0365","doi-asserted-by":"crossref","first-page":"862","DOI":"10.2519\/jospt.2014.5221","article-title":"Chronic complaints after ankle sprains: a systematic review on effectiveness of treatments","volume":"44","author":"van Ochten","year":"2014","journal-title":"Journal of Orthopaedic and Sports Physical Therapy"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0370","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0304-3959(99)00242-0","article-title":"Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art","volume":"85","author":"Vlaeyen","year":"2000","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0375","doi-asserted-by":"crossref","DOI":"10.1093\/jpepsy\/16.1.39","article-title":"The Functional Disability Inventory (FDI): Measuring a neglected dimension of child health status","volume":"16","author":"Walker","year":"1991","journal-title":"Journal of Pediatric Psychology"},{"issue":"8","key":"10.1016\/j.ynpai.2019.100038_b0380","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1097\/j.pain.0000000000000951","article-title":"Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia","volume":"158","author":"Wang","year":"2017","journal-title":"Pain"},{"issue":"13","key":"10.1016\/j.ynpai.2019.100038_b0385","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2106\/JBJS.I.01537","article-title":"The epidemiology of ankle sprains in the United States","volume":"92","author":"Waterman","year":"2010","journal-title":"J. Bone Joint Surg. Am"},{"issue":"3","key":"10.1016\/j.ynpai.2019.100038_b0390","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connectivity"},{"key":"10.1016\/j.ynpai.2019.100038_b0395","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2018.00092","article-title":"Understanding the physiopathology behind axial and radial diffusivity changes\u2014what do we know?","volume":"9","author":"Winklewski","year":"2018","journal-title":"Frontiers in Neurology"},{"issue":"Supplement","key":"10.1016\/j.ynpai.2019.100038_b0400","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2019.100038_b0405","article-title":"Ventral pallidal modulation of aversion processing","author":"Wulff","year":"2018","journal-title":"Brain Research"},{"key":"10.1016\/j.ynpai.2019.100038_b0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874440001105010001","article-title":"Caudate nucleus and insular activation during a pain suppression paradigm comparing thermal and electrical stimulation","volume":"5","author":"Wunderlich","year":"2011","journal-title":"Open Neuroimag. J."},{"issue":"1","key":"10.1016\/j.ynpai.2019.100038_b0415","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mri.2014.09.005","article-title":"In vivo evaluation of rabbit sciatic nerve regeneration with diffusion tensor imaging (DTI): correlations with histology and behavior","volume":"33","author":"Yamasaki","year":"2015","journal-title":"Magnetic Resonance Imaging"},{"issue":"15","key":"10.1016\/j.ynpai.2019.100038_b0420","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1002\/hbm.24709","article-title":"Shifting brain circuits in pain chronicity","volume":"40","author":"Youssef","year":"2019","journal-title":"Human Brain Mapping"}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X19300133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X19300133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:25:17Z","timestamp":1762529117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X19300133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":85,"alternative-id":["S2452073X19300133"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2019.100038","relation":{},"ISSN":["2452-073X"],"issn-type":[{"type":"print","value":"2452-073X"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological and behavioral markers of pain following nerve injury in humans","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2019.100038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100038"}}