{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:17:38Z","timestamp":1792811858401,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS098772"],"award-info":[{"award-number":["NS098772"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS120663"],"award-info":[{"award-number":["NS120663"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010390","name":"Saint Louis University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA042852"],"award-info":[{"award-number":["DA042852"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ynpai.2021.100082","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T12:41:19Z","timestamp":1640608879000},"page":"100082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain"],"prefix":"10.1016","volume":"11","author":[{"given":"Kathryn","family":"Braden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison J.","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Salvemini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynpai.2021.100082_b0005","doi-asserted-by":"crossref","unstructured":"Akin, E.J., Alsaloum, M., Higerd, G.P., Liu, S., Zhao, P., Dib-Hajj, F.B., Waxman, S.G., Dib-Hajj, S.D., 2021. Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7. Brain.","DOI":"10.1093\/brain\/awab113"},{"issue":"4","key":"10.1016\/j.ynpai.2021.100082_b0010","doi-asserted-by":"crossref","first-page":"e0152405","DOI":"10.1371\/journal.pone.0152405","article-title":"Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release","volume":"11","author":"Alexandrou","year":"2016","journal-title":"PloS one"},{"key":"10.1016\/j.ynpai.2021.100082_b0015","doi-asserted-by":"crossref","unstructured":"Benson, M., I\u00f1iguez-Lluh\u00ed, J.A., Martens, J. 2009. SUMO Modification of Ion Channels. In: SUMO Regulation of Cellular Processes. pp. 117-136. Ed. V.G. Wilson. Springer Netherlands: Dordrecht.","DOI":"10.1007\/978-90-481-2649-1_7"},{"key":"10.1016\/j.ynpai.2021.100082_b0020","doi-asserted-by":"crossref","unstructured":"Benson, M.D., Li, Q.-J., Kieckhafer, K., Dudek, D., Whorton, M.R., Sunahara, R.K., I\u00f1iguez-Lluh\u00ed, J.A., Martens, J.R., 2007. SUMO Modification Regulates Inactivation of the Voltage-Gated Potassium Channel Kv1.5. Proceedings of the National Academy of Sciences - PNAS 104, 1805-1810.","DOI":"10.1073\/pnas.0606702104"},{"key":"10.1016\/j.ynpai.2021.100082_b0025","doi-asserted-by":"crossref","unstructured":"Berge, O.-G., 2011. Predictive validity of behavioural animal models for chronic pain. British journal of pharmacology 164, 1195-1206.","DOI":"10.1111\/j.1476-5381.2011.01300.x"},{"key":"10.1016\/j.ynpai.2021.100082_b0030","doi-asserted-by":"crossref","first-page":"eabh1314","DOI":"10.1126\/scitranslmed.abh1314","article-title":"Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents","volume":"13","author":"Cai","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"12","key":"10.1016\/j.ynpai.2021.100082_b0035","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nsmb.3116","article-title":"Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase","volume":"22","author":"Cappadocia","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ynpai.2021.100082_b0040","first-page":"389","article-title":"Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration","volume":"21","author":"Cavaletti","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ynpai.2021.100082_b0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bcp.2019.01.018","article-title":"Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics","volume":"163","author":"Chew","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ynpai.2021.100082_b0050","doi-asserted-by":"crossref","unstructured":"Chew, L.A., Khanna, R., 2018. CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain. Neuronal Signal 2, pii: NS20170220. doi: 20170210.20171042\/NS20170220.","DOI":"10.1042\/NS20170220"},{"issue":"7121","key":"10.1016\/j.ynpai.2021.100082_b0055","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ynpai.2021.100082_b0060","doi-asserted-by":"crossref","first-page":"40883","DOI":"10.1038\/srep40883","article-title":"Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a","volume":"7","author":"Deuis","year":"2017","journal-title":"Scient. Rep."},{"key":"10.1016\/j.ynpai.2021.100082_b0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/emmm.201100134","article-title":"Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors","volume":"3","author":"Descoeur","year":"2011","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.ynpai.2021.100082_b0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn3404","article-title":"The Na(V)1.7 sodium channel: from molecule to man","volume":"14","author":"Dib-Hajj","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.ynpai.2021.100082_b0075","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"issue":"52","key":"10.1016\/j.ynpai.2021.100082_b0080","doi-asserted-by":"crossref","first-page":"E8443","DOI":"10.1073\/pnas.1610531113","article-title":"Hierarchical CRMP2 posttranslational modifications control NaV1.7 function","volume":"113","author":"Dustrude","year":"2016","journal-title":"Proceed. Natl. Acad. Sci. USA"},{"issue":"34","key":"10.1016\/j.ynpai.2021.100082_b0085","doi-asserted-by":"crossref","first-page":"24316","DOI":"10.1074\/jbc.M113.474924","article-title":"CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking","volume":"288","author":"Dustrude","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ynpai.2021.100082_b0090","article-title":"Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?","author":"Eagles","year":"2020","journal-title":"Br. J. Pharmacol. n\/a."},{"issue":"1","key":"10.1016\/j.ynpai.2021.100082_b0095","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-biochem-061909-093311","article-title":"Sumoylation: A Regulatory Protein Modification in Health and Disease","volume":"82","author":"Flotho","year":"2013","journal-title":"Ann. Rev. Biochem."},{"issue":"10","key":"10.1016\/j.ynpai.2021.100082_b0100","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1097\/j.pain.0000000000001294","article-title":"Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain","volume":"159","author":"Fran\u00e7ois-Moutal","year":"2018","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2021.100082_b0105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/19336950.2018.1491244","article-title":"Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels","volume":"12","author":"Fran\u00e7ois-Moutal","year":"2018","journal-title":"Channels (Austin)"},{"issue":"8","key":"10.1016\/j.ynpai.2021.100082_b0110","doi-asserted-by":"crossref","first-page":"e0221787","DOI":"10.1371\/journal.pone.0221787","article-title":"A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN)","volume":"14","author":"Gadgil","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ynpai.2021.100082_b0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13041-020-00714-1","article-title":"Non-SUMOylated CRMP2 decreases Na(V)1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15","volume":"14","author":"Gomez","year":"2021","journal-title":"Molecular Brain"},{"key":"10.1016\/j.ynpai.2021.100082_b0120","doi-asserted-by":"crossref","unstructured":"Gordon-Williams, R., Farquhar-Smith, P., 2020. Recent advances in understanding chemotherapy-induced peripheral neuropathy. F1000Research 9.","DOI":"10.12688\/f1000research.21625.1"},{"issue":"3","key":"10.1016\/j.ynpai.2021.100082_b0125","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1113\/jphysiol.2003.047357","article-title":"Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons","volume":"551","author":"Herzog","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.ynpai.2021.100082_b0130","doi-asserted-by":"crossref","unstructured":"Jimenez-Andrade, J.M., Herrera, M.B., Ghilardi, J.R., Vardanyan, M., Melemedjian, O.K., Mantyh, P.W., 2008. Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Mol. Pain 4, 10.","DOI":"10.1186\/1744-8069-4-10"},{"issue":"3","key":"10.1016\/j.ynpai.2021.100082_b0135","doi-asserted-by":"crossref","first-page":"427","DOI":"10.15252\/embj.201796692","article-title":"Mapping protein interactions of sodium channel Na(V)1.7 using epitope-tagged gene-targeted mice","volume":"37","author":"Kanellopoulos","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.ynpai.2021.100082_b0140","article-title":"Navigating a new path to Nav1.7 for pain","author":"Kingwell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.ynpai.2021.100082_b0145","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1523\/JNEUROSCI.0899-17.2017","article-title":"DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain","volume":"38","author":"Li","year":"2018","journal-title":"J. Neurosci."},{"issue":"29","key":"10.1016\/j.ynpai.2021.100082_b0150","doi-asserted-by":"crossref","first-page":"E2724","DOI":"10.1073\/pnas.1220844110","article-title":"Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels","volume":"110","author":"McCormack","year":"2013","journal-title":"Proceed. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ynpai.2021.100082_b0155","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1093\/brain\/awab086","article-title":"Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain","volume":"144","author":"MacDonald","year":"2021","journal-title":"Brain"},{"issue":"584","key":"10.1016\/j.ynpai.2021.100082_b0160","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9056","article-title":"Long-lasting analgesia via targeted in situ repression of Na(V)1.7 in mice","volume":"13","author":"Moreno","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"11","key":"10.1016\/j.ynpai.2021.100082_b0165","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1097\/j.pain.0000000000001951","article-title":"Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain","volume":"161","author":"Moutal","year":"2020","journal-title":"Pain"},{"issue":"11","key":"10.1016\/j.ynpai.2021.100082_b0170","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/mp.2017.117","article-title":"Blocking CRMP2 SUMOylation reverses neuropathic pain","volume":"23","author":"Moutal","year":"2018","journal-title":"Molecular psychiatry"},{"issue":"10","key":"10.1016\/j.ynpai.2021.100082_b0175","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1007\/s12035-019-1568-4","article-title":"Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions","volume":"56","author":"Moutal","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.ynpai.2021.100082_b0180","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00586-013-3076-y","article-title":"Evaluation of behavior and expression of NaV1.7 in dorsal root ganglia after sciatic nerve compression and application of nucleus pulposus in rats","volume":"23","author":"Mukai","year":"2014","journal-title":"Eur. Spine J. Off Publicat. Europ. Spine Society, Eur. Spinal Deform. Soc. Eur. Section Cerv. Spine Res. Soc."},{"key":"10.1016\/j.ynpai.2021.100082_b0185","article-title":"Innovations and advances in modelling and measuring pain in animals","author":"Sadler","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"issue":"23","key":"10.1016\/j.ynpai.2021.100082_b0190","doi-asserted-by":"crossref","first-page":"14805","DOI":"10.1074\/jbc.272.23.14805","article-title":"A Novel Tetrodotoxin-sensitive, Voltage-gated Sodium Channel Expressed in Rat and Human Dorsal Root Ganglia","volume":"272","author":"Sangameswaran","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"6433","key":"10.1016\/j.ynpai.2021.100082_b0195","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aaw2493","article-title":"Structures of human Na(v)1.7 channel in complex with auxiliary subunits and animal toxins","volume":"363","author":"Shen","year":"2019","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ynpai.2021.100082_b0200","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/cts.12712","article-title":"Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na(v) 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects","volume":"13","author":"Siebenga","year":"2020","journal-title":"Clin. Transl. Sci."},{"issue":"2","key":"10.1016\/j.ynpai.2021.100082_b0205","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuroscience.2009.08.037","article-title":"Abnormal expression of voltage-gated sodium channels Nav1. 7, Nav1. 3 and Nav1. 8 in trigeminal neuralgia","volume":"164","author":"Siqueira","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynpai.2021.100082_b0210","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnmol.2017.00174","article-title":"Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy","volume":"10","author":"Starobova","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.ynpai.2021.100082_b0215","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1471-4159.2006.04401.x","article-title":"The structure of human collapsin response mediator protein 2, a regulator of axonal growth","volume":"101","author":"Stenmark","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ynpai.2021.100082_b0220","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s12885-020-06834-0","article-title":"Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients","volume":"20","author":"Tanabe","year":"2020","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.ynpai.2021.100082_b0225","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1124\/mol.116.105437","article-title":"The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels","volume":"90","author":"Theile","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ynpai.2021.100082_b0230","doi-asserted-by":"crossref","unstructured":"Toledo-Aral, J.J., Moss, B.L., He, Z.-J., Koszowski, A.G., Whisenand, T., Levinson, S.R., Wolf, J.J., Silos-Santiago, I., Halegoua, S., Mandel, G., 1997. Identification of PN1, a Predominant Voltage-Dependent Sodium Channel Expressed Principally in Peripheral Neurons. Proceed. Natl. Acad. Sci. - PNAS 94, 1527-1532.","DOI":"10.1073\/pnas.94.4.1527"},{"issue":"6","key":"10.1016\/j.ynpai.2021.100082_b0235","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/j.pain.0000000000001177","article-title":"Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms","volume":"159","author":"Wahlman","year":"2018","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2021.100082_b0240","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/1567202617666200514113441","article-title":"Involvement of the Sodium Channel Nav1.7 in Paclitaxel-induced Peripheral Neuropathy through ERK1\/2 Signaling in Rats","volume":"17","author":"Wang","year":"2020","journal-title":"Curr. Neurovasc. Res."},{"issue":"3","key":"10.1016\/j.ynpai.2021.100082_b0245","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2013noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.ynpai.2021.100082_b0250","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2011.12.023","article-title":"Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel","volume":"203","author":"Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynpai.2021.100082_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40064-016-3351-6","article-title":"Sodium channel Nav1.7 expression is upregulated in the dorsal root ganglia in a rat model of paclitaxel-induced peripheral neuropathy","volume":"5","author":"Xiao","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.ynpai.2021.100082_b0260","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/jmg.2003.012153","article-title":"Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia","volume":"41","author":"Yang","year":"2004","journal-title":"J. Med. Genet."},{"issue":"13-14","key":"10.1016\/j.ynpai.2021.100082_b0265","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.drudis.2013.02.008","article-title":"Considering the impact drug-like properties have on the chance of success","volume":"18","author":"Yusof","year":"2013","journal-title":"Drug Discovery Today"}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X21000234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X21000234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:27:10Z","timestamp":1762529230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X21000234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":53,"alternative-id":["S2452073X21000234"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2021.100082","relation":{},"ISSN":["2452-073X"],"issn-type":[{"value":"2452-073X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2021.100082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100082"}}