{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:04:44Z","timestamp":1782327884763,"version":"3.54.5"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ynpai.2023.100118","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T18:24:23Z","timestamp":1674152663000},"page":"100118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The autonomic and nociceptive response to acute exercise is impaired in people with knee osteoarthritis"],"prefix":"10.1016","volume":"13","author":[{"given":"Neil R.","family":"Bossenger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-0940","authenticated-orcid":false,"given":"Gwyn N.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0005","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1572-0241.1999.00861.x","article-title":"Characterization of autonomic dysfunction in patients with irritable bowel syndrome by means of heart rate variability studies","volume":"94","author":"Adeyemi","year":"1999","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.semarthrit.2014.06.003","article-title":"Autonomic function and rheumatoid arthritis \u2013 A systematic review","volume":"44","author":"Adlan","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0015","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and therapeutic criteria committee of the american rheumatism association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1037\/1089-2680.10.3.229","article-title":"Heart rate variability as an index of regulated emotional responding","volume":"10","author":"Appelhans","year":"2006","journal-title":"Rev. Gen. Psych."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","article-title":"Sensitization in patients with painful knee osteoarthritis","volume":"149","author":"Arendt-Nielsen","year":"2010","journal-title":"Pain."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0030","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/acr.21669","article-title":"Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain","volume":"64","author":"Barakat","year":"2012","journal-title":"Arthritis Care Res."},{"issue":"9","key":"10.1016\/j.ynpai.2023.100118_b0035","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nrrheum.2016.93","article-title":"The brain-joint axis in osteoarthritis: nerves, circadian clocks and beyond","volume":"12","author":"Berenbaum","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0040","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/AJP.0b013e3182177654","article-title":"Quantitative sensory testing profiles in chronic back pain are distinct from those in fibromyalgia","volume":"27","author":"Blumenstiel","year":"2011","journal-title":"Clin. J. Pain."},{"issue":"2","key":"10.1016\/j.ynpai.2023.100118_b0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2340\/1650197719702239298","article-title":"Perceived exertion as an indicator of somatic stress","volume":"2","author":"Borg","year":"1970","journal-title":"Scand. J. Rehabil. Med."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0050","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s004210050585","article-title":"Cardiovascular responses to light isometric and aerobic exercise in 21- and 59-year-old males","volume":"80","author":"Boutcher","year":"1999","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.ynpai.2023.100118_b0055","series-title":"A guide for Analysing Electrodermal Activity (EDA) & Skin Conductance Responses (SCRs) for Psychological Experiments","author":"Braithwaite","year":"2013"},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1388-2457(03)00312-2","article-title":"Estimating cardiac autonomic activity during sleep: impedance cardiography, spectral analysis, and Poincar\u00e9 plots","volume":"115","author":"Burgess","year":"2004","journal-title":"Clin. Neurophysiol."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0065","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.joca.2013.12.023","article-title":"Acute resistance exercise and pressure pain sensitivity in knee osteoarthritis: a randomised crossover trial","volume":"22","author":"Burrows","year":"2014","journal-title":"Osteoarthritis Cartilage."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0070","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/AJP.0b013e31823ae69e","article-title":"Comparing pain modulation and autonomic responses in fibromyalgia and irritable bowel syndrome patients","volume":"28","author":"Chalaye","year":"2012","journal-title":"Clin. J. Pain."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0075","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.pain.2013.12.023","article-title":"The role of cardiovascular activity in fibromyalgia and conditioned pain modulation","volume":"155","author":"Chalaye","year":"2014","journal-title":"Pain"},{"issue":"11 Pt 1","key":"10.1016\/j.ynpai.2023.100118_b0080","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1540-8159.1988.tb06272.x","article-title":"Physiological principles of a new method for rate responsive pacing using the pre-ejection interval","volume":"11","author":"Chirife","year":"1988","journal-title":"Pacing Clin. Electrophysiol."},{"issue":"10","key":"10.1016\/j.ynpai.2023.100118_b0085","first-page":"755","article-title":"Autonomic nervous system derangement in fibromyalgia syndrome and related disorders","volume":"3","author":"Cohen","year":"2001","journal-title":"Isr. Med. Assoc. J."},{"issue":"4","key":"10.1016\/j.ynpai.2023.100118_b0090","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0049-0172(00)80010-4","article-title":"Autonomic dysfunction in patients with fibromyalgia: application of power spectral analysis of heart rate variability","volume":"29","author":"Cohen","year":"2000","journal-title":"Semin. Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.berh.2018.04.001","article-title":"Role of the autonomic nervous system in osteoarthritis","volume":"31","author":"Courties","year":"2017","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0100","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1152\/jappl.1995.79.6.1946","article-title":"Cutaneous vascular and sudomotor responses to isometric exercise in humans","volume":"79","author":"Crandall","year":"1995","journal-title":"J. Appl. Physiol."},{"issue":"7","key":"10.1016\/j.ynpai.2023.100118_b0105","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1212\/WNL.57.7.1296","article-title":"Pain increases during sympathetic arousal in patients with complex regional pain syndrome","volume":"57","author":"Drummond","year":"2001","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0110","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jpsychores.2013.01.011","article-title":"Painful effects of auditory startle, forehead cooling and psychological stress in patients with fibromyalgia or rheumatoid arthritis","volume":"74","author":"Drummond","year":"2013","journal-title":"J. Psychosom. Res."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0115","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0304-3959(92)90086-Q","article-title":"Do patients with primary fibromyalgia have an altered muscle sympathetic nerve activity?","volume":"48","author":"Elam","year":"1992","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.ynpai.2023.100118_b0120","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.joca.2015.02.163","article-title":"Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis","volume":"23","author":"Fingleton","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/AJP.0000000000000418","article-title":"Exercise-induced hypoalgesia in people with knee osteoarthritis with normal and abnormal conditioned pain modulation","volume":"33","author":"Fingleton","year":"2017","journal-title":"Clin. J. Pain."},{"issue":"9","key":"10.1016\/j.ynpai.2023.100118_b0130","first-page":"1787","article-title":"Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia","volume":"32","author":"Furlan","year":"2005","journal-title":"J. Rheumatol."},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0135","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/pm\/pnw176","article-title":"Isometric back exercise has different effect on pressure pain thresholds in healthy men and women","volume":"18","author":"Gajsar","year":"2016","journal-title":"Pain Med."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0140","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00421-010-1813-z","article-title":"Effects of static contraction and cold stimulation on cardiovascular autonomic indices, trapezius blood flow and muscle activity in chronic neck\u2013shoulder pain","volume":"111","author":"Hallman","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.ynpai.2023.100118_b0145","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00421-014-3066-8","article-title":"Short- and long-term reliability of heart rate variability indices during repetitive low-force work","volume":"115","author":"Hallman","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0150","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/AJP.0000000000000771","article-title":"Pretreatment exercise-induced hypoalgesia is associated with change in pain and function after standardized exercise therapy in painful knee osteoarthritis","volume":"36","author":"Hansen","year":"2020","journal-title":"Clin. J. Pain."},{"issue":"2","key":"10.1016\/j.ynpai.2023.100118_b0155","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/joor.12344","article-title":"Somatosensory evaluation in dysfunctional syndrome patients","volume":"43","author":"Hilgenberg-Sydney","year":"2016","journal-title":"J. Oral Rehabil."},{"issue":"11","key":"10.1016\/j.ynpai.2023.100118_b0160","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1249\/MSS.0b013e31817eeecc","article-title":"Dose response of isometric contractions on pain perception in healthy adults","volume":"40","author":"Hoeger Bement","year":"2008","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.ynpai.2023.100118_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00147","article-title":"Linking pain sensation to the autonomic nervous system: the role of the anterior cingulate and periaqueductal gray resting-state networks","volume":"14","author":"Hohenschurz-Schmidt","year":"2020","journal-title":"Front. Neurosci."},{"issue":"7","key":"10.1016\/j.ynpai.2023.100118_b0170","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","article-title":"The individual and socioeconomic impact of osteoarthritis","volume":"10","author":"Hunter","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0175","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejpain.2005.12.013","article-title":"The effects of static muscular contraction on blood pressure, heart rate, pain ratings and pressure pain thresholds in healthy individuals and patients with fibromyalgia","volume":"11","author":"Kadetoff","year":"2007","journal-title":"Eur. J. Pain."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0180","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/00365529850171800","article-title":"Spectral analysis of heart rate variability in patients with irritable bowel syndrome","volume":"33","author":"Karling","year":"1998","journal-title":"Scand. J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.ynpai.2023.100118_b0185","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.joca.2013.05.015","article-title":"Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis","volume":"21","author":"King","year":"2013","journal-title":"Osteoarthritis Cartilage."},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0190","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0002-8703(75)90220-3","article-title":"Effects of age on responses to isometric exercise. Isometric handgrip in noninvasive screening for cardiovascular disease","volume":"90","author":"Kino","year":"1975","journal-title":"Am. Heart J."},{"issue":"2","key":"10.1016\/j.ynpai.2023.100118_b0195","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00007256-200029020-00002","article-title":"Analgesia following exercise: a review","volume":"29","author":"Koltyn","year":"2000","journal-title":"Sports Med."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00007256-200232080-00001","article-title":"Exercise-induced hypoalgesia and intensity of exercise","volume":"32","author":"Koltyn","year":"2002","journal-title":"Sports Med."},{"issue":"11","key":"10.1016\/j.ynpai.2023.100118_b0205","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jpain.2007.06.003","article-title":"Contralateral attenuation of pain after short-duration submaximal isometric exercise","volume":"8","author":"Koltyn","year":"2007","journal-title":"J. Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0210","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1090-3801(02)00124-6","article-title":"Segmental and plurisegmental modulation of pressure pain thresholds during static muscle contractions in healthy individuals","volume":"7","author":"Kosek","year":"2003","journal-title":"Eur. J. Pain"},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0215","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0304-3959(95)00112-3","article-title":"Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls","volume":"64","author":"Kosek","year":"1996","journal-title":"Pain"},{"issue":"9","key":"10.1016\/j.ynpai.2023.100118_b0220","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.joca.2013.06.019","article-title":"Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis\u2013treatment effects of neuromuscular exercise and total joint replacement","volume":"21","author":"Kosek","year":"2013","journal-title":"Osteoarthritis Cartilage."},{"key":"10.1016\/j.ynpai.2023.100118_b0225","article-title":"Vagal tank theory: The three Rs of cardiac vagal control functioning \u2013 resting, reactivity, and recovery","volume":"12","author":"Laborde","year":"2018","journal-title":"Neurosci"},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2010.06.021","article-title":"Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia","volume":"151","author":"Lannersten","year":"2010","journal-title":"Pain."},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0235","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/acr.21898","article-title":"Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US","volume":"65","author":"Losina","year":"2013","journal-title":"Arthritis Care Res."},{"issue":"23","key":"10.1016\/j.ynpai.2023.100118_b0240","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1113\/JP282013","article-title":"The association between pain-induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey","volume":"599","author":"Makovac","year":"2021","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0245","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3899\/jrheum.110671","article-title":"Treating the pain of osteoarthritis - where do we go from here?","volume":"38","author":"Mandl","year":"2011","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0250","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1172\/JCI107731","article-title":"Autonomic mechanisms in hemodynamic responses to isometric exercise","volume":"54","author":"Martin","year":"1974","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.ynpai.2023.100118_b0255","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar2146","article-title":"Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia","volume":"9","author":"Martinez-Lavin","year":"2007","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.ynpai.2023.100118_b0260","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jpain.2012.09.006","article-title":"A meta-analytic review of the hypoalgesic effects of exercise","volume":"13","author":"Naugle","year":"2012","journal-title":"J. Pain."},{"issue":"4","key":"10.1016\/j.ynpai.2023.100118_b0265","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/pme.12312","article-title":"Isometric exercise as a test of pain modulation: effects of experimental pain test, psychological variables, and sex","volume":"15","author":"Naugle","year":"2014","journal-title":"Pain Med."},{"issue":"4","key":"10.1016\/j.ynpai.2023.100118_b0270","first-page":"361","article-title":"Influence of isometric exercise on pressure pain sensitivity in knee osteoarthritis","volume":"11","author":"Neelapala","year":"2018","journal-title":"J. Pain Manage."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0280","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1152\/jappl.1994.77.6.2778","article-title":"Enhancement of parasympathetic cardiac activity during activation of muscle metaboreflex in humans","volume":"77","author":"Nishiyasu","year":"1994","journal-title":"J. Appl. Physiol."},{"issue":"9","key":"10.1016\/j.ynpai.2023.100118_b0285","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.pain.2011.05.024","article-title":"Blunted autonomic reactivity and increased pain tolerance in somatoform patients","volume":"152","author":"Pollatos","year":"2011","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0290","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/japplphysiol.00699.2003","article-title":"Comparison of skin sympathetic nerve responses to isometric arm and leg exercise","volume":"97","author":"Ray","year":"2004","journal-title":"J. Appl. Physiol."},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0295","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/PSY.0b013e3181da91f1","article-title":"Aberrances in autonomic cardiovascular regulation in fibromyalgia syndrome and their relevance for clinical pain reports","volume":"72","author":"Reyes del Paso","year":"2010","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.ynpai.2023.100118_b0300","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jpsychores.2010.09.012","article-title":"Autonomic cardiovascular control and responses to experimental pain stimulation in fibromyalgia syndrome","volume":"70","author":"Reyes del Paso","year":"2011","journal-title":"J. Psychosom. Res."},{"issue":"11","key":"10.1016\/j.ynpai.2023.100118_b0305","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jpain.2019.03.005","article-title":"Exercise-induced hypoalgesia in pain-free and chronic pain populations: State of the art and future directions","volume":"20","author":"Rice","year":"2019","journal-title":"J. Pain"},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0310","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1152\/jappl.1990.69.6.2085","article-title":"Different responses in skin and muscle sympathetic nerve activity to static muscle contraction","volume":"69","author":"Saito","year":"1990","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.ynpai.2023.100118_b0315","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2009.07.062","article-title":"Sympathetic skin responses evoked by muscle contraction","volume":"463","author":"Schestatsky","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0320","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.1993.sp019548","article-title":"Influence of force on muscle and skin sympathetic nerve activity during sustained isometric contractions in humans","volume":"462","author":"Seals","year":"1993","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0325","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pain.2005.08.007","article-title":"Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls","volume":"118","author":"Staud","year":"2005","journal-title":"Pain"},{"issue":"10","key":"10.1016\/j.ynpai.2023.100118_b0330","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.joca.2012.06.009","article-title":"Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis","volume":"20","author":"Suokas","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0335","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1152\/jappl.1995.79.3.805","article-title":"Lesser vagal withdrawal during isometric exercise with age","volume":"79","author":"Taylor","year":"1995","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.ynpai.2023.100118_b0340","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-201X.2004.01263.x","article-title":"Mental stress inhibits pain perception and heart rate variability but not a nociceptive withdrawal reflex","volume":"180","author":"Terkelsen","year":"2004","journal-title":"Acta Physiol. Scand."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0345","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/ALN.0b013e31823bbfb0","article-title":"Heart rate variability in complex regional pain syndrome during rest and mental and orthostatic stress","volume":"116","author":"Terkelsen","year":"2012","journal-title":"Anesthesiology"},{"issue":"10","key":"10.1016\/j.ynpai.2023.100118_b0350","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.psyneuen.2005.04.014","article-title":"Psychosomatics and psychopathology: looking up and down from the brain","volume":"30","author":"Thayer","year":"2005","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0355","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jpsychores.2006.07.004","article-title":"Psychophysiological responses in patients with fibromyalgia syndrome","volume":"61","author":"Thieme","year":"2006","journal-title":"J. Psychosom. Res."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0360","doi-asserted-by":"crossref","first-page":"815","DOI":"10.4103\/ijmr.IJMR_1447_14","article-title":"Respiratory sinus arrhythmia as a non-invasive index of 'brain-heart' interaction in stress","volume":"144","author":"Tonhajzerova","year":"2016","journal-title":"Indian J. Med. Res."},{"issue":"7","key":"10.1016\/j.ynpai.2023.100118_b0365","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/j.pain.0000000000000896","article-title":"Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes","volume":"158","author":"Tour","year":"2017","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0370","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/j.pain.0000000000000360","article-title":"Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation","volume":"157","author":"Tracy","year":"2016","journal-title":"Pain"},{"issue":"9","key":"10.1016\/j.ynpai.2023.100118_b0375","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.pain.2012.04.008","article-title":"Differentiating between heat pain intensities: the combined effect of multiple autonomic parameters","volume":"153","author":"Treister","year":"2012","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0380","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.biopsycho.2010.05.008","article-title":"Examination of the dose-response relationship between pain perception and blood pressure elevations induced by isometric exercise in men and women","volume":"85","author":"Umeda","year":"2010","journal-title":"Biol. Psychol."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0385","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pain.2013.09.023","article-title":"Similarities between exercise-induced hypoalgesia and conditioned pain modulation in humans","volume":"155","author":"Vaegter","year":"2014","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0390","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/pm\/pny087","article-title":"Exercise-induced hypoalgesia after isometric wall squat exercise: a test-retest reliabilty study","volume":"20","author":"Vaegter","year":"2019","journal-title":"Pain Med."},{"issue":"8","key":"10.1016\/j.ynpai.2023.100118_b0395","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/pm\/pnx165","article-title":"Endogenous pain modulation: Association with resting heart rate variability and negative affectivity","volume":"19","author":"Van Den Houte","year":"2018","journal-title":"Pain Med."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0400","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/01.RES.69.1.228","article-title":"Stimulation of skin sympathetic nerve discharge by central command. Differential control of sympathetic outflow to skin and skeletal muscle during static exercise","volume":"69","author":"Vissing","year":"1991","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ynpai.2023.100118_b0405","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jpain.2020.04.003","article-title":"Exercise-induced hypoalgesia in healthy individuals and people with chronic musculoskeletal pain: a systematic review and meta-analysis","volume":"22","author":"Wewege","year":"2021","journal-title":"J. Pain."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0410","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","article-title":"2016 Revisions to the 2010\/2011 fibromyalgia diagnostic criteria","volume":"46","author":"Wolfe","year":"2016","journal-title":"Semin. Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ynpai.2023.100118_b0415","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1152\/japplphysiol.00245.2016","article-title":"Effects of different stresses on cardiac autonomic control and cardiovascular coupling","volume":"122","author":"Xie","year":"2017","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.ynpai.2023.100118_b0420","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11926-022-01071-9","article-title":"Autonomic nervous system dysregulation and osteoarthritis pain: Mechanisms, measurement, and future outlook","volume":"24","author":"Yeater","year":"2022","journal-title":"Curr. Rheumatol. Rep."},{"issue":"5","key":"10.1016\/j.ynpai.2023.100118_b0425","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.mehy.2006.02.026","article-title":"Osteoarthritis: an example of phenoptosis through autonomic dysfunction?","volume":"67","author":"Yun","year":"2006","journal-title":"Med. Hypotheses."},{"key":"10.1016\/j.ynpai.2023.100118_b0275","doi-asserted-by":"crossref","unstructured":"Nijs, J., Kosek, E., Van Oosterwijck, J., Meeus, M., 2012. Dysfunctional endogenous analgesia during exercise in patients with chronic pain: to exercise or not to exercise? Pain Physician. 3S;15 (3S;7), ES205-ES213.","DOI":"10.36076\/ppj.2012\/15\/ES205"}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X23000053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X23000053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:30:01Z","timestamp":1762529401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X23000053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":85,"alternative-id":["S2452073X23000053"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2023.100118","relation":{},"ISSN":["2452-073X"],"issn-type":[{"value":"2452-073X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The autonomic and nociceptive response to acute exercise is impaired in people with knee osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2023.100118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100118"}}