{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:45:24Z","timestamp":1790167524640,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":94,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 NS104789"],"award-info":[{"award-number":["R21 NS104789"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 NS096454"],"award-info":[{"award-number":["R03 NS096454"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA168524"],"award-info":[{"award-number":["P30 CA168524"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005191","name":"Craig H Neilsen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM130423"],"award-info":[{"award-number":["P20 GM130423"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001447","name":"Rita Allen Foundation","doi-asserted-by":"publisher","award":["P20 GM103418"],"award-info":[{"award-number":["P20 GM103418"]}],"id":[{"id":"10.13039\/100001447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006727","name":"University of Kansas Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["P30 HD000228"],"award-info":[{"award-number":["P30 HD000228"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007859","name":"University of Kansas","doi-asserted-by":"publisher","award":["R35GM128562"],"award-info":[{"award-number":["R35GM128562"]}],"id":[{"id":"10.13039\/100007859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007859","name":"University of Kansas","doi-asserted-by":"publisher","award":["BF"],"award-info":[{"award-number":["BF"]}],"id":[{"id":"10.13039\/100007859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007859","name":"University of Kansas","doi-asserted-by":"publisher","award":["T32 HD057850"],"award-info":[{"award-number":["T32 HD057850"]}],"id":[{"id":"10.13039\/100007859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ynpai.2024.100156","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T09:09:50Z","timestamp":1712394590000},"page":"100156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction"],"prefix":"10.1016","volume":"15","author":[{"given":"Adam B.","family":"Willits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Kader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Eller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"Bye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Strope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret D.","family":"Freudenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Umar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree","family":"Chintapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Christianson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle M.","family":"Baumbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-3608","authenticated-orcid":false,"given":"Erin E.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynpai.2024.100156_b0005","doi-asserted-by":"crossref","first-page":"e0206701","DOI":"10.1371\/journal.pone.0206701","article-title":"Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis","volume":"13","author":"Ahmed","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ynpai.2024.100156_b0010","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1089\/neu.2004.21.1371","article-title":"Targeting recovery: priorities of the spinal cord-injured population","volume":"21","author":"Anderson","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ynpai.2024.100156_b0015","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1369\/jhc.2009.953539","article-title":"Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia","volume":"57","author":"Barajon","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ynpai.2024.100156_b0020","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ynpai.2024.100156_b0025","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ynpai.2024.100156_b0030","doi-asserted-by":"crossref","first-page":"14870","DOI":"10.1523\/JNEUROSCI.2428-10.2010","article-title":"Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury","volume":"30","author":"Bedi","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2024.100156_b0035","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.886","article-title":"Generation of Mouse Spinal Cord Injury","volume":"3","author":"Bhalala","year":"2013","journal-title":"Bio Protoc"},{"key":"10.1016\/j.ynpai.2024.100156_b0040","article-title":"Pharmacological therapies for opioid induced constipation in adults with cancer","volume":"358","author":"Boland","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.ynpai.2024.100156_b0045","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1093\/jn\/nxz170","article-title":"Neonatal Diet Impacts Bioregional Microbiota Composition in Piglets Fed Human Breast Milk or Infant Formula","volume":"149","author":"Brink","year":"2019","journal-title":"J. Nutr."},{"key":"10.1016\/j.ynpai.2024.100156_b0050","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/ajcn\/nqaa076","article-title":"Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula","volume":"111","author":"Brink","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ynpai.2024.100156_b0055","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fimmu.2016.00342","article-title":"Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon","volume":"7","author":"Buettner","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ynpai.2024.100156_b0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ejp.905","article-title":"Neuropathic pain prevalence following spinal cord injury: A systematic review and meta-analysis","volume":"21","author":"Burke","year":"2017","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10790268.2017.1351051","article-title":"Pain profiles in a community dwelling population following spinal cord injury: a national survey","volume":"42","author":"Burke","year":"2019","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.ynpai.2024.100156_b0070","first-page":"26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.ynpai.2024.100156_b0075","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pain.2009.09.030","article-title":"Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury","volume":"147","author":"Carlton","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0080","unstructured":"Center, N.S.C.I.S. (2019). Facts and Figures at a Glance. In U.o. Birmingham, ed."},{"key":"10.1016\/j.ynpai.2024.100156_b0085","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12866-021-02095-4","article-title":"Rubidium chloride modulated the fecal microbiota community in mice","volume":"21","author":"Chen","year":"2021","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0090","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sc.2014.91","article-title":"Spinal cord injury models: a review","volume":"52","author":"Cheriyan","year":"2014","journal-title":"Spinal Cord"},{"key":"10.1016\/j.ynpai.2024.100156_b0095","doi-asserted-by":"crossref","first-page":"G134","DOI":"10.1152\/ajpgi.00352.2021","article-title":"Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome","volume":"323","author":"Choo","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0100","doi-asserted-by":"crossref","unstructured":"Christianson, J.A., Bielefeldt, K., Malin, S.A., and Davis, B.M. (2010). Neonatal colon insult alters growth factor expression and TRPA1 responses in adult mice. Pain 151, 540-549. S0304-3959(10)00512-9 [pii] 10.1016\/j.pain.2010.08.029 [doi].","DOI":"10.1016\/j.pain.2010.08.029"},{"key":"10.1016\/j.ynpai.2024.100156_b0105","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1682\/JRRD.2005.02.0045","article-title":"Chronicity of pain associated with spinal cord injury: A longitudinal analysis","volume":"42","author":"Cruz-Almeida","year":"2005","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.ynpai.2024.100156_b0110","doi-asserted-by":"crossref","first-page":"2485S","DOI":"10.1093\/jn\/133.7.2485S","article-title":"Inhibition of histone deacetylase activity by butyrate","volume":"133","author":"Davie","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.ynpai.2024.100156_b0115","article-title":"Comprehensive phenotyping of cutaneous afferents reveals early-onset alterations in nociceptor response properties, release of CGRP, and hindpaw edema following spinal cord injury","volume":"12","author":"Eller","year":"2022","journal-title":"Neurobiol Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0120","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20529.1","article-title":"Neurogenic bowel dysfunction","volume":"8","author":"Emmanuel","year":"2019","journal-title":"F1000Res"},{"key":"10.1016\/j.ynpai.2024.100156_b0125","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/365037","article-title":"Abdominal Pain: A Comparison between Neurogenic Bowel Dysfunction and Chronic Idiopathic Constipation","volume":"2013","author":"Faaborg","year":"2013","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.ynpai.2024.100156_b0130","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/sj.sc.3102097","article-title":"Abdominal pain in long-term spinal cord injury","volume":"46","author":"Finnerup","year":"2008","journal-title":"Spinal Cord"},{"key":"10.1016\/j.ynpai.2024.100156_b0135","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3892\/etm.2017.4132","article-title":"Calcitonin gene-related peptide protects type II alveolar epithelial cells from hyperoxia-induced DNA damage and cell death","volume":"13","author":"Fu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ynpai.2024.100156_b0140","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1097\/j.pain.0000000000002658","article-title":"Local translation in primary afferents and its contribution to pain","volume":"163","author":"Gale","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15082260","article-title":"Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer","volume":"15","author":"Gates","year":"2023","journal-title":"Cancers (basel)"},{"key":"10.1016\/j.ynpai.2024.100156_b0150","doi-asserted-by":"crossref","unstructured":"Grunkemeier, D.M., Cassara, J.E., Dalton, C.B., and Drossman, D.A. (2007). The narcotic bowel syndrome: clinical features, pathophysiology, and management. Clin Gastroenterol Hepatol 5, 1126-1139; quiz 1121-1122. 10.1016\/j.cgh.2007.06.013.","DOI":"10.1016\/j.cgh.2007.06.013"},{"key":"10.1016\/j.ynpai.2024.100156_b0155","doi-asserted-by":"crossref","first-page":"e0145878","DOI":"10.1371\/journal.pone.0145878","article-title":"Intestinal Microbiota in Patients with Spinal Cord Injury","volume":"11","author":"Gungor","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ynpai.2024.100156_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100030","article-title":"Protocol to Prepare Single-Cell Suspensions from Mouse Vagal Sensory Ganglia for Transcriptomic Studies","volume":"1","author":"Haring","year":"2020","journal-title":"STAR Protoc"},{"key":"10.1016\/j.ynpai.2024.100156_b0165","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jnr.1249","article-title":"PKC and PKA, but not PKG mediate LPS-induced CGRP release and [Ca(2+)](i) elevation in DRG neurons of neonatal rats","volume":"66","author":"Hou","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ynpai.2024.100156_b0170","doi-asserted-by":"crossref","first-page":"e0190998","DOI":"10.1371\/journal.pone.0190998","article-title":"Improvements in bladder, bowel and sexual outcomes following task-specific locomotor training in human spinal cord injury","volume":"13","author":"Hubscher","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ynpai.2024.100156_b0175","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.brainresrev.2008.12.010","article-title":"Mechanisms of chronic central neuropathic pain after spinal cord injury","volume":"60","author":"Hulsebosch","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ynpai.2024.100156_b0180","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/j.pain.0000000000000831","article-title":"The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine","volume":"158","author":"Iyengar","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40168-021-01007-y","article-title":"Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis","volume":"9","author":"Jing","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.ynpai.2024.100156_b0190","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3389\/fimmu.2020.00704","article-title":"Traumatic Spinal Cord Injury and the Gut Microbiota: Current Insights and Future Challenges","volume":"11","author":"Jogia","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ynpai.2024.100156_b0195","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"PNAS"},{"key":"10.1016\/j.ynpai.2024.100156_b0200","doi-asserted-by":"crossref","unstructured":"Johns, J.S., Krogh, K., Ethans, K., Chi, J., Queree, M., Eng, J.J., and Spinal Cord Injury Research Evidence, T. (2021). Pharmacological Management of Neurogenic Bowel Dysfunction after Spinal Cord Injury and Multiple Sclerosis: A Systematic Review and Clinical Implications. J. Clin. Med. 10. 10.3390\/jcm10040882.","DOI":"10.3390\/jcm10040882"},{"key":"10.1016\/j.ynpai.2024.100156_b0205","doi-asserted-by":"crossref","first-page":"G434","DOI":"10.1152\/ajpgi.00324.2002","article-title":"Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice","volume":"284","author":"Kamp","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0210","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fphys.2018.01249","article-title":"The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects","volume":"9","author":"Kee","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1471-4159.2007.04524.x","article-title":"Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury","volume":"102","author":"Kigerl","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ynpai.2024.100156_b0220","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1084\/jem.20151345","article-title":"Gut dysbiosis impairs recovery after spinal cord injury","volume":"213","author":"Kigerl","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ynpai.2024.100156_b0225","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0306-4522(98)00280-2","article-title":"Calcitonin gene-related peptide and prostaglandin E2 but not substance P release induced by antidromic nerve stimulation from rat skin in vitro","volume":"89","author":"Kress","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynpai.2024.100156_b0230","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/BF02055170","article-title":"Colorectal function in patients with spinal cord lesions","volume":"40","author":"Krogh","year":"1997","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.ynpai.2024.100156_b0235","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/sj.sc.3101066","article-title":"Gastrointestinal and segmental colonic transit times in patients with acute and chronic spinal cord lesions","volume":"38","author":"Krogh","year":"2000","journal-title":"Spinal Cord"},{"key":"10.1016\/j.ynpai.2024.100156_b0240","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10565-007-9043-9","article-title":"Comet Assay measurements: a perspective","volume":"25","author":"Kumaravel","year":"2009","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.ynpai.2024.100156_b0245","first-page":"308","article-title":"The Stockholm spinal cord injury study: 1. Medical problems in a regional SCI population","volume":"33","author":"Levi","year":"1995","journal-title":"Paraplegia"},{"key":"10.1016\/j.ynpai.2024.100156_b0250","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ynpai.2024.100156_b0255","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051474","article-title":"The Firmicutes\/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?","volume":"12","author":"Magne","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ynpai.2024.100156_b0260","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nprot.2006.461","article-title":"Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity","volume":"2","author":"Malin","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ynpai.2024.100156_b0265","doi-asserted-by":"crossref","first-page":"10516","DOI":"10.1523\/JNEUROSCI.2992-10.2011","article-title":"TRPV1 and TRPA1 function and modulation are target tissue dependent","volume":"31","author":"Malin","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2024.100156_b0270","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1053\/gast.2001.24848","article-title":"Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats","volume":"120","author":"McRoberts","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ynpai.2024.100156_b0275","doi-asserted-by":"crossref","first-page":"G157","DOI":"10.1152\/ajpgi.00105.2020","article-title":"Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites","volume":"319","author":"Mercer","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0280","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1097\/j.pain.0000000000001640","article-title":"Altered microbiome composition in individuals with fibromyalgia","volume":"160","author":"Minerbi","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0285","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4103\/1673-5374.228722","article-title":"Immunomodulation as a neuroprotective strategy after spinal cord injury","volume":"13","author":"Monteiro","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ynpai.2024.100156_b0290","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/SHK.0000000000001211","article-title":"Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner","volume":"52","author":"Nicholson","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.ynpai.2024.100156_b0295","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sc.2016.124","article-title":"Chronic abdominal pain in long-term spinal cord injury: a follow-up study","volume":"55","author":"Nielsen","year":"2017","journal-title":"Spinal Cord"},{"key":"10.1016\/j.ynpai.2024.100156_b0300","doi-asserted-by":"crossref","first-page":"G723","DOI":"10.1152\/ajpgi.00494.2009","article-title":"Bacterial cell products signal to mouse colonic nociceptive dorsal root ganglia neurons","volume":"299","author":"Ochoa-Cortes","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0305","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1097\/j.pain.0000000000001341","article-title":"Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain","volume":"159","author":"Odem","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0310","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1097\/j.pain.0000000000001642","article-title":"Sham surgeries for central and peripheral neural injuries persistently enhance pain-avoidance behavior as revealed by an operant conflict test","volume":"160","author":"Odem","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0315","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000315915","article-title":"Endotoxins and other sepsis triggers","volume":"167","author":"Opal","year":"2010","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.ynpai.2024.100156_b0320","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.774341","article-title":"Gender Differences in 3-Month Outcomes of Erenumab Treatment-Study on Efficacy and Safety of Treatment With Erenumab in Men","volume":"12","author":"Ornello","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ynpai.2024.100156_b0325","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1523\/JNEUROSCI.1137-21.2022","article-title":"A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models","volume":"42","author":"Paige","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2024.100156_b0330","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.aaf8933","article-title":"Neural circuits for pain: Recent advances and current views","volume":"354","author":"Peirs","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ynpai.2024.100156_b0335","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1097\/j.pain.0000000000000264","article-title":"Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic-pituitary-adrenal axis output in female mice","volume":"156","author":"Pierce","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0340","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1113\/JP279075","article-title":"Protease-dependent excitation of nodose ganglion neurons by commensal gut bacteria","volume":"598","author":"Pradhananga","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0345","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4045\/tidsskr.11.0794","article-title":"Chronic pain following spinal cord injury","volume":"132","author":"Rekand","year":"2012","journal-title":"Tidsskr. Nor. Laegeforen."},{"key":"10.1016\/j.ynpai.2024.100156_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10081673","article-title":"Neurogenic Bowel in Acute Rehabilitation Following Spinal Cord Injury: Impact of Laxatives and Opioids","volume":"10","author":"Round","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ynpai.2024.100156_b0355","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ynpai.2024.100156_b0360","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1523\/JNEUROSCI.0498-17.2017","article-title":"Insights into the Dual Role of Inflammation after Spinal Cord Injury","volume":"37","author":"Rust","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2024.100156_b0365","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ynpai.2024.100156_b0370","doi-asserted-by":"crossref","first-page":"eabf9419","DOI":"10.1126\/science.abf9419","article-title":"Tertiary lymphoid structures in cancer","volume":"375","author":"Schumacher","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ynpai.2024.100156_b0375","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0304-3959(02)00452-9","article-title":"A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury","volume":"103","author":"Siddall","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.ynpai.2024.100156_b0380","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2519\/jospt.1996.24.4.240","article-title":"Pain mechanisms involved in musculoskeletal disorders","volume":"24","author":"Sluka","year":"1996","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"10.1016\/j.ynpai.2024.100156_b0385","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00281-017-0669-2","article-title":"Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation","volume":"40","author":"Sorkin","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ynpai.2024.100156_b0390","first-page":"1114","article-title":"Chronic gastrointestinal problems in spinal cord injury patients: a prospective analysis","volume":"85","author":"Stone","year":"1990","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ynpai.2024.100156_b0395","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12974-016-0736-y","article-title":"Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship","volume":"13","author":"Sun","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ynpai.2024.100156_b0400","unstructured":"Team, S.C. (2023). What's the Real Spinal Cord Injury Cost in 2023? https:\/\/www.spinalcord.com\/blog\/what-is-the-real-spinal-cord-injury-cost."},{"key":"10.1016\/j.ynpai.2024.100156_b0405","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/NEN.0b013e31819ac71b","article-title":"Locally synthesized calcitonin gene-related Peptide has a critical role in peripheral nerve regeneration","volume":"68","author":"Toth","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ynpai.2024.100156_b0410","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2014.11.010","article-title":"NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract","volume":"1595","author":"Vance","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.ynpai.2024.100156_b0415","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00535-014-0966-7","article-title":"Treatment of abdominal pain in irritable bowel syndrome","volume":"49","author":"Vanuytsel","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ynpai.2024.100156_b0420","doi-asserted-by":"crossref","DOI":"10.3791\/4086","article-title":"Functional assessment of intestinal motility and gut wall inflammation in rodents: analyses in a standardized model of intestinal manipulation","author":"Vilz","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ynpai.2024.100156_b0425","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jnutbio.2007.08.002","article-title":"Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon","volume":"19","author":"Waldecker","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ynpai.2024.100156_b0430","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fphys.2012.00309","article-title":"Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis","volume":"3","author":"Walters","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0435","doi-asserted-by":"crossref","DOI":"10.3390\/nu11020313","article-title":"Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL\/6J Mice","volume":"11","author":"Wankhade","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ynpai.2024.100156_b0440","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41393-018-0217-5","article-title":"Sepsis in mechanically ventilated patients with spinal cord injury: a retrospective analysis","volume":"57","author":"Weiterer","year":"2019","journal-title":"Spinal Cord"},{"issue":"1844\u20131854","key":"10.1016\/j.ynpai.2024.100156_b0445","first-page":"e1841","article-title":"A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes","volume":"139","author":"Willing","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ynpai.2024.100156_b0450","article-title":"Identification of a Pain-Specific Gene Expression Profile for Pediatric Recurrent Abdominal Pain","volume":"2","author":"Willits","year":"2021","journal-title":"Front Pain Res (lausanne)"},{"key":"10.1016\/j.ynpai.2024.100156_b0455","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1523\/JNEUROSCI.5316-13.2014","article-title":"Persistent pain after spinal cord injury is maintained by primary afferent activity","volume":"34","author":"Yang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynpai.2024.100156_b0460","doi-asserted-by":"crossref","first-page":"G477","DOI":"10.1152\/ajpgi.00175.2022","article-title":"Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility","volume":"323","author":"Yip","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ynpai.2024.100156_b0465","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-62703-640-5_6","article-title":"Mouse enteric neuronal cell culture","volume":"1078","author":"Zhang","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ynpai.2024.100156_b0470","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12967-018-1735-9","article-title":"Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury","volume":"16","author":"Zhang","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ynpai.2024.100156_b0475","first-page":"4817","article-title":"Dysbiosis of gut microbiota is associated with serum lipid profiles in male patients with chronic traumatic cervical spinal cord injury","volume":"11","author":"Zhang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.ynpai.2024.100156_b0480","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X24000072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X24000072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:57:31Z","timestamp":1778889451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X24000072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":96,"alternative-id":["S2452073X24000072"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2024.100156","relation":{},"ISSN":["2452-073X"],"issn-type":[{"value":"2452-073X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2024.100156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100156"}}