{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:14:26Z","timestamp":1781010866144,"version":"3.54.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"publisher","award":["2022\/R -single\/023"],"award-info":[{"award-number":["2022\/R -single\/023"]}],"id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Pain"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ynpai.2025.100179","type":"journal-article","created":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T01:54:43Z","timestamp":1739066083000},"page":"100179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Critical reflections on medication overuse headache in patients with migraine: An unsolved riddle in nociception"],"prefix":"10.1016","volume":"17","author":[{"given":"Alberto","family":"Chiarugi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Buonvicino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ynpai.2025.100179_b0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-022-00415-0","article-title":"Medication overuse headache","volume":"2023","author":"Ashina","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"18","key":"10.1016\/j.ynpai.2025.100179_b0010","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1474-4422(19)30146-2","article-title":"Pathophysiology, prevention, and treatment of medication overuse headache","volume":"2019","author":"Diener","year":"2019","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/j.ynpai.2025.100179_b0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1474-4422(10)70008-9","article-title":"Clinical features, pathophysiology, and treatment of medication-overuse headache","volume":"2010","author":"Evers","year":"2010","journal-title":"Lancet Neurol."},{"issue":"19","key":"10.1016\/j.ynpai.2025.100179_b0020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s10194-018-0875-x","article-title":"Medication-overuse headache: a widely recognized entity amidst ongoing debate","volume":"2018","author":"Vandenbussche","year":"2018","journal-title":"J. Headache Pain"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s10194-024-01889-x","article-title":"Hallmarks of primary headache: part 1 - migraine","volume":"2024","author":"Raggi","year":"2024","journal-title":"J. Headache Pain"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s10194-024-01874-4","article-title":"Prediction models for identifying medication overuse or medication overuse headache in migraine patients: a systematic review","volume":"2024","author":"Aramruang","year":"2024","journal-title":"J. Headache Pain"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s10194-024-01766-7","article-title":"Unsatisfactory response to acute medications does not affect the medication overuse headache development in pediatric chronic migraine","volume":"2024","author":"Frattale","year":"2024","journal-title":"J. Headache Pain"},{"issue":"34","key":"10.1016\/j.ynpai.2025.100179_b0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0333102413512033","article-title":"Definitions of medication-overuse headache in population-based studies and their implications on prevalence estimates: a systematic review","volume":"2014","author":"Westergaard","year":"2014","journal-title":"Cephalalgia"},{"issue":"80","key":"10.1016\/j.ynpai.2025.100179_b0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/bip.20254","article-title":"Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure","volume":"2005","author":"Ossipov","year":"2005","journal-title":"Biopolymers"},{"issue":"2","key":"10.1016\/j.ynpai.2025.100179_b0050","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ncpneuro0236","article-title":"Is medication-overuse headache a distinct biological entity?","volume":"2006","author":"Goadsby","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"issue":"15","key":"10.1016\/j.ynpai.2025.100179_b0055","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1468-1331.2008.02050.x","article-title":"Headaches in a rheumatology clinic: when one pain leads to another","volume":"2008","author":"Williams","year":"2008","journal-title":"Eur. J. Neurol."},{"issue":"43","key":"10.1016\/j.ynpai.2025.100179_b0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1526-4610.2003.03041.x","article-title":"Does chronic daily headache arise de novo in association with regular use of analgesics?","volume":"2003","author":"Bahra","year":"2003","journal-title":"Headache"},{"issue":"67","key":"10.1016\/j.ynpai.2025.100179_b0065","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ana.21897","article-title":"Triptan-induced latent sensitization: a possible basis for medication overuse headache","volume":"2010","author":"De Felice","year":"2010","journal-title":"Ann. Neurol."},{"issue":"133","key":"10.1016\/j.ynpai.2025.100179_b0070","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1093\/brain\/awq159","article-title":"Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers","volume":"2010","author":"De Felice","year":"2010","journal-title":"Brain"},{"issue":"26","key":"10.1016\/j.ynpai.2025.100179_b0075","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tips.2004.12.008","article-title":"Medication-overuse headache: similarities with drug addiction","volume":"2005","author":"Calabresi","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0080","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1468-2982.2005.00879.x","article-title":"Medication overuse headache (MOH) is a biobehavioural disorder","volume":"2005","author":"Saper","year":"2005","journal-title":"Cephalalgia"},{"issue":"49","key":"10.1016\/j.ynpai.2025.100179_b0085","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1526-4610.2008.01257.x","article-title":"Family history for chronic headache and drug overuse as a risk factor for headache chronification","volume":"2009","author":"Cevoli","year":"2009","journal-title":"Headache"},{"issue":"14","key":"10.1016\/j.ynpai.2025.100179_b0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1129-2377-14-59","article-title":"Psychological and neuropsychological correlates of dependence-related behaviour in medication overuse headaches: a one year follow-up study","volume":"2013","author":"Radat","year":"2013","journal-title":"J. Headache Pain"},{"issue":"22","key":"10.1016\/j.ynpai.2025.100179_b0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s10194-021-01224-8","article-title":"Medication overuse and drug addiction: a narrative review from addiction perspective","volume":"2021","author":"Takahashi","year":"2021","journal-title":"J. Headache Pain"},{"issue":"21","key":"10.1016\/j.ynpai.2025.100179_b0100","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S1474-4422(22)00211-3","article-title":"Lifestyle factors and migraine","volume":"2022","author":"Seng","year":"2022","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.ynpai.2025.100179_b0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10194-011-0298-4","article-title":"What do the patients with medication overuse headache expect from treatment and what are the preferred sources of information?","volume":"2011","author":"Munksgaard","year":"2011","journal-title":"J. Headache Pain"},{"issue":"27","key":"10.1016\/j.ynpai.2025.100179_b0110","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/ene.14268","article-title":"European Academy of Neurology guideline on the management of medication-overuse headache","volume":"2020","author":"Diener","year":"2020","journal-title":"Eur. J. Neurol."},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s10194-024-01755-w","article-title":"Medication-overuse headache: a narrative review","volume":"2024","author":"Gosalia","year":"2024","journal-title":"J. Headache Pain"},{"issue":"20","key":"10.1016\/j.ynpai.2025.100179_b0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10194-019-0963-6","article-title":"Behavioral and cognitive animal models in headache research","volume":"2019","author":"Vuralli","year":"2019","journal-title":"J. Headache Pain"},{"issue":"10","key":"10.1016\/j.ynpai.2025.100179_b0125","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1586\/ern.10.16","article-title":"Animal models of headache: from bedside to bench and back to bedside","volume":"2010","author":"Andreou","year":"2010","journal-title":"Expert Rev. Neurother."},{"issue":"2024","key":"10.1016\/j.ynpai.2025.100179_b0130","article-title":"Models of Trigeminal Activation: Is There an Animal Model of Migraine?","volume":"14","author":"Spekker","year":"2024","journal-title":"Brain Sci."},{"issue":"160","key":"10.1016\/j.ynpai.2025.100179_b0135","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1097\/j.pain.0000000000001531","article-title":"Migraine understood as a sensory threshold disease","volume":"2019","author":"Peng","year":"2019","journal-title":"Pain"},{"issue":"15","key":"10.1016\/j.ynpai.2025.100179_b0140","article-title":"Pathophysiological Bases of Comorbidity in Migraine","volume":"2021","author":"Altamura","year":"2021","journal-title":"Front. Hum. Neurosci."},{"issue":"2019","key":"10.1016\/j.ynpai.2025.100179_b0145","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1038\/s41467-019-12197-3","article-title":"Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache","volume":"10","author":"Bonnet","year":"2019","journal-title":"Nat. Commun."},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0150","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s10194-024-01900-5","article-title":"Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization","volume":"2024","author":"Ryu","year":"2024","journal-title":"J. Headache Pain"},{"issue":"40","key":"10.1016\/j.ynpai.2025.100179_b0155","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/0333102420920006","article-title":"Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache","volume":"2020","author":"Rau","year":"2020","journal-title":"Cephalalgia"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0160","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s10194-024-01876-2","article-title":"Reduction of neck pain severity in patients with medication-overuse headache","volume":"2024","author":"Hong","year":"2024","journal-title":"J. Headache Pain"},{"issue":"159","key":"10.1016\/j.ynpai.2025.100179_b0165","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1097\/j.pain.0000000000001291","article-title":"Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns","volume":"2018","author":"Buonvicino","year":"2018","journal-title":"Pain"},{"issue":"62","key":"10.1016\/j.ynpai.2025.100179_b0170","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/head.14363","article-title":"Clinical characteristics of medication-overuse headache according to the class of acute medication: A cross-sectional multicenter study","volume":"2022","author":"Oh","year":"2022","journal-title":"Headache"},{"issue":"45","key":"10.1016\/j.ynpai.2025.100179_b0175","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cbpa.2018.06.005","article-title":"Modulating the masters: chemical tools to dissect CBP and p300 function","volume":"2018","author":"Breen","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"12","key":"10.1016\/j.ynpai.2025.100179_b0180","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10194-011-0352-2","article-title":"Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?","volume":"2011","author":"Mitsikostas","year":"2011","journal-title":"J. Headache Pain"},{"issue":"38","key":"10.1016\/j.ynpai.2025.100179_b0185","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/0333102417722511","article-title":"Selective cephalic upregulation of p-ERK, CamKII and p-CREB in response to glyceryl trinitrate infusion","volume":"2018","author":"Ramachandran","year":"2018","journal-title":"Cephalalgia"},{"issue":"23","key":"10.1016\/j.ynpai.2025.100179_b0190","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.jpain.2022.05.007","article-title":"Histone Deacetylase Inhibitors Counteract CGRP Signaling and Pronociceptive Sensitization in a Rat Model of Medication Overuse Headache","volume":"2022","author":"Urru","year":"2022","journal-title":"J. Pain"},{"issue":"2","key":"10.1016\/j.ynpai.2025.100179_b0195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1874467210902010095","article-title":"Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection","volume":"2009","author":"Monti","year":"2009","journal-title":"Curr. Mol. Pharmacol."},{"issue":"9","key":"10.1016\/j.ynpai.2025.100179_b0200","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40246-015-0051-1","article-title":"HDAC3 role in medication consumption in medication overuse headache patients: a pilot study","volume":"2015","author":"Pisanu","year":"2015","journal-title":"Hum. Genomics"},{"issue":"35","key":"10.1016\/j.ynpai.2025.100179_b0205","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/0333102414566200","article-title":"The place of corticosteroids in migraine attack management: A 65-year systematic review with pooled analysis and critical appraisal","volume":"2015","author":"Woldeamanuel","year":"2015","journal-title":"Cephalalgia"},{"issue":"62","key":"10.1016\/j.ynpai.2025.100179_b0210","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/head.14415","article-title":"Is prednisone still a reasonable option in the treatment of withdrawal headache in patients with chronic migraine and medication overuse headache in the age of CGRP antibodies? A narrative review","volume":"2022","author":"Kaltseis","year":"2022","journal-title":"Headache"},{"issue":"97","key":"10.1016\/j.ynpai.2025.100179_b0215","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of Migraine: A Disorder of Sensory Processing","volume":"2017","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"issue":"43","key":"10.1016\/j.ynpai.2025.100179_b0220","article-title":"The evolutionary meaning of migraine","volume":"2023","author":"Pensato","year":"2023","journal-title":"Cephalalgia"},{"issue":"46","key":"10.1016\/j.ynpai.2025.100179_b0225","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tins.2022.12.007","article-title":"Persistent nociceptor hyperactivity as a painful evolutionary adaptation","volume":"2023","author":"Walters","year":"2023","journal-title":"Trends Neurosci."},{"issue":"42","key":"10.1016\/j.ynpai.2025.100179_b0230","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1177\/03331024211067791","article-title":"Detoxification vs non-detoxification before starting an anti-CGRP monoclonal antibody in medication overuse headache","volume":"2022","author":"Pensato","year":"2022","journal-title":"Cephalalgia"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0235","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s10194-024-01753-y","article-title":"CGRP-targeted medication in chronic migraine - systematic review","volume":"2024","author":"Oliveira","year":"2024","journal-title":"J. Headache Pain"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0240","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s10194-024-01813-3","article-title":"Persistent effectiveness of CGRP antibody therapy in migraine and comorbid medication overuse or medication overuse headache - a retrospective real-world analysis","volume":"2024","author":"Scheffler","year":"2024","journal-title":"J. Headache Pain"},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0245","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s10194-024-01878-0","article-title":"Comparative efficacy and safety of different pharmacological therapies to medication overuse headache: a network meta-analysis","volume":"2024","author":"Kong","year":"2024","journal-title":"J. Headache Pain"},{"issue":"43","key":"10.1016\/j.ynpai.2025.100179_b0250","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s10072-021-05426-5","article-title":"Real-life assessment of erenumab in refractory chronic migraine with medication overuse headache","volume":"2022","author":"Pensato","year":"2022","journal-title":"Neurol. Sci."},{"issue":"21","key":"10.1016\/j.ynpai.2025.100179_b0255","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s10194-020-01143-0","article-title":"Multidimensional assessment of the effects of erenumab in chronic migraine patients with previous unsuccessful preventive treatments: a comprehensive real-world experience","volume":"2020","author":"Russo","year":"2020","journal-title":"J. Headache Pain"},{"issue":"14","key":"10.1016\/j.ynpai.2025.100179_b0260","article-title":"Monoclonal antibodies for chronic migraine and medication overuse headache: A real-world study","volume":"2023","author":"Krymchantowski","year":"2023","journal-title":"Front. Neurol."},{"issue":"103","key":"10.1016\/j.ynpai.2025.100179_b0265","article-title":"Efficacy of Atogepant in Chronic Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial","volume":"2024","author":"Goadsby","year":"2024","journal-title":"Neurology"},{"issue":"143","key":"10.1016\/j.ynpai.2025.100179_b0270","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/brain\/awaa211","article-title":"Differential medication overuse risk of novel anti-migraine therapeutics","volume":"2020","author":"Saengjaroentham","year":"2020","journal-title":"Brain"},{"issue":"40","key":"10.1016\/j.ynpai.2025.100179_b0275","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1177\/0333102420938652","article-title":"Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache","volume":"2020","author":"Navratilova","year":"2020","journal-title":"Cephalalgia"},{"issue":"142","key":"10.1016\/j.ynpai.2025.100179_b0280","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/sj.bjp.0705807","article-title":"Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat","volume":"2004","author":"Storer","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"161","key":"10.1016\/j.ynpai.2025.100179_b0285","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1111\/j.1476-5381.2010.01012.x","article-title":"Evidence for CGRP re-uptake in rat dura mater encephali","volume":"2010","author":"Gupta","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"43","key":"10.1016\/j.ynpai.2025.100179_b0290","article-title":"\u201cWearing-off\u201d efficacy of CGRP monoclonal antibodies for migraine prevention: A meta-analysis of randomized controlled trials","volume":"2023","author":"Asawavichienjinda","year":"2023","journal-title":"Cephalalgia"},{"issue":"44","key":"10.1016\/j.ynpai.2025.100179_b0295","article-title":"No wearing-off effect of erenumab or fremanezumab for chronic migraine prevention: a single-center, real-world, observational study","volume":"2024","author":"Florescu","year":"2024","journal-title":"Cephalalgia"},{"issue":"22","key":"10.1016\/j.ynpai.2025.100179_b0300","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s10194-021-01363-y","article-title":"Discontinuing monoclonal antibodies targeting CGRP pathway after one-year treatment: an observational longitudinal cohort study","volume":"2021","author":"Vernieri","year":"2021","journal-title":"J. Headache Pain"},{"issue":"19","key":"10.1016\/j.ynpai.2025.100179_b0305","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41582-023-00842-x","article-title":"The 5-HT(1F) receptor as the target of ditans in migraine - from bench to bedside","volume":"2023","author":"Mitsikostas","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"25","key":"10.1016\/j.ynpai.2025.100179_b0310","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s10194-024-01891-3","article-title":"Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache","volume":"2024","author":"Vuralli","year":"2024","journal-title":"J. Headache Pain"}],"container-title":["Neurobiology of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X25000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452073X25000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:57:24Z","timestamp":1778889444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452073X25000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":62,"alternative-id":["S2452073X25000017"],"URL":"https:\/\/doi.org\/10.1016\/j.ynpai.2025.100179","relation":{},"ISSN":["2452-073X"],"issn-type":[{"value":"2452-073X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Critical reflections on medication overuse headache in patients with migraine: An unsolved riddle in nociception","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynpai.2025.100179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100179"}}