{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:47:34Z","timestamp":1793738854650,"version":"4.6.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771141"],"award-info":[{"award-number":["31771141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003815","name":"Huaqiao University","doi-asserted-by":"publisher","award":["Z16Y0017"],"award-info":[{"award-number":["Z16Y0017"]}],"id":[{"id":"10.13039\/501100003815","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ynstr.2021.100333","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:08:35Z","timestamp":1620050915000},"page":"100333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Prenatal stress leads to deficits in brain development, mood related behaviors and gut microbiota in offspring"],"prefix":"10.1016","volume":"15","author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhen","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynstr.2021.100333_bib1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/npp.2012.253","article-title":"Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis","volume":"38","author":"Anacker","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2021.100333_bib2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0006-8993(85)90394-4","article-title":"Effects of prenatal stress on differentiation of the sexually dimorphic nucleus of the preoptic area (SDN-POA) of the rat brain","volume":"332","author":"Anderson","year":"1985","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.ynstr.2021.100333_bib3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1242\/dev.110.3.713","article-title":"Cepko. \"Cellular migration patterns in the developing mouse cerebral cortex","volume":"110","author":"Austin","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.ynstr.2021.100333_bib4","doi-asserted-by":"crossref","first-page":"14950","DOI":"10.1073\/pnas.1112213108","article-title":"Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing","volume":"108","author":"Ayoub","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100333_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO;2-G","article-title":"Maternal separaseparation disrupts the integrity of the intestinal microflora in infant rhesus monkeys","volume":"35","author":"Bailey","year":"1999","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.ynstr.2021.100333_bib6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nrn3818","article-title":"Epigenetic and transgenerational reprogramming of brain development","volume":"16","author":"Bale","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100333_bib7","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.2041-210X.2012.00224.x","article-title":"betapart: an R package for the study of beta diversity","volume":"3","author":"Baselga","year":"2012","journal-title":"Methods in Ecology and Evolution"},{"key":"10.1016\/j.ynstr.2021.100333_bib8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic immunity and the microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ynstr.2021.100333_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jad.2015.11.014","article-title":"Identifying the women at risk of antenatal anxiety and depression: a systematic review","volume":"191","author":"Biaggi","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ynstr.2021.100333_bib10","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1210\/en.2014-1040","article-title":"Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment","volume":"155","author":"Bronson","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2021.100333_bib11","article-title":"The role of stress in brain development: the gestational environment's long-term effects on the brain","volume":"2012","author":"Buss","year":"2012","journal-title":"Cerebrum"},{"key":"10.1016\/j.ynstr.2021.100333_bib12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.tem.2019.07.021","article-title":"Maternal microbiome and metabolic health Program microbiome development and health of the offspring","volume":"30","author":"Calatayud","year":"2019","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ynstr.2021.100333_bib13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.alcohol.2009.09.029","article-title":"Contribution of early environmental stress to alcoholism vulnerability","volume":"43","author":"Campbell","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.ynstr.2021.100333_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainresrev.2010.06.002","article-title":"Prenatal stress and brain development","volume":"65","author":"Charil","year":"2010","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ynstr.2021.100333_bib15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1126\/science.1074192","article-title":"Regulation of cerebral cortical size by control of cell cycle exit in neural precursors","volume":"297","author":"Chenn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ynstr.2021.100333_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2019.00034","article-title":"Systematic review of gut microbiota and major depression","volume":"10","author":"Cheung","year":"2019","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ynstr.2021.100333_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PSY.0b013e31820a62ce","article-title":"Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies","volume":"73","author":"Class","year":"2011","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.ynstr.2021.100333_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","article-title":"Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression","volume":"213","author":"Drevets","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.ynstr.2021.100333_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/NMC.0000000000000372","article-title":"The maternal gut microbiome during pregnancy","volume":"42","author":"Edwards","year":"2017","journal-title":"MCN Am. J. Matern.\/Child Nurs."},{"key":"10.1016\/j.ynstr.2021.100333_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.biopsych.2010.05.036","article-title":"Epigenetic transmission of the impact of early stress across generations","volume":"68","author":"Franklin","year":"2010","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ynstr.2021.100333_bib21","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1089\/jmf.2014.7000","article-title":"The gut microbiome and the brain","volume":"17","author":"Galland","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ynstr.2021.100333_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.aad6469","article-title":"Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap","volume":"359","author":"Gandal","year":"2018","journal-title":"Science (New York, NY)"},{"issue":"1","key":"10.1016\/j.ynstr.2021.100333_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glantz","year":"2000","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.ynstr.2021.100333_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02224","article-title":"Microbiome datasets are compositional: and this is not optional","volume":"8","author":"Gloor","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ynstr.2021.100333_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.psyneuen.2015.06.002","article-title":"Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood","volume":"60","author":"Golubeva","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100333_bib26","doi-asserted-by":"crossref","first-page":"E7398","DOI":"10.1073\/pnas.1721876115","article-title":"Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory","volume":"115","author":"Gould","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100333_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2016.12.021","article-title":"Prenatal stress affects placental cytokines and neurotrophins, commensal microbes, and anxiety-like behavior in adult female offspring","volume":"64","author":"Gur","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ynstr.2021.100333_bib28","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ynstr.2021.100333_bib29","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1210\/en.2015-1177","article-title":"Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain","volume":"156","author":"Ja\u0161arevi\u0107","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2021.100333_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/srep44182","article-title":"Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner","volume":"7","author":"Ja\u0161arevi\u0107","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ynstr.2021.100333_bib31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2217\/epi-2017-0105","article-title":"Positional effects revealed in Illumina methylation array and the impact on analysis","volume":"10","author":"Jiao","year":"2018","journal-title":"Epigenomics"},{"key":"10.1016\/j.ynstr.2021.100333_bib32","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.celrep.2016.06.101","article-title":"miR-17-92 cluster regulates adult hippocampal neurogenesis, anxiety, and depression","volume":"16","author":"Jin","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ynstr.2021.100333_bib33","doi-asserted-by":"crossref","unstructured":"Kang, E., Wen, Z., Song, H., Christian, K.M., and Ming, G.-L. Adult neurogenesis and psychiatric disorders. Cold Spring Harb Perspect Biol 8, a019026.","DOI":"10.1101\/cshperspect.a019026"},{"key":"10.1016\/j.ynstr.2021.100333_bib34","article-title":"Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children","volume":"8","author":"Kang","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.ynstr.2021.100333_bib35","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2020.08.047","article-title":"Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development: a proof-of-concept study","volume":"183","author":"Korpela","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100333_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/10253890600798109","article-title":"Prenatal stress affects the developmental trajectory of the rat amygdala","volume":"9","author":"Kraszpulski","year":"2006","journal-title":"Stress"},{"key":"10.1016\/j.ynstr.2021.100333_bib37","doi-asserted-by":"crossref","first-page":"11032","DOI":"10.1073\/pnas.97.20.11032","article-title":"Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus","volume":"97","author":"Lemaire","year":"2000","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ynstr.2021.100333_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nn.3596","article-title":"Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory","volume":"17","author":"Liu","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100333_bib39","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1146\/annurev-cellbio-100814-125353","article-title":"Generating neuronal diversity in the mammalian cerebral cortex","volume":"31","author":"Lodato","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ynstr.2021.100333_bib40","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1111\/ejn.13291","article-title":"Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus","volume":"44","author":"Luczynski","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100333_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41398-018-0240-5","article-title":"Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus","volume":"8","author":"Luo","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ynstr.2021.100333_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2018.04.003","article-title":"The brain-gut-microbiome Axis","volume":"6","author":"Martin","year":"2018","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.ynstr.2021.100333_bib43","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1002\/ece3.1155","article-title":"Choosing and using diversity indices: insights for ecological applications from the German Biodiversity Exploratories","volume":"4","author":"Morris","year":"2014","journal-title":"Ecol Evol"},{"key":"10.1016\/j.ynstr.2021.100333_bib44","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/nmo.12378","article-title":"Correlation between the human fecal microbiota and depression","volume":"26","author":"Naseribafrouei","year":"2014","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ynstr.2021.100333_bib45","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0006-3223(03)00171-9","article-title":"Neurobiology of emotion perception II: implications for major psychiatric disorders","volume":"54","author":"Phillips","year":"2003","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ynstr.2021.100333_bib46","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.celrep.2014.04.003","article-title":"Growth of the developing cerebral cortex is controlled by MicroRNA-7 through the p53 pathway","volume":"7","author":"Pollock","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ynstr.2021.100333_bib47","article-title":"Breastfeeding and postpartum depression: an overview and methodological recommendations for future Research","volume":"2016","author":"Pope","year":"2016","journal-title":"Depress Res Treat"},{"key":"10.1016\/j.ynstr.2021.100333_bib48","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ynstr.2021.100333_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-0447.2006.00895.x","article-title":"The impact of gestational stress and prenatal growth on emotional problems in offspring: a review","volume":"115","author":"Rice","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ynstr.2021.100333_bib50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-0447.2006.00895.x","article-title":"The impact of gestational stress and prenatal growth on emotional problems in offspring: a review","volume":"115","author":"Rice","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ynstr.2021.100333_bib51","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.ynstr.2021.100333_bib52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfl051","article-title":"The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals","volume":"94","author":"Sanderson","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ynstr.2021.100333_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.ynstr.2021.100333_bib54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature11094","article-title":"Cis-regulatory control of corticospinal system development and evolution","volume":"486","author":"Shim","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100333_bib55","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100333_bib56","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter modulation by the gut microbiota","volume":"1693","author":"Strandwitz","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100333_bib57","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1289\/ehp.1003253","article-title":"Stress during pregnancy and offspring pediatric disease: a National Cohort Study","volume":"119","author":"Tegethoff","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ynstr.2021.100333_bib58","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/35102174","article-title":"The development of neural stem cells","volume":"414","author":"Temple","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100333_bib59","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/164_2016_103","article-title":"Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance","volume":"239","author":"Terry","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ynstr.2021.100333_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12548","article-title":"Steroids, stress and the gut microbiome-brain axis","volume":"30","author":"Tetel","year":"2018","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ynstr.2021.100333_bib61","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fncel.2014.00396","article-title":"Neurogenesis in the embryonic and adult brain: same regulators, different roles","volume":"8","author":"Urban","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100333_bib62","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nature Microbiology"},{"key":"10.1016\/j.ynstr.2021.100333_bib63","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11920-017-0780-z","article-title":"Challenges and opportunities in global mental health: a research-to-practice perspective","volume":"19","author":"Wainberg","year":"2017","journal-title":"Curr. Psychiatr. Rep."},{"key":"10.1016\/j.ynstr.2021.100333_bib64","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ynstr.2021.100333_bib65","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.yhbeh.2010.01.007","article-title":"Early life stress increases anxiety-like behavior in Balbc mice despite a compensatory increase in levels of postnatal maternal care","volume":"57","author":"Wei","year":"2010","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ynstr.2021.100333_bib66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ynstr.2016.08.004","article-title":"Prenatal stressors in rodents: effects on behavior","volume":"6","author":"Weinstock","year":"2017","journal-title":"Neurobiology of Stress"},{"key":"10.1016\/j.ynstr.2021.100333_bib67","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jmb.2016.12.023","article-title":"Bacterial signaling to the nervous system through toxins and metabolites","volume":"429","author":"Yang","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ynstr.2021.100333_bib68","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatr."}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289521000412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289521000412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:11:42Z","timestamp":1762449102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289521000412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":68,"alternative-id":["S2352289521000412"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2021.100333","relation":{},"ISSN":["2352-2895"],"issn-type":[{"value":"2352-2895","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal stress leads to deficits in brain development, mood related behaviors and gut microbiota in offspring","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2021.100333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100333"}}