{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:08:56Z","timestamp":1791403736198,"version":"4.3.3"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2017-83430R"],"award-info":[{"award-number":["SAF2017-83430R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2015FEDER7S\u201320IU16-001945"],"award-info":[{"award-number":["2015FEDER7S\u201320IU16-001945"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Generalitat de Catalunya Agencia de Gestio d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["SGR2017-457"],"award-info":[{"award-number":["SGR2017-457"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ynstr.2021.100355","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T05:58:53Z","timestamp":1623909533000},"page":"100355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Male long-Evans rats: An outbred model of marked hypothalamic-pituitary-adrenal hyperactivity"],"prefix":"10.1016","volume":"15","author":[{"given":"Maria","family":"Sanch\u00eds-Oll\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez-Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8352-1068","authenticated-orcid":false,"given":"Silvia","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-9080","authenticated-orcid":false,"given":"Humberto","family":"Gagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0374-9546","authenticated-orcid":false,"given":"Xavier","family":"Belda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9524-3635","authenticated-orcid":false,"given":"Antonio","family":"Armario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynstr.2021.100355_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0031-9384(92)90151-Q","article-title":"Response to alarm substance in different rat strains","volume":"51","author":"Abel","year":"1992","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ynstr.2021.100355_bib2","first-page":"527","article-title":"Corticosterone: narrow range required for normal body and thymus weight and ACTH","volume":"249","author":"Akana","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ynstr.2021.100355_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/anxi.3070010602","article-title":"Increased mRNA for corticotrophin releasing hormone in the amygdala of fawn-hooded rats: a potential animal model of anxiety","volume":"1","author":"Altemus","year":"1994","journal-title":"Anxiety"},{"key":"10.1016\/j.ynstr.2021.100355_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(88)90068-4","article-title":"Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate","volume":"158","author":"Armario","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ynstr.2021.100355_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fphar.2013.00137","article-title":"Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity","volume":"4","author":"Armario","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ynstr.2021.100355_bib6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0306-4530(95)00018-6","article-title":"Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats","volume":"20","author":"Armario","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/187152706778559336","article-title":"The hypothalamic-pituitary-adrenal axis: what can it tell us about stressors?","volume":"5","author":"Armario","year":"2006","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.ynstr.2021.100355_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000125041","article-title":"Differential neuroendocrine responses to the 5-HT agonist m-chlorophenylpiperazine in Fawn-Hooded rats relative to Wistar and Sprague-Dawley rats","volume":"48","author":"Aulakh","year":"1988","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0006-8993(98)00714-8","article-title":"Effects of cocaethylene on dopamine and serotonin synthesis in Long-Evans and Sprague-Dawley brains","volume":"804","author":"Baumann","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbr.2004.03.011","article-title":"Long-term effects of a single exposure to stress in adult rats on behavior and hypothalamic-pituitary-adrenal responsiveness: comparison of two outbred rat strains","volume":"154","author":"Belda","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib11","doi-asserted-by":"crossref","first-page":"31244","DOI":"10.1038\/srep31244","article-title":"Critical features of acute stress-induced cross-sensitization identified through the hypothalamic-pituitary-adrenal axis output","volume":"6","author":"Belda","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ynstr.2021.100355_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000123529","article-title":"Vasopressin is not involved in the catecholamine-induced release of ACTH, alpha-MSH and beta-endorphin from the rat pituitary gland","volume":"37","author":"Berkenbosch","year":"1983","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.psyneuen.2008.01.001","article-title":"Characterization of central and peripheral components of the hypothalamus-pituitary-adrenal axis in the inbred Roman rat strains","volume":"33","author":"Carrasco","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib14","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbadis.2011.02.003","article-title":"Circadian rhythm of adrenal glucocorticoid: its regulation and clinical implications","volume":"1812","author":"Chung","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ynstr.2021.100355_bib15","first-page":"210","article-title":"Nycthemeral rhythm in adrenal responsiveness to ACTH","volume":"235","author":"Dallman","year":"1978","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ynstr.2021.100355_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0166-4328(00)00220-5","article-title":"Influence of single or repeated experience of rats with forced swimming on behavioural and physiological responses to the stressor","volume":"114","author":"Dal-Zotto","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000127196","article-title":"Adaptation to prolonged or repeated stress \u2013 comparison between rat strains showing intrinsic differences in reactivity to acute stress","volume":"65","author":"Dhabhar","year":"1997","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0165-5728(94)00135-B","article-title":"Differential activation of adrenal steroid receptors in neural and immune tissues of Sprague Dawley, Fischer 344, and Lewis rats","volume":"56","author":"Dhabhar","year":"1995","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ynstr.2021.100355_bib19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/nn.2599","article-title":"The reorganization and reactivation of hippocampal maps predict spatial memory performance","volume":"13","author":"Dupret","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100355_bib20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.pbb.2005.01.015","article-title":"Strain and sex alters effects of stress and nicotine on feeding, body weight, and HPA axis hormones","volume":"80","author":"Faraday","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ynstr.2021.100355_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00421183","article-title":"The reliability of the hole-board apparatus","volume":"44","author":"File","year":"1975","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.ynstr.2021.100355_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fnbeh.2014.00056","article-title":"Sex-dependent effects of an early life treatment in rats that increases maternal care: vulnerability or resilience?","volume":"8","author":"Fuentes","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100355_bib23","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/sj.npp.1300201","article-title":"Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression","volume":"28","author":"Gartside","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2021.100355_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000126973","article-title":"Hypothalamic-pituitary-adrenal response to chronic stress in five inbred rat strains: differential responses are mainly located at the adrenocortical level","volume":"63","author":"G\u00f3mez","year":"1996","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0006-8993(94)91707-8","article-title":"The effects of restraint or hypertonic saline stress on corticotrophin-releasing factor, arginine vasopressin, and proenkephalin A mRNAs in the CFY, Sprague-Dawley and Wistar strains of rat","volume":"667","author":"Harbuz","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib26","series-title":"Generalized Estimating Equations","author":"Hardin","year":"2003"},{"key":"10.1016\/j.ynstr.2021.100355_bib27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0166-4328(02)00083-9","article-title":"Place and matching-to-place spatial learning affected by rat inbreeding (Dark-Agouti, Fischer 344) and albinism (Wistar, Sprague-Dawley) but not domestication (wild rat vs. Long-Evans, Fischer-Norway)","volume":"134","author":"Harker","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0006-8993(95)00152-G","article-title":"Stress regulation of mineralocorticoid receptor heteronuclear RNA in rat hippocampus","volume":"677","author":"Herman","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/endo-122-2-421","article-title":"The role of the adrenal in generating the diurnal variation in circulating levels of corticosteroid-binding globulin in the rat","volume":"122","author":"Hsu","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib30","first-page":"209","article-title":"Response of prolactin, growth hormone and corticosterone secretion to morphine administration or stress exposure in Wistar-AVN and Long Evans rats","volume":"18","author":"Jurcovicov\u00e1","year":"1984","journal-title":"Endocrinol. Exp."},{"key":"10.1016\/j.ynstr.2021.100355_bib31","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jpsychires.2009.11.014","article-title":"Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders","volume":"44","author":"Knapman","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib32","doi-asserted-by":"crossref","first-page":"12004","DOI":"10.1073\/pnas.0803216105","article-title":"Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning","volume":"105","author":"Kolber","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100355_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2003.08.047","article-title":"Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared","volume":"992","author":"Konkle","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib34","first-page":"427","article-title":"Environmental-enrichment-related variations in behavioral, biochemical, and physiologic responses of Sprague-Dawley and Long Evans rats","volume":"49","author":"Konkle","year":"2010","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"10.1016\/j.ynstr.2021.100355_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.physbeh.2012.01.004","article-title":"Estrogen effects on the forced swim test differ in two outbred rat strains","volume":"106","author":"Koss","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ynstr.2021.100355_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuropharm.2011.08.020","article-title":"Circadian rhythms and depression: human psychopathology and animal models","volume":"62","author":"Kronfeld-Schor","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ynstr.2021.100355_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.npp.1300016","article-title":"Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression","volume":"28","author":"Leitch","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2021.100355_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0893-133X(99)00100-1","article-title":"Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test","volume":"22","author":"L\u00f3pez-Rubalcava","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2021.100355_bib39","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1210\/endo.136.8.7628364","article-title":"Increased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels","volume":"136","author":"Makino","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1677\/JOE-07-0077","article-title":"Strain differences in hypothalamic pituitary adrenocortical axis function and adipogenic effects of corticosterone in rats","volume":"195","author":"Marissal-Arvy","year":"2007","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ynstr.2021.100355_bib41","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1055\/s-0034-1383574","article-title":"Quantitative trait lici influencing abdominal fat deposition and functional variability of the HPA axis in the rat","volume":"46","author":"Marissal-Arvy","year":"2014","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbr.2005.10.004","article-title":"Influence of reactivity to novelty and anxiety on hypothalamic-pituitary-adrenal and prolactin responses to two different novel environments in adult male rats","volume":"168","author":"M\u00e1rquez","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuroscience.2003.10.016","article-title":"The hypothalamic-pituitary-adrenal and glucose responses to daily repeated immobilisation stress in rats: individual differences","volume":"123","author":"M\u00e1rquez","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynstr.2021.100355_bib44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(93)90601-D","article-title":"Effects of diazepam and desipramine in the forced swimming test: influence of previous experience with the situation","volume":"236","author":"Mart\u00ed","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ynstr.2021.100355_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF02738959","article-title":"Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors","volume":"6","author":"Mart\u00ed","year":"1997","journal-title":"Endocrine"},{"key":"10.1016\/j.ynstr.2021.100355_bib46","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1126\/science.3340858","article-title":"Effect of neonatal handling on age-related impairments associated with the hippocampus","volume":"239","author":"Meaney","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ynstr.2021.100355_bib47","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1159\/000125287","article-title":"Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat","volume":"50","author":"Meaney","year":"1989","journal-title":"Neuroendocrinology"},{"issue":"1","key":"10.1016\/j.ynstr.2021.100355_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/11.9.1","article-title":"Rat performance on visual detection task modeled with divisive normalization and adaptive decision thresholds","volume":"11","author":"Meier","year":"2011","journal-title":"J. Vis."},{"key":"10.1016\/j.ynstr.2021.100355_bib49","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/npp.2009.53","article-title":"Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder","volume":"34","author":"Minton","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2021.100355_bib50","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nrendo.2012.134-c1","article-title":"CBG: a cortisol reservoir rather than a transporter","volume":"9","author":"Moisan","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ynstr.2021.100355_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2009.07.017","article-title":"Genotype-phenotype associations in understanding the role of corticosteroid-binding globulin in health and disease animal models","volume":"316","author":"Moisan","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ynstr.2021.100355_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021426","article-title":"Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence?","volume":"6","author":"Mu\u00f1oz-Abell\u00e1n","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ynstr.2021.100355_bib53","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1210\/en.2010-0266","article-title":"Regulation of glucocorticoid receptor transcription and nuclear translocation during single and repeated immobilization stress","volume":"151","author":"Noguchi","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib54","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbr.2009.02.019","article-title":"Strain, sex, and open-field behavior: factors underlying the genetic susceptibility to helplessness","volume":"201","author":"Padilla","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib55","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0169-328X(00)00121-2","article-title":"Stress regulation of adrenocorticosteroid receptor gene transcription and mRNA expression in rat hippocampus: time-course analysis","volume":"80","author":"Paskitti","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib56","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.ynstr.2021.100355_bib57","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.physbeh.2006.07.019","article-title":"Diverse basal and stress-related phenotypes of Sprague Dawley rats from three vendors","volume":"89","author":"Pecoraro","year":"2006","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ynstr.2021.100355_bib58","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1210\/endo-129-4-2166","article-title":"Hormonal regulation of type II glucocorticoid receptor messenger ribonucleic acid in rat brain","volume":"129","author":"Peiffer","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0091-3057(86)90552-6","article-title":"Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat","volume":"24","author":"Pellow","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ynstr.2021.100355_bib60","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-328X(93)90189-V","article-title":"Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats","volume":"18","author":"Plotsky","year":"1993","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib61","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100355_bib62","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0149-7634(97)00001-8","article-title":"Stress and emotionality: a multidimensional and genetic approach","volume":"22","author":"Ramos","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ynstr.2021.100355_bib63","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.neuro.051508.135620","article-title":"The influence of stress hormones on fear circuitry","volume":"32","author":"Rodrigues","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100355_bib64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0165-3806(85)90261-5","article-title":"The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation","volume":"350","author":"Sapolsky","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1179\/014788889794651870","article-title":"A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes","volume":"12","author":"Simmons","year":"1989","journal-title":"J. Histotechnol."},{"key":"10.1016\/j.ynstr.2021.100355_bib66","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/sj.mp.4001255","article-title":"Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x Fisher 344 cross","volume":"8","author":"Solberg","year":"2003","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ynstr.2021.100355_bib67","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1152\/physiolgenomics.00052.2006","article-title":"Genetic analysis of the stress-responsive adrenocortical axis","volume":"27","author":"Solberg","year":"2006","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.ynstr.2021.100355_bib68","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1073\/pnas.86.12.4771","article-title":"A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats","volume":"86","author":"Sternberg","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100355_bib69","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/nmo.12462","article-title":"Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats","volume":"27","author":"Su","year":"2015","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ynstr.2021.100355_bib70","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1159\/000125077","article-title":"Comparison of adrenocorticotropin control in Brattleboro, Long-Evans, and Wistar rats. Measurement of corticotropin-releasing factor, arginine vasopressin, and oxytocin in hypophysial portal blood","volume":"48","author":"Tannahill","year":"1988","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib71","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.psyneuen.2008.03.013","article-title":"Mice selected for high versus low stress reactivity: a new animal model for affective disorders","volume":"33","author":"Touma","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib72","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF02244948","article-title":"Differences in fear motivated behaviors among inbred mouse strains","volume":"111","author":"Trull\u00e1s","year":"1993","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ynstr.2021.100355_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093411","article-title":"Comprehensive behavioural analysis of Long Evans and Sprague-Dawley rats reveals differential effects of housing conditions on tests relevant to neuropsychiatric disorders","volume":"9","author":"Turner","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ynstr.2021.100355_bib74","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/j.1460-9568.2008.06218.x","article-title":"Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor","volume":"27","author":"Uchida","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100355_bib75","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1152\/ajpregu.00042.2003","article-title":"Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH","volume":"290","author":"Ulrich-Lai","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ynstr.2021.100355_bib76","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jnr.490210113","article-title":"Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus","volume":"21","author":"Van Eekelen","year":"1988","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ynstr.2021.100355_bib77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3940(81)90210-X","article-title":"Hypothalamic deafferentation in the rat appears to discriminate between the anterior lobe and intermediate lobe response to stress","volume":"27","author":"Vermes","year":"1981","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ynstr.2021.100355_bib78","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainresbull.2008.05.007","article-title":"Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression","volume":"77","author":"Vieyra-Reyes","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ynstr.2021.100355_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2017.06.011","article-title":"Constitutive differences in glucocorticoid responsiveness to stress are related to variation in aggression and anxiety-related behaviors","volume":"84","author":"Walker","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2021.100355_bib80","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1113\/jphysiol.1995.sp020698","article-title":"Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone","volume":"484","author":"Watts","year":"1995","journal-title":"J. Physiol."}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289521000631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289521000631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:18:08Z","timestamp":1762449488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289521000631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":80,"alternative-id":["S2352289521000631"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2021.100355","relation":{},"ISSN":["2352-2895"],"issn-type":[{"value":"2352-2895","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Male long-Evans rats: An outbred model of marked hypothalamic-pituitary-adrenal hyperactivity","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2021.100355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100355"}}