{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:24:01Z","timestamp":1788834241070,"version":"build-2803163510"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ynstr.2021.100376","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T12:24:11Z","timestamp":1627993451000},"page":"100376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Bacteria - derived short chain fatty acids restore sympathoadrenal responsiveness to hypoglycemia after antibiotic-induced gut microbiota depletion"],"prefix":"10.1016","volume":"15","author":[{"given":"Edmund F.","family":"LaGamma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-9217","authenticated-orcid":false,"given":"Fernando","family":"Pena Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bouchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-4369","authenticated-orcid":false,"given":"Bistra B.","family":"Nankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynstr.2021.100376_bib1","doi-asserted-by":"crossref","first-page":"E1323","DOI":"10.1152\/ajpendo.90617.2008","article-title":"Evaluating the glucose tolerance test in mice","volume":"295","author":"Andrikopoulos","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ynstr.2021.100376_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbrc.2007.05.025","article-title":"Sodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA","volume":"359","author":"Aranyi","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ynstr.2021.100376_bib3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058","article-title":"Th17 cell induction by adhesion of microbes to intestinal epithelial cells","volume":"163","author":"Atarashi","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100376_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2011.04.052","article-title":"The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice","volume":"141","author":"Bercik","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ynstr.2021.100376_bib5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.4049\/jimmunol.1601247","article-title":"Microbiome-modulated metabolites at the interface of host immunity","volume":"198","author":"Blacher","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ynstr.2021.100376_bib6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13073-016-0303-2","article-title":"Impact of the gut microbiota on inflammation, obesity, and metabolic disease","volume":"8","author":"Boulange","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.ynstr.2021.100376_bib7","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/obr.12068","article-title":"Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?","volume":"14","author":"Brahe","year":"2013","journal-title":"Obes. Rev."},{"key":"10.1016\/j.ynstr.2021.100376_bib8","doi-asserted-by":"crossref","first-page":"263ra158","DOI":"10.1126\/scitranslmed.3009759","article-title":"The gut microbiota influences blood-brain barrier permeability in mice","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ynstr.2021.100376_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/IAI.05496-11","article-title":"Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis","volume":"80","author":"Buffie","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ynstr.2021.100376_bib10","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.cell.2016.06.001","article-title":"Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring","volume":"165","author":"Buffington","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100376_bib11","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ijo.2015.84","article-title":"The role of short chain fatty acids in appetite regulation and energy homeostasis","volume":"39","author":"Byrne","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.ynstr.2021.100376_bib12","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/brain\/awy131","article-title":"The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics","volume":"141","author":"Camara-Lemarroy","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.ynstr.2021.100376_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1017\/S0029665114001657","article-title":"Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?","volume":"74","author":"Chambers","year":"2015","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.ynstr.2021.100376_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s13668-018-0248-8","article-title":"Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health","volume":"7","author":"Chambers","year":"2018","journal-title":"Curr Nutr Rep"},{"key":"10.1016\/j.ynstr.2021.100376_bib15","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1099\/ijs.0.65504-0","article-title":"Bacteroides xylanisolvens sp. nov., a xylan-degrading bacterium isolated from human faeces","volume":"58","author":"Chassard","year":"2008","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100376_bib17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrmicro2876","article-title":"The interplay between the intestinal microbiota and the brain","volume":"10","author":"Collins","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cell.2014.05.052","article-title":"Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences","volume":"158","author":"Cox","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100376_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100376_bib20","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ynstr.2021.100376_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2008.09.088","article-title":"Valproic acid regulates catecholaminergic pathways by concentration-dependent threshold effects on TH mRNA synthesis and degradation","volume":"1247","author":"D'Souza","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"13","key":"10.1016\/j.ynstr.2021.100376_bib23","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/s41386-020-0732-x","article-title":"Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial","volume":"45","author":"Dalile","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2021.100376_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00065-17","article-title":"Functional changes in the gut microbiome contribute to transforming growth factor beta-deficient colon cancer","volume":"2","author":"Daniel","year":"2017","journal-title":"mSystems"},{"key":"10.1016\/j.ynstr.2021.100376_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100376_bib26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molbrainres.2005.09.002","article-title":"Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway","volume":"142","author":"Decastro","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.ynstr.2021.100376_bib27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s12864-016-2680-8","article-title":"Xylan degradation by the human gut Bacteroides xylanisolvens XB1A(T) involves two distinct gene clusters that are linked at the transcriptional level","volume":"17","author":"Despres","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.ynstr.2021.100376_bib28","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Diaz Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100376_bib29","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1136\/gutjnl-2018-317503","article-title":"Role of the microbiome in human development","volume":"68","author":"Dominguez-Bello","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.ynstr.2021.100376_bib30","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100376_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13311-017-0600-5","article-title":"Gut microbiota and the neuroendocrine system","volume":"15","author":"Farzi","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ynstr.2021.100376_bib32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ynstr.2017.03.001","article-title":"Stress & the gut-brain axis: regulation by the microbiome","volume":"7","author":"Foster","year":"2017","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.ynstr.2021.100376_bib33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbi.2016.02.020","article-title":"Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication","volume":"56","author":"Frohlich","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ynstr.2021.100376_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13442","article-title":"Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior","volume":"5","author":"Gacias","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ynstr.2021.100376_bib35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/gut.2009.202515","article-title":"Bacterial infection causes stress-induced memory dysfunction in mice","volume":"60","author":"Gareau","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.ynstr.2021.100376_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/1471-2105-11-367","article-title":"A flexible R package for nonnegative matrix factorization","volume":"11","author":"Gaujoux","year":"2010","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ynstr.2021.100376_bib37","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41390-018-0270-y","article-title":"Absence of gut microbial colonization attenuates the sympathoadrenal response to hypoglycemic stress in mice: implications for human neonates","volume":"85","author":"Giri","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tem.2011.01.002","article-title":"Effects of the gut microbiota on obesity and glucose homeostasis","volume":"22","author":"Greiner","year":"2011","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ynstr.2021.100376_bib39","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2017.09.001","article-title":"Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice","volume":"67","author":"Guida","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ynstr.2021.100376_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.psych.58.110405.085605","article-title":"The neurobiology of stress and development","volume":"58","author":"Gunnar","year":"2007","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.ynstr.2021.100376_bib41","article-title":"Microbial community profiling of human saliva using shotgun metagenomic sequencing","volume":"9","author":"Hasan","year":"2014","journal-title":"Plos One 9"},{"key":"10.1016\/j.ynstr.2021.100376_bib42","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fcimb.2017.00489","article-title":"Microbiota modulate anxiety-like behavior and endocrine abnormalities in hypothalamic-pituitary-adrenal Axis","volume":"7","author":"Huo","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ynstr.2021.100376_bib43","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1096\/fj.14-265983","article-title":"Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity","volume":"29","author":"Hwang","year":"2015","journal-title":"Faseb. J."},{"key":"10.1016\/j.ynstr.2021.100376_bib44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fnint.2020.00044","article-title":"Gut-brain Axis in the early postnatal years of life: a developmental perspective","volume":"14","author":"Jena","year":"2020","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100376_bib45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ismej.2007.3","article-title":"Long-term ecological impacts of antibiotic administration on the human intestinal microbiota","volume":"1","author":"Jernberg","year":"2007","journal-title":"ISME J."},{"key":"10.1016\/j.ynstr.2021.100376_bib46","doi-asserted-by":"crossref","first-page":"35455","DOI":"10.1038\/srep35455","article-title":"Alterations of the host microbiome affect behavioral responses to cocaine","volume":"6","author":"Kiraly","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ynstr.2021.100376_bib47","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100376_bib48","article-title":"Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia","volume":"3","author":"Kudrick","year":"2015","journal-title":"Phys. Rep."},{"key":"10.1016\/j.ynstr.2021.100376_bib49","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1152\/physrev.00042.2006","article-title":"Catecholaminergic systems in stress: structural and molecular genetic approaches","volume":"89","author":"Kvetnansky","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ynstr.2021.100376_bib50","doi-asserted-by":"crossref","first-page":"E580","DOI":"10.1152\/ajpendo.00237.2014","article-title":"Partial blockade of nicotinic acetylcholine receptors improves the counterregulatory response to hypoglycemia in recurrently hypoglycemic rats","volume":"307","author":"LaGamma","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.ynstr.2021.100376_bib51","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.1254529","article-title":"Longitudinal analysis of microbial interaction between humans and the indoor environment","volume":"345","author":"Lax","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ynstr.2021.100376_bib52","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"Li","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ynstr.2021.100376_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1757-4749-5-23","article-title":"Commensal Clostridia: leading players in the maintenance of gut homeostasis","volume":"5","author":"Lopetuso","year":"2013","journal-title":"Gut Pathog."},{"key":"10.1016\/j.ynstr.2021.100376_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib55","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1203\/01.PDR.0000119365.21770.45","article-title":"Stereospecific regulation of tyrosine hydroxylase and proenkephalin genes by short-chain fatty acids in rat PC12 cells","volume":"55","author":"Mally","year":"2004","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib56","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ynstr.2021.100376_bib57","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/gbe\/evu050","article-title":"A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria","volume":"6","author":"Meehan","year":"2014","journal-title":"Genome Biol Evol"},{"key":"10.1016\/j.ynstr.2021.100376_bib58","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.celrep.2016.04.074","article-title":"Ly6C(hi) monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis","volume":"15","author":"Mohle","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ynstr.2021.100376_bib59","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00335-013-9488-5","article-title":"The microbiome: stress, health and disease","volume":"25","author":"Moloney","year":"2014","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ynstr.2021.100376_bib60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microb."},{"key":"10.1016\/j.ynstr.2021.100376_bib61","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tim.2016.02.002","article-title":"Functional redundancy-induced stability of gut microbiota subjected to disturbance","volume":"24","author":"Moya","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103740","article-title":"Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells - possible relevance to autism spectrum disorders","volume":"9","author":"Nankova","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ynstr.2021.100376_bib63","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.chom.2019.10.011","article-title":"Recovery of the gut microbiota after antibiotics depends on host diet, community context, and environmental reservoirs","volume":"26","author":"Ng","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ynstr.2021.100376_bib64","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3389\/fimmu.2015.00639","article-title":"The treg\/Th17 Axis: a dynamic balance regulated by the gut microbiome","volume":"6","author":"Omenetti","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ynstr.2021.100376_bib65","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12866-016-0894-1","article-title":"Enrichment dynamics of Listeria monocytogenes and the associated microbiome from naturally contaminated ice cream linked to a listeriosis outbreak","volume":"16","author":"Ottesen","year":"2016","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib66","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.brainres.2006.11.013","article-title":"Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: concentration-dependent effects on transcription and RNA stability","volume":"1132","author":"Parab","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib67","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.devbrainres.2005.08.005","article-title":"Butyrate, a gut-derived environmental signal, regulates tyrosine hydroxylase gene expression via a novel promoter element","volume":"160","author":"Patel","year":"2005","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.ynstr.2021.100376_bib68","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.ynstr.2021.100376_bib69","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1073\/pnas.1523817113","article-title":"Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis","volume":"113","author":"Ponnusamy","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100376_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017996","article-title":"Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression","volume":"6","author":"Reikvam","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ynstr.2021.100376_bib71","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2021.100376_bib72","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nm.4185","article-title":"Signals from the gut microbiota to distant organs in physiology and disease","volume":"22","author":"Schroeder","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.ynstr.2021.100376_bib73","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ynstr.2021.100376_bib74","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2006.05.097","article-title":"Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein","volume":"1107","author":"Shah","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib75","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ynstr.2021.100376_bib76","doi-asserted-by":"crossref","first-page":"E455","DOI":"10.1152\/ajpendo.2001.281.3.E455","article-title":"Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation","volume":"281","author":"Shum","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.ynstr.2021.100376_bib77","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0312-19.2020","article-title":"Depletion of the microbiome alters the recruitment of neuronal ensembles of oxycodone intoxication and withdrawal","volume":"7","author":"Simpson","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.ynstr.2021.100376_bib78","first-page":"1","article-title":"Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival","volume":"10","author":"Slotkin","year":"1988","journal-title":"J. Dev. Physiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib79","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.smim.2006.10.002","article-title":"Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota","volume":"19","author":"Smith","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ynstr.2021.100376_bib80","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ynstr.2021.100376_bib81","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nri.2017.50","article-title":"The dichotomous nature of T helper 17 cells","volume":"17","author":"Stockinger","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ynstr.2021.100376_bib82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib83","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm.4142","article-title":"The microbiome in early life: implications for health outcomes","volume":"22","author":"Tamburini","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.ynstr.2021.100376_bib84","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.117.309715","article-title":"Gut microbiota in cardiovascular health and disease","volume":"120","author":"Tang","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138293","article-title":"Administration of non-absorbable antibiotics to pregnant mice to perturb the maternal gut microbiota is associated with alterations in offspring behavior","volume":"11","author":"Tochitani","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.ynstr.2021.100376_bib86","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100376_bib87","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ynstr.2021.100376_bib88","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100376_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8040573","article-title":"The controversial role of human gut Lachnospiraceae","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.ynstr.2021.100376_bib90","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.3389\/fimmu.2019.02655","article-title":"Interactions between gut microbiota and acute restraint stress in peripheral structures of the hypothalamic-pituitary-adrenal Axis and the intestine of male mice","volume":"10","author":"Vagnerova","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ynstr.2021.100376_bib91","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations","volume":"596","author":"van de Wouw","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.ynstr.2021.100376_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2014.00038","article-title":"Neural pathways that control the glucose counterregulatory response","volume":"8","author":"Verberne","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100376_bib93","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biopsych.2016.08.024","article-title":"Emerging roles for the gut microbiome in autism spectrum disorder","volume":"81","author":"Vuong","year":"2017","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ynstr.2021.100376_bib94","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-neuro-072116-031347","article-title":"The microbiome and host behavior","volume":"40","author":"Vuong","year":"2017","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2021.100376_bib95","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/pr.2017.111","article-title":"The importance of appropriate initial bacterial colonization of the intestine in newborn, child and adult health","volume":"82","author":"Walker","year":"2017","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib96","first-page":"E3029","article-title":"Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ynstr.2021.100376_bib97","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41390-018-0191-9","article-title":"The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders","volume":"85","author":"Warner","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ynstr.2021.100376_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/s12915-019-0699-4","article-title":"The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health","volume":"17","author":"Waters","year":"2019","journal-title":"BMC Biol."},{"key":"10.1016\/j.ynstr.2021.100376_bib99","first-page":"3225","article-title":"The microbiota-gut-brain axis as a key regulator of neural function and the stress response: implications for human and animal health","volume":"95","author":"Wiley","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.ynstr.2021.100376_bib100","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1038\/s41467-018-05336-9","article-title":"Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism","volume":"9","author":"Zarrinpar","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289521000849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289521000849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:06:31Z","timestamp":1762448791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289521000849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":100,"alternative-id":["S2352289521000849"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2021.100376","relation":{},"ISSN":["2352-2895"],"issn-type":[{"value":"2352-2895","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacteria - derived short chain fatty acids restore sympathoadrenal responsiveness to hypoglycemia after antibiotic-induced gut microbiota depletion","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2021.100376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100376"}}