{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:08:39Z","timestamp":1791950919314,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS-1456577"],"award-info":[{"award-number":["IOS-1456577"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ynstr.2022.100457","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T04:34:30Z","timestamp":1651811670000},"page":"100457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Pubertal changes in the pituitary and adrenal glands of male and female rats: Relevance to stress reactivity"],"prefix":"10.1016","volume":"18","author":[{"given":"Rebecca B.","family":"Kann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell D.","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynstr.2022.100457_bib1","first-page":"585","article-title":"Feedback sensitivity of the rat hypothalamo-pituitary-adrenal axis and its capacity to adjust to exogenous corticosterone","volume":"131","author":"Akana","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib2","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0306-4530(95)00018-6","article-title":"Comparison of the behavioural and endocrine response to forced swiming stress in five inbread strains of rats","volume":"20","author":"Armario","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147371","article-title":"Prepubertal and adult male rats differ in the degree and pattern of stess reactive neurons in brain regions that project to the paraventricular nucleus of the hypothalamus","volume":"1760","author":"Baker","year":"2021","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2022.100457_bib4","doi-asserted-by":"crossref","first-page":"T77","DOI":"10.1530\/JME-15-0323","article-title":"60 Years of POMC: biosynthesis, trafficking, and secretion of pro-opiomelanocortin-dervied peptides","volume":"56","author":"Cawley","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF03349692","article-title":"Sex and strain variability in the rat hypothalamus-pituitary-adrenal (HPA) axis function","volume":"18","author":"Chisari","year":"1995","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.ynstr.2022.100457_bib6","first-page":"E1173","article-title":"Estrogen potentiates adrenocortical responses to stress in female rats","volume":"292","author":"Figueiredo","year":"2007","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ynstr.2022.100457_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1530\/JOE-11-0206","article-title":"The transformation of hormonal stress responses throughout puberty and adolescence","volume":"210","author":"Foilb","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105599","article-title":"Cellular and serotonergic correlates of habituated neuroendocrine responses in male and female rats","volume":"136","author":"Goel","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000122169","article-title":"Postweaning development of negative feedback in the pituitary-adrenal system of the rat","volume":"12","author":"Goldman","year":"1973","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ygcen.2016.02.004","article-title":"Sex and stress steroids in adolescence: gonadal regulation of the hypothalamic-pituitary-adrenal axis in the rat","volume":"234","author":"Green","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/hbeh.1994.1044","article-title":"Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis","volume":"28","author":"Handa","year":"1994","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ynstr.2022.100457_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41386-018-0167-9","article-title":"Sex differences in the hypothalamic-pituitary-adrenal axis' response to stress: an important role for gonadal hormones","volume":"44","author":"Heck","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2022.100457_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.yfrne.2003.07.001","article-title":"Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamic-pituitary-adrenocortical responsiveness","volume":"24","author":"Herman","year":"2003","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2008.03620.x","article-title":"Regulation of proopiomelanocortin gene expression","volume":"1163","author":"Jenks","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ynstr.2022.100457_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.1260497","article-title":"Adolescent mental health--opportunity and obligation","volume":"346","author":"Lee","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ynstr.2022.100457_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.physbeh.2012.06.011","article-title":"Divergent stress-induced neuroendocrine and behavioral responses prior to puberty","volume":"107","author":"Lui","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ynstr.2022.100457_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tvjl.2008.02.021","article-title":"Distribution of the androgen receptor in the diencephalon and the pituitary gland in goats: co-localisation with corticotrophin releasing hormone, arginine vasopressin and corticotrophs","volume":"181","author":"Maejima","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.ynstr.2022.100457_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ygcen.2016.03.014","article-title":"Stress-induced oxytocin release and oxytocin cell number and size in prepubertal and adult male and female rats","volume":"234","author":"Minhas","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib19","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1210\/endo.139.9.6181","article-title":"Cellular distribution and gene regulation of estrogen receptors a and b in the rat pituitary","volume":"139","author":"Mitchner","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1677\/joe.1.06972","article-title":"Adrenarche in the rat","volume":"191","author":"Pignatelli","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0091-3057(99)00148-3","article-title":"Gender, sex steroids, corticotropin-releasing factor, nitric oxide, and the HPA response to stress","volume":"64","author":"Rivier","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ynstr.2022.100457_bib22","first-page":"39","article-title":"Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo","volume":"113","author":"Rivier","year":"1983","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yfrne.2017.12.003","article-title":"The metamorphosis of adolescent hormonal stress reactivity: a focus on animal models","volume":"49","author":"Romeo","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ynstr.2022.100457_bib24","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/en.2005-1432","article-title":"Stress history and pubertal development interact to shape hypothalamic pituitary adrenal axis plasticity","volume":"147","author":"Romeo","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib25","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.yhbeh.2006.06.002","article-title":"Pubertal maturation and time of day differentially affect behavioral and neuroendocrine responses following an acute stressor","volume":"50","author":"Romeo","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ynstr.2022.100457_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.psyneuen.2014.01.016","article-title":"Pubertal shifts in adrenal responsiveness to stress and andrenocorticotropic hormone in male rats","volume":"42","author":"Romeo","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib27","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ynstr.2022.100457_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0196-9781(81)80099-X","article-title":"In vivo and in vitro release of ACTH by synthetic CRF","volume":"2","author":"Turkelson","year":"1981","journal-title":"Peptides"},{"key":"10.1016\/j.ynstr.2022.100457_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/archpsyc.61.5.481","article-title":"Stress burden and the lifetime incidence of psychiatric disorder in young adults","volume":"61","author":"Turner","year":"2004","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.ynstr.2022.100457_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000064426","article-title":"Adrenal splanchnic innervation modulates adrenal cortical responses to dehydration stress","volume":"76","author":"Ulrich-Lai","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ynstr.2022.100457_bib31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2022.100457_bib32","doi-asserted-by":"crossref","first-page":"1 221","DOI":"10.1113\/jphysiol.2002.032169","article-title":"A mechanism underlying the sexually dimoprhic ACTH response to lipopolysaccharide in rats: sex steroid modulation of cytokine sites in the hypothalamus","volume":"547","author":"Watanobe","year":"2003","journal-title":"J. Physiol."}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289522000327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289522000327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:06:46Z","timestamp":1762448806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289522000327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":32,"alternative-id":["S2352289522000327"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2022.100457","relation":{},"ISSN":["2352-2895"],"issn-type":[{"value":"2352-2895","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pubertal changes in the pituitary and adrenal glands of male and female rats: Relevance to stress reactivity","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2022.100457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100457"}}