{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T22:08:09Z","timestamp":1750284489022,"version":"3.37.3"},"reference-count":203,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ynstr.2024.100695","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:49:18Z","timestamp":1732024158000},"page":"100695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior"],"prefix":"10.1016","volume":"33","author":[{"given":"Francisco J.","family":"Flores-Ramirez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Illenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9mi","family":"Martin-Fardon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynstr.2024.100695_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.alcohol.2020.06.003","article-title":"Adolescent alcohol exposure increases orexin-A\/hypocretin-1 in the anterior hypothalamus","volume":"88","author":"Amodeo","year":"2020","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/1871527313666140314163920","article-title":"Neuropeptides as therapeutic targets to combat stress-associated behavioral and neuroendocrinological effects","volume":"13","author":"Bali","year":"2014","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2042-6410-4-2","article-title":"Sex differences in stress-related receptors: ''micro'' differences with ''macro'' implications for mood and anxiety disorders","volume":"4","author":"Bangasser","year":"2013","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.ynstr.2024.100695_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pnpbp.2015.02.006","article-title":"Hypothalamic neuropeptide signaling in alcohol addiction","volume":"65","author":"Barson","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00213-005-0167-4","article-title":"Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats","volume":"183","author":"Beardsley","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ynstr.2024.100695_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-0-444-62619-6.00009-4","article-title":"Neurochemical mechanisms of alcohol withdrawal","volume":"125","author":"Becker","year":"2014","journal-title":"Handb. Clin. Neurol."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/frne.1995.1013","article-title":"Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides","volume":"16","author":"Behan","year":"1995","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ynstr.2024.100695_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2009.09.019","article-title":"Hypocretin\/orexin in arousal and stress","volume":"1314","author":"Berridge","year":"2010","journal-title":"Brain Res."},{"issue":"36","key":"10.1016\/j.ynstr.2024.100695_bib9","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1523\/JNEUROSCI.6096-08.2009","article-title":"Orexin A\/hypocretin-1 selectively promotes motivation for positive reinforcers","volume":"29","author":"Borgland","year":"2009","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2006.01.016","article-title":"Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine","volume":"49","author":"Borgland","year":"2006","journal-title":"Neuron"},{"issue":"52","key":"10.1016\/j.ynstr.2024.100695_bib11","doi-asserted-by":"crossref","first-page":"19168","DOI":"10.1073\/pnas.0507480102","article-title":"Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior","volume":"102","author":"Boutrel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"9","key":"10.1016\/j.ynstr.2024.100695_bib12","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1017\/S1461145713000333","article-title":"Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats","volume":"16","author":"Brown","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1037\/0021-843X.99.4.344","article-title":"Severity of psychosocial stress and outcome of alcoholism treatment","volume":"99","author":"Brown","year":"1990","journal-title":"J. Abnorm. Psychol."},{"issue":"12","key":"10.1016\/j.ynstr.2024.100695_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008528","article-title":"CRF1-R activation of the dynorphin\/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior","volume":"4","author":"Bruchas","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuron.2010.09.023","article-title":"Neural syntax: cell assemblies, synapsembles, and readers","volume":"68","author":"Buzsaki","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.ynstr.2024.100695_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"Buzsaki","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/164_2021_433","article-title":"Fundamentals of the dynorphins\/kappa opioid receptor system: from distribution to signaling and function","volume":"271","author":"Cahill","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.8740","article-title":"The dual orexin receptor antagonist suvorexant in alcohol use disorder and comorbid insomnia: a case report","volume":"12","author":"Campbell","year":"2024","journal-title":"Clin Case Rep"},{"issue":"1\u20132","key":"10.1016\/j.ynstr.2024.100695_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00213-002-1283-z","article-title":"A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats","volume":"168","author":"Capriles","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/jpet.105.092304","article-title":"Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats","volume":"316","author":"Carlezon","year":"2006","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-012-2902-y","article-title":"Role of orexin\/hypocretin in conditioned sucrose-seeking in rats","volume":"226","author":"Cason","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"4531","key":"10.1016\/j.ynstr.2024.100695_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.6120570","article-title":"Dynorphin is a specific endogenous ligand of the kappa opioid receptor","volume":"215","author":"Chavkin","year":"1982","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuron.2020.01.033","article-title":"Prefrontal cortex corticotropin-releasing factor neurons control behavioral style selection under challenging situations","volume":"106","author":"Chen","year":"2020","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib25","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00429-013-0626-3","article-title":"Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks","volume":"219","author":"Chen","year":"2014","journal-title":"Brain Struct. Funct."},{"issue":"19","key":"10.1016\/j.ynstr.2024.100695_bib26","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.21-19-j0003.2001","article-title":"Orexin (hypocretin) neurons contain dynorphin","volume":"21","author":"Chou","year":"2001","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib27","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.96.2.748","article-title":"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems","volume":"96","author":"Date","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.biopsych.2006.07.034","article-title":"Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone","volume":"61","author":"Dayas","year":"2007","journal-title":"Biol. Psychiatr."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biopsych.2007.02.002","article-title":"Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse","volume":"63","author":"Dayas","year":"2008","journal-title":"Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"9","key":"10.1016\/j.ynstr.2024.100695_bib31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nn.4091","article-title":"Optogenetics: 10 years of microbial opsins in neuroscience","volume":"18","author":"Deisseroth","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fnbeh.2015.00161","article-title":"Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats","volume":"9","author":"Dong","year":"2015","journal-title":"Front. Behav. Neurosci."},{"issue":"100365","key":"10.1016\/j.ynstr.2024.100695_bib202","article-title":"Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear","volume":"15","author":"Dutta","year":"2021","journal-title":"Neurobiol. Stress"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib33","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1530-0277.1994.tb00109.x","article-title":"Delayed pro-opiomelanocortin activation after ethanol intake in man","volume":"18","author":"Ekman","year":"1994","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib34","first-page":"121","article-title":"Effect of ethanol on plasma corticosterone levels","volume":"153","author":"Ellis","year":"1966","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1460-9568.2009.07065.x","article-title":"The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system","volume":"31","author":"Espana","year":"2010","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/cne.902490302","article-title":"Distribution of dynorphin and enkephalin peptides in the rat brain","volume":"249","author":"Fallon","year":"1986","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1530-0277.2007.00379.x","article-title":"Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41)","volume":"31","author":"Finn","year":"2007","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"12","key":"10.1016\/j.ynstr.2024.100695_bib38","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1038\/npp.2014.146","article-title":"The hypocretin\/orexin system mediates the extinction of fear memories","volume":"39","author":"Flores","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2024.100695_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.1085882","article-title":"Alternative use of suvorexant (Belsomra((R))) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence","volume":"16","author":"Flores-Ramirez","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109046","article-title":"Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: evidence of interaction between CRF(1) and orexin receptor signaling","volume":"210","author":"Flores-Ramirez","year":"2022","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/alcalc\/agz022","article-title":"Sex differences in aversion-resistant ethanol intake in mice","volume":"54","author":"Fulenwider","year":"2019","journal-title":"Alcohol Alcohol"},{"issue":"44","key":"10.1016\/j.ynstr.2024.100695_bib42","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1523\/JNEUROSCI.3096-06.2006","article-title":"Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats","volume":"26","author":"Funk","year":"2006","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/cne.20738","article-title":"Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers","volume":"492","author":"Gabbott","year":"2005","journal-title":"J. Comp. Neurol."},{"issue":"44","key":"10.1016\/j.ynstr.2024.100695_bib44","doi-asserted-by":"crossref","first-page":"18156","DOI":"10.1073\/pnas.1116523109","article-title":"Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking","volume":"109","author":"George","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib45","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1523\/JNEUROSCI.23-08-03106.2003","article-title":"Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal","volume":"23","author":"Georgescu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.conb.2014.07.006","article-title":"Hypocretin (orexin) neuromodulation of stress and reward pathways","volume":"29","author":"Giardino","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.alcohol.2013.05.001","article-title":"Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin\/kappa opioid receptor system","volume":"47","author":"Gillett","year":"2013","journal-title":"Alcohol"},{"issue":"9","key":"10.1016\/j.ynstr.2024.100695_bib48","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/j.1530-0277.2008.00745.x","article-title":"Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats","volume":"32","author":"Gilpin","year":"2008","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"12","key":"10.1016\/j.ynstr.2024.100695_bib49","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1073\/pnas.76.12.6666","article-title":"Dynorphin-(1-13), an extraordinarily potent opioid peptide","volume":"76","author":"Goldstein","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib50","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/jamapsychiatry.2015.0584","article-title":"Epidemiology of DSM-5 alcohol use disorder: results from the national epidemiologic survey on alcohol and related conditions III","volume":"72","author":"Grant","year":"2015","journal-title":"JAMA Psychiatr."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib51","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archpsyc.61.8.807","article-title":"Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"61","author":"Grant","year":"2004","journal-title":"Arch. Gen. Psychiatr."},{"issue":"14","key":"10.1016\/j.ynstr.2024.100695_bib52","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1523\/JNEUROSCI.1848-20.2021","article-title":"Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics","volume":"41","author":"Guyon","year":"2021","journal-title":"J. Neurosci."},{"issue":"7058","key":"10.1016\/j.ynstr.2024.100695_bib53","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib54","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1460-9568.2011.07808.x","article-title":"Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats","volume":"34","author":"Hata","year":"2011","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib55","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib56","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.tins.2007.06.006","article-title":"A key role for corticotropin-releasing factor in alcohol dependence","volume":"30","author":"Heilig","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib57","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.physbeh.2013.10.005","article-title":"Optogenetic examination identifies a context-specific role for orexins\/hypocretins in anxiety-related behavior","volume":"130","author":"Heydendael","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ynstr.2024.100695_bib58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbr.2017.11.019","article-title":"Brain-derived neurotrophic factor (BDNF) determines a sex difference in cue-conditioned alcohol seeking in rats","volume":"339","author":"Hogarth","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s002130000601","article-title":"Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats","volume":"153","author":"Holter","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib60","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.npep.2013.10.009","article-title":"Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?","volume":"47","author":"Hoyer","year":"2013","journal-title":"Neuropeptides"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib61","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1101\/lm.77704","article-title":"Postextinction infusion of a mitogen-activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear","volume":"11","author":"Hugues","year":"2004","journal-title":"Learn. Mem."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib62","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0306-4522(96)00002-4","article-title":"Differential messenger RNA expression of prodynorphin and proenkephalin in the human brain","volume":"72","author":"Hurd","year":"1996","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00213-012-2820-z","article-title":"Alcohol in excess: CRF(1) receptors in the rat and mouse VTA and DRN","volume":"225","author":"Hwa","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib64","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/bbrc.2000.2412","article-title":"Possible involvement of orexin in the stress reaction in rats","volume":"270","author":"Ida","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ynstr.2024.100695_bib65","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fendo.2013.00018","article-title":"The physiological role of orexin\/hypocretin neurons in the regulation of sleep\/wakefulness and neuroendocrine functions","volume":"4","author":"Inutsuka","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ynstr.2024.100695_bib66","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnbeh.2014.00244","article-title":"Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats","volume":"8","author":"James","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12799","article-title":"A randomized, double-blind, placebo-controlled study of the kappa opioid receptor antagonist, CERC-501, in a human laboratory model of smoking behavior","volume":"25","author":"Jones","year":"2020","journal-title":"Addiction Biol."},{"key":"10.1016\/j.ynstr.2024.100695_bib68","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2011.03.045","article-title":"The orexin(1) receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats","volume":"1391","author":"Jupp","year":"2011","journal-title":"Brain Res."},{"issue":"2\u20133","key":"10.1016\/j.ynstr.2024.100695_bib69","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF03033809","article-title":"Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry","volume":"14","author":"Kalivas","year":"2008","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ynstr.2024.100695_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146742","article-title":"Dynorphin and its role in alcohol use disorder","volume":"1735","author":"Karkhanis","year":"2020","journal-title":"Brain Res."},{"issue":"Pt A","key":"10.1016\/j.ynstr.2024.100695_bib71","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuropharm.2016.07.006","article-title":"Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats","volume":"110","author":"Kastman","year":"2016","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/cercor\/13.4.400","article-title":"Coordination of actions and habits in the medial prefrontal cortex of rats","volume":"13","author":"Killcross","year":"2003","journal-title":"Cerebr. Cortex"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib73","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/acer.14264","article-title":"Possible role of CRF-Hcrt interaction in the infralimbic cortex in the emergence and maintenance of compulsive alcohol-seeking behavior","volume":"44","author":"Kim","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib74","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1101\/lm.1463909","article-title":"Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear","volume":"16","author":"Knapska","year":"2009","journal-title":"Learn. Mem."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib75","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1124\/jpet.119.262097","article-title":"The rewarding and anxiolytic properties of ethanol within the central nucleus of the amygdala: mediated by genetic background and nociceptin","volume":"374","author":"Knight","year":"2020","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib76","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1124\/jpet.107.127415","article-title":"Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats","volume":"323","author":"Knoll","year":"2007","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2008.06.012","article-title":"A role for brain stress systems in addiction","volume":"59","author":"Koob","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ynstr.2024.100695_bib78","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2009.03.038","article-title":"Brain stress systems in the amygdala and addiction","volume":"1293","author":"Koob","year":"2009","journal-title":"Brain Res."},{"issue":"5335","key":"10.1016\/j.ynstr.2024.100695_bib79","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.278.5335.52","article-title":"Drug abuse: hedonic homeostatic dysregulation","volume":"278","author":"Koob","year":"1997","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib80","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0893-133X(00)00195-0","article-title":"Drug addiction, dysregulation of reward, and allostasis","volume":"24","author":"Koob","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib81","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/JNEUROSCI.23-01-00007.2003","article-title":"Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins\/hypocretins","volume":"23","author":"Korotkova","year":"2003","journal-title":"J. Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.ynstr.2024.100695_bib82","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4088\/JCP.13011su1c","article-title":"Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system","volume":"74","author":"Krystal","year":"2013","journal-title":"J. Clin. Psychiatry"},{"issue":"9","key":"10.1016\/j.ynstr.2024.100695_bib83","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1097\/00001756-200006260-00034","article-title":"Centrally administered orexin\/hypocretin activates HPA axis in rats","volume":"11","author":"Kuru","year":"2000","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib84","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/npp.2014.306","article-title":"The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study","volume":"40","author":"Kwako","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036871","article-title":"Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal","volume":"7","author":"Laorden","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib86","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/sj.bjp.0706789","article-title":"The orexin system regulates alcohol-seeking in rats","volume":"148","author":"Lawrence","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"36","key":"10.1016\/j.ynstr.2024.100695_bib87","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1523\/JNEUROSCI.2053-12.2012","article-title":"Repeated stress dysregulates kappa-opioid receptor signaling in the dorsal raphe through a p38alpha MAPK-dependent mechanism","volume":"32","author":"Lemos","year":"2012","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0741-8329(91)90618-7","article-title":"Prolactin and cortisol levels following acute alcohol challenges in women with and without a family history of alcoholism","volume":"8","author":"Lex","year":"1991","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib89","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00213-010-1948-y","article-title":"Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats","volume":"212","author":"Li","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"issue":"50","key":"10.1016\/j.ynstr.2024.100695_bib90","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1523\/JNEUROSCI.3380-06.2006","article-title":"Differential target-dependent actions of coexpressed inhibitory dynorphin and excitatory hypocretin\/orexin neuropeptides","volume":"26","author":"Li","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib91","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0741-8329(00)00118-X","article-title":"Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain","volume":"22","author":"Lindholm","year":"2000","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib92","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-4328(00)00368-5","article-title":"The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat","volume":"120","author":"Lindholm","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib93","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/npp.2009.209","article-title":"CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL\/6J mice independent of the HPA axis","volume":"35","author":"Lowery","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib94","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1530-0277.2007.00573.x","article-title":"The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB\/cJ mice","volume":"32","author":"Lowery","year":"2008","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"10","key":"10.1016\/j.ynstr.2024.100695_bib95","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1523\/JNEUROSCI.6256-11.2012","article-title":"Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL\/6J mice","volume":"32","author":"Lowery-Gionta","year":"2012","journal-title":"J. Neurosci."},{"issue":"162","key":"10.1016\/j.ynstr.2024.100695_bib203","first-page":"1","article-title":"Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle","volume":"21","author":"Lu","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib96","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ebiom.2017.03.043","article-title":"Sexually dimorphic changes of hypocretin (orexin) in depression","volume":"18","author":"Lu","year":"2017","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib97","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.physbeh.2011.06.017","article-title":"Effects of recovery from immobilization stress on striatal preprodynorphin- and kappa opioid receptor-mRNA levels of the male rat","volume":"104","author":"Lucas","year":"2011","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib98","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41572-022-00406-1","article-title":"Hazardous drinking and alcohol use disorders","volume":"8","author":"MacKillop","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"1\u20132","key":"10.1016\/j.ynstr.2024.100695_bib99","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3940(94)90559-2","article-title":"U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats","volume":"181","author":"Maisonneuve","year":"1994","journal-title":"Neurosci. Lett."},{"issue":"42","key":"10.1016\/j.ynstr.2024.100695_bib100","doi-asserted-by":"crossref","first-page":"14102","DOI":"10.1523\/JNEUROSCI.4079-10.2010","article-title":"Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction","volume":"30","author":"Marchant","year":"2010","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib101","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib102","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1073\/pnas.0511159103","article-title":"Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex","volume":"103","author":"Margolis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ynstr.2024.100695_bib103","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnbeh.2012.00075","article-title":"Orexin\/hypocretin (Orx\/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?","volume":"6","author":"Martin-Fardon","year":"2012","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib104","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-3-642-28720-6_202","article-title":"Modeling relapse in animals","volume":"13","author":"Martin-Fardon","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1369-1600.2012.00480.x","article-title":"N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking","volume":"19","author":"Martin-Fardon","year":"2014","journal-title":"Addiction Biol."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib106","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/npp.2017.250","article-title":"Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence","volume":"43","author":"Matzeu","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2024.100695_bib107","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2020.599710","article-title":"Blockade of orexin receptors in the posterior paraventricular nucleus of the thalamus prevents stress-induced reinstatement of reward-seeking behavior in rats with a history of ethanol dependence","volume":"14","author":"Matzeu","year":"2020","journal-title":"Front. Integr. Neurosci."},{"issue":"7","key":"10.1016\/j.ynstr.2024.100695_bib108","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1523\/JNEUROSCI.4177-03.2004","article-title":"Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior","volume":"24","author":"McFarland","year":"2004","journal-title":"J. Neurosci."},{"issue":"13","key":"10.1016\/j.ynstr.2024.100695_bib109","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1523\/JNEUROSCI.23-13-05674.2003","article-title":"Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses","volume":"23","author":"McLaughlin","year":"2003","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.ynstr.2024.100695_bib110","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1523\/JNEUROSCI.4062-12.2013","article-title":"Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence","volume":"33","author":"Meinhardt","year":"2013","journal-title":"J. Neurosci."},{"issue":"6911","key":"10.1016\/j.ynstr.2024.100695_bib111","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nature01138","article-title":"Neurons in medial prefrontal cortex signal memory for fear extinction","volume":"420","author":"Milad","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib112","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1037\/0735-7044.118.2.389","article-title":"Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner","volume":"118","author":"Milad","year":"2004","journal-title":"Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib113","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bbr.2010.10.037","article-title":"Extinction of drug seeking","volume":"217","author":"Millan","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib114","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00213-005-0067-7","article-title":"A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats","volume":"182","author":"Mitchell","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"39","key":"10.1016\/j.ynstr.2024.100695_bib115","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0682-24.2024","article-title":"Distinct neuromodulatory effects of endogenous orexin and dynorphin corelease on projection-defined ventral tegmental dopamine neurons","volume":"44","author":"Mohammadkhani","year":"2024","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib116","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.alcohol.2009.07.002","article-title":"Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol--preferring Sprague--Dawley rats","volume":"43","author":"Moorman","year":"2009","journal-title":"Alcohol"},{"issue":"30","key":"10.1016\/j.ynstr.2024.100695_bib117","doi-asserted-by":"crossref","first-page":"9472","DOI":"10.1073\/pnas.1507611112","article-title":"Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction","volume":"112","author":"Moorman","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"Pt A","key":"10.1016\/j.ynstr.2024.100695_bib118","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2014.12.024","article-title":"Differential roles of medial prefrontal subregions in the regulation of drug seeking","volume":"1628","author":"Moorman","year":"2015","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib119","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF00432213","article-title":"Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning","volume":"86","author":"Mucha","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"issue":"16","key":"10.1016\/j.ynstr.2024.100695_bib120","doi-asserted-by":"crossref","first-page":"E1648","DOI":"10.1073\/pnas.1315542111","article-title":"Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area","volume":"111","author":"Muschamp","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib121","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s002130050894","article-title":"Bremazocine reduces unrestricted free-choice ethanol self-administration in rats without affecting sucrose preference","volume":"142","author":"Nestby","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib122","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0306-4603(98)00087-2","article-title":"Stress, cognitive factors, and coping resources as predictors of relapse in alcoholics","volume":"24","author":"Noone","year":"1999","journal-title":"Addict. Behav."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib123","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1530-0277.1997.tb03792.x","article-title":"Effect of three different modes of alcohol administration on the activity of the rat hypothalamic-pituitary-adrenal axis","volume":"21","author":"Ogilvie","year":"1997","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib124","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neulet.2008.08.015","article-title":"Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning","volume":"444","author":"Ovari","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.ynstr.2024.100695_bib125","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/j.1530-0277.2007.00445.x","article-title":"Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats","volume":"31","author":"Overstreet","year":"2007","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1\u20133","key":"10.1016\/j.ynstr.2024.100695_bib126","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(00)00549-5","article-title":"Stress-induced expression of co-localized neuropeptides in hypothalamic and amygdaloid neurons","volume":"405","author":"Palkovits","year":"2000","journal-title":"Eur. J. Pharmacol."},{"year":"1986","author":"Paxinos","series-title":"The Rat Brain in Stereotaxic Coordinates","key":"10.1016\/j.ynstr.2024.100695_bib127"},{"issue":"7","key":"10.1016\/j.ynstr.2024.100695_bib128","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1073\/pnas.92.7.2969","article-title":"Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart","volume":"92","author":"Perrin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ynstr.2024.100695_bib129","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1749-6632.1999.tb08687.x","article-title":"Corticotropin releasing factor receptors and their ligand family","volume":"885","author":"Perrin","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"23","key":"10.1016\/j.ynstr.2024.100695_bib130","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1523\/JNEUROSCI.1045-08.2008","article-title":"Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats","volume":"28","author":"Peters","year":"2008","journal-title":"J. Neurosci."},{"issue":"23","key":"10.1016\/j.ynstr.2024.100695_bib131","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"issue":"14","key":"10.1016\/j.ynstr.2024.100695_bib132","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1523\/JNEUROSCI.0026-18.2018","article-title":"Choice for drug or natural reward engages largely overlapping neuronal ensembles in the infralimbic prefrontal cortex","volume":"38","author":"Pfarr","year":"2018","journal-title":"J. Neurosci."},{"issue":"4765","key":"10.1016\/j.ynstr.2024.100695_bib133","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1126\/science.3016896","article-title":"Psychotomimesis mediated by kappa opiate receptors","volume":"233","author":"Pfeiffer","year":"1986","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib134","article-title":"Rational development of addiction pharmacotherapies: successes, failures, and prospects","volume":"2","author":"Pierce","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"10","key":"10.1016\/j.ynstr.2024.100695_bib135","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1111\/acer.13860","article-title":"Sex differences in motivation to self-administer alcohol after 2 Weeks of abstinence in young-adult heavy drinkers","volume":"42","author":"Plawecki","year":"2018","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib136","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsych.2011.06.025","article-title":"Hypocretin\/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal","volume":"71","author":"Plaza-Zabala","year":"2012","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ynstr.2024.100695_bib137","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.neuropharm.2015.06.017","article-title":"Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala","volume":"99","author":"Pleil","year":"2015","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib138","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.biopsych.2011.05.021","article-title":"Repeated exposure to the kappa-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity","volume":"70","author":"Potter","year":"2011","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ynstr.2024.100695_bib139","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fendo.2016.00134","article-title":"An update on CRF mechanisms underlying alcohol use disorders and dependence","volume":"7","author":"Quadros","year":"2016","journal-title":"Front. Endocrinol."},{"issue":"16","key":"10.1016\/j.ynstr.2024.100695_bib140","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1523\/JNEUROSCI.20-16-06225.2000","article-title":"The role of ventromedial prefrontal cortex in the recovery of extinguished fear","volume":"20","author":"Quirk","year":"2000","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib141","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00213-008-1122-y","article-title":"Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system","volume":"200","author":"Redila","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib142","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/npp.2017.205","article-title":"Repeated administration of opra kappa (LY2456302), a novel, short-acting, selective KOP-r antagonist, in persons with and without cocaine dependence","volume":"43","author":"Reed","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2024.100695_bib143","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.919773","article-title":"Opioid receptor-mediated regulation of neurotransmission in the brain","volume":"15","author":"Reeves","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib144","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000365284","article-title":"Prevalence of and potential influencing factors for alcohol dependence in Europe","volume":"21","author":"Rehm","year":"2015","journal-title":"Eur. Addiction Res."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00213-008-1136-5","article-title":"Inhibition of orexin-1\/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats","volume":"199","author":"Richards","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"issue":"8","key":"10.1016\/j.ynstr.2024.100695_bib146","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1460-9568.2008.06455.x","article-title":"Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state","volume":"28","author":"Richardson","year":"2008","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib147","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1530-0277.1993.tb00853.x","article-title":"Female rats release more corticosterone than males in response to alcohol: influence of circulating sex steroids and possible consequences for blood alcohol levels","volume":"17","author":"Rivier","year":"1993","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib148","first-page":"127","article-title":"Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF)","volume":"229","author":"Rivier","year":"1984","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib149","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.ynstr.2024.100695_bib150","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00213-019-05195-2","article-title":"Individual variability in the recall of fear extinction is associated with phosphorylation of mitogen-activated protein kinase in the infralimbic cortex","volume":"236","author":"Russo","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib151","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00213-006-0546-5","article-title":"Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats","volume":"189","author":"Sabino","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib152","first-page":"1","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ynstr.2024.100695_bib153","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuropharm.2018.09.034","article-title":"The role of the orexin system in stress response","volume":"154","author":"Sargin","year":"2019","journal-title":"Neuropharmacology"},{"issue":"11","key":"10.1016\/j.ynstr.2024.100695_bib154","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1111\/j.1530-0277.2007.00510.x","article-title":"Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin","volume":"31","author":"Schneider","year":"2007","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"12","key":"10.1016\/j.ynstr.2024.100695_bib155","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1038\/npp.2016.61","article-title":"The CRF1 antagonist verucerfont in anxious alcohol-dependent women: translation of neuroendocrine, but not of anti-craving effects","volume":"41","author":"Schwandt","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib156","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pharmthera.2009.05.006","article-title":"30 years of dynorphins--new insights on their functions in neuropsychiatric diseases","volume":"123","author":"Schwarzer","year":"2009","journal-title":"Pharmacol. Ther."},{"issue":"50","key":"10.1016\/j.ynstr.2024.100695_bib157","doi-asserted-by":"crossref","first-page":"20260","DOI":"10.1073\/pnas.1320325110","article-title":"Orexin\/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus","volume":"110","author":"Sears","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib158","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cne.902900205","article-title":"Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin","volume":"290","author":"Sesack","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ynstr.2024.100695_bib159","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2009.07.028","article-title":"Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking","volume":"1314","author":"Shalev","year":"2010","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib160","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/FBP.0b013e32832f01ba","article-title":"Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice","volume":"20","author":"Sharpe","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ynstr.2024.100695_bib161","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.2001.tb03558.x","article-title":"Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems","volume":"937","author":"Shippenberg","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib162","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1471-4159.2004.02589.x","article-title":"Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects","volume":"90","author":"Shirayama","year":"2004","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib163","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00213-010-2127-x","article-title":"Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement","volume":"215","author":"Shoblock","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"10.1016\/j.ynstr.2024.100695_bib164","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/j.1460-9568.2006.05014.x","article-title":"Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction","volume":"24","author":"Sierra-Mercado","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib165","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/adb.12024","article-title":"Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395","volume":"19","author":"Simms","year":"2014","journal-title":"Addiction Biol."},{"issue":"16","key":"10.1016\/j.ynstr.2024.100695_bib166","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172883","article-title":"Stress and substance use disorders: risk, relapse, and treatment outcomes","volume":"134","author":"Sinha","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib167","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.yhbeh.2013.12.014","article-title":"The orexin-1 receptor antagonist SB-334867 attenuates anxiety in rats exposed to cat odor but not the elevated plus maze: an investigation of Trial 1 and Trial 2 effects","volume":"65","author":"Staples","year":"2014","journal-title":"Horm. Behav."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib168","first-page":"468","article-title":"Stress and the HPA axis: role of glucocorticoids in alcohol dependence","volume":"34","author":"Stephens","year":"2012","journal-title":"Alcohol Res"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib169","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0924-977X(00)00102-4","article-title":"Involvement of dynorphin in immobilization stress-induced antinociception in the mouse","volume":"10","author":"Suh","year":"2000","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib170","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00213-004-1956-x","article-title":"The role of prefrontal cortex D1-like and D2-like receptors in cocaine-seeking behavior in rats","volume":"177","author":"Sun","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib171","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2005.03.002","article-title":"Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior","volume":"1044","author":"Suzuki","year":"2005","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib172","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000123454","article-title":"Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study","volume":"36","author":"Swanson","year":"1983","journal-title":"Neuroendocrinology"},{"issue":"447","key":"10.1016\/j.ynstr.2024.100695_bib173","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4953","article-title":"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy","volume":"10","author":"Thannickal","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib174","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbr.2010.09.028","article-title":"A role for hypocretin\/orexin in motivation","volume":"217","author":"Thompson","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ynstr.2024.100695_bib175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnbeh.2013.00028","article-title":"Role of orexin in modulating arousal, feeding, and motivation","volume":"7","author":"Tsujino","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2024.100695_bib176","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12199","article-title":"Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons","volume":"7","author":"Tung","year":"2016","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib177","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0306-4522(97)00639-8","article-title":"Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain","volume":"85","author":"Turchan","year":"1998","journal-title":"Neuroscience"},{"issue":"4514","key":"10.1016\/j.ynstr.2024.100695_bib178","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","article-title":"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin","volume":"213","author":"Vale","year":"1981","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib179","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neubiorev.2009.11.016","article-title":"Prefrontal cortex plasticity mechanisms in drug seeking and relapse","volume":"35","author":"Van den Oever","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib180","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/1096-9861(20001211)428:2<191::AID-CNE1>3.0.CO;2-U","article-title":"Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse","volume":"428","author":"Van Pett","year":"2000","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib181","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/syn.10279","article-title":"Differential projections of the infralimbic and prelimbic cortex in the rat","volume":"51","author":"Vertes","year":"2004","journal-title":"Synapse"},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib182","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.yhbeh.2011.08.017","article-title":"Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence","volume":"60","author":"von der Goltz","year":"2011","journal-title":"Horm. Behav."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib183","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.npp.1301438","article-title":"Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence","volume":"33","author":"Walker","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2024.100695_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2010.05.003","article-title":"Chasing the cell assembly","author":"Wallace","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib185","first-page":"119","article-title":"The influence of stress on the transition from drug use to addiction","volume":"31","author":"Wand","year":"2008","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.ynstr.2024.100695_bib186","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jpsychires.2019.06.005","article-title":"Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers","volume":"116","author":"Wang","year":"2019","journal-title":"J. Psychiatr. Res."},{"issue":"25","key":"10.1016\/j.ynstr.2024.100695_bib187","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1523\/JNEUROSCI.0140-16.2016","article-title":"Distinct fos-expressing neuronal ensembles in the ventromedial prefrontal cortex mediate food reward and extinction memories","volume":"36","author":"Warren","year":"2016","journal-title":"J. Neurosci."},{"issue":"4577","key":"10.1016\/j.ynstr.2024.100695_bib188","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.6128790","article-title":"Comparison of the distribution of dynorphin systems and enkephalin systems in brain","volume":"218","author":"Watson","year":"1982","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib189","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00213-010-1825-8","article-title":"The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse","volume":"210","author":"Wee","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"issue":"36","key":"10.1016\/j.ynstr.2024.100695_bib190","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1523\/JNEUROSCI.3761-16.2017","article-title":"Bidirectional modulation of intrinsic excitability in rat prelimbic cortex neuronal ensembles and non-ensembles after operant learning","volume":"37","author":"Whitaker","year":"2017","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib191","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/ejn.12031","article-title":"The role of medial prefrontal cortex in extinction and reinstatement of alcohol-seeking in rats","volume":"37","author":"Willcocks","year":"2013","journal-title":"Eur. J. Neurosci."},{"issue":"50","key":"10.1016\/j.ynstr.2024.100695_bib192","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","article-title":"Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response","volume":"24","author":"Winsky-Sommerer","year":"2004","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.ynstr.2024.100695_bib193","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax4043","article-title":"Advances in the science and treatment of alcohol use disorder","volume":"5","author":"Witkiewitz","year":"2019","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.ynstr.2024.100695_bib194","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrn1033","article-title":"Human prefrontal cortex: processing and representational perspectives","volume":"4","author":"Wood","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib195","first-page":"151","article-title":"Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: an in vivo fast-cyclic voltammetry study","volume":"284","author":"Xi","year":"1998","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5","key":"10.1016\/j.ynstr.2024.100695_bib196","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1530-0277.2008.00632.x","article-title":"Restraint stress and ethanol consumption in two mouse strains","volume":"32","author":"Yang","year":"2008","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.ynstr.2024.100695_bib197","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.3340","article-title":"Sobering perspectives on the treatment of alcohol use disorder","volume":"7","author":"Yaseen","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.ynstr.2024.100695_bib198","doi-asserted-by":"crossref","first-page":"8448","DOI":"10.1038\/s41598-023-35432-w","article-title":"Subpopulations of hypocretin\/orexin neurons differ in measures of their cell proliferation, dynorphin co-expression, projections, and response to embryonic ethanol exposure","volume":"13","author":"Yasmin","year":"2023","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.ynstr.2024.100695_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e36402","article-title":"Sex-dimorphic functions of orexin in neuropsychiatric disorders","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib200","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/ijo.2017.276","article-title":"Neuromodulation of orexin neurons reduces diet-induced adiposity","volume":"42","author":"Zink","year":"2018","journal-title":"Int. J. Obes."},{"issue":"4","key":"10.1016\/j.ynstr.2024.100695_bib201","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/alcalc\/agv129","article-title":"Orexin in patients with alcohol dependence treated for relapse prevention: a pilot study","volume":"51","author":"Ziolkowski","year":"2016","journal-title":"Alcohol Alcohol"}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289524000912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289524000912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T15:57:49Z","timestamp":1732982269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289524000912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":203,"alternative-id":["S2352289524000912"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2024.100695","relation":{},"ISSN":["2352-2895"],"issn-type":[{"type":"print","value":"2352-2895"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2024.100695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100695"}}