{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:20:06Z","timestamp":1780514406100,"version":"3.54.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA020024"],"award-info":[{"award-number":["AA020024"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA020023"],"award-info":[{"award-number":["AA020023"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA019767"],"award-info":[{"award-number":["AA019767"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016651","name":"Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016651","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ynstr.2025.100779","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:57:32Z","timestamp":1766131052000},"page":"100779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Adolescent adversity persistently induces proinflammatory HMGB1 signaling and disrupts the basal forebrain cholinergic system in female rats"],"prefix":"10.1016","volume":"40","author":[{"given":"Hayley","family":"Ross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makayla","family":"Adelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan E.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Latham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Macht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulton T.","family":"Crews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-395X","authenticated-orcid":false,"given":"Ryan P.","family":"Vetreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ynstr.2025.100779_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41583-023-00677-x","article-title":"Basal forebrain cholinergic signalling: development, connectivity and roles in cognition","volume":"24","author":"Ananth","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1176\/jnp.2008.20.3.292","article-title":"Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development","volume":"20","author":"Andersen","year":"2008","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.smim.2018.02.011","article-title":"High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells","volume":"38","author":"Andersson","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ynstr.2025.100779_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"key":"10.1016\/j.ynstr.2025.100779_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000487056","article-title":"Neuroinflammation in response to intracerebral injections of different HMGB1 redox isoforms","volume":"10","author":"Aucott","year":"2018","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.ynstr.2025.100779_bib6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11682-012-9215-y","article-title":"Impact of early vs. late childhood early life stress on brain morphometrics","volume":"7","author":"Baker","year":"2013","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.ynstr.2025.100779_bib7","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuron.2016.09.006","article-title":"Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline","volume":"91","author":"Ballinger","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ynstr.2025.100779_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(95)02021-7","article-title":"Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions","volume":"53","author":"Bartolini","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ynstr.2025.100779_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/neuro.08.014.2009","article-title":"Early-life programming of later-life brain and behavior: a critical role for the immune system","volume":"3","author":"Bilbo","year":"2009","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib10","article-title":"Basal forebrain cholinergic system and memory","author":"Blake","year":"2017","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.ynstr.2025.100779_bib11","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1038\/s41380-023-02229-2","article-title":"Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour","volume":"28","author":"Borsini","year":"2023","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ynstr.2025.100779_bib12","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.micinf.2004.08.004","article-title":"RAGE (receptor for advanced glycation end products): a central player in the inflammatory response","volume":"6","author":"Chavakis","year":"2004","journal-title":"Microb. Infect."},{"key":"10.1016\/j.ynstr.2025.100779_bib13","article-title":"Acupuncture ameliorates depressive behaviors by modulating the expression of hippocampal Iba-1 and HMGB1 in rats exposed to chronic restraint stress","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ynstr.2025.100779_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.602708","article-title":"Fluoxetine and ketamine reverse the depressive but not anxiety behavior induced by lesion of cholinergic neurons in the horizontal limb of the diagonal band of broca in Male rat","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nprot.2006.83","article-title":"The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on","volume":"1","author":"Chomczynski","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ynstr.2025.100779_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.652494","article-title":"Loss of basal forebrain cholinergic neurons following adolescent binge ethanol exposure: recovery with the cholinesterase inhibitor galantamine","volume":"15","author":"Crews","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-023-02160-6","article-title":"HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype","author":"Crews","year":"2023","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ynstr.2025.100779_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0741-8329(04)00081-3","article-title":"Exercise reverses ethanol inhibition of neural stem cell proliferation","volume":"33","author":"Crews","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.ynstr.2025.100779_bib19","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/acer.14154","article-title":"Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA consortium findings","volume":"43","author":"Crews","year":"2019","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ynstr.2025.100779_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1124\/pr.115.012138","article-title":"Adolescent alcohol exposure persistently impacts adult neurobiology and behavior","volume":"68","author":"Crews","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ynstr.2025.100779_bib22","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s00213-017-4560-6","article-title":"Toll-like receptor signaling and stages of addiction","volume":"234","author":"Crews","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ynstr.2025.100779_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.992627","article-title":"Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype","volume":"15","author":"Crews","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41386-022-01427-w","article-title":"Basal forebrain cholinergic signaling in the basolateral amygdala promotes strength and durability of fear memories","volume":"48","author":"Crimmins","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ynstr.2025.100779_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100838","article-title":"Physical restraint mouse models to assess immune responses under stress with or without habituation","volume":"2","author":"Ding","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.ynstr.2025.100779_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0165-3806(92)90009-L","article-title":"The development of neurons in the nuclei of the horizontal and vertical limb of the diagonal band of broca of the rat: a qualitative and quantitative analysis of golgi preparations","volume":"65","author":"Dinopoulos","year":"1992","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.ynstr.2025.100779_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311405","article-title":"Voluntary wheel running exercise rescues behaviorally-evoked acetylcholine efflux in the medial prefrontal cortex and epigenetic changes in ChAT genes following adolescent intermittent ethanol exposure","volume":"19","author":"Fecik","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ynstr.2025.100779_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1531628","article-title":"Adolescent binge alcohol exposure accelerates Alzheimer's disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling","volume":"17","author":"Fisher","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib28","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.bbi.2019.05.014","article-title":"Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures","volume":"80","author":"Frank","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ynstr.2025.100779_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ynstr.2015.12.004","article-title":"Stress-induced neuroinflammatory priming: a liability factor in the etiology of psychiatric disorders","volume":"4","author":"Frank","year":"2016","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.ynstr.2025.100779_bib30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejphar.2019.03.035","article-title":"The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice","volume":"853","author":"Fu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ynstr.2025.100779_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1742-2094-8-151","article-title":"Origin and consequences of brain toll-like receptor 4 pathway stimulation in an experimental model of depression","volume":"8","author":"Garate","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ynstr.2025.100779_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biopsych.2012.07.005","article-title":"Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway","volume":"73","author":"Garate","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ynstr.2025.100779_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/exnr.1998.6789","article-title":"Impairment of basal forebrain cholinergic neurons associated with aging and long-term loss of ovarian function","volume":"151","author":"Gibbs","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ynstr.2025.100779_bib34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0006-8993(78)90267-6","article-title":"Effects of repeated immobilization stress on glutamate decarboxylase and choline acetyltransferase in discrete brain regions","volume":"152","author":"Gottesfeld","year":"1978","journal-title":"Brain Res."},{"key":"10.1016\/j.ynstr.2025.100779_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-3806(89)90293-9","article-title":"Basal forebrain neurons undergo somatal and dendritic remodeling during postnatal development: a single-section golgi and choline acetyltransferase analysis","volume":"46","author":"Gould","year":"1989","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.ynstr.2025.100779_bib36","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0361-9230(91)90209-3","article-title":"Postnatal development of cholinergic neurons in the rat: I. Forebrain","volume":"27","author":"Gould","year":"1991","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ynstr.2025.100779_bib37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.nlm.2008.07.001","article-title":"Habituation to repeated stress: get used to it","volume":"92","author":"Grissom","year":"2009","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ynstr.2025.100779_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0306-4522(94)90252-6","article-title":"Two types of cholinergic projections to the rat amygdala","volume":"60","author":"Hecker","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynstr.2025.100779_bib39","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1017\/S1461145713000060","article-title":"Effects of chronic social defeat stress on behaviour, endoplasmic reticulum proteins and choline acetyltransferase in adolescent mice","volume":"16","author":"Huang","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ynstr.2025.100779_bib40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1134\/S0006297917030075","article-title":"Role of nerve growth factor in plasticity of forebrain cholinergic neurons","volume":"82","author":"Isaev","year":"2017","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.ynstr.2025.100779_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2012.12.023","article-title":"Microglia: new roles for the synaptic stripper","volume":"77","author":"Kettenmann","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ynstr.2025.100779_bib42","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bpsgos.2022.03.001","article-title":"Enhanced immune activation following acute social stress among adolescents with early-life adversity","volume":"3","author":"Kuhlman","year":"2023","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"10.1016\/j.ynstr.2025.100779_bib43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/cne.903320106","article-title":"Development of the rat septohippocampal projection: tracing with DiI and electron microscopy of identified growth cones","volume":"332","author":"Linke","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ynstr.2025.100779_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ynstr.2025.100779_bib45","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0014-4886(85)90108-6","article-title":"Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats","volume":"89","author":"Luine","year":"1985","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ynstr.2025.100779_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10110785","article-title":"Adolescent alcohol exposure produces protracted cognitive-behavioral impairments in adult Male and female rats","volume":"10","author":"Macht","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.ynstr.2025.100779_bib47","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1113\/JP279666","article-title":"Neuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress","volume":"598","author":"Matovic","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.ynstr.2025.100779_bib48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0012-1606(74)90196-1","article-title":"Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity","volume":"36","author":"Matthews","year":"1974","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ynstr.2025.100779_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2013.01.024","article-title":"Neuroimmune signaling: a key component of alcohol abuse","author":"Mayfield","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ynstr.2025.100779_bib51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bandc.2009.06.003","article-title":"Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models","volume":"72","author":"Mccormick","year":"2010","journal-title":"Brain Cognit."},{"key":"10.1016\/j.ynstr.2025.100779_bib50","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroscience.2012.08.063","article-title":"From the stressed adolescent to the anxious and depressed adult: investigations in rodent models","volume":"249","author":"Mccormick","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynstr.2025.100779_bib52","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/jamapsychiatry.2017.0270","article-title":"Allostasis and the epigenetics of brain and body health over the life course: the brain on stress","volume":"74","author":"Mcewen","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ynstr.2025.100779_bib53","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1111\/acer.14694","article-title":"Primed for addiction: a critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking","volume":"45","author":"Melbourne","year":"2021","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ynstr.2025.100779_bib54","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0306-4522(83)90108-2","article-title":"Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6)","volume":"10","author":"Mesulam","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.ynstr.2025.100779_bib55","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0012-1606(74)90197-3","article-title":"Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities","volume":"36","author":"Nadler","year":"1974","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ynstr.2025.100779_bib56","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4196\/kjpp.2010.14.6.371","article-title":"Effects of glycyrrhizae radix on repeated restraint stress-induced neurochemical and behavioral responses","volume":"14","author":"Park","year":"2010","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.ynstr.2025.100779_bib57","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1074\/jbc.M306793200","article-title":"Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein","volume":"279","author":"Park","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ynstr.2025.100779_bib58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnagi.2015.00043","article-title":"Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment","volume":"7","author":"Paul","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib59","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2014"},{"key":"10.1016\/j.ynstr.2025.100779_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-0327(00)00331-1","article-title":"Adolescent life events as predictors of adult depression","volume":"68","author":"Pine","year":"2002","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ynstr.2025.100779_bib61","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbi.2013.01.075","article-title":"Sex differences in the effects of adolescent stress on adult brain inflammatory markers in rats","volume":"30","author":"Pyter","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ynstr.2025.100779_bib62","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.ynstr.2025.100779_bib63","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/0963721413475445","article-title":"The teenage brain: the stress response and the adolescent brain","volume":"22","author":"Romeo","year":"2013","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"10.1016\/j.ynstr.2025.100779_bib64","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/en.2005-1432","article-title":"Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity","volume":"147","author":"Romeo","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.ynstr.2025.100779_bib65","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3389\/fimmu.2017.01905","article-title":"Neuroinflammation: microglia and T cells get ready to tango","volume":"8","author":"Schetters","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ynstr.2025.100779_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12626","article-title":"Adolescent maturation of the prefrontal cortex: role of stress and sex in shaping adult risk for compromise","volume":"19","author":"Shaw","year":"2020","journal-title":"Gene Brain Behav."},{"key":"10.1016\/j.ynstr.2025.100779_bib67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/npr2.12093","article-title":"Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB\/cAJcl mice","volume":"40","author":"Shoji","year":"2020","journal-title":"Neuropsychopharmacol Rep"},{"key":"10.1016\/j.ynstr.2025.100779_bib68","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ynstr.2025.100779_bib69","series-title":"The Behavioral Neuroscience of Adolescence","author":"Spear","year":"2009"},{"key":"10.1016\/j.ynstr.2025.100779_bib70","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.dcn.2011.08.001","article-title":"Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data","volume":"1","author":"Spear","year":"2011","journal-title":"Developmental cognitive neuroscience"},{"key":"10.1016\/j.ynstr.2025.100779_bib71","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2174\/1871527313666140806144831","article-title":"Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress","volume":"13","author":"Tobon-Velasco","year":"2014","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.ynstr.2025.100779_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12731","article-title":"Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: restoration with voluntary exercise","volume":"25","author":"Vetreno","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ynstr.2025.100779_bib75","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fnins.2018.00200","article-title":"Persistent adult neuroimmune activation and loss of hippocampal neurogenesis following adolescent ethanol exposure: blockade by exercise and the anti-inflammatory drug indomethacin","volume":"12","author":"Vetreno","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnins.2015.00035","article-title":"Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning","volume":"9","author":"Vetreno","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ynstr.2025.100779_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204500","article-title":"Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin","volume":"13","author":"Vetreno","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ynstr.2025.100779_bib76","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pnpbp.2017.06.015","article-title":"Impact of juvenile chronic stress on adult cortico-accumbal function: implications for cognition and addiction","volume":"79","author":"Watt","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ynstr.2025.100779_bib77","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado1508","article-title":"Distinct septo-hippocampal cholinergic projections separately mediate stress-induced emotional and cognitive deficits","volume":"10","author":"Wu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ynstr.2025.100779_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2025.1584320","article-title":"Serum HMGB1 as a diagnostic biomarker and mediator of childhood trauma in adolescent depression","volume":"16","author":"Xiang","year":"2025","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ynstr.2025.100779_bib79","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(93)91714-4","article-title":"Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression","volume":"601","author":"Zahalka","year":"1993","journal-title":"Brain Res."}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289525000736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289525000736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:47:09Z","timestamp":1773928029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289525000736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":79,"alternative-id":["S2352289525000736"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2025.100779","relation":{},"ISSN":["2352-2895"],"issn-type":[{"value":"2352-2895","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adolescent adversity persistently induces proinflammatory HMGB1 signaling and disrupts the basal forebrain cholinergic system in female rats","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2025.100779","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100779"}}