{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:52:14Z","timestamp":1789131134676,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005142","name":"Banco Bilbao Vizcaya Argentaria","doi-asserted-by":"publisher","award":["PID2020-112705RB-I00"],"award-info":[{"award-number":["PID2020-112705RB-I00"]}],"id":[{"id":"10.13039\/501100005142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH129856"],"award-info":[{"award-number":["R01MH129856"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["CD24\/00027"],"award-info":[{"award-number":["CD24\/00027"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL156134"],"award-info":[{"award-number":["R01HL156134"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC19\/00077"],"award-info":[{"award-number":["AC19\/00077"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031366","name":"ERA-Net NEURON","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science Innovation and Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["HR22-00737"],"award-info":[{"award-number":["HR22-00737"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MCIN EUR2023-143469"],"award-info":[{"award-number":["MCIN EUR2023-143469"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MCIN \/ AEI \/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN \/ AEI \/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007747","name":"Spanish Multiple Sclerosis Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007406","name":"BBVA Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Stress"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ynstr.2026.100823","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T15:43:31Z","timestamp":1779464611000},"page":"100823","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The progesterone to estradiol ratio predicts fear extinction in mice and humans"],"prefix":"10.1016","volume":"43","author":[{"given":"Jaime F.","family":"Nab\u00e1s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fabregat-Safont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lida","family":"Alechaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gomez-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Torrent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana G.","family":"Fronza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed R.","family":"Milad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Torrubia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel A.","family":"Fullana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Schultebraucks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Andero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"188","key":"10.1016\/j.ynstr.2026.100823_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005656","article-title":"Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD","volume":"5","author":"Andero","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ynstr.2026.100823_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2022.105994","article-title":"Not within spitting distance: salivary immunoassays of estradiol have subpar validity for predicting cycle phase","volume":"149","author":"Arslan","year":"2023","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.ynstr.2026.100823_bib3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1101\/lm.053597.122","article-title":"Impact of hormonal contraceptives on sex differences in fear conditioning and fear extinction in PTSD","volume":"29","author":"Bartholomew","year":"2022","journal-title":"Learning & Memory (Cold Spring Harbor, N.Y.)"},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib4","first-page":"1","article-title":"Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles","volume":"2","author":"Bull","year":"2019","journal-title":"Npj Digital Med. 2019"},{"key":"10.1016\/j.ynstr.2026.100823_bib5","article-title":"Activity of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis reduces anxiety-potentiated startle in female rats in an estrous phase\u2013dependent manner","author":"Chudoba","year":"2025","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/joe.0.1200037","article-title":"Feedback regulation by progesterone of stress-induced prolactin release in rats","volume":"120","author":"Deis","year":"1989","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ynstr.2026.100823_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.343313","article-title":"Towards the non-invasive determination of estradiol levels: development and validation of an LC-MS\/MS assay for quantification of salivary estradiol at sub-pg\/mL level","volume":"1331","author":"Fabregat-Safont","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ynstr.2026.100823_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100818","article-title":"The role of hippocampal estradiol in synaptic plasticity and memory: a systematic review","volume":"56","author":"Finney","year":"2020","journal-title":"Front. Neuroendocrinol."},{"issue":"11","key":"10.1016\/j.ynstr.2026.100823_bib9","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1038\/s41380-017-0006-0","article-title":"Lost in translation: how to upgrade fear memory research","volume":"23","author":"Flores","year":"2018","journal-title":"Mol. Psychiatr."},{"issue":"5","key":"10.1016\/j.ynstr.2026.100823_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.102","article-title":"Direct and indirect measurements of sex hormones in rodents during fear conditioning","volume":"1","author":"Florido","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.ynstr.2026.100823_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk3365","article-title":"Sex differences in neural projections of fear memory processing in mice and humans","volume":"10","author":"Florido","year":"2024","journal-title":"Sci. Adv."},{"issue":"1\u20132","key":"10.1016\/j.ynstr.2026.100823_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0166-4328(01)00255-8","article-title":"High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory","volume":"126","author":"Galea","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biopsych.2012.02.031","article-title":"Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder","volume":"72","author":"Glover","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ynstr.2026.100823_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105520","article-title":"Determination of the steroid profile in alternative matrices by liquid chromatography tandem mass spectrometry","volume":"197","author":"Gomez-Gomez","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ynstr.2026.100823_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.psyneuen.2017.02.023","article-title":"High endogenous estradiol is associated with enhanced cognitive emotion regulation of physiological conditioned fear responses in women","volume":"80","author":"Graham","year":"2017","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.ynstr.2026.100823_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.biopsych.2012.09.018","article-title":"Blockade of estrogen by hormonal contraceptives impairs fear extinction in female rats and women","volume":"73","author":"Graham","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.ynstr.2026.100823_bib17","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1016\/j.psyneuen.2013.07.020","article-title":"Estradiol concentrations and working memory performance in women of reproductive age","volume":"38","author":"Hampson","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ynstr.2026.100823_bib18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ynstr.2016.02.006","article-title":"Stress-induced increases in progesterone and cortisol in naturally cycling women","volume":"3","author":"Herrera","year":"2016","journal-title":"Neurobiol. Stress"},{"issue":"5","key":"10.1016\/j.ynstr.2026.100823_bib19","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1037\/0735-7044.116.5.928","article-title":"Low levels of estradiol facilitate, whereas high levels of estradiol impair, working memory performance on the radial arm maze","volume":"116","author":"Holmes","year":"2002","journal-title":"Behav. Neurosci."},{"issue":"5","key":"10.1016\/j.ynstr.2026.100823_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.yhbeh.2006.06.005","article-title":"Impairment of spatial learning by estradiol treatment in female mice is attenuated by estradiol exposure during development","volume":"50","author":"Imwalle","year":"2006","journal-title":"Horm. Behav."},{"issue":"10","key":"10.1016\/j.ynstr.2026.100823_bib21","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/s41386-020-0748-2","article-title":"Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex","volume":"45","author":"Jovanovic","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-024-03079-4","article-title":"Effects of separate and combined estradiol and progesterone administration on fear extinction in healthy pre-menopausal women","volume":"14","author":"Kaczmarczyk","year":"2024","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.ynstr.2026.100823_bib23","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1503\/jpn.140336","article-title":"Sex differences in conditioned stimulus discrimination during context-dependent fear learning and its retrieval in humans: the role of biological sex, contraceptives and menstrual cycle phases","volume":"40","author":"Lonsdorf","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.ynstr.2026.100823_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neubiorev.2017.02.026","article-title":"Don't fear \u2018fear conditioning\u2019: methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear","volume":"77","author":"Lonsdorf","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ynstr.2026.100823_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nlm.2016.03.013","article-title":"Immediate extinction promotes the return of fear","volume":"131","author":"Merz","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"issue":"3","key":"10.1016\/j.ynstr.2026.100823_bib26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.neuroscience.2009.09.011","article-title":"Estrous cycle phase and gonadal hormones influence conditioned fear extinction","volume":"164","author":"Milad","year":"2009","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.ynstr.2026.100823_bib27","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.neuroscience.2010.04.030","article-title":"The influence of gonadal hormones on conditioned fear extinction in healthy humans","volume":"168","author":"Milad","year":"2010","journal-title":"Neuroscience"},{"issue":"sup4","key":"10.1016\/j.ynstr.2026.100823_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2017.1351204","article-title":"Sex and gender differences in post-traumatic stress disorder: an update","volume":"8","author":"Olff","year":"2017","journal-title":"Eur. J. Psychotraumatol."},{"issue":"S1","key":"10.1016\/j.ynstr.2026.100823_bib29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/aja.1000520402","article-title":"The sexual cycle in the human female as revealed by vaginal smears","volume":"52","author":"Papanicolaou","year":"1933","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.ynstr.2026.100823_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113592","article-title":"Estradiol effects on spatial memory in women","volume":"417","author":"Patel","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56408-9","article-title":"ezTrack: an open-source video analysis pipeline for the investigation of animal behavior","volume":"9","author":"Pennington","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ynstr.2026.100823_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1037\/abn0000138","article-title":"Extinction retention and the menstrual cycle: different associations for women with posttraumatic stress disorder","volume":"125","author":"Pineles","year":"2016","journal-title":"J. Abnorm. Psychol."},{"issue":"6","key":"10.1016\/j.ynstr.2026.100823_bib33","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1080\/10253890.2021.1891220","article-title":"The gonadal response to social stress and its relationship to cortisol","volume":"24","author":"Pletzer","year":"2021","journal-title":"Stress"},{"issue":"12","key":"10.1016\/j.ynstr.2026.100823_bib34","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.biopsych.2014.12.018","article-title":"Neural mechanism of a sex-specific risk variant for posttraumatic stress disorder in the type i receptor of the pituitary adenylate cyclase activating polypeptide","volume":"78","author":"Pohlack","year":"2015","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.ynstr.2026.100823_bib35","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0002-9378(99)70120-1","article-title":"The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices","volume":"181","author":"Rivera","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s40750-014-0004-2","article-title":"Elevated psychological stress predicts reduced estradiol concentrations in young women","volume":"1","author":"Roney","year":"2015","journal-title":"Adaptive Human Behav. Physiol."},{"issue":"2","key":"10.1016\/j.ynstr.2026.100823_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/EDE.0000000000000238","article-title":"Perceived stress, reproductive hormones, and ovulatory function","volume":"26","author":"Schliep","year":"2015","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib38","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2020.1723857","article-title":"Translational studies of estradiol and progesterone in fear and PTSD","volume":"11","author":"Seligowski","year":"2020","journal-title":"Eur. J. Psychotraumatol."},{"issue":"7","key":"10.1016\/j.ynstr.2026.100823_bib39","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/da.22903","article-title":"Autonomic responses to fear conditioning among women with PTSD and dissociation","volume":"36","author":"Seligowski","year":"2019","journal-title":"Depress. Anxiety"},{"issue":"2","key":"10.1016\/j.ynstr.2026.100823_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/10253899909001120","article-title":"Acute stress persistently enhances estrogen levels in the female rat","volume":"3","author":"Shors","year":"1999","journal-title":"Stress"},{"key":"10.1016\/j.ynstr.2026.100823_bib41","series-title":"Manual Del Cuestionario De Ansiedad Estado\/Rasgo (STAI). TEA Ediciones","author":"Spielberger","year":"1982"},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1027\/1618-3169\/a000005","article-title":"Affect 4.0: a free software package for implementing psychological and psychophysiological experiments","volume":"57","author":"Spruyt","year":"2009","journal-title":"Exp. Psychol."},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/02687039708248455","article-title":"Visual analogue mood scales to measure internal mood state in neurologically impaired patients: description and initial validity evidence","volume":"11","author":"Stern","year":"1997","journal-title":"Aphasiology"},{"key":"10.1016\/j.ynstr.2026.100823_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2015.00359","article-title":"Modulation of Fear Extinction by Stress, Stress Hormones and Estradiol: A Review","volume":"9","author":"Stockhorst","year":"2016","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"10.1016\/j.ynstr.2026.100823_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2018.00276","article-title":"Extinction of fear memory attenuates conditioned cardiovascular fear reactivity","volume":"12","author":"Swiercz","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ynstr.2026.100823_bib46","series-title":"World Family Planning 2022: Meeting the Changing Needs for Family Planning: Contraceptive Use by Age and Method","year":"2022"},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-31442-w","article-title":"PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus","volume":"13","author":"Velasco","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ynstr.2026.100823_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsycho.2024.108981","article-title":"The PAC1 receptor risk genotype does not influence fear acquisition, extinction, or generalization in women with no trauma\/low trauma","volume":"194","author":"Velasco","year":"2025","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.ynstr.2026.100823_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nlm.2014.10.001","article-title":"Low levels of estradiol are associated with elevated conditioned responding during fear extinction and with intrusive memories in daily life","volume":"116","author":"Wegerer","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ynstr.2026.100823_bib50","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.nlm.2016.08.011","article-title":"Estradiol levels in women predict skin conductance response but not valence and expectancy ratings in conditioned fear extinction","volume":"134","author":"White","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"issue":"1","key":"10.1016\/j.ynstr.2026.100823_bib51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biopsycho.2006.06.007","article-title":"Relationship between salivary cortisol and progesterone levels in humans","volume":"74","author":"Wirth","year":"2007","journal-title":"Biol. Psychol."},{"issue":"10","key":"10.1016\/j.ynstr.2026.100823_bib52","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.biopsych.2011.05.016","article-title":"Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats","volume":"70","author":"Zeidan","year":"2011","journal-title":"Biol. Psychiatry"}],"container-title":["Neurobiology of Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289526000457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352289526000457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:32:52Z","timestamp":1784187172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352289526000457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":52,"alternative-id":["S2352289526000457"],"URL":"https:\/\/doi.org\/10.1016\/j.ynstr.2026.100823","relation":{},"ISSN":["2352-2895"],"issn-type":[{"value":"2352-2895","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The progesterone to estradiol ratio predicts fear extinction in mice and humans","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Stress","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ynstr.2026.100823","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100823"}}