{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:48:50Z","timestamp":1778816930915,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Preventive Medicine"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ypmed.2016.01.007","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T10:32:12Z","timestamp":1453804332000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Orthostatic hypotension and the risk of incidental cardiovascular diseases: A meta-analysis of prospective cohort studies"],"prefix":"10.1016","volume":"85","author":[{"given":"Wei","family":"Xin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhua","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ypmed.2016.01.007_bb0005","doi-asserted-by":"crossref","unstructured":"Alagiakrishnan, K., Patel, K., Desai, R.V., Ahmed, M.B., Fonarow, G.C., Forman, D.E., White, M., Aban, I.B., Love, T.E., et al., 2013. Orthostatic hypotension and incident heart failure in community-dwelling older adults. J. Gerontol. A Biol. Sci. Med. Sci.","DOI":"10.1093\/gerona\/glt086"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ajh.2010.146","article-title":"Morbidity and mortality of orthostatic hypotension: implications for management of cardiovascular disease","volume":"24","author":"Benvenuto","year":"2011","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.atherosclerosis.2005.03.037","article-title":"Arterial baroreflex dysfunction promotes atherosclerosis in rats","volume":"183","author":"Cai","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0020","series-title":"Orthostatic Hypotension Does Not Increase Cardiovascular Risk in the Elderly at a Population Level","author":"Casiglia","year":"2013"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0025","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.jacc.2007.08.043","article-title":"Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function","volume":"50","author":"De Ferrari","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0035","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/01.STR.31.10.2307","article-title":"Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987\u20131996","volume":"31","author":"Eigenbrodt","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0040","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ajh.2010.76","article-title":"Disorders of orthostatic blood pressure response are associated with cardiovascular disease and target organ damage in hypertensive patients","volume":"23","author":"Fan","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0045","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/joim.12021","article-title":"Syndromes of orthostatic intolerance: a hidden danger","volume":"273","author":"Fedorowski","year":"2013","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0050","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/HJH.0b013e32834fa860","article-title":"Orthostatic blood pressure response, carotid intima-media thickness, and plasma fibrinogen in older nondiabetic adults","volume":"30","author":"Fedorowski","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/eurheartj\/ehp329","article-title":"Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (the Malmo Preventive Project)","volume":"31","author":"Fedorowski","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0060","doi-asserted-by":"crossref","unstructured":"Fedorowski, A., Wahlstrand, B., Hedner, T., Melander, O., 2013. Systolic and diastolic component of orthostatic hypotension and cardiovascular events in hypertensive patients: the Captopril Prevention Project. J. Hypertens.","DOI":"10.1097\/HJH.0b013e328365cd59"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0065","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0070","first-page":"e6","article-title":"Heart disease and stroke statistics\u20142013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0075","series-title":"The Cochrane Collaboration","article-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0","author":"Higgins","year":"2011"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0080","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0085","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/CIRCULATIONAHA.112.108357","article-title":"Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor","volume":"126","author":"Hosokawa","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02291236","article-title":"Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy","volume":"6","author":"Kaufmann","year":"1996","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0095","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(97)11144-8","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators","volume":"351","author":"La Rovere","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0100","first-page":"2530","article-title":"Correlation between orthostatic hypotension and cardiovascular risks in elderly population","volume":"91","author":"Lin","year":"2011","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0105","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ageing\/afs061","article-title":"Efficacy of treatments for orthostatic hypotension: a systematic review","volume":"41","author":"Logan","year":"2012","journal-title":"Age Ageing"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0110","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/01.hjh.0000202816.25706.64","article-title":"Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam study","volume":"24","author":"Mattace-Raso","year":"2006","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0115","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1253\/circj.CJ-09-0960","article-title":"Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart disease","volume":"74","author":"Okada","year":"2010","journal-title":"Circ. J."},{"issue":"Suppl. 1","key":"10.1016\/j.ypmed.2016.01.007_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s10286-007-1004-0","article-title":"The pathophysiology and diagnosis of orthostatic hypotension","volume":"18","author":"Robertson","year":"2008","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0125","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0895-7061(99)00257-5","article-title":"Orthostatic hypotension and the incidence of coronary heart disease: the Atherosclerosis Risk in Communities study","volume":"13","author":"Rose","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0130","series-title":"The Cardiovascular Health Study","first-page":"508","article-title":"Orthostatic hypotension in older adults","volume":"19","author":"Rutan","year":"1992"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0135","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.amjmed.2007.05.009","article-title":"Orthostatic hypotension-related hospitalizations in the United States","volume":"120","author":"Shibao","year":"2007","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0140","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1475-097X.2012.01165.x","article-title":"Baroreflex sensitivity in asymptomatic coronary atherosclerosis","volume":"33","author":"Simula","year":"2013","journal-title":"Clin. Physiol. Funct. Imaging"},{"issue":"Pt 1","key":"10.1016\/j.ypmed.2016.01.007_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-7793.1999.0001o.x","article-title":"Pathophysiological basis of orthostatic hypotension in autonomic failure","volume":"519","author":"Smit","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0150","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0155","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/STROKEAHA.108.519967","article-title":"Impaired baroreceptor reflex sensitivity in acute stroke is associated with insular involvement, but not with carotid atherosclerosis","volume":"40","author":"Sykora","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0160","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1532-5415.2008.01946.x","article-title":"Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study","volume":"56","author":"Verwoert","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.ypmed.2016.01.007_bb0165","series-title":"The Newcastle\u2013Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses","author":"Wells","year":"2010"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063169","article-title":"Orthostatic hypotension and the risk of congestive heart failure: a meta-analysis of prospective cohort studies","volume":"8","author":"Xin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ypmed.2016.01.007_bb0175","article-title":"Orthostatic hypotension and mortality risk: a meta-analysis of cohort studies","author":"Xin","year":"2013","journal-title":"Heart"}],"container-title":["Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743516000219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743516000219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:01:41Z","timestamp":1758794501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091743516000219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":35,"alternative-id":["S0091743516000219"],"URL":"https:\/\/doi.org\/10.1016\/j.ypmed.2016.01.007","relation":{},"ISSN":["0091-7435"],"issn-type":[{"value":"0091-7435","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orthostatic hypotension and the risk of incidental cardiovascular diseases: A meta-analysis of prospective cohort studies","name":"articletitle","label":"Article Title"},{"value":"Preventive Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ypmed.2016.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}