{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:05:31Z","timestamp":1772262331771,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Preventive Medicine"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ypmed.2021.106445","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T13:58:41Z","timestamp":1614952721000},"page":"106445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Elimination of HPV\u2013associated oropharyngeal cancers in Nordic countries"],"prefix":"10.1016","volume":"144","author":[{"given":"Tuomas","family":"Lehtinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Miriam","family":"Elfstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Nyg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simopekka","family":"V\u00e4nsk\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pawlita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Dillner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Waterboer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ypmed.2021.106445_bib0257","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1002\/lary.26772","article-title":"Prophylactic vaccination with human papillomavirus vaccine induces oral immunity in mice","volume":"128","author":"Ahn","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ypmed.2021.106445_bb0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pvr.2016.07.003","article-title":"HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection","volume":"2","author":"Beachler","year":"2016","journal-title":"Papillomavirus Res."},{"key":"10.1016\/j.ypmed.2021.106445_bb0030","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv302","article-title":"Multisite HPV16\/18 vaccine efficacy against cervical, anal and oral HPV infection","volume":"108","author":"Beachler","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ypmed.2021.106445_bb0040","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3201\/eid1809.111731","article-title":"Prevalence of oral human papillomavirus infection among youth, Sweden","volume":"18","author":"Du","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ypmed.2021.106445_bb0045","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1002\/ijc.32623","article-title":"Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status","volume":"145","author":"Gangkofner","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ypmed.2021.106445_bb0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ygyno.2018.08.033","article-title":"SPERANZA project: HPV vaccination after treatment for CIN2","volume":"151","author":"Ghelardi","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ypmed.2021.106445_bib0258","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1056\/NEJMoa0909537","article-title":"Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males","volume":"364","author":"Giuliano","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ypmed.2021.106445_bb0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.annepidem.2014.11.005","article-title":"Concepts and pitfalls in measuring and interpreting attributable fractions, prevented fractions, and causation probabilities","volume":"25","author":"Greenland","year":"2015","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pvr.2017.05.002","article-title":"Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years","volume":"4","author":"Haeggblom","year":"2017","journal-title":"Papillomavirus Res."},{"key":"10.1016\/j.ypmed.2021.106445_bb0065","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-019005","article-title":"Long-term incidence trends of HPV-related cancers, and cases preventable by HPV vaccination: a registry-based study in Norway","volume":"8","author":"Hansen","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.ypmed.2021.106445_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/aogs.13732","article-title":"Age at first intercourse, number of partners and sexually transmitted infection prevalence among Danish, Norwegian and Swedish women: estimates and trends from nationally representative cross-sectional surveys of more than 100 000 women","volume":"99","author":"Hansen","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.ypmed.2021.106445_bb0075","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S1473-3099(10)70182-1","article-title":"Cervix cancer incidence can increase despite HPV vaccination","volume":"10","author":"Harper","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ypmed.2021.106445_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068329","article-title":"Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica","volume":"8","author":"Herrero","year":"2013","journal-title":"PLoS One"},{"issue":"212","key":"10.1016\/j.ypmed.2021.106445_bb0085","first-page":"e1","article-title":"Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment","volume":"215","author":"Hildesheim","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0090","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/ijc.30697","article-title":"Sensitivity and specificity of antibodies against HPV16 E6 and other early proteins for the detection of HPV16-driven oropharyngeal squamous cell carcinoma","volume":"140","author":"Holzinger","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ypmed.2021.106445_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e1401","article-title":"Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data","volume":"344","author":"Joura","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.ypmed.2021.106445_bb0100","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ygyno.2013.04.050","article-title":"Is vaccination with quadrivalent HPV vaccine after loop electrosurgical excision procedure effective in preventing recurrence in patients with high-grade cervical intraepithelial neoplasia (CIN2-3)?","volume":"130","author":"Kang","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0105","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1200\/JCO.2014.57.8435","article-title":"Human papillomavirus antibodies and future risk of anogenital cancer: a nested case-control study in the European prospective investigation into cancer and nutrition study","volume":"33","author":"Kreimer","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0110","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/annonc\/mdz138","article-title":"Timing of HPV16-E6 antibody seroconversion before OPSCC: findings from the HPVC3 consortium","volume":"30","author":"Kreimer","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0115","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1158\/1078-0432.CCR-19-1490","article-title":"Antibody responses to cancer antigens identify patients with a poor prognosis among HPV-positive and HPV-negative head and neck squamous cell carcinoma patients","volume":"25","author":"Laban","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ypmed.2021.106445_bb0120","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/s41416-018-0053-6","article-title":"Nationwide comprehensive human papillomavirus (HPV) genotyping of invasive cervical cancer","volume":"118","author":"Lagheden","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ypmed.2021.106445_bb0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.canep.2016.03.003","article-title":"Characterization of human papillomavirus antibodies in individuals with head and neck cancer","volume":"42","author":"Lang Kuhs","year":"2016","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0130","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1002\/cncr.30966","article-title":"HPV16E6 antibodies are sensitive for HPV-driven oropharyngeal cancer and associated with recurrence","volume":"123","author":"Lang Kuhs","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.ypmed.2021.106445_bb0135","unstructured":"Laukkanen, P., 2012. PhD Thesis, University of Oulu."},{"key":"10.1016\/j.ypmed.2021.106445_bib0261","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.vaccine.2014.12.019","article-title":"Characteristics of a cluster-randomized, phase IV human papillomavirus vaccination effectiveness trial","volume":"33","author":"Lehtinen","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.ypmed.2021.106445_bib0259","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrclinonc.2013.84","article-title":"Clinical HPV vaccine trials and beyond","volume":"10","author":"Lehtinen","year":"2013","journal-title":"Nature Rev. Clin. Oncol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0140","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/bmj.312.7030.537","article-title":"Serological diagnosis of human papillomavirus type 16 infection and the risk of cervical carcinoma","volume":"312","author":"Lehtinen","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.ypmed.2021.106445_bib0260","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/ijc.31618","article-title":"Gender-neutral provides improved control of human papillomavirus types 18\/31\/33\/35 through herd immunity: Results of a community randomized trial (III)","volume":"143","author":"Lehtinen","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ypmed.2021.106445_bb0170","article-title":"Familial association of oropharyngeal and anogenital HPV-cancers is calendar-time dependent","author":"Lehtinen","year":"2020","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0250","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J. Pathol."},{"key":"10.1016\/j.ypmed.2021.106445_bb0255","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM199911253412201","article-title":"Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer","volume":"341","author":"Wallin","year":"1999","journal-title":"N. Engl. J. Med."}],"container-title":["Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743521000293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743521000293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:11:19Z","timestamp":1758795079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091743521000293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":31,"alternative-id":["S0091743521000293"],"URL":"https:\/\/doi.org\/10.1016\/j.ypmed.2021.106445","relation":{},"ISSN":["0091-7435"],"issn-type":[{"value":"0091-7435","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elimination of HPV\u2013associated oropharyngeal cancers in Nordic countries","name":"articletitle","label":"Article Title"},{"value":"Preventive Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ypmed.2021.106445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106445"}}