{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:31:07Z","timestamp":1783002667700,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Preventive Medicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.ypmed.2022.106963","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:06:56Z","timestamp":1642676816000},"page":"106963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Effect of maternal alcohol consumption during the pre-pregnancy\/early-pregnancy period on congenital heart disease: A prospective cohort study in Central China"],"prefix":"10.1016","volume":"155","author":[{"given":"Tingting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senmao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ypmed.2022.106963_bb0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1056\/NEJM200002243420802","article-title":"Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units","volume":"342","author":"Carey","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ypmed.2022.106963_bb0010","series-title":"Clinical Practice Guidelines: Pregnancy Care","author":"Department of Health","year":"2018"},{"issue":"11","key":"10.1016\/j.ypmed.2022.106963_bb0015","first-page":"1432","article-title":"Prevalence of alcohol drinking and influencing factors in female adults in China, 2010-2012 [in Chinese]","volume":"39","author":"Fang","year":"2012","journal-title":"Chinese J. Epidemiol."},{"key":"10.1016\/j.ypmed.2022.106963_bb0020","series-title":"Perspectives in Pediatric Cardiology Series","first-page":"1","article-title":"Epidemiology of congenital heart disease: The Baltimore-Washington Infant Study, 1981\u20131989","author":"Ferencz","year":"1993"},{"issue":"Suppl. 1","key":"10.1016\/j.ypmed.2022.106963_bb0025","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2105\/AJPH.2013.301416","article-title":"Shifts in intended and unintended pregnancies in the United States, 2001-2008","volume":"104","author":"Finer","year":"2014","journal-title":"Am. J. Public Health"},{"issue":"10","key":"10.1016\/j.ypmed.2022.106963_bb0030","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.annepidem.2007.04.001","article-title":"Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The generation R study","volume":"17","author":"Jaddoe","year":"2007","journal-title":"Ann. Epidemiol."},{"issue":"7815","key":"10.1016\/j.ypmed.2022.106963_bb0035","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(73)91291-9","article-title":"Pattern of malformation in offspring of chronic alcoholic mothers","volume":"1","author":"Jones","year":"1973","journal-title":"Lancet."},{"issue":"11","key":"10.1016\/j.ypmed.2022.106963_bb0040","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/acer.13495","article-title":"Supplementation with the methyl donor betaine prevents congenital defects induced by prenatal alcohol exposure","volume":"41","author":"Karunamuni","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.ypmed.2022.106963_bb0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/ejhf.228","article-title":"Alcohol consumption and risk of heart failure: a dose-response meta-analysis of prospective studies","volume":"17","author":"Larsson","year":"2015","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.ypmed.2022.106963_bb0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyz009","article-title":"Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Liu","year":"2019","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.ypmed.2022.106963_bb0055","first-page":"e38","article-title":"Heart disease and stroke Statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.ypmed.2022.106963_bb0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4172\/2329-6488.1000257","article-title":"Fetal alcohol exposure: the common toll","volume":"5","author":"Nakhoul","year":"2017","journal-title":"J Alcohol Drug Depend."},{"issue":"6","key":"10.1016\/j.ypmed.2022.106963_bb0065","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/GCO.0b013e328332a74c","article-title":"Brief alcohol intervention to prevent drinking during pregnancy: an overview of research findings","volume":"21","author":"Nilsen","year":"2009","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.ypmed.2022.106963_bb0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2393-13-49","article-title":"Preterm birth and small for gestational age in relation to alcohol consumption during pregnancy: stronger associations among vulnerable women? Results from two large Western-European studies","volume":"13","author":"Pfinder","year":"2013","journal-title":"BMC Preg. Childbirth."},{"issue":"3","key":"10.1016\/j.ypmed.2022.106963_bb0075","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1016\/S2214-109X(17)30021-9","article-title":"Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis","volume":"5","author":"Popova","year":"2017","journal-title":"Lancet Glob. Health"},{"issue":"10","key":"10.1016\/j.ypmed.2022.106963_bb0085","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/dvdy.24015","article-title":"Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid","volume":"242","author":"Sarmah","year":"2013","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.ypmed.2022.106963_bb0090","doi-asserted-by":"crossref","first-page":"75.e7","DOI":"10.1016\/j.ajog.2010.03.017","article-title":"Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate","volume":"203","author":"Serrano","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ypmed.2022.106963_bb0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.dnarep.2017.06.023","article-title":"Ginger extract mitigates ethanol-induced changes of alpha and beta - myosin heavy chain isoforms gene expression and oxidative stress in the heart of male wistar rats","volume":"57","author":"Shirpoor","year":"2017","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.ypmed.2022.106963_bb0100","first-page":"CD004228","article-title":"Psychological and\/or educational interventions for reducing alcohol consumption in pregnant women and women planning pregnancy","volume":"2","author":"Stade","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.ypmed.2022.106963_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103085","article-title":"How do women prepare for pregnancy? Preconception experiences of women attending antenatal services and views of health professionals","volume":"9","author":"Stephenson","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ypmed.2022.106963_bb0110","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/EDE.0b013e318225c2be","article-title":"DAGitty: a graphical tool for analyzing causal diagrams","volume":"22","author":"Textor","year":"2011","journal-title":"Epidemiology."},{"issue":"1","key":"10.1016\/j.ypmed.2022.106963_bb0115","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrcardio.2010.166","article-title":"The changing epidemiology of congenital heart disease","volume":"8","author":"van der Bom","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"issue":"12","key":"10.1016\/j.ypmed.2022.106963_bb0120","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"12","author":"von Elm","year":"2014","journal-title":"Int. J. Surg."},{"issue":"1","key":"10.1016\/j.ypmed.2022.106963_bb0125","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12884-016-0984-y","article-title":"Women\u2019s perceptions of antenatal care: are we following guideline recommended care?","volume":"16","author":"Waller","year":"2016","journal-title":"BMC Preg. Childbirth."},{"issue":"10","key":"10.1016\/j.ypmed.2022.106963_bb0130","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012030","article-title":"Congenital heart disease and risk of cardiovascular disease: a meta-analysis of cohort studies","volume":"8","author":"Wang","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ypmed.2022.106963_bb0135","series-title":"Guidelines for the Identification and Management of Substance use and Substance use Disorders in Pregnancy","author":"World Health Organization","year":"2014"},{"key":"10.1016\/j.ypmed.2022.106963_bb0080","series-title":"Pregnancy, Childbirth, Postpartum and Newborn Care: A Guide for Essential Practice","year":"2015"},{"key":"10.1016\/j.ypmed.2022.106963_bb0140","series-title":"WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience","author":"World Health Organization","year":"2016"},{"key":"10.1016\/j.ypmed.2022.106963_bb0145","series-title":"Global Status Report on Alcohol and Health 2018","author":"World Health Organization","year":"2018"},{"issue":"4","key":"10.1016\/j.ypmed.2022.106963_bb0150","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-0028-1103156","article-title":"Comparison of maternal risk factors between placental abruption and placenta previa","volume":"26","author":"Yang","year":"2009","journal-title":"Am. J. Perinatol."},{"issue":"6","key":"10.1016\/j.ypmed.2022.106963_bb0155","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.nut.2015.11.013","article-title":"Alcohol consumption and risk of coronary artery disease: a dose-response meta-analysis of prospective studies","volume":"32","author":"Yang","year":"2016","journal-title":"Nutrition."},{"issue":"4","key":"10.1016\/j.ypmed.2022.106963_bb0160","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/2047487319874530","article-title":"Parental alcohol consumption and the risk of congenital heart diseases in offspring: an updated systematic review and meta-analysis","volume":"27","author":"Zhang","year":"2020","journal-title":"Eur. J. Prev. Cardiol."}],"container-title":["Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743522000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743522000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:16:14Z","timestamp":1758795374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091743522000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":32,"alternative-id":["S0091743522000111"],"URL":"https:\/\/doi.org\/10.1016\/j.ypmed.2022.106963","relation":{},"ISSN":["0091-7435"],"issn-type":[{"value":"0091-7435","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of maternal alcohol consumption during the pre-pregnancy\/early-pregnancy period on congenital heart disease: A prospective cohort study in Central China","name":"articletitle","label":"Article Title"},{"value":"Preventive Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ypmed.2022.106963","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106963"}}