{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:33:33Z","timestamp":1792503213717,"version":"4.5.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Preventive Medicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.ypmed.2022.107384","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T11:07:34Z","timestamp":1670411254000},"page":"107384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity"],"prefix":"10.1016","volume":"167","author":[{"given":"W.H. Wilson","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habte","family":"Yimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Tummala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Chul","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Hubbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn N.","family":"Kurtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Swanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis R.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ypmed.2022.107384_bb0005","author":"American Cancer Society. Cancer Facts & Figures"},{"key":"10.1016\/j.ypmed.2022.107384_bb0010","author":"Cancer Disparities - National Cancer Institute"},{"issue":"5","key":"10.1016\/j.ypmed.2022.107384_bb0015","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1158\/1055-9965.EPI-19-1366","article-title":"Projected reductions in absolute cancer\u2013related deaths from diagnosing cancers before metastasis, 2006\u20132015","volume":"29","author":"Clarke","year":"2020","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"3","key":"10.1016\/j.ypmed.2022.107384_bb0020","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1158\/1055-9965.EPI-21-0823","article-title":"Racial\/ethnic differences in cancer diagnosed after metastasis: absolute burden and deaths potentially avoidable through earlier detection","volume":"31","author":"Clarke","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ypmed.2022.107384_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7141050","article-title":"Alternative confidence interval methods used in the diagnostic accuracy studies","volume":"2016","author":"Erdo\u011fan","year":"2016","journal-title":"Comput. Math. Methods Med."},{"issue":"3","key":"10.1016\/j.ypmed.2022.107384_bb0030","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1158\/1055-9965.EPI-20-1134","article-title":"Modeled reductions in late-stage cancer with a multi-cancer early detection test","volume":"30","author":"Hubbell","year":"2021","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ypmed.2022.107384_bb0035","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ypmed.2019.04.010","article-title":"Trends in cervical cancer incidence rates by age, race\/ethnicity, histological subtype, and stage at diagnosis in the United States","volume":"123","author":"Islami","year":"2019","journal-title":"Prev. Med."},{"issue":"9","key":"10.1016\/j.ypmed.2022.107384_bb0040","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.annonc.2021.05.806","article-title":"Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set","volume":"32","author":"Klein","year":"2021","journal-title":"Ann. Oncol."},{"issue":"10","key":"10.1016\/j.ypmed.2022.107384_bb0045","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.20303","article-title":"Variation in breast Cancer subtype incidence and distribution by race\/ethnicity in the United States from 2010 to 2015","volume":"3","author":"Kong","year":"2020","journal-title":"JAMA Netw. Open"},{"issue":"6","key":"10.1016\/j.ypmed.2022.107384_bb0050","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.annonc.2020.02.011","article-title":"Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA","volume":"31","author":"Liu","year":"2020","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.ypmed.2022.107384_bb0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13148-021-01180-9","article-title":"Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity","volume":"13","author":"Pinzon Cortes","year":"2021","journal-title":"Clin. Epigenetics"},{"issue":"2","key":"10.1016\/j.ypmed.2022.107384_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.trecan.2019.12.006","article-title":"Diagnostic power of DNA methylation classifiers for early detection of Cancer","volume":"6","author":"Roy","year":"2020","journal-title":"Trends Cancer"},{"issue":"Suppl. 7","key":"10.1016\/j.ypmed.2022.107384_bb0065","doi-asserted-by":"crossref","first-page":"S961","DOI":"10.1016\/j.annonc.2022.07.1029","article-title":"A prospective study of a multi-cancer early detection blood test","volume":"33","author":"Schrag","year":"2022","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ypmed.2022.107384_bb0070","author":"Surveillance, Epidemiology, and End Results (SEER) Program"},{"issue":"4","key":"10.1016\/j.ypmed.2022.107384_bb0075","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ccell.2019.09.003","article-title":"Toward the early detection of cancer by decoding the epigenetic and environmental fingerprints of cell-free DNA","volume":"36","author":"van der Pol","year":"2019","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.ypmed.2022.107384_bb0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41416-020-01038-6","article-title":"Cancer health disparities in racial\/ethnic minorities in the United States","volume":"124","author":"Zavala","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.ypmed.2022.107384_bb0085","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4161\/epi.6.5.15335","article-title":"Significant differences in global genomic DNA methylation by gender and race\/ethnicity in peripheral blood","volume":"6","author":"Zhang","year":"2011","journal-title":"Epigenetics."}],"container-title":["Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743522004492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091743522004492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:16:40Z","timestamp":1758795400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091743522004492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":17,"alternative-id":["S0091743522004492"],"URL":"https:\/\/doi.org\/10.1016\/j.ypmed.2022.107384","relation":{},"ISSN":["0091-7435"],"issn-type":[{"value":"0091-7435","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity","name":"articletitle","label":"Article Title"},{"value":"Preventive Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ypmed.2022.107384","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107384"}}