{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:51:53Z","timestamp":1792065113595,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1016\/j.yrtph.2003.07.003","type":"journal-article","created":{"date-parts":[[2003,10,11]],"date-time":"2003-10-11T09:41:53Z","timestamp":1065865313000},"page":"368-377","source":"Crossref","is-referenced-by-count":37,"title":["Detection of endocrine-modulating effects of the antithyroid acting drug 6-propyl-2-thiouracil in rats, based on the \u201cEnhanced OECD Test Guideline 407\u201d"],"prefix":"10.1016","volume":"38","author":[{"given":"W.","family":"Mellert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Deckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gfatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"van Ravenzwaay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2003.07.003_BIB1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s002040100214","volume":"75","author":"Andrews","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s00204-002-0337-7","article-title":"Sensitive detection of the endocrine effects of the estrogen analogue ethinylestradiol using a modified enhanced subacute rat study protocol (OECD Test Guideline No. 407)","volume":"76","author":"Andrews","year":"2002","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0887-2333(01)00045-5","article-title":"Endocrine disrupters\u2014testing strategies to assess human hazard","volume":"15","author":"Baker","year":"2001","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/taap.1994.1158","article-title":"Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: different effects of in utero versus lactational exposure","volume":"127","author":"Bjerke","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB5","unstructured":"BMU, 2002. Chemicals Act, Chemikaliengesetz [Act on the Protection against Hazardous Substances]. Section 6: Good laboratory practice (GLP). Federal Environmental Ministry, Bonn"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0022-3476(75)80721-9","article-title":"Granulocytopenia and hemolytic anemia as complications of propylthiouracil therapy","volume":"86","author":"Breese","year":"1975","journal-title":"J. Pediatr."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/019262339702500109","article-title":"Mechanistic data and risk assessment of selected toxic end points of the thyroid gland","volume":"25","author":"Capen","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/393498","article-title":"Endocrine disruptors: present issues, future directions","volume":"75","author":"Crews","year":"2000","journal-title":"J. Q. Rev. Biol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0025-7125(16)30993-2","article-title":"Mechanism of action of thyroid hormones","volume":"69","author":"Dillmann","year":"1985","journal-title":"Med. Clin. North. Am."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB10","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/01621459.1955.10501294","article-title":"A multiple comparison procedure for comparing several treatments with a control","volume":"50","author":"Dunnett","year":"1955","journal-title":"JASA"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2307\/2528490","article-title":"New tables for multiple comparisons with a control","volume":"20","author":"Dunnett","year":"1964","journal-title":"Biometrics"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0041-008X(89)90098-7","article-title":"Reproductive toxicity of 2-methoxyethanol applied dermally to occluded and nonoccluded sites in male rats","volume":"100","author":"Feuston","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0026-0495(75)90079-7","article-title":"Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats","volume":"24","author":"Frumess","year":"1975","journal-title":"J. Metabol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/10408440091159185","article-title":"Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid activity in the female rat. A focus on the EDSTAC recommendations","volume":"30","author":"Goldman","year":"2000","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB15","first-page":"735","article-title":"Propylthiouracil-induced hemolytic anemia","volume":"64","author":"Kuo","year":"2001","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB16","first-page":"865","article-title":"Effects of diethylstilbestrol and propylthiouracil on the rat pituitary. An immunohistochemical and ultrastructural study","volume":"79","author":"Lloyed","year":"1987","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/toxsci\/60.1.63","article-title":"Evaluation of the male pubertal assay\u2019s ability to detect thyroid inhibitors and dopaminergic agents","volume":"60","author":"Marty","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB18","first-page":"205","article-title":"Mechanism of action of thyroid hormones at the cellular level","volume":"44","author":"Menezes-Ferreira","year":"1983","journal-title":"Ann. Endocrinol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB19","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/019262330002800311","article-title":"Endocrine modulators in the food chain and environment","volume":"28","author":"Nilsson","year":"2000","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/toxsci\/51.1.54","article-title":"Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure","volume":"51","author":"O\u2019Connor","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB21","unstructured":"OECD, 1981. Decision of the Council Concerning the Mutual Acceptance of Data in the Assessment of Chemicals [C(81)30(Final)] (Adopted by the Council at its 535th meeting on May 12, 1981). In OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring, No. 1. The OECD Principles of Good Laboratory Practice, Environmental Monograph No. 45. Environment Directorate, Organisation for Economic Co-operation and Development, Paris, 1992"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB22","doi-asserted-by":"crossref","unstructured":"OECD, 1995. OECD Guideline No. 407. OECD Test Guidelines for Testing of Chemicals, Section 4, Health Effects (updated 27 July, 1995). Organisation for Economic Co-operation and Development, Paris","DOI":"10.1787\/9789264070967-en"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB23","unstructured":"OECD, 1999. OECD Protocol for Investigating the Efficacy of the Enhanced Test Guideline 407 (issued 4 August, 1999). Organisation for Economic Co-operation and Development, Paris"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB24","unstructured":"OECD, 2000. OECD Protocol for Investigating the Efficacy of the Enhanced TG 407 Test Guideline (Phase 2). Rationale for the investigation, and description of the protocol (issued 4 May, 2000). Organisation for Economic Co-operation and Development, Paris"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s002040100273","article-title":"A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the \u2018enhanced OECD Test Guideline 407\u2019 for screening endocrine-disrupting chemicals","volume":"75","author":"Okazaki","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00204-001-0292-8","article-title":"A repeated 28-day oral dose toxicity study of 17alpha-methyltestosterone in rats, based on the \u2018enhanced OECD Test Guideline 407\u2019 for screening the endocrine-disrupting chemicals","volume":"75","author":"Okazaki","year":"2002","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00204-002-0376-0","article-title":"A repeated 28-day oral dose toxicity study of genistein in rats, based on the \u2018Enhanced OECD Test Guideline 407\u2019 for screening endocrine-disrupting chemicals","volume":"76","author":"Okazaki","year":"2002","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB28","first-page":"806","article-title":"Propylthiouracil-associated hemolytic anemia, thrombocytopenia, and antinuclear antibodies in cats with hyperthyroidism","volume":"184","author":"Peterson","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB29","series-title":"Non-Parametric Statistics for the Behavioural Sciences","author":"Siegel","year":"1956"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB30","first-page":"30,197","article-title":"Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Endocrine Disrupter Screening and Testing Advisory Committee","author":"Stoker","year":"2000","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/endo-98-4-1031","article-title":"The mechanism of action of the thioureylene antithyroid drugs","volume":"98","author":"Taurog","year":"1976","journal-title":"Endocrinology"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s002040050664","article-title":"Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the \u2018Enhanced OECD Test Guideline 407\u2019 for screening for endocrine-disrupting chemicals","volume":"74","author":"Toyoda","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB33","first-page":"668","article-title":"The use of antithyroid drugs in the medical management of feline hyperthyroidism","volume":"2","author":"Trepanier","year":"1990","journal-title":"Probl. Vet. Med."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1203\/00006450-198102000-00019","article-title":"Control of puberty in female rats: the effect of PTU-induced hypothyroidism and systemic undernutrition","volume":"15","author":"Wilen","year":"1981","journal-title":"Pedriatr. Res."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00204-001-0319-1","article-title":"Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the \u2018Enhanced OECD Test Guideline No. 407\u2019","volume":"76","author":"Yamasaki","year":"2002","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2003.07.003_BIB36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0300-483X(02)00160-9","article-title":"Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the \u2018Enhanced OECD Test Guideline No. 407\u2019","volume":"176","author":"Yamasaki","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2003.07.003_BIB37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00204-002-0371-5","article-title":"Comparison of toxicity studies based on the draft protocol for the \u2018Enhanced OECD Test Guideline No. 407\u2019 and the research protocol of \u2018Pubertal Development and Thyroid Function in Immature Male Rats\u2019 with 6-n-propyl-2-thiouracil","volume":"76","author":"Yamasaki","year":"2002","journal-title":"Arch. Toxicol."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230003001028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230003001028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T18:26:29Z","timestamp":1550687189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230003001028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0273230003001028"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2003.07.003","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}