{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:35:08Z","timestamp":1791311708818,"version":"4.3.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.yrtph.2003.12.006","type":"journal-article","created":{"date-parts":[[2004,2,28]],"date-time":"2004-02-28T10:31:43Z","timestamp":1077964303000},"page":"158-183","source":"Crossref","is-referenced-by-count":376,"title":["Ranking and prioritization of environmental risks of pharmaceuticals in surface waters"],"prefix":"10.1016","volume":"39","author":[{"given":"Hans","family":"Sanderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Reitsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Brain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2003.12.006_BIB1","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1897\/01-386","article-title":"Mixture toxicity and its modeling by quantitative structure\u2013activity relationships","volume":"22","author":"Altenburger","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB2","unstructured":"Ashton, D., Kennedy, J., Thomas, K., Hilton, M., 2003. Evaluating the environmental risks of pharmaceuticals. Poster at SETAC 13th annual meeting Hamburg"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB3","doi-asserted-by":"crossref","unstructured":"ASTM, 1216, 1993. In: Gorsuch, J.W., Dwyer, F.J., Ingersoll, C.G., LaPoint, T.W. (Eds.), Environmental Toxicology and Risk Assessment, vol. 2, pp. 521\u2013619. Section on SAR\/QSAR in the Office of Pollution Prevention and Toxics. ASTM STP 1216, American Society for Testing and Materials, PA, USA","DOI":"10.1520\/STP1216-EB"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0378-4274(03)00067-5","article-title":"Prioritization of veterinary medicines in the UK environment","volume":"142","author":"Boxall","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1021\/es032519b","article-title":"Are veterinary medicines causing environmental risks?","volume":"37","author":"Boxall","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB6","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1897\/01-234","article-title":"Overview of data and conceptual approaches for deviation of Quantitative Structure-Activity Relationships for ecotoxicological effects of organic chemicals","volume":"22","author":"Bradbury","year":"2003","journal-title":"Environ. Tox. Chem."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB7","unstructured":"Canada, 2001. A Canadian perspective on the precautionary approach\/principle, discussion document. http:\/\/www.pco-bcp.gc.ca\/raoics-srdc\/docs\/precaution\/Discussion\/discussion_e.htm"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1021\/es020158e","article-title":"Stregic survey of therapeutic drugs in the rivers Po and Lambro in northern Italia","volume":"37","author":"Calamari","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB9","doi-asserted-by":"crossref","first-page":"147A","DOI":"10.1021\/es0324003","article-title":"Does ecotoxicology inform ecological risk assessment?","volume":"37","author":"Calow","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB10","unstructured":"Carlsen, L., 2003. An Introduction to QSAR for Regulatory Applications. Nordisk Minister\u00e5, Copenhagen, Denmark, in press"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB11","unstructured":"CDER, 1998. Guidance for industry. Environmental assessment of human drug and biologics applications. USFDA. www.fda.gov\/cder\/guidance\/index.htm"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/rtph.1998.1253","article-title":"Pharmaceuticals in the environment\u2014A human risk?","volume":"28","author":"Christensen","year":"1998","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB13","unstructured":"CLASSIC, 2002. In: Giddings, J.M. (Ed.), Community Level Aquatic System Studies\u2014Interpretation Criteria. SETAC"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB14","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1021\/es00006a009","article-title":"Fugacity analysis and model of organic chemical fate in a sewage treatment plant","volume":"29","author":"Clark","year":"1995","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-4274(03)00068-7","article-title":"Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects","volume":"142","author":"Cleuvers","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB16","doi-asserted-by":"crossref","unstructured":"Cleuvers, M., 2004. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid. Ecotoxicol. Environ. Saf., in press","DOI":"10.1016\/S0147-6513(03)00141-6"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB17","unstructured":"Cunningham, V.L., Constable, D.C., 2002. Preliminary GSK model for estimating POTW removals for pharmaceutical compounds. Poster P-421, SETAC 23rd Annual Meeting in North America, 16\u201320 November, Salt Lake City Utah, US"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","article-title":"Special report. Pharmaceuticals and personal care products in the environment: agents of subtle change?","volume":"107","author":"Daughton","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1289\/ehp.5947","article-title":"Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. 1. Rationale for and avenues toward a green pharmacy","volume":"111","author":"Daughton","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB20","unstructured":"Danish Board of Technology, 1996. The non-assessed chemicals in EU. Report 1996\/5"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB21","unstructured":"DK-EPA, 2001. Report on the advisory list for selfclassification of dangerous substances. Environmental Project No. 636. Danish Environmental Protection Agency"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1353\/pbm.2002.0067","article-title":"Proof of causality","volume":"45","author":"Doll","year":"2002","journal-title":"Perspect. Biol. Med."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB23","unstructured":"EMEA, 2003. The European Agency for the Evaluation of Medicinal Products Pre-Authorization Evaluation of Medicines for Human Use. Committee for proprietary medicinal products, draft note for guidance on environmental risk assessment of medicinal products for human use. CPMP\/SWP\/4447\/00 draft. www.emea.eu.int"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB24","doi-asserted-by":"crossref","unstructured":"Environmental Toxicology and Chemistry, 2003. In: Walker, J.D. (Ed.), Special Issue on QSAR, vol. 22, No. 8","DOI":"10.1897\/03-189"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB25","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1021\/es015848h","article-title":"Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs and mixture effects. A critical review","volume":"36","author":"Escher","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB26","unstructured":"EU, 2000. Communication from the commission on the precautionary principle. COM (2000) 1. Brussels 2\/2-2000. http:\/\/europa.eu.int\/eur-lex\/en\/com\/cnc\/2000\/com2000_0001en01.pdf"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB27","unstructured":"EU, 2001a. CSTEE. Discussion paper on environmental risk assessment of medical products for human use (non-genetically modified organisms (non-GMO) containing). CPMPpaperRAssessHumPharm12062001\/D(01). Brussels, Belgium"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB28","unstructured":"EU, 2001b. White paper. Strategy for a future chemicals policy, COM (2001) 88 Final. http:\/\/europa.eu.int\/comm\/environment\/chemicals\/0188_16en.pdf (accessed 08-08-03)"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB29","unstructured":"EU, 2001c. Communication from the commission on a community strategy against antimicrobial resistance. http:\/\/europa.eu.int\/comm\/health\/ph\/others\/antimicrob_resist\/am_02_en.pdf (accessed 08-08-03)"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB30","unstructured":"EU, 2002. EU Food Law News (02-137) Commission press release (IP\/02\/1891), 16-12-02. Council backs prohibition of antibiotics as growth promoters: Byrne welcomes political agreement on feed additives. http:\/\/www.foodlaw.rdg.ac.uk\/news\/eu-02137.htm (accessed 08-08-03)."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB31","unstructured":"FDA, 1995. Centre for drug evaluation and research (CDER). Guidance for industry for the submission of an environmental assessment in human drug applications and supplements, Food and Drug Administration, 1995"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0045-6535(97)00354-8","article-title":"Occurrence, fate and effects of pharmaceutical substances in the environment\u2014a review","volume":"36","author":"Halling-S\u00f8rensen","year":"1998","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","article-title":"Occurrence, fate, and removal of pharmaceutical residues in the aquatic envionment: a review of recent research data","volume":"131","author":"Heberer","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0048-9697(98)00337-4","article-title":"Occurrence of antibiotics in the aquatic environment","volume":"225","author":"Hirsch","year":"1999","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB35","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/713609967","article-title":"The precautionary principle in practice: applying the Ashford framework to technological risk","volume":"9","author":"Hornbaker","year":"2003","journal-title":"Hum. Ecol. Risk Assess."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB36","unstructured":"Howard, P.H., 1998. User\u2019s guide for the SMILES CAS program. http:\/\/esc.syrres.com\/interkow\/docsmile.htm (0707-2003)"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB37","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1080\/09593332208618186","article-title":"Human pharmaceuticals in the aquatic environment\u2014a review","volume":"22","author":"Jones","year":"2001","journal-title":"Environ. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB38","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1016\/S0043-1354(02)00227-0","article-title":"Aquatic environmental assessment of the top 25 English prescription pharmaceuticals","volume":"36","author":"Jones","year":"2002","journal-title":"Water Res."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB39","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0045-6535(99)00438-5","article-title":"Editorial: drugs in the environment","volume":"40","author":"J\u00f8rgensen","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2166\/wqrj.1999.006","article-title":"A note of caution to users of ECOSAR","volume":"34","author":"Kaiser","year":"1999","journal-title":"Water Qual. Res. J. Can."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB41","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/etc.5620190225","article-title":"Multiple computer-automated structure evaluation study of aquatic toxicity II. Fathead minnow","volume":"19","author":"Klopman","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB42","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","article-title":"Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S streams, 1999\u20132000: a national reconnaissance","volume":"36","author":"Kolpin","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB43","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0045-6535(01)00144-8","article-title":"Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources\u2014a review","volume":"45","author":"K\u00fcmmerer","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB44","doi-asserted-by":"crossref","unstructured":"Lam, M.W., Young, C.J., Brain, R.A., Johnson, D.J., Hanson, M.A., Wilson, C.J., Richards, S.M., Solomon, K.R., Mabury, S.A., 2003. The aquatic persistence of eight pharmaceuticals in outdoor microcosms monitored by HPLC-UV and LC\u2013MS-MS using electrospray ionization. Environ. Toxicol. Chem., in press","DOI":"10.1897\/03-421"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB45","unstructured":"Martindale, 2002. In: Sweetman, S.C. (Ed.), Martindale, The Complete Drug Reference, 33rd ed. Pharmaceutical Press Chicago, USA, 2483 pp"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB46","series-title":"User\u2019s Guide for the ECOSAR & EPIWIN Class Programs","author":"Meyland","year":"1998"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB47","series-title":"User\u2019s guide for the EPIWIN suite","author":"Meyland","year":"1999"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0048-9697(98)00338-6","article-title":"The exposure assessment of veterinary medicinal products","volume":"225","author":"Montsford","year":"1999","journal-title":"Sci. Tot. Env."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB49","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1897\/00-361","article-title":"A comparison of model performance for six quantitative structure\u2013activity relationship packages that predict acute toxicity to fish","volume":"22","author":"Moore","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB50","doi-asserted-by":"crossref","unstructured":"Nabholz, V.J., Clements, R.G., Zeeman, M.G., Osborn, K.C., Wedge, R., 1993. Validation of structure activity relationships used by the USEPA\u2019s office of pollution prevention and toxics for the environmental hazard assessment of industrial chemicals. In: Gorsuch, J.W., Dwyer, F.J., Ingersoll, C.G., LaPoint, T.W. (Eds.), Environmental Toxicology and Risk Assessment, vol. 2, ASTM, 1216. 1993. ASTM STP 1216, American Society for Testing and Materials, PA, USA, pp. 571\u2013591","DOI":"10.1520\/STP13178S"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB51","unstructured":"Nabholz, V.J., 2001. SAR validation study. Poster Presentation at Society of Toxicology annual meeting March 2001 in San Francisco, USA"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB52","first-page":"10","article-title":"Human health impact and regulatory issuses involving antimicrobial resistance in the food animal production environment","volume":"1","author":"Nawaz","year":"2001","journal-title":"Reg. Res. Persp."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB53","unstructured":"NSF, 2003. A 10-year outlook for the United States National Science Foundation: Complex environmental systems, synthesis for earth, life, and society in the 21st century. http:\/\/www.nsf.gov\/geo\/ere\/ereweb\/acere_synthesis_rpt.cfm (accessed 08-08-03)"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/20028091056836","article-title":"The health of ecology and the ecology of health","volume":"8","author":"Rapport","year":"2002","journal-title":"Hum. Ecol. Risk Assess."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB55","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0045-6535(02)00387-9","article-title":"Identification and significance of phenazone drugs and their metabolites in ground- and drinking water","volume":"49","author":"Reddersen","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB56","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0045-6535(03)00573-3","article-title":"Ecotoxicity prediction using mechanism- and non-mechanism-based QSARs: a preliminary study","volume":"53","author":"Ren","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2042-7158.1985.tb04922.x","article-title":"The fate of pharmaceutical chemicals in the aquatic environment\u2014a review","volume":"37","author":"Richardson","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB58","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB59","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02987494","article-title":"Power analysis as a reflexive scientific tool for interpretation and implementation of the precautionary principle in the European Union","volume":"9","author":"Sanderson","year":"2002","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB60","unstructured":"Sanderson, H., 2002. Design, analysis and interpretation of higher tier risk assessment of chemicals in aquatic microcosms. Doctoral dissertation, University of Roskilde, Denmark. http:\/\/www.ruc.dk\/teksam\/phdinfo\/hans (accessed 08-08-03)"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB61","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-4274(03)00257-1","article-title":"Probabilistic hazard assessment of environmentally ccurring pharmaceuticals acute toxicity to fish, daphnids and algae by ECOSAR screening","volume":"144","author":"Sanderson","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB62","unstructured":"Sanderson, H., Dyer, S., Nabholz, V.J., 2004. QSAR\u2019s and extrapolation. In: Solomon, KR., Sibley, PL., Sanderson, H., Richards, SM., Dyer, S., Brock, TCM., van den Brink, P., Posthuma, L., de Zwart, D., Extrapolation practice for ecological effect characterization of chemicals (EXPECT), SETAC Press, In prep"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB63","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1897\/01-345","article-title":"Quantitative structure\u2013activity relation models for prediction of estrogen receptor binding affinity of structurally diverse chemicals","volume":"22","author":"Schmieder","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-4274(02)00045-0","article-title":"Pharmacodynamic activity of drugs and ecotoxicology\u2014can the two be connected?","volume":"131","author":"Seiler","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB65","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-4274(02)00049-8","article-title":"Environmental risk assessment for new human pharmaceuticals in the Euorpean Union according to the draft guideline\/discussion paper of January 2001","volume":"131","author":"Straub","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB66","unstructured":"Stuer-Lauridsen, F., Hansen, L., Birkved, M., Kj\u00f8lholt, J., Mikkelsen, S., 2002. Litteraturudredning vedr\u00f8rende human medicin i milj\u00f8et. Milj\u00f8projekt Nr. 661. Danish EPA"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB67","first-page":"1","article-title":"Development of quantitative structure\u2013activity relations (QSARs) and their use for priority setting in the testing strategy of endocrine disruptors","volume":"1","author":"Tong","year":"2002","journal-title":"Reg. Res. Perspect."},{"key":"10.1016\/j.yrtph.2003.12.006_BIB68","unstructured":"US Federal Register, 1999. Category for persistent, bioaccumulation and toxic new chemical substances, Environmental Protection Agency, vol. 64, No. 213, November 4, p. 60198"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB69","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.1090956","article-title":"Genetic analysis of a high-level Vancomycin-resistant isolate of Stphylococcus aureus","volume":"302","author":"Weigel","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB70","unstructured":"WHO, 1997. The medical impact of antimicrobial use in food animals. World Health Organization emerging and other communicable diseases, surveillance and control. Berlin, Germany"},{"key":"10.1016\/j.yrtph.2003.12.006_BIB71","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/10629369508234003","article-title":"U.S. EPA regulatory perspectives on the use of QSAR for new and existing chemical evaluations","volume":"3","author":"Zeeman","year":"1995","journal-title":"SAR QSAR Environ. Res."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230004000029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230004000029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T07:06:44Z","timestamp":1585638404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230004000029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0273230004000029"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2003.12.006","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}