{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:27:01Z","timestamp":1790641621820,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.yrtph.2006.01.001","type":"journal-article","created":{"date-parts":[[2006,2,11]],"date-time":"2006-02-11T12:14:43Z","timestamp":1139660083000},"page":"268-281","source":"Crossref","is-referenced-by-count":15,"title":["Development of a reference dose for the persistent congeners of weathered toxaphene based on in vivo and in vitro effects related to tumor promotion"],"prefix":"10.1016","volume":"44","author":[{"given":"Ted","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2006.01.001_bib1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0045-6535(96)00024-0","article-title":"Capillary GC-ECD and ECNI GCMS characterization of toxaphene residues in primate tissues during a feeding study","volume":"32","author":"Andrews","year":"1996","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2006.01.001_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0045-6535(99)00121-6","article-title":"The role of biotic and abiotic degradation processes during the formation of typical toxaphene peak patterns in aquatic biota","volume":"39","author":"Angerhofer","year":"1999","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2006.01.001_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3402\/ijch.v63i3.17720","article-title":"Heart defects and other malformations in the Inuit in Canada: a baseline study","volume":"63","author":"Arbour","year":"2004","journal-title":"Int. J. Circumpolar Health"},{"key":"10.1016\/j.yrtph.2006.01.001_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/009841000156970","article-title":"Toxaphene is antiestrogenic in a human breast-cancer cell assay","volume":"59","author":"Arcaro","year":"2000","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.yrtph.2006.01.001_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0278-6915(00)00151-4","article-title":"Toxicological consequences of toxaphene ingestion by cynomolgus (Macaca fascicularis) monkeys. Part 1: pre-mating phase","volume":"39","author":"Arnold","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0009-2797(97)03759-9","article-title":"The ability to alter gap junction protein expression outside GST-P positive foci in liver of rats was associated to the tumour promotion potency of different polychlorinated biphenyls","volume":"103","author":"Bager","year":"1997","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.yrtph.2006.01.001_bib7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0273-2300(88)90047-5","article-title":"Reference dose (RfD): description and use in health risk assessments","volume":"8","author":"Barnes","year":"1988","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00244-003-3128-0","article-title":"Measurement of toxaphene congeners in pooled human serum collected in three US cities using high-resolution mass spectrometry","volume":"46","author":"Barr","year":"2004","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mrgentox.2004.09.007","article-title":"Genotoxic activity of a technical toxaphene mixture and its photodegradation products in SOS genotoxicity tests","volume":"565","author":"Bartos","year":"2005","journal-title":"Mutation Res."},{"key":"10.1016\/j.yrtph.2006.01.001_bib10","first-page":"113","article-title":"In vitro and in vivo tumor promoting potency of technical toxaphene, uv-irradiated toxaphene, and biotransformed toxaphene","volume":"47","author":"Besselink","year":"2000","journal-title":"Organohalogen Compounds"},{"key":"10.1016\/j.yrtph.2006.01.001_bib11","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1016\/j.atmosenv.2004.01.047","article-title":"Interlaboratory study of toxaphene analysis in ambient air","volume":"38","author":"Bidleman","year":"2004","journal-title":"Atmos. Environ."},{"issue":"1\u20132","key":"10.1016\/j.yrtph.2006.01.001_bib12","first-page":"156","article-title":"Studies on the tissue deposition and fate of [14C]toxaphene in Japanese Quail","volume":"28","author":"Biessman","year":"1983","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2006.01.001_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/009841001455490","article-title":"Exposure of Inuit in Greenland to organochlorines through the marine diet","volume":"62","author":"Bjerregaard","year":"2001","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.yrtph.2006.01.001_bib14","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/carcin\/18.8.1651","article-title":"Effect of toxaphene on estrogen receptor functions in human breast cancer cells","volume":"18","author":"Bonefield","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yrtph.2006.01.001_bib15","first-page":"385","article-title":"The use of a microsomal in vitro assay to study phase I biotransformation of chlorobornanes (Toxaphene) in marine mammals and birds. Possible consequences of biotransformation for bioaccumulation and genotoxicity","volume":"121","author":"Boon","year":"1998","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.yrtph.2006.01.001_bib16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0278-6915(01)00068-0","article-title":"Effects elicited by toxaphene in cynomolgus monkey (Macaca fascicularis): a pilot study","volume":"29","author":"Bryce","year":"2001","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.yrtph.2006.01.001_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2486\/indhealth.42.321","article-title":"Cancer risk assessment of toxaphene","volume":"42","author":"Buranatrevedh","year":"2004","journal-title":"Ind. Health"},{"key":"10.1016\/j.yrtph.2006.01.001_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-483X(97)00145-5","article-title":"Toxaphene congeners differ from toxaphene mixtures in their dysmorphogenic effects on cultured rat embryos","volume":"124","author":"Calciu","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2006.01.001_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-483X(02)00075-6","article-title":"Interactive dysmorphogenic effects of toxaphene or toxaphene congeners and hyperglycemia on cultured whole rat embryos during organogenesis","volume":"175","author":"Calciu","year":"2002","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.yrtph.2006.01.001_bib20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1289\/ehp.97105316","article-title":"Evaluation of the population distribution of dietary contaminant exposure in an arctic population using monte carlo statistics","volume":"105","author":"Chan","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2006.01.001_bib21","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0045-6535(97)10075-3","article-title":"Determination of toxaphene in biological samples using high-resolution GC couples with ion trap MS\/MS","volume":"36","author":"Chan","year":"1998","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2006.01.001_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0045-6535(99)00479-8","article-title":"Total toxaphene and specific congeners in fish from the Yukon, Canada","volume":"41","author":"Chan","year":"2000","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.yrtph.2006.01.001_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/03601238809372591","article-title":"Reproduction study of toxaphene in the rat","volume":"23","author":"Chu","year":"1988","journal-title":"J. Environ. Sci. Health B"},{"key":"10.1016\/j.yrtph.2006.01.001_bib24","first-page":"339","article-title":"An improved procedure for low-dose carcinogenic risk assessment from animal data","volume":"5","author":"Crump","year":"1984","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0041-008X(72)90192-5","article-title":"Detection of chemical mutagens by the dominant lethal assay in the mouse","volume":"23","author":"Epstein","year":"1972","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2006.01.001_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1289\/ehp.00108s113","article-title":"Mechanisms underlying children\u2019s susceptibility to environmental toxicants","volume":"108","author":"Faustman","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2006.01.001_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jcb.240410206","article-title":"Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis","volume":"41","author":"Fitzgerald","year":"1989","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yrtph.2006.01.001_bib28","first-page":"23","article-title":"Cancer incidence by ethnic group in the Northwest Territories","volume":"5","author":"Gaudette","year":"1993","journal-title":"Health Rep."},{"issue":"2","key":"10.1016\/j.yrtph.2006.01.001_bib29","first-page":"29","article-title":"Trends in breast cancer incidence and mortality","volume":"8","author":"Gaudette","year":"1996","journal-title":"Health Rep."},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2006.01.001_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1289\/ehp.99107s1115","article-title":"Environmental occurrence, analysis, and toxicology of toxaphene compounds","volume":"107","author":"de Geus","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2006.01.001_bib31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1039\/b002867n","article-title":"Toxaphene: a challenging analytical problem","volume":"2","author":"de Geus","year":"2000","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.yrtph.2006.01.001_bib32","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0045-6535(96)00243-3","article-title":"Congener specific analysis of toxaphene in serum using ECNI-MS","volume":"33","author":"Gill","year":"1996","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2006.01.001_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/55.1.3","article-title":"Reevaluation of the cancer potency factor of toxaphene: recommendations from a peer review panel","volume":"55","author":"Goodman","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2006.01.001_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0045-6535(00)00419-7","article-title":"Environmental fate of chlorinated bornanes estimated by theoretical descriptors","volume":"43","author":"Heimstad","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2006.01.001_bib35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1126\/science.377495","article-title":"Toxaphene, a complex mixture of polychlorinated terpenes and a major insecticide, is mutagenic","volume":"205","author":"Hooper","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.yrtph.2006.01.001_bib36","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/0192623389017004108","article-title":"Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker","volume":"17","author":"Ito","year":"1989","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib37","first-page":"192","article-title":"Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixture","volume":"104","author":"Kang","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2006.01.001_bib38","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/carcin\/16.3.531","article-title":"Two types of normal human breast epithelial cells derived from reduction mammoplasty: phenotypic characterisation and response to SV40 transfection","volume":"16","author":"Kao","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yrtph.2006.01.001_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0300-483X(00)00162-1","article-title":"Inhibition of gap-junctional intercellualar communication in intact rat liver by nongenotoxic hepatocarcinogens","volume":"146","author":"Kolaja","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2006.01.001_bib40","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/carcin\/12.9.1701","article-title":"Sequential changes of gap junctional intercellular communications during multistage rat liver carcinogenesis: direct measurements of communication in vivo","volume":"112","author":"Krutovskikh","year":"1991","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.yrtph.2006.01.001_bib41","doi-asserted-by":"crossref","first-page":"A313","DOI":"10.1289\/ehp.021100313","article-title":"Chemical contaminants in breast milk and their impacts on children\u2019s health: an overview","volume":"110","author":"Landrigan","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2006.01.001_bib42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3402\/ijch.v63i0.17819","article-title":"Mortality in the Kivalliq Region of Nunavut, 1987\u20131996","volume":"63","author":"Macaulay","year":"2004","journal-title":"Int. J. Circumpolar Health"},{"key":"10.1016\/j.yrtph.2006.01.001_bib43","doi-asserted-by":"crossref","unstructured":"Maruya, K., 2000. Analysis of Toxaphene Residues in Fin- and Shellfish from Terry\/Dupree Creek, Glynn County, GA, submitted to Dr. Randall Manning, Georgia EPD.","DOI":"10.2307\/1353259"},{"key":"10.1016\/j.yrtph.2006.01.001_bib44","unstructured":"MATT, 2000. Final Report, Investigation into the Monitoring, Analysis and Toxicity of Toxaphene in Marine Foodstuffs FAIR CT PL.96.3131."},{"key":"10.1016\/j.yrtph.2006.01.001_bib45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1039\/B403169E","article-title":"Baseline survey of concentrations of toxaphene congeners in fish from European waters","volume":"6","author":"McHugh","year":"2004","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.yrtph.2006.01.001_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00119297","article-title":"Limitations of the scrape-loading\/dye transfer technique to quantify inhibition of gap junctional intercellular communication","volume":"8","author":"McKarns","year":"1982","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib47","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3109\/02841869609096989","article-title":"Breast cancer in circumpolar Inuit 1969\u20131988","volume":"35","author":"Miller","year":"1996","journal-title":"Acta Oncol"},{"issue":"4","key":"10.1016\/j.yrtph.2006.01.001_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01234484","article-title":"Fate and specific tissue retention of toxaphene in mice","volume":"54","author":"Mohammed","year":"1983","journal-title":"Arch. Toxicol."},{"issue":"Suppl. 7","key":"10.1016\/j.yrtph.2006.01.001_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.2860080802","article-title":"Salmonella mutagenicity tests II. Results from the testing of 270 chemicals","volume":"8","author":"Mortelsman","year":"1986","journal-title":"Environ. Mutagen."},{"key":"10.1016\/j.yrtph.2006.01.001_bib50","unstructured":"National Toxicology Program (NTP), 1979. Bioassay of Toxaphene for Possible Carcinogenicity."},{"key":"10.1016\/j.yrtph.2006.01.001_bib51","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3109\/02841869609096996","article-title":"Cancer in circumpolar Inuit 1969\u20131988. A summary","volume":"35","author":"Nielsen","year":"1996","journal-title":"Acta Oncol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib52","unstructured":"OEHHA (CAL-EPA), 2003. Public health goal document for toxaphene in drinking water. <http:\/\/www.oehha.ca.gov\/water\/phg\/pdf\/Ph4Toxap92603.pdf\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib53","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF01055378","article-title":"Behavioral effects of juvenile rats from perinatal exposure to low levels of toxaphene and its toxic components, toxicant A and toxicant B","volume":"9","author":"Olson","year":"1980","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0048-9697(02)00492-8","article-title":"Geographic variation of chlorinated pesticides, toxaphenes and PCBs in human milk from sub-arctic and arctic locations in Russia","volume":"306","author":"Polder","year":"2003","journal-title":"Sci. Tot. Environ."},{"issue":"6","key":"10.1016\/j.yrtph.2006.01.001_bib55","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/03601238209372347","article-title":"The elimination, distribution, and metabolism of 14C-toxaphene in the pregnant rat","volume":"17","author":"Pollock","year":"1982","journal-title":"J. Environ. Sci. Health B"},{"issue":"1","key":"10.1016\/j.yrtph.2006.01.001_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/15287398009529836","article-title":"Excretion and storage of [14C]toxaphene and two isolated [14C]toxaphene fractions","volume":"6","author":"Pollock","year":"1980","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.yrtph.2006.01.001_bib57","unstructured":"Receveur, O., Kassi, N., Chan, H.M., Berti, P.R., Kuhnlein, H.V., 1998. Yukon first nations\u2019 assessment dietary benefit\/risk. Centre for Indigenous Peoples\u2019 Nutrition and Environment, Macdonald Campus of McGill University. <http:\/\/www.contaminants.ca\/done\/dietaryRiskStudy\/\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib58","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1897\/02-605","article-title":"Anaerobic transformation of compounds of technical toxaphene. 1. Regiospecific reaction of chlorobornanes with geminal chlorine atoms","volume":"22","author":"Ruppe","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2006.01.001_bib59","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1897\/03-221","article-title":"Anaerobic transformation of compounds of technical toxaphene. 2. Fate of compounds lacking geminal chlorine atoms","volume":"23","author":"Ruppe","year":"2004","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2006.01.001_bib60","first-page":"24","article-title":"Chromosomal aberrations and the character of satellite associations following accidental exposure of the human body to polychlorocamphene","volume":"8","author":"Samosh","year":"1974","journal-title":"Tsitol. Genet."},{"key":"10.1016\/j.yrtph.2006.01.001_bib61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0048-9697(02)00491-6","article-title":"Persistent Organic Pollutants in plasma of delivering women in Arkhangelsk","volume":"306","author":"Sandanger","year":"2003","journal-title":"Sci. Tot. Environ."},{"key":"10.1016\/j.yrtph.2006.01.001_bib62","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1021\/es010141g","article-title":"Analysis of \u201cTotal Toxaphene\u201d and selected single congeners in biota by ion trap HRGC-EI-MS\/MS using congener-optimized parent ion dissociations","volume":"36","author":"Skopp","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib63","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1039\/b200133k","article-title":"Enantiomer ratios, patterns and levels of toxaphene congeners in human milk from Germany","volume":"4","author":"Skopp","year":"2002","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.yrtph.2006.01.001_bib64","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00333901","article-title":"Cytogenic and cytogenetic effect of agricultural chemicals on human lymphoid cells in vitro. II. Organochlorine pesticides","volume":"52","author":"Sobti","year":"1983","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/neu.480110103","article-title":"Electrical and dye coupling in an identified group of neurons in a coelenterate","volume":"11","author":"Spencer","year":"1980","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib66","first-page":"243","article-title":"Mutagenicity studies with toxaphene congeners","volume":"35","author":"Steinberg","year":"1998","journal-title":"Organohalogen Compounds"},{"key":"10.1016\/j.yrtph.2006.01.001_bib67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0027-5107(90)90038-6","article-title":"SCE induction and cell cycle delay by toxaphene","volume":"230","author":"Steinel","year":"1990","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yrtph.2006.01.001_bib68","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0300-483X(99)00093-1","article-title":"The relative estrogenic activity of technical toxaphene mixture and two individual congeners","volume":"138","author":"Stelzer","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2006.01.001_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0278-6915(99)00122-2","article-title":"Effects of toxaphene on the immune system of cynomolgus (Macaca fascicularis) monkeys. A pilot study","volume":"38","author":"Tryphonas","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib70","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0278-6915(01)00035-7","article-title":"Effects of toxaphene on the immune system of cynomolgus (Macaca fascicularis) monkeys","volume":"39","author":"Tryphonas","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2006.01.001_bib71","unstructured":"USEPA, 1978. Occupational exposure to toxaphene. A Final Report by the Epidemiological Studies Program. OPPTS."},{"key":"10.1016\/j.yrtph.2006.01.001_bib72","unstructured":"USEPA, 1997a. Exposure factors handbook. <http:\/\/cfpub.epa.gov\/ncea\/cfm\/recordisplay.cfm?deid=12464\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib73","unstructured":"USEPA, 1997b. Summary of the US EPA Colloquia on a Framework for Human Health Risk Assessment, vol. 1, 1997. Washington, DC, EPA\/600\/R-99\/001."},{"key":"10.1016\/j.yrtph.2006.01.001_bib74","unstructured":"USEPA, 1998. Summary of the US EPA Colloquium on a Framework for Human Health Risk Assessment, vol. 2, 1998. Risk Assessment Forum, Washington, DC."},{"key":"10.1016\/j.yrtph.2006.01.001_bib75","unstructured":"USEPA, 2000. Benchmark Dose Technical Guidance Document, EPA 630\/R01\/001. <http:\/\/cfpub.epa.gov\/ncea\/cfm\/recordisplay.cfm?deid=20871\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib76","unstructured":"USEPA, 2004a. PROUCL Software v. 3.0. <http:\/\/www.epa.gov\/nerlesd1\/tsc\/software.htm\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib77","unstructured":"USEPA, 2004b. Preliminary Remediation Goals. <http:\/\/www.epa.gov\/region09\/waste\/sfund\/prg\/index.html\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib78","unstructured":"USEPA, 2005. Guidelines for Carcinogen Risk Assessment, EPA\/630\/P-03\/001F. <http:\/\/www.epa.gov\/ncea\/>."},{"key":"10.1016\/j.yrtph.2006.01.001_bib79","doi-asserted-by":"crossref","unstructured":"Van Oostdam, J., Donaldson, S.G., Feeley, M., Arnold, D., Ayotte, P., Bondy, G., Chan, L., Dewaily, E., Furgal, C.M., Kuhnlein, H., Loring, E., Muckle, G., Myles, E., Receveur, O., Tracy, B., Gill, U., Kalhok, S., 2005. Human health implications of environmental contaminants in Arctic Canada: A review. Sci Total Environ., 351\u2013352:165\u2013246 Epub.","DOI":"10.1016\/j.scitotenv.2005.03.034"},{"key":"10.1016\/j.yrtph.2006.01.001_bib80","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0048-9697(02)00319-4","article-title":"Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada","volume":"302","author":"Walker","year":"2003","journal-title":"Sci. Tot. Environ."},{"key":"10.1016\/j.yrtph.2006.01.001_bib81","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/carcin\/11.7.1051","article-title":"Gap junctional intercellular communication and carcinogenesis","volume":"11","author":"Yamasaki","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yrtph.2006.01.001_bib82","unstructured":"Young, J.C., Freeman, A.D., 2001. Bioavailability and mutagenicity of toxaphene after aging in anoxic soil environments. Report of work conducted under agreement 9C-R570 NASA with USEPA\u2019s ORD."},{"key":"10.1016\/j.yrtph.2006.01.001_bib83","unstructured":"Young, J.C., Freeman, A.D., 2004. Comparing the mutagenicity of toxaphene after aging in anoxic soils and accumulating in fish. Report of work conducted under agreement 1C-R234 NASA with USEPA\u2019s ORD."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027323000600002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027323000600002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T21:52:10Z","timestamp":1555451530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027323000600002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S027323000600002X"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2006.01.001","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}