{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:48:07Z","timestamp":1777600087398,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.yrtph.2008.05.010","type":"journal-article","created":{"date-parts":[[2008,5,24]],"date-time":"2008-05-24T05:17:34Z","timestamp":1211606254000},"page":"S57-S67","source":"Crossref","is-referenced-by-count":42,"special_numbering":"S","title":["Biomonitoring Equivalents (BE) dossier for acrylamide (AA) (CAS No. 79-06-1)"],"prefix":"10.1016","volume":"51","author":[{"given":"Sean M.","family":"Hays","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesa L.","family":"Aylward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2008.05.010_bib1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1289\/ehp.7337","article-title":"Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements","volume":"113","author":"Barr","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2008.05.010_bib2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0041-008X(91)90036-E","article-title":"Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat","volume":"111","author":"Bergmark","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1080\/00498250500356506","article-title":"Determination and quantification of urinary metabolites after dietary exposure to acrylamide","volume":"35","author":"Bjellaas","year":"2005","journal-title":"Xenobiotica"},{"key":"10.1016\/j.yrtph.2008.05.010_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/toxsci\/kfm091","article-title":"Comparison of estimated dietary intake of acrylamide with haemoglobin adducts of acrylamide and glycidamide","volume":"98","author":"Bjellaas","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2008.05.010_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jchromb.2005.07.042","article-title":"Determination of the major mercapturic acids of acrylamide and glycidamide in human urine by LC-ESI-MS\/MS","volume":"824","author":"Boettcher","year":"2005","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.yrtph.2008.05.010_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrgentox.2004.11.010","article-title":"Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population","volume":"580","author":"Boettcher","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yrtph.2008.05.010_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00204-005-0011-y","article-title":"Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide","volume":"80","author":"Boettcher","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib8","first-page":"157","article-title":"Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery","volume":"4","author":"Burek","year":"1980","journal-title":"J. Environ. Pathol. Toxicol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.taap.2005.03.003","article-title":"Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats","volume":"208","author":"Doerge","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mrgentox.2004.10.013","article-title":"DNA adducts derived from administration of acrylamide and glycidamide to mice and rats","volume":"580","author":"Doerge","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yrtph.2008.05.010_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfg165","article-title":"Risk assessment of acrylamide in foods","volume":"75","author":"Dybing","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2008.05.010_bib12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.fct.2004.11.004","article-title":"Human exposure and internal dose assessments of acrylamide in food","volume":"43","author":"Dybing","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib13","unstructured":"European Chemicals Bureau (ECB), 2002. European risk assessment report: acrylamide. Accessed 11\/30\/07 at http:\/\/ecb.jrc.it\/DOCUMENTS\/Existing-Chemicals\/RISK_ASSESSMENT\/REPORT\/acrylamidereport011.pdf."},{"key":"10.1016\/j.yrtph.2008.05.010_bib14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/toxsci\/kfi069","article-title":"Metabolism and hemoglobin adduct formation of acrylamide in humans","volume":"85","author":"Fennell","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2008.05.010_bib15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/toxsci\/kfl069","article-title":"Kinetics of elimination of urinary metabolites of acrylamide in humans","volume":"93","author":"Fennell","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2008.05.010_bib16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1158\/1055-9965.EPI-05-0647","article-title":"Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity","volume":"15","author":"Fuhr","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.yrtph.2008.05.010_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/annhyg\/meh019","article-title":"Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration","volume":"48","author":"Garde","year":"2004","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.yrtph.2008.05.010_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/toxsci\/kfi307","article-title":"Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts","volume":"88","author":"Ghanayem","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2008.05.010_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mrgentox.2004.11.008","article-title":"Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender","volume":"580","author":"Hagmar","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yrtph.2008.05.010_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yrtph.2006.08.004","article-title":"Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective","volume":"47","author":"Hays","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib21","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.yrtph.2008.05.004","article-title":"Guidelines for the derivation of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents Expert Workshop","volume":"51","author":"Hays","year":"2008","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0041-008X(86)90109-2","article-title":"Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats","volume":"85","author":"Johnson","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/15287390306368","article-title":"A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat","volume":"66","author":"Kirman","year":"2003","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.yrtph.2008.05.010_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/sj.jea.7500384","article-title":"Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State","volume":"15","author":"Kissel","year":"2005","journal-title":"J. Expo. Anal. Environ. Epidemiol."},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2008.05.010_bib25","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.yrtph.2008.05.007","article-title":"Guidelines for the communication of biomonitoring equivalents: report from the biomonitoring equivalents expert workshop","volume":"51","author":"LaKind","year":"2008","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/sj.jea.7500343","article-title":"Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination Survey (NHANES-III)","volume":"14","author":"Mage","year":"2004","journal-title":"J. Expo. Anal. Environ. Epidemiol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2005.12.001","article-title":"Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene","volume":"214","author":"Nong","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/sj.jea.7500119","article-title":"Pesticide exposure and creatinine variation among young children","volume":"10","author":"O\u2019Rourke","year":"2000","journal-title":"J. Expo. Anal. Environ. Epidemiol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0027-5107(76)90256-6","article-title":"Evaluation of genetic risks of alkylating agents. II. Hemoglobin as a dose monitor","volume":"34","author":"Osterman-Golkar","year":"1976","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yrtph.2008.05.010_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/0-387-24980-X_11","article-title":"In vitro studies of the influence of certain enzymes on the detoxification of acrylamide and glycidamide in blood","volume":"561","author":"Paulsson","year":"2005","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib31","doi-asserted-by":"crossref","first-page":"R700","DOI":"10.1152\/ajpregu.00500.2006","article-title":"Sex difference in urine concentration across differing ages, sodium intake, and level of kidney disease","volume":"292","author":"Perucca","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/ajcn\/75.3.561","article-title":"Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research","volume":"75","author":"Remer","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yrtph.2008.05.010_bib33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/ajcn.83.3.639","article-title":"Longitudinal examination of 24-h urinary iodine excretion in schoolchildren as a sensitive, hydration status-independent research tool for studying iodine status","volume":"83","author":"Remer","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yrtph.2008.05.010_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/10408440600851377","article-title":"Acrylamide: review of toxicity data and dose\u2013response analyses for cancer and noncancer effects","volume":"36","author":"Shipp","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.taap.2006.07.013","article-title":"Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide","volume":"217","author":"Tareke","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2008.05.010_bib36","unstructured":"United States Environmental Protection Agency (USEPA), 2007a. Acrylamide. Integrated Risk Information System (IRIS) record accessed 11\/30\/07 at http:\/\/toxnet.nlm.nih.gov\/."},{"key":"10.1016\/j.yrtph.2008.05.010_bib37","unstructured":"United States Environmental Protection Agency (USEPA), 2007b. Toxicological review of acrylamide (CAS No. 79-06-1). In support of summary information on the Integrated Risk Information System (IRIS) http:\/\/cfpub.epa.gov\/ncea\/cfm\/recordisplay.cfm?deid=187729."},{"key":"10.1016\/j.yrtph.2008.05.010_bib38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/tx600287w","article-title":"Physiologically based pharmacokinetic\/pharmacodynamic model for acrylamide and its metabolites in mice, rats, and humans","volume":"20","author":"Young","year":"2007","journal-title":"Chem. Res. Toxicol."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230008001049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230008001049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T12:45:57Z","timestamp":1557578757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230008001049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0273230008001049"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2008.05.010","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}